ライフサイエンスコーパス: glial cell

1 tor cortex correlating with Iba1 expression (glial cells).

2 pinephrine acts directly on these ubiquitous glial cells.

3 nters the brain through a permeable layer of glial cells.

4 he direct transdifferentiation of sex-shared glial cells.

5 risk variants could affect the physiology of glial cells.

6 and functionally regulate neurons and other glial cells.

7 g-derived epithelial cells, neural cells and glial cells.

8 based on their origins from neural crest or glial cells.

9 train rates of murine central nervous system glial cells.

10 significantly less expressed on normal human glial cells.

11 ral sensory neurons interact intimately with glial cells.

12 eptor expressed by vECs, neuronal cells, and glial cells.

13 axons is juxtaposed to concentric layers of glial cells.

14 n (alpha-syn) protein fibrils in neurons and glial cells.

15 ystem and limited access of human neuronal & glial cells.

16 iated mitochondrial fragmentation within the glial cells.

17 cle cells, cardiac muscle cells, neurons and glial cells.

18 ood vessels and the responses of neighboring glial cells.

19 human TDP-43 focally within small groups of glial cells.

20 ify and measure specific types of neurons or glial cells.

21 igment epithelium and for neighboring Muller glial cells.

22 tatory and inhibitory neurons, as well as in glial cells.

23 Epigenetic factors are also enriched in glial cells.

24 d apoptosis and inflammation in neuronal and glial cells.

25 gulation when its function is manipulated in glial cells.

26 acroautophagy, and in some cases transfer to glial cells.

27 rectifying K(+) channel Kir4.1 in satellite glial cells.

28 all the nuclei along their course belong to glial cells.

29 es in their cell type-specific expression in glial cells.

30 anges in the culture medium were measured in glial cells.

31 nding of the nervous system must incorporate glial cells.

32 removal of Pcdhgs from pyramidal neurons or glial cells.

33 ant metabolic housekeeping function of these glial cells.

34 resence of bile acid receptors on immune and glial cells.

35 lls recruited to the CNS and by CNS-resident glial cells.

36 including pre- and post-synaptic neurons and glial cells; 60 papers were included in this review.

37 Thanks to the persistence of radial glial cells acting as neural stem cells, the brain of th

38 We suggest that glial cells activated by pro-inflammatory cytokines can

39 pain-related characteristics such as spinal glial cell activation and reduced locomotion.

40 studies have suggested that it also inhibits glial cell activation in rodents, and may alter opioid-m

41 enzyme expression, fragmented mitochondria, glial cell activation, muscle atrophy, weight loss, and

42 tory mediators, which could further initiate glial cell activation.

43 Polarized glial-cell activation, white-matter lesion formation and

44 KEY POINTS: The role of enteric glial cell activity in the acute regulation of epithelia

45 But whether glial cell activity regulates these functions acutely un

46 An early and persistent alteration of glial cell activity takes place at the neuromuscular jun

47 Neurofascin-155 (Nfasc155) is an essential glial cell adhesion molecule expressed in paranodal sept

48 Here, we discuss how glial cell adhesion molecules and the extracellular matr

49 ediated by rabconnectin-3alpha in neurons or glial cells afferent to GnRH neurons.

50 ptor expression was detected in a variety of glial cells after ischemic brain injury, including oligo

51 y and reduce the resistance of U87 malignant glial cells against TMZ.

52 process, it is increasingly recognized that glial cells also play a critical role.

53 NG2(+) glial cells (also called oligodendrocyte progenitors or

54 ncase the motor nerve despite this change in glial cell and myelin composition, remains unknown.

55 uncommon bilateral retinal disease, in which glial cell and photoreceptor degeneration leads to centr

56 al carbon metabolism in primary mouse Muller glial cells and a human Muller glia cell line (M10-M1 ce

57 tion and premature differentiation of radial glial cells and aberrant positioning of newborn neurons.

58 oblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in a spheroid.

59 with multiple cell types, including neurons, glial cells and blood vessels, and are involved or impli

60 mammalian astrocytes that derive from radial glial cells and elaborate processes to establish their t

61 he nervous system.SIGNIFICANCE STATEMENT The glial cells and extracellular matrix play important role

62 The function of perineurial glial cells and how they interact with the extracellular

63 In primary cultures of glial cells and in the in vivo mouse model, EcoHIV expos

64 ation in vitro, in primary cultures of mouse glial cells and in vivo, in a mouse model of EcoHIV-asso

65 TMEM24 is enriched in neurons versus glial cells and its levels increase in parallel with neu

66 us of research away from neurons and towards glial cells and neuroinflammation.

67 mesenchyme, differentiated into neurons and glial cells and showed neuronal activity, as measured by

68 een linked to a loss in the retina of Muller glial cells and the amino acid serine, synthesized by th

69 a commonly used sedative, pentobarbital, on glial cells and their uptake of nanoparticles.

70 derstanding of CNS angiogenesis by postnatal glial cells and unveil a glial cell type-dependent HIFal

71 TSPO is upregulated in glial cells and used as a measure of neuroinflammation i

72 T3 activity, endoplasmic reticulum stress in glial cells, and cognitive function.

73 mitochondrial dysfunction, severe damage to glial cells, and impaired vision.

74 ells, their antineuroinflammatory effects on glial cells, and the ability to ameliorate nesting behav

75 ons of presynaptic and postsynaptic neurons, glial cells, and the extracellular matrix, which togethe

76 effects of the gut microbiota on T cells and glial cells, and their relevance for the control of infl

77 neurovascular unit, which includes neurons, glial cells, and vascular cells, plays crucial roles in

78 Glial cells are abundant in the CNS and are essential fo

79 has in human disease.SIGNIFICANCE STATEMENT Glial cells are an essential support to neurons in adult

80 se mutation (S140G), neurons accumulate, and glial cells are dispersed along the rostral migratory st

81 the primary immune responders in the brain, glial cells are implicated as key players in the onset a

82 data collectively suggest that hypothalamic glial cells are leading targets for the effects of FGF1

83 field (SMF) on Central Nervous System (CNS) glial cells are less investigated.

84 Glial cells are of utmost importance in regulating the n

85 ABSTRACT: Enteric glial cells are often implicated in the regulation of ep

86 Those observations indicated that Muller glial cells are the primary contributor to phagocytosis.

87 Astrocytes, a major type of glial cells, are emerging as a critical component in mos

88 here are also terminal Schwann cells (tSCs), glial cells associated with motor neurons and their func

89 As ATP is the primary signaling molecule of glial cells (astrocytes, microglia), responding to metab

90 fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse mod

91 tead form membranous attachments to a single glial cell at the nose, reminiscent of dendrite-glia con

92 Here, we reveal that glial cells at disease-vulnerable NMJs often fail to gui

93 These results show that glial cells at the NMJ elaborate an inappropriate respon

94 erations in perisynaptic Schwann cell (PSC), glial cells at this synapse, may impact their ability to

95 basic unit in the brain, including neurons, glial cells, blood vessels and extracellular matrix.

96 brain, especially in excitatory neurons and glial cells, but shows a more restricted pattern in Dros

97 mbly where pericytes, under instruction from glial cells, can stabilize the quiescent microvasculatur

98 ar deficits in well myelinated mice in which glial cells cannot fully support axons metabolically.

99 onserved gene modules from both neuronal and glial cell classes.

100 day 16 of differentiation, in the absence of glial cell co-culture.

101 gesting an integrated network of immune cell-glial cell communication.

102 onception revealed high expression in radial glial cells, compatible with a role in neurogenesis.

103 Ultrastructurally, glial cells contain glial filaments and make intimate co

104 AT1-, STAT2-, or IRF9-deficient murine mixed glial cell cultures (MGCs).

105 We also performed primary glial cell cultures and sorted brain CD45(-)CD11b(-)CD31

106 Invaginations in the glial cell cytoplasm house the neurites, an association

107 limod (FTY720) attenuates psychosine-induced glial cell death and demyelination both in vitro and ex

108 system require the same transcription factor glial cells deficient/glial cells missing (Glide/Gcm) fo

109 While they both require the glial cells deficient/glial cells missing (Glide/Gcm) tr

110 By adulthood, neocortical glial cell density and gene expression were decreased, w

111 e at trend level, but decreased D3KO PL area glial cell density.

112 Many functions of glial cells depend on the formation of selective glial n

113 We studied whether administration of glial cell derived neurotrophic factor (GDNF) induces en

114 The effects of neither glial cell-derived neurotrophic factor (GDNF) nor seroto

115 tic neurons by the addition of tetracycline, glial cell-derived neurotrophic factor (GDNF), and dibut

116 ctor, brain-derived neurotrophic factor, and glial cell-derived neurotrophic factor and release axon-

117 em (e.g., neurogenesis, synaptic plasticity, glial cell development) and immune functions (e.g., immu

118 to Abeta-burdened neurons, since neighboring glial cells did not express similar molecules.

119 Genes involved in MG cell migration and glial cell differentiation are up-regulated by hypophosp

120 in, demonstrating that, although perineurial glial cells display plasticity despite myelin perturbati

121 ance and exaggerated release of glutamate by glial cells during immune activation leads to glutamate

122 Inflammation, ischemia, and glial cell dysfunction contribute to this persistent bra

123 in tissue pathology, including inflammation, glial cell dysfunction, and angiogenesis, its role in th

124 GFAP and other markers of enteric glial cells (eg, p75 and S100B), colocalized with gastri

125 was designed to examine the role of enteric glial cells (EGCs) in colonic neuromuscular dysfunctions

126 As both neurons and glial cells express cannabinoid receptor 1, genetic vuln

127 have used transgenic reporter mice in which glial cells express DsRed fluorescent protein to study t

128 bleaching and photoconversion experiments in glial cells expressing vimentin, glial fibrillary acidic

129 t Zfp36l1 as a molecular nexus for balancing glial cell-fate decision and controlling gliomagenesis.

130 ced reelin signaling and disorganized radial glial cell fibers.

131 Primary enteric glial cells from C57BL/6 mice were incubated with gastri

132 othesize that complement-mediated changes in glial cell function significantly contribute to RICD.

133 dition to their role in synaptic refinement, glial cells have also been implicated in pathological sy

134 Evidence suggests glial cells have an essential and underappreciated role

135 After traumatic brain injury (TBI), glial cells have both beneficial and deleterious roles i

136 Glial cells have emerged as key players in the central c

137 APOJ, and SORL) that are mainly expressed by glial cells (ie, astrocytes, microglia, and oligodendroc

138 nalysis revealed perivascular, neuronal, and glial cells immunoreactive to IL-9, and quantitative ana

139 e show that in human neuronal precursors and glial cells in culture, ZIKV infection activates both mT

140 stand the interplay between the vascular and glial cells in initiating and driving acute neuroinflamm

141 nic cation transporter 2 (OCT2) in satellite glial cells in oxaliplatin-induced neurotoxicity, and de

142 By highlighting a role for glial cells in schizophrenia, these studies potentially

143 There is increasing evidence that supporting/glial cells in sensory systems function in sensory trans

144 strocytes, the most abundant cell type among glial cells in the brain, in Abeta clearance.

145 Glial cells in the cortex and corpus callosum underwent

146 a) is essential for migration of neurons and glial cells in the developing mouse brain.

147 and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human fore

148 maintain the balance between the neural and glial cells in the embryonic retina by coordinating the

149 ns, in this effect; there are relatively few glial cells in the insect brain and they are rarely asso

150 Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulat

151 ction of neurons, more recently, the role of glial cells in the processing of sensory input has gaine

152 at IH(30) increased the proportion of radial glial cells in the subgranular zone, yet decreased the p

153 d mouse primary astrocytes and in Drosophila glial cells in vivo.

154 haII-spectrin breakdown products, SBDPs) and glial cell injury biomarker, glial fibrillary acidic pro

155 he first systematic quantitative analysis of glial cell insertions at central nodes of Ranvier.

156 Astrocytic glial cells interact with synapses throughout the whole

157 ic transmission via neuronal-glial and glial-glial cell interactions, as well as the involvement of s

158 Assembled alpha-synuclein in nerve cells and glial cells is the defining pathological feature of neur

159 lded proteins inside and outside neurons and glial cells, leading to a loss of cellular protein homeo

160 t dysfunction of astrocytes, a major type of glial cell, leads to neuronal vulnerability.

161 , we analyzed the expression and function of glial cell line-derived neurotrophic factor (GDNF) and i

162 Glial cell line-derived neurotrophic factor (GDNF) binds

163 Glial cell line-derived neurotrophic factor (GDNF) binds

164 he potential of this approach for delivering glial cell line-derived neurotrophic factor (GDNF) direc

165 rophic effects, the therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) has b

166 nt sensitization and increased expression of glial cell line-derived neurotrophic factor (GDNF) in in

167 We investigated the effects of glial cell line-derived neurotrophic factor (GDNF) in Pa

168 , we describe a novel, biphasic function for glial cell line-derived neurotrophic factor (GDNF) in th

169 Glial cell line-derived neurotrophic factor (GDNF) is a

170 Glial cell line-derived neurotrophic factor (GDNF) is a

171 While previous studies have reported that glial cell line-derived neurotrophic factor (GDNF) promo

172 m.SIGNIFICANCE STATEMENT Delivery of ectopic glial cell line-derived neurotrophic factor (GDNF) promo

173 s macrophages transfected ex vivo to produce glial cell line-derived neurotrophic factor (GDNF) readi

174 reatment of a single extraocular muscle with glial cell line-derived neurotrophic factor (GDNF) to pr

175 ic factor (BDNF), neurotrophin-3 (NT-3), and glial cell line-derived neurotrophic factor (GDNF) were

176 hages deliver therapeutics to CNS, including glial cell line-derived neurotrophic factor (GDNF), and

177 We also found that intraspinally expressed glial cell line-derived neurotrophic factor (GDNF), but

178 and agonism are independent of a coreceptor glial cell line-derived neurotrophic factor family recep

179 tivation and stress response cytokine of the glial cell line-derived neurotrophic factor family withi

180 ich is required by the natural growth factor glial cell line-derived neurotrophic factor, and are sel

181 Glial cell-line-derived neurotrophic factor levels were

182 ive PCR measurements and protein analyses of glial cell-line-derived neurotrophic factor, a crucial f

183 The ability of the HS-binding neuropeptide glial-cell-line-derived neurotrophic factor (GDNF) to in

184 eatly reduced sphingosine phosphorylation in glial cells, linking loss of SK2 activity and S1P in AD

185 ponent of the postnatal SVZ, promotes radial glial cell maintenance and proliferation in an autocrine

186 Hyalocytes, contractile myofibroblasts, glial cells, matrix metalloproteinases-2 and -9, and col

187 Muller glial cells (MG) generate retinal progenitor (RPC)-like

188 ostaining of all specimens were positive for glial cells, microglia, and hyalocytes.

189 d experimental work supporting the idea that glial cells might contribute to the development of schiz

190 We also learned that glial cells missing (GCM), a key transcription factor of

191 -dependent monooxygenase family 3 (FMO3) and glial cells missing (GCM).

192 e transcription factor glial cells deficient/glial cells missing (Glide/Gcm) for their development.

193 they both require the glial cells deficient/glial cells missing (Glide/Gcm) transcription factor, gl

194 ] and fusogenic [syncytin 1, syncytin 2, and glial cells missing 1 (GCM1)] genes in first trimester p

195 hromatin, in contrast to the pioneer factor, Glial cells missing, which facilitates Hox binding by in

196 mammals [8], there is also evidence that fly glial cells modulate the neuronal circuits controlling r

197 lizable genetic methods to study neuronal or glial cell morphology in the mammalian brain.

198 ontrary to observations made in neuronal and glial cells, n-3 PUFA treatment attenuated cAMP accumula

199 opeptide processing and secretion suppressed glial cell nonautonomous induction of the UPR(ER) and li

200 overexpression of sEH in the retinal Muller glial cells of non-diabetic mice resulted in similar ves

201 n cell culture and in individual neurons and glial cells of the aging adult fly.

202 demonstrate that the glial cells of the C. elegans amphid apparatus serve as

203 nd the TNF receptor Grindelwald in pigmented glial cells of the Drosophila retina leads to age-relate

204 Studies of K(+) content in glial cells of the fly brain were also performed using a

205 a an elegant biochemical mechanism in Muller glial cells of the neural retina that can contribute to

206 Schwann cells, the principal glial cells of the peripheral nervous system, are now co

207 ly was found in the cytoplasm of neurons and glial cells of the prefrontal cortex at 4 and 24 hours p

208 Glial cells offer protection against AD by engulfing ext

209 , neurons are generated directly from radial glial cells or indirectly via basal progenitors.

210 y morphological or functional changes in the glial cells or vasculature of Jedi-1 knockout mice.

211 Glial cell- or neuron-specific Aldh2 deficiency did not

212 "Pre-OPCs" that originate from outer radial glial cells (oRGs) and undergo mitotic somal translocati

213 early stage of retinal degeneration, Muller glial cells participated in the phagocytosis of dying or

214 In healthy retinas of wild-type mice, Muller glial cells phagocytosed cell bodies of dead rod photore

215 Thus, astrocyte-like glial cells play a role in regulating organismal ER stre

216 lls or polydendrocytes, which are a resident glial cell population in the mature mammalian central ne

217 iated hemichannel activity specifically in a glial cell population.

218 ormed RNA-sequencing on total homogenate and glial cell populations isolated from mouse prefrontal co

219 patterns of differential gene expression in glial cell populations.

220 ts of a series of tight axon layers and long glial cell processes that wrap the circumference of the

221 s and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neu

222 ontains Pax6(+)/Hopx(+) outer (basal) radial glial cells producing astrocytes and oligodendrocytes un

223 ers in neuronal circuits-the neurons and the glial cells, providing the foundation necessary for stud

224 bapical regions of photoreceptors and Muller glial cells; rather, it localizes to a small region of c

225 increase is also observed in APOE-deficient glial cells, reflecting impaired brain cholesterol trans

226 nificance of autonomic circuit modulation by glial cells remain largely unknown.

227 scular, as well as neuronal cell changes and glial cell remodeling.

228 For instance, enteric glia, a collection of glial cells residing within the walls of the intestinal

229 protein 18 kDa (TSPO), a marker of activated glial cell response, in a cohort of National Football Le

230 Single-cell RNA sequencing of vascular and glial cells revealed that apoE4 in VMCs was associated w

231 Aromatase expression was observed in radial glial cells, revealed by co-localization with the glial

232 r pioglitazone) in primary cultures of mouse glial cells reversed EcoHIV-induced inflammatory genes (

233 Radial glial cells (RGCs) are the most abundant macroglia in th

234 gularly spaced, tiled organization of radial glial cells (RGCs) serves as a framework to generate and

235 deling shows reduced proliferation of radial glial cells (RGCs), leading to smaller organoids charact

236 Glial cells serve as fundamental regulators of the centr

237 ocytes, a highly heterogeneous population of glial cells, serve as essential regulators of brain deve

238 regulate nerve repair, but whether satellite glial cells (SGC), which completely envelop the neuronal

239 Satellite glial cells (SGCs) closely envelop cell bodies of neuron

240 dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by relea

241 atory neuronal layers, it is unclear whether glial cells show distinct layering.

242 This results in the loss of glial cells, significant disruptions in myelination, and

243 We find that glial cell-specific loss of the chromatin modifier gene

244 ts catalytic inactivation, causes defects in glial cell specification.

245 Draper/MEGF10 signaling in glia, indicating glial cells spread injury signals and actively suppress

246 lay the main peripheral sensory neuronal and glial cell subtypes.

247 Our findings emphasize the ability of glial cells such as OPCs to positively respond to modera

248 Recent work suggests adaptations made by glial cells, such as astrocytes and microglia, regulate

249 al mediated by gliotrophic FGF signaling.How glial cells, such as astrocytes, acquire their character

250 ed in the nuclei of unmyelinated neurons and glial cells, suggesting the existence of a molecular mac

251 found that the iP is upregulated in reactive glial cells surrounding amyloid beta (Abeta) deposits in

252 ion with structural changes in astrocytes, a glial cell that influences neural communication.

253 Astrocytes are a type of glial cell that tile the CNS.

254 Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the

255 lectively enriched in subsets of neurons and glial cells that degenerate in ALS.

256 a complex network constituted of neurons and glial cells that ensures the intrinsic innervation of th

257 EcI is highly expressed in surface glial cells that form the BBB, and EcI knockdown in the

258 Enteric glial cells that stained positive for glial fibrillary a

259 n two processes that require phagocytosis by glial cells, the immune cells in the brain: neuronal cle

260 As with all glial cells, the major role of retinal Muller glia (MG)

261 ous system is ensheathed by a layer of outer glial cells, the perineurial glia, and a specialized ext

262 n differentiated co-cultures of neuronal and glial cells, the preferential interaction of non-muscle

263 Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differe

264 p in the submucosa, might arise from enteric glial cells through hormone-dependent PKA signaling.

265 eural stem cells (NSCs) generate neurons and glial cells throughout embryonic and postnatal brain dev

266 jury requires the mobilization of immune and glial cells to form a protective barrier that seals the

267 pathway that affects the critical support of glial cells to neurons in the HD brain.

268 sion, explaining the apparent sensitivity of glial cells to Pico/Ras(V12) overexpression.

269 a transcriptional regulation, the ability of glial cells to support neurons in the glutamate/GABA/glu

270 Rgr+/+ retinas following treatment with the glial cell toxin, alpha-aminoadipic acid.

271 nt, and Drak cooperated with EGFR to promote glial cell transformation.

272 SVGAs), an immortalized, mixed population of glial cells transformed with simian virus 40 (SV40) T an

273 Despite the importance of this heterogeneous glial cell type for brain development and function, the

274 oxicity, and the requirement of a particular glial cell type in neurodegeneration, are still unclear.

275 ression is essential for proper neuronal and glial cell type specification.

276 enesis by postnatal glial cells and unveil a glial cell type-dependent HIFalpha-Wnt axis in regulatin

277 c lineage decisions to generate neuronal and glial cell types from neural stem cells (NSCs).

278 n and cell migration regulation of different glial cell types in response to EF stimulation.

279 ecifically target expression to neuronal and glial cell types in the mouse and non-human primate reti

280 Targeting genes to specific neuronal or glial cell types is valuable for both understanding and

281 across diverse hypothalamic cell types, with glial cell types responding much more robustly than neur

282 S) represents a vast network of neuronal and glial cell types that develops entirely from migratory n

283 ively) are composed of distinct neuronal and glial cell types with specialized functional properties.

284 ive tissue comprised of six neuronal and one glial cell types, each of which develops in prescribed p

285 esulted in a unified taxonomy of neuronal or glial cell types, partly due to limited data.

286 ressed in human brain, and both neuronal and glial cell types.

287 ate interactions between resident neural and glial cell types.

288 ow the complex interplay between neurons and glial cells ultimately lead to the degeneration of motor

289 N1 is mostly expressed by neurons and not by glial cells under normal conditions, similar to the expr

290 sophila by elevating levels of fly Dube3a in glial cells using repo-GAL4, not neurons.

291 is, meningitis, and meningoencephalitis, and glial cells were identified as principal targets of infe

292 hows a more restricted pattern in Drosophila glial cells where its disruption affects behavioral outc

293 X2B-progenitor domain generates neuronal and glial cells which together are involved in chemosensory

294 e severely affected, especially outer radial glial cells, which mouse embryonic cortex lacks.

295 entromedial and dorsomedial neurons and some glial cells, which persist into adulthood.

296 igger compensatory responses from supporting glial cells, which subsequently increase rCBF to affecte

297 , and differentiation of enteric neurons and glial cells, with restoration of normal architecture of

298 on channel, which is abundantly expressed in glial cells within the central nervous system and in the

299 We focused on neurons and glial cells within the olfactory bulb because the virus

300 Highly specialized glial cells wrap axons with a multilayered myelin membra