ライフサイエンスコーパス: glomerulus

1 e (reduced number of podocytes per volume of glomerulus).

2 greater propensity for ROS generation in the glomerulus.

3 agents across the filtration barrier of the glomerulus.

4 ctionally elegant structure called the renal glomerulus.

5 olfactory bulb, where they target the gamma-glomerulus.

6 lantation due to reduced podocyte number per glomerulus.

7 the 3-dimensional conformation of the native glomerulus.

8 ovel podocyte-specific protein of the kidney glomerulus.

9 ntaining podocyte function within the kidney glomerulus.

10 ther noradrenaline induces plasticity at the glomerulus.

11 g the reabsorption of Ca(2+) filtered by the glomerulus.

12 ll death and irreversible destruction of the glomerulus.

13 L particles capable of filtering through the glomerulus.

14 e structural and functional integrity of the glomerulus.

15 microscopy enables live imaging of the renal glomerulus.

16 t of cells in the tubulointerstitium and the glomerulus.

17 e could perceive the stimulation of a single glomerulus.

18 rly bifurcate and project into more than one glomerulus.

19 e to sniffing were discriminated through one glomerulus.

20 reof, and sends their axons to a stereotyped glomerulus.

21 position of complement proteins in the renal glomerulus.

22 BA(B) receptor expression in the conditioned glomerulus.

23 that ponzr1 is required for formation of the glomerulus.

24 ainst intrinsic or deposited antigens in the glomerulus.

25 is a general term for scarring of the kidney glomerulus.

26 ons conveying information centrally from the glomerulus.

27 artate receptors (NMDA-Rs) at the cerebellar glomerulus.

28 ed from dendrodendritic synapses within each glomerulus.

29 ngial and endothelial cells to form a mature glomerulus.

30 e of PG cells versus excitatory neurons at a glomerulus.

31 glomerulus initiated inhibition of the same glomerulus.

32 o dissect the contribution of each activated glomerulus.

33 divergence of each ORN onto every PN in its glomerulus.

34 itability and synchronize firing within each glomerulus.

35 maintaining the structural integrity of the glomerulus.

36 tes (visceral epithelial cells) of the renal glomerulus.

37 p a system for targeted drug delivery to the glomerulus.

38 ase GABA neurotransmission at the cerebellar glomerulus.

39 display asymmetry at the level of the single glomerulus.

40 bolic waste into urine by means of the renal glomerulus.

41 s secretion has a functional role within the glomerulus.

42 rt neuropeptide F interact in the LC12 optic glomerulus.

43 ion and axon pruning in the target olfactory glomerulus.

44 onal coupling between sister MCs at the same glomerulus.

45 ons, instructs ensheathing glia to wrap each glomerulus.

46 min, has been almost entirely focused on the glomerulus.

47 ed the average creatinine clearance rate per glomerulus.

48 tigate NET formation in the acutely inflamed glomerulus.

49 in the major cell lineages that compose the glomerulus.

50 nd characterize its expression in the kidney glomerulus.

51 hile a smaller number project to the lateral glomerulus 1 protoglomerulus.

52 The filtration unit of the kidney is the glomerulus, a capillary network supported by mesangial c

53 tion between principal neurons from the same glomerulus, a circuit that reduces the firing rate and p

54 in the mammalian kidney, particularly in the glomerulus, a site of cellular damage in chronic kidney

55 visual field, but whose axons form a single glomerulus-a structure without obvious retinotopic organ

56 We thus suggest that the time of glomerulus activation can be exploited to extract odor-r

57 strategies reduced deposition of IgM in the glomerulus after administration of adriamycin and attenu

58 antibody binds to neoepitopes exposed in the glomerulus after nonimmune insults, triggering activatio

59 er cells of renin lineage can repopulate the glomerulus after podocyte injury and serve as glomerular

60 duced by peritoneal B cells binds within the glomerulus after renal I/R and contributes to functional

61 Furthermore, we show that the beta-glomerulus also reacts to pressure pulses delivered to t

62 e) predominantly bifurcate before entering a glomerulus and 59 and 50% connect to multiple glomeruli

63 They contain protein and RNA from the glomerulus and all sections of the nephron and represent

64 d their matrix form the central stalk of the glomerulus and are part of a functional unit interacting

65 s are relatively freely filtered through the glomerulus and are reabsorbed by the proximal tubule.

66 s of the selective filtration barrier of the glomerulus and are susceptible to oxidative damage.

67 ha-enolase and annexin AI predominate in the glomerulus and can be detected in serum.

68 that circulating hepcidin is filtered by the glomerulus and degraded to smaller isoforms detected in

69 fied the number of CSDn active zones in each glomerulus and found that CSDn output is not uniform, bu

70 multiple cell types downstream of LC6 in the glomerulus and found that they more strongly respond to

71 ntegrin immunoliposomes were detected in the glomerulus and glomerular mesangial cells after tail vei

72 The study of the patho-physiology of the glomerulus and identification of therapeutic targets are

73 s a protective functional role in the normal glomerulus and in glomerulonephritis.

74 ithelium also induced responses in the gamma-glomerulus and in mitral cells.

75 combination of decreased podocyte number per glomerulus and increased glomerular volume.

76 nctional circuitry, with excitation from one glomerulus and inhibition from a broad field of glomerul

77 pro, whose gene products are enriched in the glomerulus and interact with HIV-1 proteins.

78 ion of extracellular matrix (ECM) within the glomerulus and interstitium characterizes renal fibrosis

79 s characterized by segmental scarring of the glomerulus and is a leading cause of kidney failure.

80 ncentration of vinegar excites an additional glomerulus and is less attractive to flies.

81 Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule by the

82 egulation of FGFBP1 was most apparent in the glomerulus and juxtaglomerular space.

83 nt membrane type IV collagen antigens in the glomerulus and lung alveolus.

84 ergic PG cells ramify principally within one glomerulus and participate in uniglomerular circuits.

85 he average number of synapses between a bulb glomerulus and piriform neuron is invariant at one.

86 on of the outer ring of a single "principal" glomerulus and sparse arborization in the core of other

87 itivity closely resembles that of the parent glomerulus and surrounding JGNs, and their spontaneous a

88 role of excessive NPY-NPY2R signaling in the glomerulus and that inhibiting NPY-NPY2R signaling in al

89 ys in the development and maintenance of the glomerulus and the progression of disease.

90 ogenetic stimulation of a specific olfactory glomerulus and the US with optogenetic stimulation of di

91 owever, the dynamics of NET formation in the glomerulus and their functional contribution to acute gl

92 tissue, miR-214 was detected in cells of the glomerulus and tubules as well as in infiltrating immune

93 pathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little

94 Larger glomerular volume, larger cortex per glomerulus, and higher percentage of globally sclerotic

95 genes with cell-type specific expression in glomerulus, and in proximal and distal nephron.

96 s; mean glomerular volume, cortex volume per glomerulus, and mean cross-sectional tubular area to mea

97 lculate glomerular volume, cortex volume per glomerulus, and percentage of globally sclerotic glomeru

98 ed VEGF receptor alterations in the diabetic glomerulus, and promoted both glomerular protection and

99 lian microvessels of choroid, renal tubules, glomerulus, and psoas muscle all showed similar lateral

100 e each respectively activate the LC2 and AM2 glomerulus, and remarkably, the AM2 glomerulus is also s

101 dent IC processing by blood cells and in the glomerulus, and the importance of CFH as a plasma comple

102 ion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion.

103 form only a sparse, open network around each glomerulus; and glial processes invade the synaptic neur

104 The capillary diameters throughout the glomerulus appeared to correspond with the amount of blo

105 rphological processes forming the pronephric glomerulus are astoundingly different between medaka and

106 clearly of great importance, changes in the glomerulus are not the major determinant of renal progno

107 that initiate and drive inflammation in the glomerulus are still poorly understood.

108 iles of the interstitium, urinary lumen, and glomerulus-areas that are not resolved by traditional in

109 prevents the early structural changes in the glomerulus associated with diabetic nephropathy.

110 med large-scale gene expression profiling of glomerulus-associated G protein-coupled receptors (GPCRs

111 us at immunofluorescence microscopy, and one glomerulus at electron microscopy.

112 least 10 glomeruli at light microscopy, one glomerulus at immunofluorescence microscopy, and one glo

113 This is corroborated by a mosaic, glomerulus-based pattern of expression of the HCN2 (hype

114 Loss of ponzr1 results in a nonfunctional glomerulus but retention of a functional pronephros, an

115 cells were present in the nephron including glomerulus but they were not stained by markers for podo

116 acid sensitivity is not only focused to one glomerulus, but is also integrated in the odor processin

117 r, does not appear at the input level of the glomerulus, but is restricted to the projection neuron l

118 d Ki-67-positive and pERK-positive cells per glomerulus by 52% (P < 0.01 and P < 0.005, respectively)

119 that regulates inflammatory response in the glomerulus by modulating the NF-kappaB signaling pathway

120 Ultrastructural studies of the glomerulus by transmission electron microscopy (TEM) and

121 erular gap junctions between MCs at the same glomerulus can greatly enhance synchronized activity of

122 ic periglomerular (PG) cells that surround a glomerulus can prevent activation of a glomerulus throug

123 Our data suggest that each glomerulus can transmit odor information using identity,

124 Notably, the ontology of the glomerulus coincides with induction of unique transcript

125 three connectivity schemes: selective (each glomerulus connects to few others with heterogeneous str

126 The glomerulus contains unique cellular and extracellular ma

127 arietal epithelial cells (PECs) of the renal glomerulus contribute to the formation of both cellular

128 meruli in the main olfactory bulb, with each glomerulus corresponding to a specific receptor.

129 man podocytes (HPCs), a key cell type in the glomerulus critical for kidney filtration function.

130 a synergistic response in the cVA-responsive glomerulus DA1.

131 nt in future analyses of medaka mutants with glomerulus defects.

132 idney magnetic resonance imaging dataset for glomerulus detection.

133 teleost models to understand the pronephric glomerulus development.

134 , wherein all mitral cells affiliated with a glomerulus either engaged in prolonged spike bursts or d

135 the visceral epithelial cells of the kidney glomerulus, elaborate primary and interdigitating second

136 The glomerulus exercises its filtration barrier function by

137 provide an atlas of in vivo phosphorylated, glomerulus-expressed proteins, including podocyte-specif

138 The capillary network of the kidney glomerulus filters small molecules from the blood.

139 eed to filter large volumes of plasma at the glomerulus followed by active reabsorption of nearly 99%

140 tion of output mitral cells (MCs) at another glomerulus for interstimulus intervals of 20-50 ms and g

141 s and Orco are expressed before the onset of glomerulus formation, and Orco protein is trafficked to

142 , single-cell transcriptomic profiles of the glomerulus from healthy and injured mice provides resour

143 vely characterized the types of cells in the glomerulus from healthy mice and from four different dis

144 In both sexes and all castes, the largest glomerulus (G1) was located at a similar position relati

145 rmation of the size-exclusion barrier of the glomerulus/glomus and recruit mesangial and endothelial

146 nse to signals passed from the tubule to the glomerulus: high levels of glucose in the glomerular fil

147 Cells of the glomerulus, however, have been largely underrepresented

148 Using a novel 3D whole-glomerulus imaging ex vivo assay, we revealed the involv

149 M activates the complement system within the glomerulus in an animal model of glomerulosclerosis.

150 nary proteins that leak through the abnormal glomerulus in nephrotic syndrome may affect tubular tran

151 ron (PN) targets its dendrites to a specific glomerulus in the antennal lobe and its axon stereotypic

152 Or83c neurons innervate the DC3 glomerulus in the antennal lobe and projection neurons r

153 Each PN targets dendrites to a specific glomerulus in the antennal lobe and projects axons stere

154 ed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activat

155 n the antenna, form connections in a ventral glomerulus in the antennal lobe, and mediate avoidance.

156 These neurons converge on the DA1 glomerulus in the antennal lobe.

157 are broadly tuned to odors and target every glomerulus in the antennal lobe.

158 teins, each of which corresponds to a unique glomerulus in the first olfactory relay of the brain.

159 The different segments of the nephron and glomerulus in the kidney balance the processes of water

160 e, we show that for a genetically identified glomerulus in the mouse olfactory bulb, early odorant ex

161 cted localization of the MICA antigen to the glomerulus in the normal kidney, because this was confir

162 We present a glomerulus in the olfactory bulb (OB) activated by very

163 Here, we present data on the beta-glomerulus in the olfactory bulb of Xenopus laevis tadpo

164 the brain and show that they form a distinct glomerulus in the posterior antennal lobe (PAL).

165 haracterize cleaved podocyte proteins in the glomerulus in vivo We found evidence that defined proteo

166 n maintaining the filtration function of the glomerulus, in part through signaling events mediated by

167 six major renal structures: glomerular tuft, glomerulus including Bowman's capsule, tubules, arteries

168 ic and injury type-specific responses in the glomerulus, including acute activation of the Hippo path

169 recapitulates functions and structure of the glomerulus, including permselectivity.

170 The occurrence of a major glomerulus-infiltrating CD11b(+)F4/80(-)I-A(-) macrophag

171 etic bead-purified glomeruli have identified glomerulus-infiltrating leukocyte populations in NZM2328

172 ic effect of CD11b(+)F4/80(-)I-A(-) M2b-like glomerulus-infiltrating macrophages in LN and reinforce

173 Glomerular damage mediated by glomerulus-infiltrating myeloid-derived cells is a key p

174 neous chronic GN and severe proteinuria, few glomerulus-infiltrating PMN were found, leaving macropha

175 ned to one glomerulus, such that ORNs at one glomerulus initiated inhibition of the same glomerulus.

176 Rather, homotypic MT neurons from the same glomerulus innervate broad regions that differ between i

177 normally target to a particular dorsolateral glomerulus instead mistarget to incorrect glomeruli with

178 The glomerulus is a highly specialized microvascular bed tha

179 The glomerulus is a primary site of diabetic injury, and pod

180 The glomerulus is a specialized capillary bed that is involv

181 and AM2 glomerulus, and remarkably, the AM2 glomerulus is also sensitive to N,N-diethyl-meta-toluami

182 ed that thermo-induced activity in the gamma-glomerulus is conveyed to the mitral cells innervating t

183 uggest that synchronous activity within each glomerulus is dependent on segregation of synaptic subco

184 We show that activation of the extra glomerulus is necessary and sufficient to mediate the be

185 in fish, the morphogenesis of the pronephric glomerulus is not stereotypical.

186 However, the odor tuning of a glomerulus is not strongly correlated with its spatial p

187 Activation of each glomerulus is relayed to higher cortical processing cent

188 ation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and

189 In the kidney, SS1P passes through the glomerulus, is taken up by proximal tubular cells, and t

190 e report another unique feature of the gamma-glomerulus: it receives ipsilateral and contralateral af

191 s of both neurons converge on a single optic glomerulus LC12, suggesting a key pathway linking visual

192 Albuminuria associated with sclerosis of the glomerulus leads to a progressive decline in renal funct

193 ular capsule, a change we term the "uncapped glomerulus lesion." Glomerulotubular disconnection was c

194 hat early postnatal odor exposure to the M72 glomerulus ligand acetophenone increased the strength of

195 l cells, and structural elements surrounding glomerulus-like capillary beds.

196 igenesis and markedly expands the numbers of glomerulus-like structures and that tumor formation is s

197 We found that the Ipc terminal boutons form glomerulus-like structures in the superficial and interm

198 At a glomerulus, local interneurons reliably code visual prim

199 In the renal glomerulus, MAGI-2 is exclusively expressed in podocytes

200 ng the number of M/TCs connected to a single glomerulus may also increase the influence of that glome

201 ons, and that homogenous odor inputs to each glomerulus may be parsed and processed in different fash

202 that MICA is preferentially localized to the glomerulus may explain both immunoregulatory and pathoge

203 mitral and external tufted cells within the glomerulus may involve both direct and indirect componen

204 gs of this study support the notion that the glomerulus may serve as an amplification reservoir for Z

205 rites that normally target to a dorsolateral glomerulus mistarget to medial glomeruli in the antennal

206 PTP1B was markedly up-regulated in the glomerulus, notably in podocytes, in three rodent models

207 podocytes are stationary cells in the intact glomerulus of a translucent zebrafish with fluorescently

208 nd minimized pathological alterations in the glomerulus of STZ-Nrf2(+/+) mice.

209 nt study examined cellular components of the glomerulus of the human kidney for ZIKV infectivity.

210 nd constrain the vascular network within the glomerulus of the kidney.

211 aining integrins are highly expressed in the glomerulus of the kidney; however their role in glomerul

212 s project unbranched axons into one specific glomerulus of the olfactory bulb.

213 The glomerulus of the vertebrate kidney links the vasculatur

214 to one glomerulus on the medial face and one glomerulus on the lateral face of the bulb.

215 ng a given receptor typically project to one glomerulus on the medial face and one glomerulus on the

216 ulus may also increase the influence of that glomerulus on the OB network and on OB output.

217 ar layer was observed repeatedly in the beta-glomerulus only, mechanosensitive modulation of mitral c

218 In the glomerulus, Opn immunostaining was increased specificall

219 nd drive intraglomerular inhibition to shape glomerulus output to downstream olfactory networks.

220 owever, repeated in vivo imaging of the same glomerulus over extended periods of time and the study o

221 Change in mesangial fractional volume per glomerulus over the 5-year period did not differ signifi

222 negatively with total filtration surface per glomerulus (partial r = -0.26, P = 0.01; and partial r =

223 PCx firing was insensitive to single-glomerulus photostimulation.

224 nvestigate the necessity of cofilin-1 in the glomerulus, podocyte-specific Cfl1 null mice were genera

225 y to the specialized epithelial cells of the glomerulus (podocytes) underlies the pathogenesis of all

226 Within the glomerulus, podocytes--differentiated epithelial cells c

227 We show that this glomerulus possesses an unusually broad response pattern

228 number of nonviable cells per examined area (glomerulus, proximal, and distal tubules).

229 PN axons from the same glomerulus reconverge in the lateral horn, where pooling

230 ila brain, focal activation of even a single glomerulus recruits GABAergic interneurons in all glomer

231 lls, whose processes are limited to a single glomerulus, regulate intraglomerular processing and (2)

232 tions exert their deleterious effects on the glomerulus remain elusive.

233 at project their apical dendrite to the same glomerulus represent unique functional networks.

234 ponse to large numbers of odorants at single glomerulus resolution.

235 3) (P<0.001) albumin-containing vesicles per glomerulus, respectively, compared with none at baseline

236 ion of an axon bundle entering an individual glomerulus revealed that mitral cells receive monosynapt

237 Strikingly, silencing of glomerulus-selective OSNs extends the CP for structural

238 hibition slowed podocyte loss (podocytes per glomerulus +/-SEM at 8 weeks: 667+/-40, n=4; at 20 weeks

239 n, our data demonstrate the existence of one glomerulus sensitive to both a large number of amino aci

240 Mitral cells within a glomerulus show highly synchronized activity as assessed

241 projection neurons associated with a single glomerulus significantly, a dramatic and long-lasting st

242 igh-risk genotype (CXCL9, CXCL11, and UBD in glomerulus; SNOR14B and MUC13 in tubulointerstitium).

243 rse set of presynaptic partners, rather than glomerulus-specific differences in synaptic output, whic

244 exposure increases M/TC number by >40% in a glomerulus-specific fashion.

245 techniques, we found that the CSDns received glomerulus-specific input from olfactory receptor neuron

246 but not unconditioned odor exposure, induces glomerulus-specific long-term potentiation (LTP) of syna

247 hat the equilibrium is a requirement for the glomerulus-specific size changes which are a morphologic

248 lomerulus, thus representing a new potential glomerulus-specific targeted intervention.

249 Ca(2+) activity profiles are distinct and glomerulus-specific.

250 ay a strong role in either axonal sorting or glomerulus stabilization and that in the adult, glial pr

251 Single-glomerulus stimulation was also detected on an intense o

252 ntribute to different diseases affecting the glomerulus, such as FSGS, IgA nephropathy, lupus nephrit

253 ll activation appeared to be confined to one glomerulus, such that ORNs at one glomerulus initiated i

254 erminally differentiated cells of the kidney glomerulus that are essential for the integrity of the k

255 ifferentiated epithelial cells in the kidney glomerulus that are exposed to glomerular capillary pres

256 cellular matrix (ECM) compartment within the glomerulus that contains tissue-restricted isoforms of c

257 wnstream cell types form circuits within the glomerulus that enable spatial readout of visual feature

258 e specialized epithelial cells in the kidney glomerulus that play important structural and functional

259 escribes a group of pathologies of the renal glomerulus that result in the classic triad of heavy pro

260 The glomerulus, the filtering unit in the kidney, is one goo

261 In the mouse olfactory bulb glomerulus, the GABAergic periglomerular (PG) cells prov

262 During formation of the renal glomerulus, the glomerular capillary becomes enveloped b

263 Within each labeled TrpM5-positive glomerulus, the level of TrpM5-GFP expression was simila

264 mber of the filtration barrier in the kidney glomerulus, the podocyte is in a unique geographical pos

265 t sites of C3 fragment deposition within the glomerulus, the renal tubulointerstitium, and the poster

266 It is composed of a glomerulus, the site of ultrafiltration, and a renal tub

267 d to IgM and was selectively filtered by the glomerulus, thereby excreted in urine.

268 und a glomerulus can prevent activation of a glomerulus through inhibitory inputs targeted onto excit

269 rget a specific signaling pathway within the glomerulus, thus representing a new potential glomerulus

270 equate cases (5%), six were lacking only one glomerulus to achieve minimal status.

271 ction neurons relaying information from this glomerulus to higher brain centers target a region of th

272 In mapping the position of a glomerulus to its odor tuning, we found only a coarse re

273 eomics of the entire urinary system from the glomerulus to the bladder.

274 technique, that the projections from the DA1 glomerulus to the protocerebrum are sexually dimorphic.

275 et al. analyze a model system, the olfactory glomerulus, to show how neurovascular coupling involves

276 on of their dendritic arbors within a single glomerulus (uniglomerular).

277 The beta-glomerulus uses the classical cAMP-mediated pathway, as

278 y impaired development of a single olfactory glomerulus, VA1v, which normally displays extensive slee

279 deposited in the tubulointerstitium and peri-glomerulus via binding to heparan sulphate (HS) chains o

280 At this time the podocyte number per glomerulus was not yet reduced although podocytes were a

281 hibition onto TCs, but not MCs, when the M72 glomerulus was stimulated.

282 nstruction of all LC6 synaptic inputs to the glomerulus, we found that LC6 and downstream cell types

283 the presence of five or more leukocytes per glomerulus, we sought to assess the reproducibility of t

284 All cell types in the glomerulus were identified using unsupervised clustering

285 odor-evoked intrinsic optical signals at the glomerulus were persistently weakened after LC activatio

286 D68+ cells more than 12 in the most inflamed glomerulus were strongly associated with TG, donor-speci

287 co-expressed within podocytes in the kidney glomerulus, where they localize to the slit diaphragm (S

288 ollowed the response time course of the beta-glomerulus, whereas many others were strongly inhibited

289 riolar smooth muscle cells upstream from the glomerulus, which can transiently acquire the embryonic

290 m the sensory epithelia to an olfactory bulb glomerulus, which is selectively innervated by only one

291 in the Xenopus tadpole system that the gamma-glomerulus, which receives input from olfactory neurons,

292 glomeruli is fused at the midline to form a glomerulus, while in medaka the two parts remain unmerge

293 We focus on a glomerulus whose receptor neurons converge in an all-to-

294 t neuropeptide F sensitizes an antennal lobe glomerulus wired for attraction, while tachykinin (DTK)

295 le tachykinin (DTK) suppresses activity of a glomerulus wired for aversion.

296 Pairing optogenetic activation of a single glomerulus with foot shock in mice induces freezing to l

297 ression is especially prominent in the renal glomerulus within podocytes.

298 neuron axons exclusively connect to a single glomerulus without any axonal branching.

299 reported to be freely filtered at the renal glomerulus without reabsorption at the tubule.

300 obe, the CSDn differentially innervates each glomerulus, yet surprisingly, this variability reflects