ライフサイエンスコーパス: globular

1 CaMKII dissociation from surface-immobilized globular actin exhibited a monoexponential dwell-time di

2 ynaptosomal F-actin accompanied by increased globular-actin (G-actin) at as early as 1 month of age i

3 At the time, the Globular Amphora culture (3300-2700 BCE) existed over la

4 grave from southern Poland belonging to the Globular Amphora culture and containing the remains of 1

5 lly shaped proteins (for example, small, non-globular and asymmetric particles), produces more repres

6 P4 DNA recognition consensus sequence as the globular and disordered regions bind synergistically to

7 With any DFT functional, globular and planar structures coexist across the size r

8 Distinct yellow globular and red elongated crystalline chromoplasts were

9 We attribute this result to their globular and single particle nature together with its ex

10 Many globular and structural proteins have repetitions in the

11 The globular and tail regions of rProtein uL23 are distincti

12 alibrated FA denaturation using three small, globular, and acid-resistant proteins.

13 esults suggest that phosphorylation sites on globular, as distinct from disordered, parts of the prot

14 on, encapsulation, and surface decoration of globular assemblies, known as vesicles, represent key ea

15 , elongated twisted structure, with a double globular base.

16 have a short, retracted face beneath a large globular braincase that is distinctively different from

17 Globular bushy cells reliably and faithfully transfer sp

18 on protein (PrP(C)) comprises two domains: a globular C-terminal domain and an unstructured N-termina

19 isingly, this inhibitory effect required the globular C-terminal domain of PrP(C), which has not been

20 two largely disordered regions followed by a globular C-terminal domain that binds the template.

21 activity is tightly regulated in cis by the globular C-terminal domain.

22 onnecting the protein's toxic N-terminal and globular C-terminal domains.

23 The globular C1q receptor (gC1qR) has been shown to interact

24 r interacts with the adjacent IgM-Fab(2) and globular C1q-recognition unit.

25 membrane (TM) helix that is connected to the globular catalytic domain by a flexible linker sequence.

26 ains an off-pathway intermediate with molten globular characteristics.

27 Only yellow globular chromoplasts were observed in Newhall flesh.

28 solar masses when the dynamical state of the globular cluster is probed with pulsars.

29 progenitor is distinct from the present-day globular cluster population in the local Universe.

30 it being the tidally disrupted remains of a globular cluster.

31 Globular clusters (GCs) are dense, gravitationally bound

32 hical triple systems produced dynamically in globular clusters are a primary formation channel for bl

33 idence for a 'metallicity floor', whereby no globular clusters are found with chemical (metal) abunda

34 Globular clusters are some of the oldest bound stellar s

35 Its existence implies that globular clusters below the metallicity floor have proba

36 represents the debris of the most metal-poor globular clusters discovered so far, and its progenitor

37 icated observational campaigns have targeted globular clusters for many decades, searching for signat

38 Observations of globular clusters in the Milky Way, and a wide variety o

39 act with JIA positive serum, presented great globular clusters irregularly distributed.

40 ius of 25 kiloparsecs the population of halo globular clusters is rotating in alignment with the stel

41 e found two ultraluminous flaring sources in globular clusters or ultracompact dwarf companions of pa

42 Many of the globular clusters outside a radius of 25 kiloparsecs are

43 um mass and a maximum redshift for surviving globular clusters to form-both critical components for u

44 eport an analysis of the kinematics of these globular clusters.

45 e ubiquitous multiple stellar populations in globular clusters.

46 an do dynamical formation channels involving globular clusters; our predicted detection rate of these

47 However, massive, old 'globular' clusters--those with ages greater than ten bil

48 n important subset of membrane proteins have globular, cofactor-containing extracytoplasmic domains r

49 We identify tentacle-like helices and a globular complex capping the portal vertex that is not o

50 to 6.1 angstrom resolution reveals a compact globular complex of PCBP2 interacting with the cruciform

51 FlaF and sFlaG of Pyrococcus furiosus form a globular complex, whereas sFlaG alone forms a filament,

52 e introduced in alpha-RgIA fixed the favored globular conformation and suppressed disulfide scramblin

53 in solution as an ensemble of rather compact globular conformations with distinct topology and inter-

54 Native alpha-conotoxins preferably adopt the globular connectivity, and previous studies of alpha-con

55 The scattering data support a compact and globular core FERM domain with a more flexible and exten

56 4 tail induce a conformational change in the globular core of histone H3 that reorients K79 from an i

57 ith our MD experiments, suggesting a compact globular core with peripheral flexible regions.

58 the residues extending C-terminally from the globular core, which are lacking in the Rad14 construct.

59 adily into the FG-meshwork compared to their globular counterparts of identical volume and surface ch

60 ave three possible disulfide connectivities: globular (Cys(I)-Cys(III) and Cys(II)-Cys(IV)), ribbon (

61 sis of individual lamin filaments resolves a globular-decorated fibre appearance and shows that A- an

62 nvolving its internal 150-residue N-terminal globular domain (N-domain).

63 cking further gamma rotation, while the zeta globular domain anchors it to the closed alphaDP/betaDP

64 Adiponectin consists of a globular domain and a collagen-like domain, and it occur

65 architecture featuring a C-terminal soluble globular domain and a predicted N-terminal membrane-asso

66 inding sites, one located within its central globular domain and another within its disordered N term

67 uctural determinants present within the Scl1 globular domain and facilitated GAS adherence and biofil

68 is of deletion mutants demonstrated that the globular domain and middle region of eL19 are essential

69 disturbing specific contacts between the H1 globular domain and nucleosomal DNA.

70 We observed that the ColN globular domain associates with the extracellular surfac

71 Moreover, we show that the adiponectin globular domain can be engineered to enhance its binding

72 s primarily to a single linker, while the H1 globular domain contacts the nucleosome dyad and both li

73 , we determined the crystal structure of the globular domain in complex with a PAN RNA MRE, revealing

74 We confirmed the orientations of the globular domain in the membrane observed in the simulati

75 The H1.0 globular domain is bound to Impbeta, whereas the acidic

76 is anchored on the cytosolic side, with the globular domain located on the extracellular end of the

77 Many globular domain mutations are homologous to yeast mutant

78 We found that T-cadherin binds to the globular domain of adiponectin, relying on structural st

79 rray condensed by either the GH5_pMut or the globular domain of Drosophila H1 displayed a similar sed

80 nucleosome array condensed by the wild-type globular domain of H5 showed a much larger sedimentation

81 sequence conservation with the corresponding globular domain of H5, are consistent with an on-dyad bi

82 DOT1L methylates lysine 79 in the globular domain of histone H3 (H3K79).

83 versatile modifications at Lys31 within the globular domain of histone H4 that crucially determine g

84 Although structures of the central globular domain of human XPA and data on binding of DNA

85 wo crystal structures of soluble periplasmic globular domain of PbgA from S. typhimurium and E. coli,

86 tamers, A1 and A2, were selected against the globular domain of recombinant murine PrP (rPrP(90-231))

87 d receptors through interactions between the globular domain of the chemokine and the receptor amino

88 namics simulations of chromatosomes with the globular domain of two linker histone variants, generic

89 X-ray crystal structures of the central globular domain of yeast XPA (Rad14) with lesion-contain

90 fate A, indicating binding to the N-terminal globular domain or type I repeats of hTSP-1.

91 full-length human linker histone H1.0, whose globular domain shares high sequence conservation with t

92 ning the putative WH2 domains is folded as a globular domain that cooperates with other parts of the

93 shows that the FIP200 CTR contains a dimeric globular domain that we designated the "Claw" for its sh

94 iponectin and T-cadherin, and our engineered globular domain variants may be useful tools for further

95 nce which indicated that, in addition to the globular domain, a flanking intrinsically disordered reg

96 otein eL19 that is composed of an N-terminal globular domain, a middle region, and a long C-terminal

97 mprises three distinct structural domains: a globular domain, an extended arm-like P-domain, and a C-

98 n complexes, such as linker DNA, the histone globular domain, and nucleosome spacing.

99 evolutionarily conserved nucleosome-binding globular domain, GH1.

100 s elegans SAS-6, a segment of the N-terminal globular domain, unresolved in crystallographic structur

101 an structures functional for binding laminin globular domain-containing proteins.

102 s, via a second, lower-affinity P-domain and globular domain-dependent, but calcium-independent bindi

103 xtended coiled coil and a dimeric N-terminal globular domain.

104 ed the membrane interactions of the CYP 17A1 globular domain.

105 sites in the influenza A virus hemagglutinin globular domain.

106 ificity of DNA interactions in tandem with a globular domain.

107 RAS4b is largely determined by the protein's globular domain.

108 The globular domains are often omitted in recombinant spidro

109 The horns are assembled from repeated globular domains attached to a central spine, presumably

110 dependent RNA polymerase and an appendage of globular domains containing an mRNA capping region and a

111 oline-rich loop promotes binding between the globular domains of actin and NAA80, and thus acetylatio

112 The globular domains of all three H1 isoforms bound to the n

113 rinsically disordered linkers connecting the globular domains of Gag, remains unclear.

114 observed canonical interactions between the globular domains of M/R and DNA, we observe transient in

115 mately 80% of the interaction surface of the globular domains of NEC proteins.

116 imurium and E. coli, which revealed that the globular domains of PbgA resemble the structures of the

117 Here, we analyzed protein globular domains to understand how genetic mutations aff

118 arin-binding sites of laminin, including the globular domains, and also attached to laminin expressed

119 of highly homologous N-terminal catalytic or globular domains, plus C-terminal hypervariable regions

120 ectively, characterized by flexibly tethered globular domains.

121 e than 400 proteins via one or more of their globular domains.

122 cattered throughout both the coiled-coil and globular domains.

123 pression foci for each expressed gene in the globular embryo, which revealed the importance of phytoh

124 verse division of vascular precursors in mid-globular embryos and second asymmetric division of groun

125 ssociated with an abnormally low filamentous/globular (F/G)-actin ratio that may be the underlying ca

126 Globular fat and serum solids in butter-based emulsions

127 n the presence of tRFs, hBEX3 adopts compact globular fold, which is very distinct from the elongated

128 s are distinctive in several ways: novel non-globular folds are more common, and domains from previou

129 charge states, indicative of a predominantly globular form and some population in more extended state

130 ically have lower potency at nAChRs than the globular form.

131 Profilins bind to globular (G-)actin and regulate actin filament formation

132 Like progressive supranuclear palsy, globular glial tauopathy and argyrophilic grain disease(

133 ning TiC nanoparticles not only exhibit fine globular grains and a modified secondary phase, both whi

134 imeric HA (cHA) vaccine with consensus H5 as globular head and consensus H1 as stem was shown to elic

135 ted in a region located near the base of the globular head and its junction with the alpha-helical st

136 a-biased Ab response directed against the HA globular head and stem regions.

137 accine candidates based on the hemagglutinin globular head and the thoughts about using this antigen

138 The HA is composed of a globular head domain for receptor binding and a stem dom

139 ng mAbs targeted a new antigenic site on the globular head domain of F, designated here antigenic sit

140 tibodies against the variable immunodominant globular head domain of the viral hemagglutinin protein.

141 Mutations in the globular head domain that decrease enzymatic activity bu

142 ed on chimeric hemagglutinins, consisting of globular head domains from exotic influenza A viruses an

143 to a novel and well-conserved epitope on the globular head of H3 HA and that it differs from other an

144 libraries possessing random mutations in the globular head of the haemagglutinin protein (which inclu

145 The globular head of Uso1 binds to Ypt1 and its coiled-coil

146 Structurally, 78/2 and 69/1 Fabs bound the globular head or base of the head domain of influenza he

147 We determined the crystal structure of the globular head region of SosV-RBP, revealing that while t

148 jor antigenic sites of HA are located in the globular head subdomain, which is highly tolerant of ami

149 x, a separate short compact tether, and ZipA globular head which binds FtsZ.

150 ng of a transmembrane region, a stalk, and a globular head with sialidase activity.

151 by glycan accumulation on the hemagglutinin globular head, and hemagglutinin receptor binding has ch

152 en bond network at the base of the F-protein globular head.

153 avidity stable binding of two or more of C1q globular heads initiates the downstream reactions of the

154 ; surface-bound ApoE predominantly bound C1q globular heads, whereas ApoE in a solution favored the h

155 lobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocyte

156 More recently, modifications affecting the globular histone core have been uncovered as being cruci

157 e histones, in both the N-terminal tails and globular histone fold domains, and at or near residues t

158 ights into the genomic basis of the uniquely globular human brain.

159 Nitrocellulose membrane functionalized with globular hydroxyaminodendrimers was used to covalently c

160 n isomers of GeXIVA are more potent than the globular isomer, with low nanomolar half-maximal inhibit

161 dies of alpha-conotoxins have focused on the globular isomers as the ribbon and bead isomers typicall

162 r matrix protein containing multiple laminin globular (LG) domains, and in protein O-mannose beta1, 2

163 de F5-, noncollagenous 1 (NC1)-, and laminin globular (LG)3/4/5-peptide, to modulate cellular events

164 ense mutation (V1727F) in the second laminin globular (LG2) domain of agrin that causes severe congen

165 blue appearance of the fruits is produced by globular lipid inclusions arranged in a disordered multi

166 ]2 sub-complexes to the surface results in a globular macromolecule with a diameter of approximately

167 Demixing of DNA from other globular macromolecules results from the overall repulsi

168 w that actin filaments convert directly into globular material.

169 cyanic vacuolar inclusions (AVIs), from more globular, membrane-bound anthocyanoplasts.

170 he fossil record occurring as dense packs of globular microbodies.

171 systemic injection of 3-NP in mice promotes globular mitochondria, accumulation of mitophagosomes, a

172 atal neuronal cell line shows Rhes surrounds globular mitochondria, recruits lysosomes, and ultimatel

173 The globular molecular shape and rigidified peptide loops en

174 While most classic PCs belong to simple globular molecular systems, a vast number of examples in

175 Fluorine NMR data on the 7-kDa globular N-terminal SH3 domain of Drosophila signal tran

176 3 consists of curved leucine-rich-repeat and globular NACHT domains, and the C-terminal lobe of NEK7

177 sion (CBL) of the central body and a pair of globular noduli.

178 rphology from one with scant cytoplasm and a globular nucleus to one with increased cytoplasm, extens

179 Each SSB subunit contains an N-terminal globular oligonucleotide/oligosaccharide binding fold (O

180 lting in the formation of branched chains of globular particles made of partially misfolded and total

181 by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured

182 consist of a membrane domain on which sits a globular periplasmic domain.

183 Today, synthetic globular polymers of several million molecular weight ar

184 hat derives from increased prominence of the globular polyQ domain.

185 from Sulfolobus solfataricus (Sso AcP) is a globular protein able to aggregate in vitro from a nativ

186 How is a water-soluble globular protein able to spontaneously cross a cellular

187 the Protein Data Bank contains some 100,000 globular protein and 3,000 membrane protein structures,

188 function, we report that ComW is a predicted globular protein and that it interacts with DNA, indepen

189 thod to characterize subunit interactions in globular protein complexes.

190 It utilizes a model of a globular protein connected, through a single point (smal

191 Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs)

192 -ligand binding affinities, mutation induced globular protein folding free energy changes, and mutati

193 isordered proteins appear to follow rules of globular protein folding, such as the cooperative nature

194 In this study, we show that a typical globular protein is able to undergo significant changes

195 o those of lysozyme that is taken as a model globular protein of similar molecular mass.

196 =+3) is virtually as compact and stable as a globular protein of the same number of amino-acids.

197 y bimodal while those obtained by trapping a globular protein or individual fluorophores are not.

198 multivalent ions in a net negatively charged globular protein solution (BSA) can either cause simple

199 ded volume effect, similar to that found for globular protein solvents.

200 other existing methods in the predictions of globular protein stability changes upon mutation.

201 ons based on contact statistics among folded globular protein structures reproduce the overall experi

202 ein fibronectin circulates in the blood as a globular protein that dimerizes through disulfide bridge

203 kinase PINK1 phosphorylates the well-folded, globular protein ubiquitin (Ub) at a relatively protecte

204 ate internal long-range contacts in this non-globular protein.

205 we extend the consensus strategy to design a globular protein.

206 In addition, globular proteins (EB1 and PRC1) diffuse more slowly tha

207 il reaching 20% at 10h with disappearance of globular proteins and generation of low molecular weight

208 Globular proteins are not permanently folded but spontan

209 a wide range of food products with gluten or globular proteins as functional agents.

210 The functional native states of globular proteins become unstable at low temperatures, r

211 tudy the effects of pH on the charge of four globular proteins by expanding their surface charge dist

212 The dynamics of globular proteins can be described in terms of transitio

213 co-protein effects in mixtures of gluten and globular proteins during heating at 100 degrees C.

214 Most globular proteins exhibit a characteristic sigmoidal wat

215 Biomolecular force fields optimized for globular proteins fail to properly reproduce properties

216 We conclude that NIS competes with globular proteins for association with SDS, making it po

217 Although the interfacial behavior of globular proteins has been extensively studied, experime

218 As these small, globular proteins have many interactors, it has been dif

219 s is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments

220 and experiments for a diverse set of soluble globular proteins indicates that the cluster model appli

221 Amyloid formation of folded, globular proteins is commonly initiated by partial or co

222 is the primary effect driving the folding of globular proteins is nearly universally accepted (includ

223 ted that the sizes of the unfolded states of globular proteins should decrease as the denaturant conc

224 iposome surfaces and find the DW dynamics on globular proteins to be significantly more heterogeneous

225 f amyloid aggregate formations by structured globular proteins under conditions close to physiologica

226 dodecyl sulfate (SDS) denatures and unfolds globular proteins under most conditions.

227 Here, we investigate whether globular proteins unfolded by SDS can be refolded upon a

228 s and the surface hydrophobicity of unfolded globular proteins were the main characteristics in deter

229 The intrinsic protein characteristics of globular proteins which enhance polymerization in mixtur

230 ophobic collapse for an unstructured and two globular proteins while directly measuring initial cotra

231 rating the potential for consensus design of globular proteins with increased stability, these result

232 mpare and contrast the folding mechanisms of globular proteins with the emerging features of binding-

233 anionic (e.g., DNA, ribosomes, RNA, and most globular proteins).

234 In contrast to globular proteins, a single protein sequence can aggrega

235 e average solvent exposure of amino acids in globular proteins, as well as with polarity indices and

236 s succeeded in generating a large variety of globular proteins, but the construction of protein scaff

237 ome of the classic paradigms established for globular proteins, pointing to important similarities in

238 Globular proteins, such as cytochrome c (cyt c), display

239 so designed to encapsulate and release bulky globular proteins, such as mCherry, in a light-dependent

240 It is also observed that for almost all globular proteins, the quality of contact prediction dic

241 However, in several soluble-globular proteins, we identified a class of nonconserved

242 ly leads to a globular shape, thus mimicking globular proteins.

243 its role in the onset of global dynamics in globular proteins.

244 sensitive to pressure than folded states of globular proteins.

245 inkers can contract to similar dimensions as globular proteins.

246 understand the folding process of many small globular proteins.

247 by native contacts in determining folding of globular proteins.

248 omogeneous nucleation typically observed for globular proteins.

249 packed tertiary structure of natively folded globular proteins.

250 forces that are the highest yet reported for globular proteins.

251 trinsically different from those observed in globular proteins.

252 extension of capsid protein VP3 folds into a globular protruding (P) domain, exposed on the virion su

253 ibosome every 200 to 900 nucleotides and are globular rather than elongated in shape.

254 Given the binding promiscuity of C1q's globular region (gC1q), we hypothesized that C1q concurr

255 The mechanism involves PbgA's periplasmic globular region (residues 245 to 586), but the biologica

256 particle EM nanostructure of the N-terminal globular region of the alpha4 chain confirmed the C-shap

257 proteolytic processing within the C-terminal globular region of the collagen VI alpha3 chain plays a

258 For the globular region of the rProtein, folding is independent

259 y, the alpha1, alpha2, and alpha4 C-terminal globular regions dimerize.

260 N- and C-terminal globular regions of collagen VI were recombinantly expre

261 "blobs" of 4-15 residues representing local globular regions or linkers.

262 sordered polyampholyte linker separating two globular regions.

263 s resulted from an evolutionary radiation of globular S-crystallin proteins.

264 f the sequence and by destabilization of the globular segment of the protein.

265 second generation dendrimer with persistent globular shape and well-defined cavities.

266 evolving traits such as the acquisition of a globular shape may be the result of direct or indirect s

267 rom our extinct relatives and ancestors is a globular shape of the braincase [1-4].

268 mensional fashion that eventually leads to a globular shape, thus mimicking globular proteins.

269 time, host cell F-actin aggregated to form a globular-shaped plug beneath the CpEF1alpha patch.

270 rly all approaches have been developed using globular, soluble proteins.

271 sassociation from partially unfolded, molten globular species during early disassembly and late-stage

272 inside of the marginal cells as crystals or globular spheres.

273 these genes results in embryo arrest at the globular stage of development.

274 We show that embryo development through the globular stage specifically requires synthesis of R5P ra

275 soybean and Arabidopsis methylomes from the globular stage through dormancy and germination to under

276 ad cell division defects and arrested at the globular stage, revealing an absolute requirement for th

277 ntly, embryo development was arrested at the globular stage.

278 the arrest of embryo development before the globular stage.

279 00 MPa; however, tightly-packed complexes of globular starch granules-protein-cell wall fiber formed

280 teins can explore desolvated pockets and dry globular states numerous times before reaching the nativ

281 rophobic interaction favoring random coil or globular states, respectively.

282 ental scientific interest owing to planar to globular structural transformation at an anomalously hig

283 intrinsically disordered with extended, non-globular structure in solution.

284 ke quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C

285 ins are typically characterized by a defined globular structure, along with a peptide-binding site lo

286 llerene C60-with a unique symmetrical and 3D globular structure-as biocompatible carbon platforms for

287 side chains that give it a rigid polycyclic globular structure.

288 s, the p53 rescue motif described here and a globular-structured SUMO-binding catalytic domain, to st

289 brills in the self-assembly of Abeta1-40 and globular structures in the short fragment Abeta15-21 in

290 We have found that steric zippers form globular structures on route to making fibers and exhibi

291 wed force plateau steps, suggesting that the globular structures were composed of chains that were un

292 CTRP6 contains collagen and globular structures, resembling the pattern recognition

293 we identified as the triangle, dumbbell, and globular structures.

294 s interactions, on the other hand, stabilize globular structures.

295 egaterium GerK(3) GR, revealing two distinct globular subdomains bisected by a cleft, a fold with str

296 allographic structural information about the globular subdomains, along with coevolutionary informati

297 long repetitive protein strands, flanked by globular terminal domains.

298 one methylation mark and supports collapsed, globular three-dimensional conformations rather than reg

299 re large-scale conformational changes of the globular viscumin A chain in a complex environment - com

300 protein carbonylation than soy proteins and globular were more susceptible than fibrillar proteins.