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1  growth hormone secretagogue receptor (GHSR; ghrelin receptor).
2 the GH secretagogue receptor 1a (GHSR1a, ie, ghrelin receptor).
3 ing that the GHSR is a biologically relevant ghrelin receptor.
4  that the GHSR is a physiologically relevant ghrelin receptor.
5 p with the high constitutive activity of the ghrelin receptor.
6 one (GH), a major downstream effector of the ghrelin receptor.
7 he functional and structural behavior of the ghrelin receptor.
8 nverse agonist K-(d-1-Nal)-FwLL-NH(2) at the ghrelin receptor.
9 sepsis by vagus nerve activation via central ghrelin receptors.
10 uced gut barrier dysfunction through central ghrelin receptors.
11 the growth hormone secretagogue receptor 1a (ghrelin receptor), a peptidic G-protein-coupled receptor
12 the amygdala and behavioral insensitivity to ghrelin receptor agonism.
13        Repeated systemic administration of a ghrelin receptor agonist enhanced fear memory but did no
14         Repeated intraamygdala infusion of a ghrelin receptor agonist produced a similar enhancement
15 y members, together with anamorelin (Ana), a ghrelin receptor agonist, to reverse muscle dysfunction
16                        Anamorelin is an oral ghrelin-receptor agonist with appetite-enhancing and ana
17              We assessed anamorelin, a novel ghrelin-receptor agonist, on cachexia in patients with a
18                                              Ghrelin receptor, also known as growth hormone secretago
19                                          The ghrelin receptor, also known as the growth hormone secre
20 hormone secretagogues act as agonists at the ghrelin receptor and have been described as "ago-alloste
21  dual peptides simultaneously inhibiting the ghrelin receptor and stimulating the Y2 receptor.
22 s prepared from cells coexpressing the human ghrelin receptor and the G protein Galpha(o1), N-[1(R)-1
23 g that dopaminergic cells of the VTA express ghrelin receptors and D5R, but not D1R, we investigated
24 ents of the ghrelin system, including native ghrelin, receptors and the recently discovered splicing
25                                              Ghrelin receptor antagonism during repeated stress aboli
26 ventricular (LV) ghrelin increased, while LV ghrelin receptor antagonism suppressed the magnitude of
27  and improved glucose tolerance, whereas the ghrelin receptor antagonist D-Lys GHRP-6 reduced plasma
28                 Notably, administration of a ghrelin receptor antagonist further reduced blood glucos
29           The Notch inhibitor PF-03084014 or ghrelin receptor antagonist GHRP-6 reversed the phenotyp
30 ng by pretreatment with JMV2959, a selective ghrelin receptor antagonist, dose-dependently inhibits r
31 ng by pretreatment with JMV2959, a selective ghrelin receptor antagonist, dose-dependently inhibits r
32  programs aimed at delivering small molecule ghrelin receptor antagonists and inverse agonists to the
33 t cells containing both leptin receptors and ghrelin receptors are mainly located in the medial part
34 ntly identified hormone that antagonizes the ghrelin receptor, are inversely correlated with those of
35 with a model system composed of the purified ghrelin receptor assembled into lipid discs.
36 relin in regulating feeding and memory makes ghrelin receptors attractive targets for associated diso
37 ce for the high constitutive activity of the ghrelin receptor being an intrinsic property of the prot
38                 Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption.
39 e pathways, for example, the ghrelin system (ghrelin receptor blockade), incretin mimetics (glucagon-
40                                  However, no ghrelin receptor blockers have been administered to heav
41 st- and signaling protein-induced changes in ghrelin receptor conformation, thus preventing it from a
42 ly on distinct neuronal populations and that ghrelin receptor deficiency does not affect sensitivity
43 red fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-ty
44 ptor distribution, we explored the effect of ghrelin receptor deletion on leptin sensitivity.
45 uring this anticipatory phase of feeding via ghrelin-receptor-dependent increases in postsynaptic inh
46 et-derived growth factor by inhibiting, in a ghrelin-receptor-dependent manner, Rac1 activation and c
47  Surprisingly, we found that deletion of the ghrelin receptor did not affect the sensitivity to exoge
48                                          The ghrelin receptor displays a high constitutive activity s
49 memories, and pharmacological agonism of the ghrelin receptor during the memory consolidation period
50 ly occurring truncated splice variant of the ghrelin receptor exerts a dominant negative effect on gh
51 ould allow localization and visualization of ghrelin receptor expressing carcinomas using PET imaging
52 stingly, both leptin receptor expression and ghrelin receptor expression have been observed within ma
53                 Notably, selective hindbrain ghrelin receptor expression was not sufficient to restor
54              Here we report that ghrelin and ghrelin receptor expression within the thymus diminished
55                            Plasma GH levels, ghrelin receptor expression, and neuronal activity in th
56  histological mapping of leptin receptor and ghrelin receptor expression, we found that cells contain
57                              In mice lacking ghrelin receptors, FAA is significantly reduced.
58 es the first functional documentation of the ghrelin receptor family member GPR39 in the kidney.
59 phila and Anopheles) and to neuromedin U and ghrelin receptors from vertebrates.
60  and properties of an indane based series of ghrelin receptor full agonists which led to a sustained
61 sses for representative GPCRs, including the ghrelin receptor, gamma aminobutyric acid B receptor, ap
62 lin secretion, and both are mediated through ghrelin receptor GHS-R.
63                             In this context, ghrelin receptor GHS-R1a is a peculiar receptor in the s
64  the high ligand-independent activity of the ghrelin receptor GHS-R1a on the physiology of excitatory
65 omeric complexes that include the functional ghrelin receptor GHS-R1a, its truncated nonsignaling iso
66 ing and signaling of the full and functional ghrelin receptor GHS-R1a.
67 Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin (UAG) posse
68  of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offe
69 otein-coupled receptors (GPCRs), such as the ghrelin receptor (GHS-R1a), the melanocortin 3 receptor
70  The mechanism must accommodate noncanonical ghrelin receptor (GHS-R1a)-G-protein coupling to Galpha(
71     The hunger hormone ghrelin activates the ghrelin receptor GHSR to stimulate food intake and growt
72 d weight gain in transgenic mice lacking the ghrelin receptor (Ghsr(-/-) mice).
73                           One such GPCR, the ghrelin receptor (GHSR(1a)), has a crucial role in resto
74 microbial peptide 2 (LEAP2) is an endogenous ghrelin receptor (GHSR) antagonist and inverse agonist a
75 hrelin action, we have examined the roles of ghrelin receptor (GHSR) expression in the mouse hindbrai
76 the distribution of neurons that express the ghrelin receptor (GHSR) in the medulla oblongata.
77           Genetic ablation of ghrelin or the ghrelin receptor (GHSR) increased SNpc DA cell loss and
78       We show this effect is mediated by the ghrelin receptor (GHSR), with EWcp(peptidergic) inhibiti
79 hippocampal neurogenesis in depression-prone ghrelin receptor (Ghsr)-null mice to that in wild-type l
80                        The G protein-coupled ghrelin receptor GHSR1a is a potential pharmacological t
81                                          The ghrelin receptor (GHSR1a) and dopamine receptor-1 (DRD1)
82 nly be averted in the combined presence of a ghrelin receptor (GHSR1a) antagonist and an inverse agon
83 e dopamine receptor subtype-2 (DRD2) and the ghrelin receptor (GHSR1a).
84 ral responses in mice, and mice with deleted ghrelin receptors (GHSRs) exhibit exaggerated depressive
85         In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypog
86 tive and/or agonist-induced signaling of the ghrelin receptor, GPR119, the beta(2)-adrenergic recepto
87 -acyl ghrelin, although devoid of binding to ghrelin receptor (GRLN), exerts many biological effects,
88                                          The ghrelin receptor growth hormone secretagogue 1 receptor
89                  The truncated non-signaling ghrelin receptor growth hormone secretagogue R1b (GHS-R1
90 mics to delineate how local hydration of the ghrelin receptor growth hormone secretagogue receptor (G
91 l for several physiological functions of the ghrelin receptor growth hormone secretagogue receptor 1a
92  are guided largely by the expression of the ghrelin receptor growth hormone secretagogue type 1a (GH
93            Here we demonstrate that Ghrl and ghrelin receptor (growth hormone secretagogue receptor (
94                                   Endogenous ghrelin receptors [growth hormone secretagogue receptor
95 reproghrelin gene, but not those lacking the ghrelin receptor, have impaired abilities to manifest an
96 s affect the conformational landscape of the ghrelin receptor in different ways.
97 phobic pocket between TM-III and TM-V in the ghrelin receptor in four of five positions impaired rece
98 ype levels by selective re-expression of the ghrelin receptor in the hindbrain.
99  Furthermore, to confirm the role of central ghrelin receptors in ghrelin's effect, ghrelin (1 nmol)
100                       We recently identified ghrelin receptors in olfactory circuits in the brain.
101          Ghrelin treatment, mediated through ghrelin receptors in the brain, attenuates sepsis-induce
102  investigate the distribution and density of ghrelin receptors in the rodent hypothalamus.
103 o somatostatin receptors (sst2 and sst5) and ghrelin receptor, induction of cAMP and p38-mitogen-acti
104 l evidence of safety and tolerability of the ghrelin receptor inverse agonist PF-5190457 when co-admi
105 namic (PD) and behavioral effects of a novel ghrelin receptor inverse agonist, PF-5190457, when co-ad
106 bility compared to that of the highly stable ghrelin receptor inverse agonist.
107 hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits inv
108 d that the high constitutive activity of the ghrelin receptor is dependent upon flexibility in the C-
109 n function (r = 0.99) for both wild-type and ghrelin receptor knockout animals, with the latter havin
110 of cell proliferation via the mediation of a ghrelin receptor, likely a novel unidentified subtype.
111                                Activation of ghrelin receptors localized in the ventral tegmental are
112 lin.SIGNIFICANCE STATEMENT The activation of ghrelin receptors localized in the ventral tegmental are
113 a provide direct evidence of a mechanism for ghrelin receptor-mediated Gq signaling in which transiti
114                                              Ghrelin receptor mRNA and immunoreactivity were detected
115 relin secretion, and with an upregulation of ghrelin receptor mRNA levels in the ventral tegmental ar
116 relin secretion, and with an upregulation of ghrelin receptor mRNA levels in the ventral tegmental ar
117 elin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasti
118  in overnight-fasted, streptozotocin-treated ghrelin receptor-null mice that were administered GcgR m
119                                    Thus, the ghrelin receptor occurs in the medulla oblongata in 1) s
120 urally activated by ghrelin binding onto the ghrelin receptors on the neuron surface during starvatio
121                                          The ghrelin receptor or growth hormone secretagogue receptor
122 onstituted system, we show that the isolated ghrelin receptor per se activates G(q) in the absence of
123 growth hormone secretagogue receptor (GHSR) (ghrelin receptor) plays an important role in the regulat
124 pite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG m
125   The Y2 receptor induces satiety, while the ghrelin receptor promotes hunger and weight gain.
126 ass A G protein-coupled receptor (GPCR), the ghrelin receptor, reconstituted as a monomer into lipid
127 ion should also facilitate the design of new ghrelin receptor-selective drugs.
128 e the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and star
129 block the fear-enhancing effects of repeated ghrelin receptor stimulation.
130 elease from amygdala neurons was enhanced by ghrelin receptor stimulation.
131 primer sequence of the previously identified ghrelin receptor subtypes detected no signal.
132 lin (a pentapeptide-selective agonist of the ghrelin receptor that speeds gastric emptying in patient
133 d rats, ghrelin activation of a postsynaptic ghrelin receptor, the growth hormone secretagogue recept
134 s occur mainly via binding to the only known ghrelin receptor, the growth hormone secretagogue recept
135 on of the high constitutive signaling of the ghrelin receptor, this loop was subjected to a detailed
136                    Selectively targeting the ghrelin receptor using fluorine-18 tagged entities would

 
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