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1 11%, P = 0.002), NEFA (-21%, P = 0.009), and glucagon-like peptide 1 (-31%, P = 0.001) areas under th
2 w focuses on two peptide drugs - insulin and glucagon-like peptide 1 (GLP-1) - for treatment of type
3 fy 37 T2D patients who were actively using a Glucagon-like peptide 1 (GLP-1) agonist in addition to a
7 ipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues, can increase
12 sized that enteroendocrine L-cells producing glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) may
13 ssed on enteroendocrine L cells that release glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) whe
15 pendent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted postprandia
16 nsulin increased by 120% +/- 15% (P = 0.02), glucagon-like peptide 1 (GLP-1) by 60% +/- 20% (P < 0.01
17 ecretion of the prosurvival incretin hormone glucagon-like peptide 1 (GLP-1) by alpha cells and acts
25 e-dependent insulinotropic peptide (GIP) and glucagon-like peptide 1 (GLP-1) is characterized by thei
33 armacological activation of the hypothalamic glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) promot
37 al models of type 2 diabetes have shown that glucagon-like peptide 1 (GLP-1) receptor agonists preven
38 e-18]fluoro-levodopa [(18)F-DOPA] PET-CT and glucagon-like peptide 1 (GLP-1) receptor imaging), and d
42 gon released from pancreatic alpha cells and glucagon-like peptide 1 (GLP-1) released from intestinal
43 proposed pathway was not influenced by local glucagon-like peptide 1 (GLP-1) secretion from alpha-cel
47 enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve
49 proof-of-principle, the clinically relevant glucagon-like peptide 1 (GLP-1) was functionalized with
51 ty acids (FFAs), insulin, glucose, glucagon, glucagon-like peptide 1 (GLP-1), and gastric inhibitory
52 in plasma cholecystokinin, peptide YY (PYY), glucagon-like peptide 1 (GLP-1), and glucagon-like pepti
53 ) inhibitor that inhibits the degradation of glucagon-like peptide 1 (GLP-1), and has been approved f
54 peptide YY3-36 (PYY3-36), lithium chloride, glucagon-like peptide 1 (GLP-1), and leptin shows the pr
55 kinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide tyrosine ty
56 wn at regular intervals for cholecystokinin, glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) an
57 elated to changes in blood peptide YY (PYY), glucagon-like peptide 1 (GLP-1), glucose, or insulin con
58 ing glucose, lipids (fasting only), insulin, glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and g
60 RC1), general control nonrepressed 2 (GCN2), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), serot
62 diabetes associated with the stimulation of glucagon-like peptide 1 (GLP-1), which is known to slow
64 S) in the circulation and thereby stimulates glucagon-like peptide 1 (GLP-1)-mediated insulin secreti
66 studies in subjects with diabetes receiving glucagon-like peptide 1 (GLP-1)-targeted therapies have
69 tus and obesity, exemplified by the licensed glucagon-like peptide 1 (GLP1) mimetics and dipeptidyl p
71 , dipeptidyl peptidase 4 [DPP-4] inhibitors, glucagon-like peptide 1 [GLP-1] receptor agonists, and s
72 ite-related hormones (active ghrelin, active glucagon-like peptide 1 [GLP-1], total peptide YY [PYY],
73 The cardiovascular effects of semaglutide, a glucagon-like peptide 1 analogue with an extended half-l
74 The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard
75 ontrolled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patien
76 ulation of cells expressing the precursor of glucagon-like peptide 1 and are glutamatergic; able to m
77 with PS-CF and normal control subjects, and glucagon-like peptide 1 and gastric inhibitory polypepti
81 ocrine cells (EECs) produce hormones such as glucagon-like peptide 1 and peptide YY that regulate foo
83 ther dose affected plasma ghrelin, glucagon, glucagon-like peptide 1 and peptide YY, or pyloric and d
84 of 14.6% +/- 2.6% and elevated postprandial glucagon-like peptide 1 compared with controls (49.2 +/-
85 g, enhanced postprandial cholecystokinin and glucagon-like peptide 1 concentrations, and reduced ghre
86 in human beta-cells, using forskolin or the glucagon-like peptide 1 mimetic Exendin-4, inhibits the
87 Strikingly, when P-NT was combined with the glucagon-like peptide 1 mimetic liraglutide, the two pep
90 icacy and ability to reduce the body weight, glucagon-like peptide 1 receptor (GLP-1R) agonism has em
91 abetic C57BL/6J mice treated with either the glucagon-like peptide 1 receptor (GLP-1R) agonist liragl
97 like peptide-1 (GLP-1) signaling through the glucagon-like peptide 1 receptor (GLP-1R) is a key regul
99 und that exendin-4 (Ex-4), an agonist of the glucagon-like peptide 1 receptor (GLP-1R), stimulates hu
102 ering glucose, incretin drugs, which include glucagon-like peptide 1 receptor (GLP1R) agonists and di
104 treatment with thiazolidinedione therapy or glucagon-like peptide 1 receptor agonism alone or in com
106 ctivities of NRTN relative to liraglutide, a glucagon-like peptide 1 receptor agonist, in Zucker diab
108 odium glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists have consisten
110 In nonfasted rats, central antagonism of glucagon-like peptide 1 receptors partially mimics the e
111 ntragastric infusion test sessions), whereas glucagon-like peptide 1 responses to milkshake intake we
112 enome editing to controllably release GLP-1 (glucagon-like peptide 1), a critical incretin that regul
113 y reports activation in response to insulin, glucagon-like peptide 1, and agents that raise cAMP leve
114 ve for either prolactin-releasing peptide or glucagon-like peptide 1, and attenuates the activation o
115 onists, including ADP, arginine vasopressin, glucagon-like peptide 1, and forskolin, and, surprisingl
116 ut hormones, fibroblast growth factor 19 and glucagon-like peptide 1, and the BA transport systems, a
117 nsional ultrasound), plasma cholecystokinin, glucagon-like peptide 1, glucose-dependent insulinotropi
118 h plasma concentrations of acylated ghrelin, glucagon-like peptide 1, insulin, glucose, and nonesteri
119 accompanied by higher secretion of insulin, glucagon-like peptide 1, peptide YY, and cholecystokinin
120 l motility, plasma ghrelin, cholecystokinin, glucagon-like peptide 1, peptide YY, insulin, glucagon,
122 tidyl-peptidase 4-inhibitor sitagliptin, the glucagon-like peptide 1-receptor agonist lixisenatide ba
123 We assessed the effects of lixisenatide, a glucagon-like peptide 1-receptor agonist, on cardiovascu
127 es of glucose, insulin, C-peptide, glucagon, glucagon-like peptides 1 and 2, gastric inhibitory pepti
128 udy assessing the occupancy of the dual GCGR/glucagon like peptide-1 receptor agonist SAR425899.
130 (OR 0.68, 95% CI 0.58-0.79; p < 0.001), and glucagon-like peptide-1 (GLP-1) agonists (OR 0.37, 95% C
132 dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) analogs, are important n
134 ed the efficacy and safety of semaglutide, a glucagon-like peptide-1 (GLP-1) analogue in clinical dev
139 ate the anorectic effects of both endogenous glucagon-like peptide-1 (GLP-1) and exogenous GLP-1 rece
140 creting glucagon, insulin, and the incretins glucagon-like peptide-1 (GLP-1) and GIP (glucose-depende
142 , Tukey's post hoc, P < 0.05]; and increased glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) com
143 e of enteroendocrine L-cell derived hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in
144 elease of gastrointestinal peptides, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), fr
145 lation to two clinically important peptides: glucagon-like peptide-1 (GLP-1) and the parathyroid horm
146 circulating glucose, insulin, glucagon, and glucagon-like peptide-1 (GLP-1) concentrations and subje
147 d plasma cholecystokinin (CCK), ghrelin, and glucagon-like peptide-1 (GLP-1) concentrations, appetite
150 The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as ups
152 Pharmacological evidence suggests a role for glucagon-like peptide-1 (GLP-1) in modulating stress res
153 e acid synthesis and intestinal secretion of glucagon-like peptide-1 (GLP-1) in wild-type, Fxr(-/-),
158 The multiple physiological properties of glucagon-like peptide-1 (GLP-1) make it a promising drug
160 impaired; this impairment is ameliorated by glucagon-like peptide-1 (GLP-1) or by GLP-1 receptor ago
166 maglutide is the first oral formulation of a glucagon-like peptide-1 (GLP-1) receptor agonist develop
167 d to investigate the association between the glucagon-like peptide-1 (GLP-1) receptor agonist dulaglu
171 exposed to thiazolidinediones (glitazones), glucagon-like peptide-1 (GLP-1) receptor agonists and di
179 body of preclinical evidence indicates that glucagon-like peptide-1 (GLP-1) receptor agonists reduce
183 rlap between signaling and regulation of the glucagon-like peptide-1 (GLP-1) receptor by the non-pept
186 Recent evidence indicates that activation of glucagon-like peptide-1 (GLP-1) receptors in the ventral
188 oid these systemic effects while stimulating glucagon-like peptide-1 (GLP-1) secreting enteroendocrin
189 021 to be an especially potent stimulator of glucagon-like peptide-1 (GLP-1) secretion in vitro.
190 etate and early-phase insulin, C-peptide and glucagon-like peptide-1 (GLP-1) secretion were increased
193 an 11-residue analogue of the N-terminus of glucagon-like peptide-1 (GLP-1) to investigate effects o
194 lasma levels of insulin, leptin, amylin, and glucagon-like peptide-1 (GLP-1) were assessed using Lumi
195 CK in enteroendocrine cells (EECs) that were glucagon-like peptide-1 (GLP-1)(+)/Peptide YY (PYY(-)) i
196 for their production of the incretin hormone glucagon-like peptide-1 (GLP-1), also release other neur
198 , we use the validated diabetes therapeutic, glucagon-like peptide-1 (GLP-1), and the target of clini
199 lucose, plasma insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insul
200 bolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insul
201 FAs and 2-OG, on enteroendocrine secretions [glucagon-like peptide-1 (GLP-1), glucose-dependent insul
202 on of glucose-regulating hormones, including glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and i
203 ll-bowel motility, other MRI parameters, and glucagon-like peptide-1 (GLP-1), polypeptide YY (PYY), a
205 ed receptors (GPCRs) for glucagon (GluR) and glucagon-like peptide-1 (GLP-1R) are normally considered
207 visceral or cognitive threats that increase glucagon-like peptide-1 (GLP1) signaling from the caudal
208 together with the beneficial effects of the glucagon-like peptide-1 agonist exendin-4 in transgenic
209 odium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 agonists, and suggest how such d
210 vestigate the neuroprotective effects of the glucagon-like peptide-1 analog exenatide in resuscitated
212 trophy mice and further demonstrate that the glucagon-like peptide-1 analogue exendin-4, a well-toler
214 f target engagement for clinical trials with glucagon-like peptide-1 analogues in multiple system atr
215 rolonging the half-life of incretins such as glucagon-like peptide-1 and gastric inhibitory peptide,
216 ates Ca(2+) , cAMP, and insulin responses to glucagon-like peptide-1 and its metabolites following il
217 n of a long-acting analog of the gut-hormone glucagon-like peptide-1 highlights the therapeutic poten
219 ffects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we
221 ble incretin mimetic based upon the specific glucagon-like peptide-1 receptor (GLP-1R) agonist liragl
226 Therapeutic intervention to activate the glucagon-like peptide-1 receptor (GLP-1R) enhances gluco
227 We have shown previously that the incretin glucagon-like peptide-1 receptor (GLP-1R) internalizes f
231 first orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) noncompetitive
232 tivated positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R), a class B GPC
234 f intraduodenal metformin, and both duodenal glucagon-like peptide-1 receptor (Glp-1r)-protein kinase
238 smotic pump to give continuous delivery of a glucagon-like peptide-1 receptor agonist for 6-12 months
241 e available for the subcutaneous form of the glucagon-like peptide-1 receptor agonist semaglutide but
242 we evaluated the efficacy of a short-course glucagon-like peptide-1 receptor agonist therapy-specifi
243 als, including cholecystokinin, exendin-4 (a glucagon-like peptide-1 receptor agonist), amylin, and m
245 ons in the dipeptidyl peptidase-4 inhibitor, glucagon-like peptide-1 receptor agonist, and sodium-glu
247 lucose-lowering medication occurred, and for glucagon-like peptide-1 receptor agonists (GLP-1 RAs; 3.
250 However, the distinction may be crucial for glucagon-like peptide-1 receptor agonists and other anti
251 es and consensus statements have recommended glucagon-like peptide-1 receptor agonists and sodium-glu
253 Indeed, in several of the new statements, glucagon-like peptide-1 receptor agonists are suggested
255 to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical
259 f dipeptidyl peptidase-4 inhibitors and some glucagon-like peptide-1 receptor agonists, at least in t
260 to micelles, and these micelles activate the glucagon-like peptide-1 receptor with a potency comparab
261 in vivo We further demonstrate that an ileal glucagon-like peptide-1 receptor-dependent neuronal netw
263 l literature suggests that targeting central glucagon-like peptide-1 receptors (GLP-1Rs) may represen
264 us of the stria terminalis (alBST) expresses glucagon-like peptide-1 receptors (GLP1Rs) and receives
267 rs in hippocampal neurons to reduce (leptin, glucagon-like peptide-1) or increase (ghrelin) food inta
268 ucose cotransporter 2) inhibitors and GLP-1 (glucagon-like peptide-1) receptor agonists, has changed
270 lunted the body weight-lowering effects of a glucagon-like peptide-1-estrogen (GLP-1-estrogen) conjug
271 nt research has indicated a crucial role for glucagon-like peptide-1-producing preproglucagon (PPG) n
272 , we investigated the effects of G49, a dual glucagon-like peptide-1/glucagon receptor agonist, on NA
274 , insulin, C-peptide, and incretin hormones; glucagon-like peptide-1; and glucose-dependent insulinot
275 us of the solitary tract (cNTS) that produce glucagon-like peptide-1; published work in rodents indic
277 e effects of once-weekly exenatide (a GLP-1 [glucagon-like peptide-1] receptor agonist) versus placeb
278 haracterization, and clinical development of glucagon-like-peptide-1 (GLP-1) spans more than 30 years
279 Here, we investigated whether amylin- and glucagon-like-peptide-1 (GLP-1)-based combination therap
282 (PYY), glucagon-like peptide 1 (GLP-1), and glucagon-like peptide 2 (GLP-2) concentrations was great
287 Here I provide an overview of the actions of glucagon-like peptide (GLP)-1 and GLP-2, the two major e
290 eduction in circulating DPP4 and increase in Glucagon-like peptide (GLP)-1 levels as compared to the
293 Growing evidence suggests that agonists of glucagon-like peptide (GLP-1) receptor exert neuroprotec
294 r suggested the presence of the gut hormone, glucagon-like peptide (GLP-1), in deep short axon cells
295 dase (DPP4i), which prevents the cleavage of glucagon-like peptide (GLP-1), to adult RIPCreER-EYFP mi
296 e effect of diacetyl on the satiety hormone, glucagon-like peptide (GLP-1), using the enteroendocrine
297 ncretin-based, antidiabetes therapies (i.e., glucagon-like peptide [GLP]-1 receptor agonists and dipe
299 o-express several molecules including Glp1r (glucagon-like peptide one receptor) and manipulations of