ライフサイエンスコーパス: germinal

1 of their alpha-tanycyte descendants from the germinal 3V wall.

2 This work identified the role of germinal cell kinase four (GCK-IV) kinases in cell death

3 lls to limit naive and, to a greater extent, germinal center (GC) B cell numbers.

4 While it is known that GHVs utilize host germinal center (GC) B cell responses during latency est

5 The mechanisms that regulate germinal center (GC) B cell responses in the spleen are

6 2 wk in the skin, correlating with increased germinal center (GC) B cell responses, a ~1,300-fold inc

7 or M2.loxP MHV68 in mice that express Cre in germinal center (GC) B cells (AID-Cre).

8 Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the for

9 Germinal center (GC) B cells at viral replication sites

10 However, it is mechanistically unclear how germinal center (GC) B cells differentiate into MBCs.

11 Germinal center (GC) B cells feature repression of many

12 cing analysis, we identified a population of germinal center (GC) B cells in the process of different

13 govern the differentiation of high-affinity germinal center (GC) B cells into memory B cells versus

14 hia muris infection in mice causes a loss of germinal center (GC) B cells that is accompanied by the

15 lly, FLs originate from highly proliferative germinal center (GC) B cells with proliferation strictly

16 oncentration of autoantibodies, frequency of germinal center (GC) B cells, and antigen-specific plasm

17 he relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart of

18 ent Ag encounter, naive B cells develop into germinal center (GC) B cells, which can further differen

19 defects in the development of follicular and germinal center (GC) B cells.

20 highly proliferative neoplasms derived from germinal center (GC) B cells.

21 ns of follicular helper T (T(fh)) cells with germinal center (GC) B cells.

22 Clearance of HIV-infected germinal center (GC) CD4(+) follicular helper T cells (T

23 dTomato(+)) ASC were most prevalent prior to germinal center (GC) formation, but total tdTomato(+) B

24 a B cell-specific coactivator essential for germinal center (GC) formation, forms a ternary complex

25 eletion of ATM in mice leads to reduction in germinal center (GC) frequency and size in response to i

26 on variable immunodeficiency (CVID) suggests germinal center (GC) hypoplasia, yet a subset of patient

27 High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by

28 ular helper (T(FH)) cells are fundamental in germinal center (GC) maturation and selection of antigen

29 They are considered to originate from pre-germinal center (GC) naive B cells.

30 posed, including B cell immunodominance and germinal center (GC) quantity and quality.

31 cGVHD is often driven by the germinal center (GC) reaction, in which T follicular hel

32 of highly specific Abs by B cells during the germinal center (GC) reaction.

33 cular helper T cells (Tfh) are essential for germinal center (GC) reactions in the lymph node that ge

34 Cs), cell types canonically generated during germinal center (GC) reactions.

35 ses but Tfh cells play critical roles during germinal center (GC) reactions.

36 revious evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desen

37 onstrated that the development of T(FH)s and germinal center (GC) response were crucially dependent o

38 timulation blockade (belatacept) to mitigate germinal center (GC) responses might increase efficacy a

39 Germinal center (GC) responses potentiate the generation

40 Germinal center (GC) responses require B cells to respon

41 Efficient generation of germinal center (GC) responses requires directed movemen

42 were found to regulate early, but not late, germinal center (GC) responses to control antigen-specif

43 n of TLR7-mediated Ab-forming cell (AFC) and germinal center (GC) responses, and SLE development has

44 articipate in either extrafollicular (EF) or germinal center (GC) responses.

45 Although the germinal center (GC) size and the number of GC B cells r

46 tion factor (TF) BACH2 at the expense of the germinal center (GC) TF BCL6, leading to pre-memory tran

47 uppressor functions in IgE production in the germinal center (GC) that work together to facilitate th

48 the receptor HVEM, is frequently mutated in germinal center (GC)-derived B cell lymphomas.

49 e into pathogenic T helper (Th)-17 cells and germinal center (GC)-promoting T follicular helper (Tfh)

50 ptor NR4A1/Sp1 complex bound to the proximal germinal center (GC)-rich region of the PD-L1 gene promo

51 ic antibodies, the B cell-response axis from germinal center activation to plasma cell differentiatio

52 e checkpoints during vaccination can promote germinal center activity and enhance HIV-1 Env antibody

53 n, providing evidence for the persistence of germinal center activity long after the period of active

54 HCV-specific neutralizing antibodies and the germinal center activity.CONCLUSIONWe identified a popul

55 roles in regulating Tfr-cell activity in the germinal center and in the development of ST2(+) Treg ce

56 or metastable transcriptional reprogramming (germinal center and memory B cells).

57 romotes autoreactive B cell expansion in the germinal center and serum autoantibody production, even

58 h nodes of STAT3-HIES patients showed normal germinal center architecture and CD138(+) plasma cells r

59 rotein levels linearly dictated expansion of germinal center B (GCB) cells and isotype-switched plasm

60 d a differentiated efficacy profile in human germinal center B and activated B cell-DLBCL cell lines

61 blocking or OX40 agonist antibodies increase germinal center B and T follicular helper cells and plas

62 As a consequence, loss of Pdap1 reduces germinal center B cell formation and impairs CSR and SHM

63 ly higher follicular T helper cell (Tfh) and germinal center B cell frequencies than adults.

64 As expected, PE-specific germinal center B cell production required Tfh cells.

65 These CD8(+) Tfh cells regulate the germinal center B cell response and control autoantibody

66 licular helper (Tfh) cells are essential for germinal center B cell responses.

67 Germinal center B cells (GCBCs) are critical for generat

68 , with 4 discrete COO phases: early and late germinal center B cells (GCBs) and early and late activa

69 ing T follicular helper cells, and increases germinal center B cells and autoantibodies in mice aged

70 1 by XBP-1s can enhance viral replication in germinal center B cells and contribute to the pathogenes

71 orrelated with decreased MHCII expression in germinal center B cells and diffuse large B cell lymphom

72 iggered T cells reduce the numbers of target germinal center B cells and follicular dendritic cells,

73 associated with reductions in the numbers of germinal center B cells and follicular dendritic cells.

74 ith cdAMP/Nano-11 expanded the population of germinal center B cells and follicular helper T cells in

75 s as well as the generation of IgE-producing germinal center B cells and PCs subsequent to primary an

76 IgA response revealed an expansion of IgA(+) germinal center B cells and plasma cells in mesenteric l

77 13 showed decreased numbers of Tfh cells and germinal center B cells and produced significantly fewer

78 dly lost their ability to differentiate into germinal center B cells and secrete donor-specific antib

79 Because germinal center B cells are thought to be the target of

80 centers and a striking reduction in Bcl-6(+) germinal center B cells but preservation of AID(+) B cel

81 onse in combination with robust infection of germinal center B cells is thought to precipitate lympho

82 , which was isolated from lymph-node-derived germinal center B cells of an elite controller and exhib

83 mbers of IgA-secreting cells, while elevated germinal center B cells were found in the mesenteric lym

84 tolerance requires the control of bystander germinal center B cells with low or no affinity for the

85 ctly binds to B cells, especially light-zone germinal center B cells, as well as to T follicular help

86 protein response and expressed in developing germinal center B cells, can induce Kaposi's sarcoma-ass

87 loss and those up-regulated in Foxo1-deleted germinal center B cells, even though Foxo1 typically act

88 4(high) CD4 T cells as well as CD95(+)GL7(+) germinal center B cells, indicating that the long-term c

89 (BCL6), which is critical for development of germinal center B cells, is dependent on IRF8 and PU.1 i

90 g somatic hypermutation (SHM) of Ig genes in germinal center B cells, lesions introduced by activatio

91 eir results suggest that SFTSV-infected post-germinal center B cells, plasmablasts, and macrophages a

92 cal exposures to the allergen induced IgE(+) germinal center B cells, serum IgE, and likely activated

93 process generated allergen-specific IgG1(+) germinal center B cells, serum IgG1, and anaphylaxis tha

94 itionally delete Hdac3 to define its role in germinal center B cells, which represent the cell of ori

95 and PIK3IP1 is not appreciably expressed in germinal center B cells.

96 ntiation into plasmablasts at the expense of germinal center B cells.

97 ) cell frequency, numbers, and generation of germinal center B cells.

98 t break formation in J(H) introns from mouse germinal center B cells.

99 lator of T follicular helper (Tfh) cells and germinal center B cells.

100 sion and viral transduction of primary human germinal center B cells.

101 e-encoded IgM autoantibody and hypermutating germinal center B cells.

102 eficient in establishing latent infection in germinal center B cells.

103 XBP-1s is also present in large amounts in germinal center B cells.

104 Mice developed expanded germinal center B lymphocyte populations as in other mod

105 f ATR and WEE1 inhibitors in a subset of non-germinal center B-cell (GCB) diffuse large B-cell lympho

106 q25, whereas DLBCL, NOS was predominantly of germinal center B-cell (GCB) subtype and carried gene mu

107 expression signature that identifies 27% of germinal center B-cell DLBCLs (GCB-DLBCLs) as having a d

108 stimate that the initial transformation of a germinal center B-cell usually occurred during the first

109 tients, including 192 patients classified as germinal center B-cell-like (GCB)/non-GCB and MYC/BCL2 e

110 14.1 months, and 51% of the patients had non-germinal center B-cell-like (non-GCB) DLBCL, 33% had tra

111 divided into 2 major molecular subtypes: the germinal center B-cell-like and the aggressive activated

112 owed no evidence of worse outcome than other germinal center B-cell-like cases.

113 patients (9%), with 75 in the cell-of-origin germinal center B-cell-like group.

114 onal repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been propose

115 y characterized by a putative non-light zone germinal center cell of origin and a distinct mutational

116 generate short- and long-lived plasma cells, germinal center cells, and memory cells; and how each pa

117 1 alterations were highly enriched among non-germinal center DLBCLs and exhibited robust PD-L1 protei

118 is study, we develop a mathematical model of germinal center dynamics and use it to predict the event

119 Cd19-Cre-Hdac3-/- mice showed impaired germinal center formation along with a defect in plasmab

120 3IP1 in the extrafollicular response because germinal center formation and affinity maturation were n

121 centers, and mice genetically deficient for germinal center formation had strongly reduced atheroscl

122 ed T cell help, but proceed independently of germinal center formation via short-lived antibody-formi

123 d for optimal T(H)2 responses, Be2 function, germinal center formation, and T follicular helper cells

124 variants reduced T follicular helper cells, germinal center formation, immunoglobulin, and collagen

125 ecruitment of B cells and initiating ectopic germinal center formation.

126 ted roles in activating naive B cells and in germinal center formation.

127 anti-RABV antibodies via the facilitation of germinal center formation.

128 ts role at the hypermutating Ig locus in the germinal center is unexplored.

129 wo novel cytokinetic ring components, GCK-1 (germinal center kinase-1) and CCM-3 (cerebral cavernous

130 BioTarget tool to BCL6, a TF associated with germinal center lymphocytes, we observed that patients w

131 ent predominantly exhibited an immature, pro-germinal center phenotype (PDL-2(-) CD80(-) CD35(+) CD73

132 terminal differentiation of B-cells via the germinal center reaction is a complex multi-step process

133 and Ab responses is highly dependent on the germinal center reaction, a well-orchestrated process in

134 itch recombination, affinity maturation, and germinal center reaction, as well as plasmablast differe

135 :T mutagenesis during SHM increased during a germinal center reaction, but this was in part defective

136 asts resulted in nutrient deprivation of the germinal center reaction, limiting the generation of mem

137 phenotype and provided poor help to support germinal center reactions and humoral immune responses b

138 of bronchiolitis obliterans (BO), driven by germinal center reactions and resulting in target organ

139 ory B cells readily participate in secondary germinal center reactions, allowing further modification

140 role in T cell-dependent B cell activation, germinal center reactions, and humoral immunity and how

141 phase, indicating antigen-responsiveness and germinal center reentry.

142 The virus's manipulation of the germinal center response and B cell differentiation to e

143 intrinsic manner, usurp IRF-1 to promote the germinal center response and expansion of the latent res

144 he murine gammaherpesvirus 68 (MHV68)-driven germinal center response and expansion of the viral late

145 To investigate targeting the germinal center response and plasma cells as a desensiti

146 response was associated with enhanced early germinal center response and rapid elicitation of Abs to

147 c IRF-1 expression promoted the MHV68-driven germinal center response and the establishment of chroni

148 cells, enhances the gammaherpesvirus-driven germinal center response and the establishment of chroni

149 ression supports the gammaherpesvirus-driven germinal center response and the establishment of viral

150 The gammaherpesvirus-driven germinal center response in combination with robust infe

151 s and subsequently drive a robust polyclonal germinal center response in order to amplify the latent

152 lectively affect the gammaherpesvirus-driven germinal center response remain poorly understood.

153 e B cell differentiation process through the germinal center response to ensure latent infection of l

154 pressor, selectively attenuates MHV68-driven germinal center response, a phenotype that we originally

155 e establishment of chronic infection and the germinal center response, indicating that MHV68 may, in

156 rp B cell differentiation, specifically, the germinal center response, to establish long-term latency

157 licular helper cells followed by an enhanced germinal center response.

158 ation of host and viral factors that promote germinal center responses during gammaherpesvirus infect

159 nd in vivo mouse studies, Tfh generation and germinal center responses were enhanced by reducing CD39

160 te to transplantation tolerance by foregoing germinal center responses while retaining their ability

161 g both early extrafollicular plasma cell and germinal center responses, in a CD4(+) T-cell-dependent

162 duces bone marrow plasma cells, disorganizes germinal center responses, reduces donor-specific antibo

163 B cell responses and gammaherpesvirus-driven germinal center responses, with the latter thought to be

164 ctedly hindered parasite control by impeding germinal center responses.

165 licular regulatory (Tfr) cells that regulate germinal center responses.

166 The germinal center stage of B cell differentiation is impor

167 re transcriptionally and clonally similar to germinal center Tfh cells.

168 pond to interactions with other cells in the germinal center that provide survival and differentiatio

169 4-Ig led to superior inhibition of Tfh cell, germinal center, and DSA responses in vivo and better co

170 duced upon B cell activation, entry into the germinal center, and plasmablast differentiation.

171 ormulated in alum elicited greatly increased germinal center, antibody, neutralizing antibody, memory

172 emory B cells, while failing to re-enter the germinal center, create an affinity-restricted, diversif

173 However, within the germinal center, peripheral tolerance was still enforced

174 self-reactive B cells are recruited into the germinal center, their development does not proceed, pos

175 i fusion proteins have higher frequencies of germinal center-activated B cells and CD4bs-directed mem

176 (cHL) is a tumor composed of rare, atypical, germinal center-derived B cells (Hodgkin Reed-Sternberg

177 red in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or C

178 ibitor and examined nascent transcription in germinal center-derived cell lines.

179 We propose that germinal center-derived IgG antibodies promote the size

180 , (2) with mice that had selectively ablated germinal center-derived IgG production, or (3) through i

181 as naive B cells exit quiescence to enter a germinal center-like differentiation program, which culm

182 T follicular helper (T(FH)) activity within germinal center.

183 et that most resembles preT(FH)/T(FH) in the germinal center.

184 n (CREBBP) and EP300 are commonly mutated in germinal-center-derived B cell lymphomas, and their inac

185 al resolution the dynamics of these cells in germinal centers (GC) and their cross-talk with B cells

186 immunity in mice, but its role in regulating germinal centers (GC) is controversial.

187 HF enhanced the formation of germinal centers (GCs) and increased the production of t

188 vaccine strategies, occurs in B cells within germinal centers (GCs) and requires rate-limiting "help"

189 he role of affinity in B cell selection into germinal centers (GCs) and the memory B cell compartment

190 Germinal centers (GCs) are confined anatomic regions whe

191 Germinal centers (GCs) are sites at which B cells prolif

192 Germinal centers (GCs) are sites wherein B cells prolife

193 B cells in germinal centers (GCs) cycle between light zone (LZ) and

194 per (Tfh) cells interact with B cells in the germinal centers (GCs) of lymph nodes to generate vaccin

195 molding new specificities through secondary germinal centers (GCs) or by selecting preexisting clone

196 ntiate into extrafollicular PCs or mature in germinal centers (GCs) to produce high-affinity memory B

197 reting cells with high antigenic affinity in germinal centers (GCs) within secondary lymphoid organs.

198 on of costimulatory molecules and cytokines, germinal centers (GCs), and DSA formation in an RTx mode

199 Formation of germinal centers (GCs), and follicular B- and T-cell dif

200 Within germinal centers (GCs), complex and highly orchestrated

201 igens, mature B cells are stimulated to form germinal centers (GCs), the sites of B cell affinity mat

202 mutated MBCs is infrequent within secondary germinal centers (GCs), which instead consist predominan

203 nated by plasmablasts (PBs), with few-if any-germinal centers (GCs), yet it generates protective immu

204 re identified, but not in situ generation of germinal centers (GCs).

205 ng, it is generally considered a hallmark of germinal centers (GCs).

206 follicular helper (Tfh) cell development in germinal centers (GCs).

207 cialized subset of CD4(+) T cells needed for germinal centers (the microanatomical sites of B cell mu

208 -CoV-2 infection and observed the absence of germinal centers and a striking reduction in Bcl-6(+) ge

209 by lymphocytes and organized localization of germinal centers and B-cell follicles.

210 alpha signaling on B cells was essential for germinal centers and in the effector phase of allergic r

211 Absence of germinal centers correlated with an early specific block

212 ent Ag induced increased B cell expansion in germinal centers from Duox1(-/-) mice relative to WT and

213 A virus infection-induced pulmonary ectopic germinal centers give rise to more broadly cross-reactiv

214 cell (FDC) network and then concentrated in germinal centers in a complement-, mannose-binding lecti

215 e exhibited intact intestinal tissue, active germinal centers in mesenteric lymph nodes, IgG(+) and I

216 T follicular helper (Tfh) cells in germinal centers of secondary lymphoid organs are pivota

217 Currently, the epithelia and lymphoid germinal centers of the oropharynx have been identified

218 Analysis of Hdac3-/- germinal centers revealed a reduction in dark zone centr

219 oliferating circulating Tfh (cTfh) cells and Germinal Centers Tfh (GC-Tfh).

220 We examine scenarios that lead to germinal centers that are composed of B-cells that come

221 gene expression changes observed in Hdac3-/- germinal centers were a result of direct effects of Hdac

222 hemagglutinin (HA)-specific B cells arose in germinal centers, acquired memory B cell markers, and pe

223 ulations in samples from individual animals, germinal centers, and epithelial tissues.

224 IgG antibodies were shown to be derived from germinal centers, and mice genetically deficient for ger

225 HL)) affinity BCRs were primed, recruited to germinal centers, and they affinity matured, and formed

226 ion of helper T cells (CD4+) with B cells in germinal centers, changes in the microenvironment, and t

227 iable Tfh defect was associated with reduced germinal centers, compromised Ig switch and low avidity

228 etition to complex antigens, particularly in germinal centers, has emerged as an important hurdle in

229 rsity of viruses in oropharyngeal epithelia, germinal centers, probang samples (oropharyngeal scrapin

230 n currently in clinical trials, recruited to germinal centers, secrete class-switched antibodies, und

231 affinities across the antibody population in germinal centers.

232 FH) cells to form T(FH):B cell conjugates in germinal centers.

233 or light zone gene signatures as observed in germinal centers.

234 s promotes affinity maturation by B cells in germinal centers.

235 dominant B cell type that populate secondary germinal centers.

236 her lipid species preferentially enriched in germinal centers.

237 ular dendritic cells network, and functional germinal centers.

238 c neoplasm of the lymphoid tissue displaying germinal centre (GC) B cell differentiation.

239 with sustained allergen exposure, alongside germinal centre (GC) B cells.

240 in progression-free survival in the combined germinal centre and activated B-cell population between

241 30-month progression-free survival, for the germinal centre and activated B-cell population.

242 Between 12% and 88% of the responding germinal centre B cell clones overlapped with B cells de

243 investigate the dynamics and specificity of germinal centre B cell responses after influenza vaccina

244 uencing analyses detected activated B cells, germinal centre B cells and ASCs within the tumour micro

245 we show that antigen-specific activated and germinal centre B cells as well as plasma cells can be f

246 Germinal centre B cells that bind to influenza vaccine c

247 ht participants, we detected vaccine-binding germinal centre B cells up to nine weeks after vaccinati

248 wn as H1f2 and H1f4, respectively) conferred germinal centre B cells with enhanced fitness and self-r

249 UHRF1, DNMT1 and DNMT3B are upregulated in germinal centre B cells, the Burkitt's lymphoma cell of

250 Germinal centre B-cell or non-germinal centre B-cell tum

251 tention-to-treat population of activated and germinal centre B-cell population.

252 Germinal centre B-cell or non-germinal centre B-cell tumour subtype and double or trip

253 e-induced B cell clones detected only in the germinal centre compartment exhibited significantly lowe

254 rmine their cell of origin, corresponding to germinal centre or activated B cell.

255 This demonstrates that the poor germinal centre reaction in aged animals is not irrevers

256 nza virus vaccination in humans can elicit a germinal centre reaction that recruits B cell clones tha

257 ear whether such vaccination can also induce germinal centre reactions in the draining lymph nodes, w

258 ters of activated B cells indicating ongoing germinal centre reactions.

259 signals and transcription factors regulating germinal centre-derived MBC development and function.

260 P2RY8 is frequently mutated in germinal-centre B cell-like diffuse large B cell lymphom

261 ed the chemokine-mediated migration of human germinal-centre B cells and T follicular helper cells, a

262 nized the induction of phosphorylated AKT in germinal-centre B cells.

263 s at steady state, despite rapid turnover of germinal-centre B cells.

264 at is involved in organizing and controlling germinal-centre responses.

265 Germinal centres (GCs) are T follicular helper cell (Tfh

266 atic hypermutation and cellular selection in germinal centres (GCs)(2,3).

267 e evidence for the relative contributions of germinal centres and long-lived plasma cells as sources

268 in normal numbers; however, the formation of germinal centres and the production of antigen-specific

269 oid organs associated with the gut, however, germinal centres are chronically present.

270 in SPF mice, and winner B cells in germ-free germinal centres are enriched in 'public' clonotypes fou

271 Germinal centres are important sites for antibody divers

272 Despite being made up of motile cells, germinal centres are tightly confined within B cell foll

273 These gut-associated germinal centres can support targeted antibody responses

274 cells, we find that 5-10% of gut-associated germinal centres from specific-pathogen-free (SPF) mice

275 frequency of highly selected gut-associated germinal centres is markedly higher in germ-free than in

276 an take place in steady-state gut-associated germinal centres, at a rate that is tunable over a wide

277 Germinal centres, the structures in which B cells evolve

278 ownstream examination of 137,410 somatic and germinal insertion sites revealed that 50% of the tagged

279 , secondary proliferation zone: the external germinal layer (EGL).

280 antisense ZAM-derived piRNAs that display a germinal molecular signature.

281 m of NLRP3-AIDs appears to be related to the germinal/mosaic status and localization of the underlyin

282 c Mu insertion sites and 41,086 high quality germinal Mu insertions covering 16,392 of the annotated

283 )-family of the BonnMu libraries captured 37 germinal Mu insertions in genes of the Filtered Gene Set

284 Mutations found only in germinal state could, therefore, be asymptomatic in mosa

285 ould be incompatible with life if present in germinal state.

286 y 8 of 90 mutations were found in mosaic and germinal states.

287 nt in early meiosis after a delay; thus, the germinal transcriptional program is cell autonomous and

288 g meiotic progression, leading to defects in germinal vesicle breakdown (GVBD), anaphase-promoting co

289 Ccnb2 (-/-) oocytes underwent delayed germinal vesicle breakdown and showed defects during the

290 elevated reactive oxygen species in immature germinal vesicle oocytes, exhibit a significant over-acc

291 growth-to-maturation transition begins with germinal vesicle or nuclear envelope breakdown (GVBD) an

292 The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear env

293 and had larger ventricles as well as thinner germinal wall.

294 orphogenic events, environmental cues in the germinal zone (GZ) instructing neuron polarization and t

295 so delays the timing of CGN differentiation, germinal zone exit, and migration initiation through tra

296 the Pax6 expression changes from the mitotic germinal zone in the ventricular zone to become distribu

297 medulloblastoma subtypes to arise in either germinal zone.

298 cular zone and the rhombic lip, two distinct germinal zones of the embryonic cerebellum.

299 terneurons undergo long-range migration from germinal zones, a process regulated by the innervation o

300 ique expansion and maintenance of cerebellar germinal zones, reminiscent of processes in the developi