ライフサイエンスコーパス: germinal centre

1 cription and subsequent B-cell exit from the germinal centre.

2 ing that all B cells scan antigen trapped in germinal centres.

3 erated, secreted cytokines and formed normal germinal centres.

4 omas (DLCLs), which are tumours derived from germinal centres.

5 f follicular B cells to proliferate and form germinal centres.

6 tic hypermutation is thought to occur within germinal centres.

7 not absolutely dependent on the presence of germinal centres.

8 for the formation and maintenance of B-cell germinal centres.

9 ural and functional evidence of NR1-specific germinal centres.

10 eptors by follicular helper T (TFH) cells in germinal centres.

11 pleen and can develop even in the absence of germinal centres.

12 ng help to B lymphocytes in the induction of germinal centres.

13 we aimed to characterize and identify human germinal centres actively participating in NMDAR-specifi

14 l responses underlying the activation of the germinal centre activities leading to the generation of

15 od were identified, demonstrating continuous germinal centre activity and selection for at least 191

16 Bm12.Kd.IE heart grafts provoked strong germinal centre alloantibody and autoantibody responses

17 egs at transplant or 3 weeks later abrogated germinal centre alloantibody responses and blocked devel

18 reports, Th17 cells were not detected inside germinal centres, although they were found in close prox

19 in progression-free survival in the combined germinal centre and activated B-cell population between

20 30-month progression-free survival, for the germinal centre and activated B-cell population.

21 c B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-cen

22 on is sufficient to recruit B cells into the germinal centre and induce memory and plasma cell respon

23 t pre-existing high-affinity antibodies bias germinal centre and memory B cell selection through two

24 lar dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by dire

25 e evidence for the relative contributions of germinal centres and long-lived plasma cells as sources

26 with this there was enhanced persistence of germinal centres and of plasma-cell responses, which per

27 cell help-undergo affinity maturation within germinal centres and persist as long-lived IgG plasma ce

28 in normal numbers; however, the formation of germinal centres and the production of antigen-specific

29 It is essential for the formation of germinal centres and the production of high-affinity ant

30 ong-lived IgG plasma cells, which develop in germinal centres and then home to the bone marrow, IgM p

31 During the secondary response in the germinal centres, antibodies are diversified by somatic

32 oid organs associated with the gut, however, germinal centres are chronically present.

33 in SPF mice, and winner B cells in germ-free germinal centres are enriched in 'public' clonotypes fou

34 We tested whether germinal centres are essential for maturation of antibod

35 Germinal centres are important sites for antibody divers

36 Germinal centres are specialized microenvironments where

37 Germinal centres are specialized structures wherein B ly

38 Germinal centres are the engines of antibody evolution.

39 Despite being made up of motile cells, germinal centres are tightly confined within B cell foll

40 GANP (germinal- centre associated nuclear protein) promotes th

41 MCM3 acetylase (MCM3AP) and germinal-centre associated nuclear protein (GANP) are tr

42 Mammalian TREX-2 is based on a germinal-centre associated nuclear protein (GANP) scaffo

43 ic B cells might tolerize against a group of germinal-centre-associated antigens, including disease-r

44 an take place in steady-state gut-associated germinal centres, at a rate that is tunable over a wide

45 t an underlying change in the Tfh-B cell and germinal centre axis in a subset of immunotherapy patien

46 without further immunization, we demonstrate germinal centre B (B(GC)) cells that last for at least 6

47 shows that KDM6B transcriptional targets in germinal centre B (GC B) cells are significantly enriche

48 Between 12% and 88% of the responding germinal centre B cell clones overlapped with B cells de

49 h activated B-cell disease, 475 (51.7%) with germinal centre B cell disease, and 199 (21.7%) with unc

50 fferentiation, plasmablast proliferation and germinal centre B cell formation.

51 The normal germinal centre B cell is the presumed cell of origin fo

52 d vaccination of humans induces a persistent germinal centre B cell response, which enables the gener

53 investigate the dynamics and specificity of germinal centre B cell responses after influenza vaccina

54 ooster immunizations in humans induce robust germinal centre B cell responses and can generate de nov

55 ) mRNA vaccine induced robust spike-specific germinal centre B cell responses in humans.

56 cell-of-origin subtype of each participant (germinal centre B cell, activated B cell, or unclassifie

57 eparately from a common precursor, usually a germinal centre B cell.

58 One type expressed genes characteristic of germinal centre B cells ('germinal centre B-like DLBCL')

59 uencing analyses detected activated B cells, germinal centre B cells and ASCs within the tumour micro

60 viral challenge abrogated the generation of germinal centre B cells and class-switched plasma cells,

61 f deletion causes increased proliferation of germinal centre B cells and extrafollicular plasmablasts

62 Galpha13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were u

63 landscape of Peyer's patches with increased germinal centre B cells and IgA-secreting antigen-specif

64 High frequencies of S-binding germinal centre B cells and plasmablasts were sustained

65 DALT contain germinal centre B cells and support the generation of so

66 mmune system, most notably in class switched germinal centre B cells and the production of Immunoglob

67 me cells move to the follicle centre, become germinal centre B cells and undergo antibody affinity ma

68 we show that antigen-specific activated and germinal centre B cells as well as plasma cells can be f

69 point mutations into immunoglobulin genes in germinal centre B cells during an immune response.

70 himaeras, EBI2-deficient B cells phenocopied germinal centre B cells in preferentially localizing to

71 amics of antibody-secreting plasmablasts and germinal centre B cells induced by these vaccines in hum

72 S-binding monoclonal antibodies derived from germinal centre B cells predominantly targeted the recep

73 Germinal centre B cells that bind to influenza vaccine c

74 draining axillary lymph nodes, we identified germinal centre B cells that bound S protein in all part

75 ressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in

76 ansgene mutation was considerably reduced in germinal centre B cells that poorly expressed the transg

77 AID is a cytosine deaminase expressed in germinal centre B cells to mediate genomic antibody dive

78 ht participants, we detected vaccine-binding germinal centre B cells up to nine weeks after vaccinati

79 virus-specific B(RM) cells, plasma cells and germinal centre B cells were identified, with evidence o

80 wn as H1f2 and H1f4, respectively) conferred germinal centre B cells with enhanced fitness and self-r

81 he PCR amplified JH flanking region DNA from germinal centre B cells yields mismatched heteroduplexes

82 Phenotypically resembling germinal centre B cells, all types of BL are characteriz

83 on is unaffected, but marginal zone B cells, germinal centre B cells, and plasmablasts are significan

84 We find that, similar to germinal centre B cells, T follicular helper cells under

85 UHRF1, DNMT1 and DNMT3B are upregulated in germinal centre B cells, the Burkitt's lymphoma cell of

86 Germinal centre B cells, unlike most lymphocytes, are ti

87 olecular features of germinal centre or post-germinal centre B cells.

88 er activation, before being downregulated in germinal centre B cells.

89 ither mechanism and accumulated mutations in germinal centre B cells.

90 ription factor that is normally expressed in germinal centre B cells.

91 to perturbed processing of antibody genes in germinal centre B cells.

92 transgenes are targets for hypermutation in germinal centre B cells.

93 ation of CD11c(+) age-associated B cells and germinal centre B cells.

94 of their ability to interact cognately with germinal centre B cells.

95 s growth regulation and local confinement of germinal centre B cells.

96 differentiation, AKNA is mainly expressed by germinal centre B lymphocytes, a stage in which receptor

97 a distinct distribution of MNK1 and MNK2 in germinal centre B-cell (GCB) and activated B-cell (ABC)

98 CL-6 is a transcription factor essential for germinal centre B-cell development.

99 eficiency in Galpha13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and bloo

100 ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination.

101 requently mutated residue, with up to 22% of germinal centre B-cell DLBCL and follicular lymphoma har

102 lignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement v

103 Germinal centre B-cell or non-germinal centre B-cell tum

104 tention-to-treat population of activated and germinal centre B-cell population.

105 wide distributions in related states of post-germinal centre B-cell transformation.

106 Germinal centre B-cell or non-germinal centre B-cell tumour subtype and double or trip

107 o S1P, and Galpha13-deficient mice developed germinal centre B-cell-derived lymphoma.

108 ntre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma.

109 tor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lym

110 y and clinically distinct subtypes including germinal centre B-cell-like (GCB) and activated B-cell-l

111 88 TIR domain, occurring in both the ABC and germinal centre B-cell-like (GCB) DLBCL subtypes.

112 Germinal centre B-cell-like diffuse large B-cell lymphom

113 n activated B-cell-like DLBCL cells, but not germinal centre B-cell-like DLBCL cells, shRNAs targetin

114 BCL), termed activated B-cell-like DLBCL and germinal centre B-cell-like DLBCL.

115 dose, five (71%) of seven patients with the germinal centre B-cell-like subtype and two (100%) patie

116 subtype and two (100%) patients with the non-germinal centre B-cell-like subtype had a complete respo

117 upon molecular features with similarities to germinal centre B-cells (GCB-like) or activated B-cells

118 onal repressor, which is highly expressed in germinal centre B-cells and is essential for germinal ce

119 Patients with germinal centre B-like DLBCL had a significantly better

120 characteristic of germinal centre B cells ('germinal centre B-like DLBCL'); the second type expresse

121 transcription factor BCL6, which directs the germinal-centre B cell and follicular T-helper cell prog

122 P2RY8 is frequently mutated in germinal-centre B cell-like diffuse large B cell lymphom

123 ed the chemokine-mediated migration of human germinal-centre B cells and T follicular helper cells, a

124 these mutations are not detectable in normal germinal-centre B cells or in other germinal-centre-deri

125 at an important function of BCL6 is to allow germinal-centre B cells to tolerate the physiological DN

126 nd, accordingly, p53 expression is absent in germinal-centre B cells where BCL6 is highly expressed.

127 In germinal-centre B cells, AID is highly expressed, and ha

128 Here we show that B-1 cells, like germinal-centre B cells, can express recombinase-activat

129 es DNA damage-induced apoptotic responses in germinal-centre B cells.

130 enes are subject to somatic hypermutation in germinal-centre B cells.

131 n lymphoma, a malignancy often deriving from germinal-centre B cells.

132 s at steady state, despite rapid turnover of germinal-centre B cells.

133 nized the induction of phosphorylated AKT in germinal-centre B cells.

134 were motile and physically restricted to the germinal centre but migrated bi-directionally between da

135 was found in 13 of 24 (54%) clones from the germinal centre but only in 1 of 24 (4%) clones from the

136 ssed in both B cells and CD4+ T cells within germinal centres, but its precise function is unknown.

137 irect visualization of B cells in lymph node germinal centres by two-photon laser-scanning microscopy

138 finity maturation of antibodies occurring in germinal centres, by multiple cycles of random mutation

139 These gut-associated germinal centres can support targeted antibody responses

140 , another B-cell malignancy of atypical post-germinal-centre cell origin.

141 IgE germinal centre cells are transient, most IgE cells are

142 was required to maintain BCL6 expression in germinal centre cells by avoiding BCL6-negative autoregu

143 Unexpectedly, germinal centre cells were identified consistently in ma

144 entre dynamics or the migratory behaviour of germinal-centre cells in vivo.

145 germinal centre and become rapidly dividing germinal-centre centroblasts that give rise to dark zone

146 se (AID), which is expressed specifically in germinal-centre centroblasts, is required for this proce

147 ents with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue.

148 e-induced B cell clones detected only in the germinal centre compartment exhibited significantly lowe

149 icular B cells were frequent visitors to the germinal-centre compartment, suggesting that all B cells

150 These results offer an explanation for the germinal centre defect due to SAP deficiency and provide

151 H) mice, autoimmunity was not ameliorated by germinal-centre deficiency, suggesting an extrafollicula

152 signals and transcription factors regulating germinal centre-derived MBC development and function.

153 n normal germinal-centre B cells or in other germinal-centre-derived lymphomas, suggesting a DLCL-ass

154 The precise function of BCL6 in germinal-centre development and lymphomagenesis is uncle

155 However, there have been no studies of germinal-centre dynamics or the migratory behaviour of g

156 We conclude that the open structure of germinal centres enhances competition and ensures that r

157 that control the selection of B cells in the germinal centre, far less is understood about the clonal

158 ns as a transcriptional switch that controls germinal centre formation and may also modulate specific

159 germinal centre B-cells and is essential for germinal centre formation and T-dependent antibody respo

160 ncoded by SH2D1a) cause a profound defect in germinal centre formation by an as yet unknown mechanism

161 ccord with the defective isotype production, germinal centre formation is absent in these mutant mice

162 cells, a reduction in B cell activation and germinal centre formation, and the inhibition of antigen

163 ype class switching, accompanied by impaired germinal centre formation.

164 normally leading to B cell proliferation and germinal centre formation.

165 nscriptional repressor that is necessary for germinal-centre formation and is implicated in the patho

166 Despite prominent spontaneous germinal-centre formation in Tlr7(Y264H) mice, autoimmun

167 ined in experiments in mice that showed that germinal centres formed in the presence of the same anti

168 cells, we find that 5-10% of gut-associated germinal centres from specific-pathogen-free (SPF) mice

169 cells in PLWH displayed evidence of reduced germinal centre (GC) activity, homing capacity, and clas

170 c neoplasm of the lymphoid tissue displaying germinal centre (GC) B cell differentiation.

171 ed protein 2 (EBI2), but significantly fewer germinal centre (GC) B cells compared with tonsil.

172 the course of antibody affinity maturation, germinal centre (GC) B cells mutate their immunoglobulin

173 with sustained allergen exposure, alongside germinal centre (GC) B cells.

174 in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza.

175 use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silenc

176 The germinal centre (GC) is required for the generation of h

177 el which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immu

178 During the germinal centre (GC) reaction, mature B cells undergo ra

179 few days of infection, resulting in a weaker germinal centre (GC) response and diminished immune memo

180 igh-affinity antibody production through the germinal centre (GC) response is a pivotal process in ad

181 The germinal centre (GC) response is critical for the genera

182 ls is required for optimal maturation of the germinal centre (GC) response.

183 le Pfs25, as well as to significantly higher germinal centre (GC) responses.

184 relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear.

185 +) PC development pathway, namely (i) IgE(+) germinal centre (GC)-like B cells, (ii) IgE(+) PC-like '

186 Germinal centres (GC) are lymphoid structures in which B

187 Germinal centres (GCs) are T follicular helper cell (Tfh

188 Germinal centres (GCs) promote humoral immunity and vacc

189 atic hypermutation and cellular selection in germinal centres (GCs)(2,3).

190 rsification of their immunoglobulin genes in germinal centres (GCs).

191 commensals induce the formation of classical germinal centres in the lymph node associated with immun

192 h nodes or Peyer's patches, and fail to form germinal centres in the spleen.

193 pment of the germinal centre response and/or germinal centre-independent events, consistent with thei

194 hway for peripheral T cells and suggest that germinal centres induce a lymphocyte phenotype necessary

195 The germinal centre is a dynamic microenvironment in which B

196 frequency of highly selected gut-associated germinal centres is markedly higher in germ-free than in

197 asing the amount of antigen presented in the germinal centre leads to increased division of T follicu

198 T follicular helper cells, myeloid cells and germinal centre-like B cells, often arising from single

199 Germinal-centre-like reactions are well-documented in th

200 f NP-OVA, even though they failed to produce germinal centres, manifested a high-affinity anti-NP IgG

201 atomas with dense B cell foci expressing the germinal centre marker BCL6, CD21+ follicular dendritic

202 c mutation typical of antigen-selected (post-germinal-centre) memory cells.

203 ad been thought to arise preferentially from germinal centres, novel genetic tools have revealed that

204 rimary and secondary immune responses in the germinal centres of lymphoid organs have been studied in

205 rmine their cell of origin, corresponding to germinal centre or activated B cell.

206 emble human DLBCL with molecular features of germinal centre or post-germinal centre B cells.

207 induced T-B-cell interactions increase total germinal centre output and accelerate it by days.

208 e phylogenies spanning more than the 6-month germinal centre period were identified, demonstrating co

209 r helper (Tfh) cells is vital in driving the germinal centre reaction and high affinity antibody form

210 This demonstrates that the poor germinal centre reaction in aged animals is not irrevers

211 Here we report that the defective germinal centre reaction in Peyer's patches of aged mice

212 rmutation several days before the end of the germinal centre reaction is beneficial for affinity matu

213 nza virus vaccination in humans can elicit a germinal centre reaction that recruits B cell clones tha

214 o antigen-dependent selection throughout the germinal centre reaction that results in differential pr

215 cells was antagonized, participation in the germinal centre reaction was impaired.

216 control the magnitude and specificity of the germinal centre reaction, but how regulation is containe

217 rm antibody-mediated immunity depends on the germinal centre reaction, which requires cooperation bet

218 in a nascent germinal centre to sustain the germinal centre reaction.

219 f T follicular helper cell clones during the germinal centre reaction.

220 for every on-target IGHV mutation during the germinal centre reaction.

221 hich have been implicated in controlling the germinal centre reaction.

222 follicular helper cell repertoire during the germinal centre reaction.

223 antigen-specific B cells participating in a germinal-centre reaction were motile and physically rest

224 cific B cells can be recruited to an ongoing germinal-centre reaction.

225 ations with cholera toxin, without affecting germinal centre reactions in peripheral lymph nodes.

226 ear whether such vaccination can also induce germinal centre reactions in the draining lymph nodes, w

227 ent paradigm of humoral immunity posits that germinal centre reactions occurring within secondary lym

228 unclear whether the additional doses induce germinal centre reactions whereby re-engaged B cells can

229 ters of activated B cells indicating ongoing germinal centre reactions.

230 the draining lymph node, leading to stronger germinal centre reactions.

231 partners of regulatory T cells and identify germinal centre-resident T follicular helper cells on th

232 earlier in the initiation/development of the germinal centre response and/or germinal centre-independ

233 The germinal centre response persisted for at least eight we

234 zed subset of lymphocytes that influence the germinal centre response through interactions with folli

235 results in impaired TFH-cell development and germinal centre response.

236 Thus, TFR contribute to inefficient germinal centre responses and inhibit HIV and SIV cleara

237 and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies,

238 lper CD4 T cells (Tfh) which are involved in germinal centre responses.

239 t defective T-cell-dependent plasma cell and germinal centre responses.

240 are important in supporting plasma cell and germinal centre responses.

241 raise AQP4-specific antibodies in productive germinal-centre responses.

242 at is involved in organizing and controlling germinal-centre responses.

243 hat have failed the physiological process of germinal centre selection into memory.

244 T cells that preferentially expand in the germinal centre show increased expression of genes downs

245 filing showed that both light- and dark-zone germinal centre states were sustained.

246 Here we show that in splenic germinal centres, T cells regain thymocyte-like sensitiv

247 help to B cells, supporting the formation of germinal centres that allow affinity maturation of antib

248 he spontaneous formation of T-cell-dependent germinal centres that are enriched with B cells expressi

249 In germinal centres the feedback loop is overridden, with B

250 Germinal centres, the structures in which B cells evolve

251 ently recruited to and retained in a nascent germinal centre to sustain the germinal centre reaction.

252 patience can have great value for tuning of germinal centres to maximize antibody responses.

253 ubiquitination and degradation of YY1, a key germinal centre transcription factor.

254 nization or infection, which localize to the germinal centre where they control the magnitude of the

255 thought to migrate to the light zone of the germinal centre, which is rich in antigen-trapping folli

256 ty of P2RY8 to promote B cell confinement to germinal centres, which indicates that GGT5 establishes

257 of NMDAR-autoantibody production from active germinal centres within both intratumoral tertiary lymph

258 Although germinal centres within follicles were described in 1885

259 In germinal centres within mature TLS, B cell clones are se