ライフサイエンスコーパス: gluconeogenesis

1 iver glycogen and newly synthesized glucose (gluconeogenesis).

2 oactivator 1 alpha (PGC1alpha), resulting in gluconeogenesis.

3 promoted both hepatic insulin resistance and gluconeogenesis.

4 sulin resistance, hepatic triglycerides, and gluconeogenesis.

5 regulator that promotes FOXO1-driven hepatic gluconeogenesis.

6 ic FBP1 complex, the rate-limiting enzyme in gluconeogenesis.

7 chondrial dysfunctions, and enhanced hepatic gluconeogenesis.

8 activity may play an important role in cell gluconeogenesis.

9 -1 (Pck1) expression, suggesting a link with gluconeogenesis.

10 y for mitochondrial respiration and reducing gluconeogenesis.

11 ze its transcriptional activities in hepatic gluconeogenesis.

12 affected many metabolic processes, including gluconeogenesis.

13 cetyl coenzyme A (acetyl-CoA) production and gluconeogenesis.

14 ases FOXO1 protein but also enhances hepatic gluconeogenesis.

15 -phosphatase (G6Pase) and suppressed hepatic gluconeogenesis.

16 of glucose and the large sugar phosphates is gluconeogenesis.

17 s ER stress, insulin resistance, and hepatic gluconeogenesis.

18 balance between respiration and anaplerosis/gluconeogenesis.

19 ts of hypoxia and iron deficiency on hepatic gluconeogenesis.

20 uvate and decreased pyruvate utilization for gluconeogenesis.

21 al coactivator PGC-1alpha to control hepatic gluconeogenesis.

22 kinase (PEPCK) is well known for its role in gluconeogenesis.

23 rve a beneficial role in suppressing hepatic gluconeogenesis.

24 ntain glucose balance by stimulating hepatic gluconeogenesis.

25 enes in human liver cells, thereby enhancing gluconeogenesis.

26 the pathogenesis of diabetes by upregulating gluconeogenesis.

27 iminished substrate availability for hepatic gluconeogenesis.

28 thway has now been characterized for hepatic gluconeogenesis.

29 ) ratio diverts glucose precursors away from gluconeogenesis.

30 stimulation of Pck1 expression and increased gluconeogenesis.

31 in which statin treatment suppresses hepatic gluconeogenesis.

32 d after GBP and bile acids are inhibitors of gluconeogenesis.

33 atty acid oxidation, glucose utilization, or gluconeogenesis.

34 sed the effects of dietary iron on circadian gluconeogenesis.

35 s, and loss of Wnt-3a-mediated repression of gluconeogenesis.

36 slation regulation, DNA damage response, and gluconeogenesis.

37 iption factors form a complex that regulates gluconeogenesis.

38 glucose production to an enhanced intestinal gluconeogenesis.

39 trate would stimulate glycolysis and inhibit gluconeogenesis.

40 ediated hepatic inflammation, steatosis, and gluconeogenesis.

41 organs and provides necessary substrate for gluconeogenesis.

42 ing enzyme requirements of glycolysis versus gluconeogenesis.

43 showed increased inflammatory responses and gluconeogenesis.

44 n sensitivity and enhanced pyruvate-mediated gluconeogenesis.

45 ng pyruvate injections, indicating increased gluconeogenesis.

46 ible to genetic disruption of glycolysis and gluconeogenesis.

47 protein O1 and subsequently promoted hepatic gluconeogenesis.

48 male mice, which indicated impaired hepatic gluconeogenesis.

49 o1 plays a central role in the regulation of gluconeogenesis.

50 ncluding cardiolipin (CL)], lipogenesis, and gluconeogenesis.

51 low or absent glucose, cells make it through gluconeogenesis.

52 s to irregular feeding patterns and constant gluconeogenesis.

53 octanoate, two sources of energy to support gluconeogenesis.

54 sulin resistance via FoxO1-dependent hepatic gluconeogenesis.

55 in the fly brain is capable of carrying out gluconeogenesis.

56 quired for E(2) action on the suppression of gluconeogenesis.

57 /threonine kinase signalling, glycolysis and gluconeogenesis.

58 ted a repressive effect of TCF7L2 on hepatic gluconeogenesis, a recent study using liver-specific Tcf

59 es favorable fluxes in the TCA cycle and the gluconeogenesis-anaplerosis nodes, despite decrease in s

60 In particular, gluconeogenesis and amino acid catabolism are affected b

61 ssical Warburg effect, the downregulation of gluconeogenesis and amino acid metabolism, and the upreg

62 GLPX and GPM2 is required for disruption of gluconeogenesis and attenuation of Mtb in a mouse model

63 Liver-specific deletion of MKP-1 enhances gluconeogenesis and causes hepatic insulin resistance in

64 st-translational control of FoxO1, regulates gluconeogenesis and controls metabolic pathways via mito

65 ular processes such as glucose reabsorption, gluconeogenesis and cytoskeletal remodelling.

66 F4A), a transcription factor associated with gluconeogenesis and diabetes, as a central regulatory hu

67 ion of SIRT1 (through its effects to promote gluconeogenesis and fatty acid oxidation) drives ketogen

68 b-3p, and -92b-3p co-regulate the glycolysis/gluconeogenesis and focal adhesion in cancers of kidney,

69 CF7L2DN, but not wild-type TCF7L2, increased gluconeogenesis and gluconeogenic gene expression.

70 rosis complex 1 (Tsc1) in the liver promotes gluconeogenesis and glucose intolerance.

71 o fuel high energy-demanding pathways (e.g., gluconeogenesis and glyceroneogenesis), whereas opposite

72 was no association with the contribution of gluconeogenesis and glycogenolysis to EGP.

73 an enzyme which catalyses the final step of gluconeogenesis and glycogenolysis.

74 ater hepatic glycogen synthesis and impaired gluconeogenesis and glycolysis related to low cytosolic

75 r fructose-6-P, which likely influences both gluconeogenesis and glycolysis.

76 te pathway, substrate-level phosphorylation, gluconeogenesis and glycolysis.

77 owed reduced expression of genes involved in gluconeogenesis and glycolysis.

78 sis, mitochondrial electron chain functions, gluconeogenesis and glycolytic processes while transcrip

79 in postreceptor IR, FFA contributes to both gluconeogenesis and hepatic steatosis.TRIAL REGISTRATION

80 Tmem127 loss: liver Tmem127 promotes hepatic gluconeogenesis and inhibits peripheral glucose uptake,

81 derangement that is associated with greater gluconeogenesis and insulin resistance.

82 carbon flux through the glyoxylate shunt and gluconeogenesis and into synthesis of trehalose, a disac

83 mechanisms of transcriptional regulation of gluconeogenesis and into the roles of chromatin readers

84 In Aspergillus fumigatus, AcuM governs gluconeogenesis and iron acquisition in vitro and virule

85 taacuK DeltaacuM double mutants had impaired gluconeogenesis and iron acquisition, similar to the Del

86 sphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and is frequently lost in various types

87 kinase 1 (PEPCK1) is the critical enzyme for gluconeogenesis and is linked with type II diabetes.

88 n this study, we analysed starvation-induced gluconeogenesis and ketogenesis in mouse strains lacking

89 The principal molecular stimulus to gluconeogenesis and ketogenesis is activation of SIRT1 (

90 tations of this fasting mimicry are enhanced gluconeogenesis and ketogenesis, which are not seen with

91 aling plays a key role in the maintenance of gluconeogenesis and lipid metabolism in males.

92 the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress re

93 glucocorticoid excess, and increased hepatic gluconeogenesis and lipogenesis.

94 These findings reveal that PRMT1 modulates gluconeogenesis and mediates glucose homeostasis under p

95 ts the hepatic TGF-beta pathway, influencing gluconeogenesis and mitochondrial bioenergetics in the U

96 /cataplerotic pathways that are essential to gluconeogenesis and other biosynthetic activities.

97 erate independent of glucose due to enhanced gluconeogenesis and oxidations of glutamine and branched

98 ment of intrahepatic glucose due to enhanced gluconeogenesis and reduced glucose use through the pent

99 ol reactions being essential for glycolysis, gluconeogenesis and related processes.

100 ression, skin androgenisation, disruption of gluconeogenesis and reproductive performance.

101 el; 2.70% dietary arginine level upregulated gluconeogenesis and resulted in high plasma glucose cont

102 on of baseline and 1-y changes in glycolysis/gluconeogenesis and TCA cycle metabolites with insulin r

103 ns of baseline and 1-y changes in glycolysis/gluconeogenesis and TCA cycle metabolites with subsequen

104 ied cytosolic isoform (PEPCK-C) potentiating gluconeogenesis and TCA flux.

105 y of glucose leads to the down-regulation of gluconeogenesis and the activation of glycolysis, leadin

106 also participates in the reverse reaction in gluconeogenesis and the Calvin-Benson cycle.

107 e microbiome functional potential identified gluconeogenesis and the putrefaction and fermentation pa

108 fatty acids like acetic acid, which induces gluconeogenesis and thereby accounts for glucose intoler

109 ysis and amino acid release to sustain liver gluconeogenesis and tissue protein synthesis.

110 es away from the energy-consuming process of gluconeogenesis and toward the anabolic process of growt

111 Glycolysis/gluconeogenesis and tricarboxylic acid (TCA) cycle metab

112 PPARalpha near genes involved in glycolysis/gluconeogenesis and uncovered a role for this factor in

113 y rat hepatocytes with amino acids increased gluconeogenesis and ureagenesis and, despite nutrient ex

114 the opposing effects of atRA and insulin on gluconeogenesis, and also suggest an interaction between

115 posite effects from metformin on glycolysis, gluconeogenesis, and cell G6P.

116 ssociated with lipid accumulation, abolished gluconeogenesis, and extensive liver damage.

117 rmentation, and altered hepatic lipogenesis, gluconeogenesis, and glycogenolysis in an AHR-dependent

118 systemic glucose tolerance, reduced hepatic gluconeogenesis, and increased insulin sensitivity.

119 eted metabolite profiling to the glycolysis, gluconeogenesis, and Krebs cycle (n = 48) and an explora

120 ed browning of the adipose tissue, decreased gluconeogenesis, and less hepatic steatosis.

121 ayed elevated gluconeogenic gene expression, gluconeogenesis, and loss of Wnt-3a-mediated repression

122 meiosis, cholesterol metabolism, glycolysis/gluconeogenesis, and MAPK, PI3K-AKT, HIPPO and calcium s

123 including the citrate acid cycle, glycolysis/gluconeogenesis, and metabolism of branched chain amino

124 e autophagy, preserve triglycerides, enhance gluconeogenesis, and prevent hypoglycemia in calorie-res

125 rate the dependence of key metabolic fluxes, gluconeogenesis, and signaling on the cytosolic or mitoc

126 inct pathways including inositide signaling, gluconeogenesis, and sulfur assimilation.

127 ssion, whereas mRNAs involved in glycolysis, gluconeogenesis, and T cell activation were unaffected.

128 pregulated blood glucose level by increasing gluconeogenesis, and upregulated the hepatic inflammator

129 hosphoenolpyruvate carboxykinase to initiate gluconeogenesis; and (v) (13)C-MFA together with RNA-seq

130 tabolism at the level of both glycolysis and gluconeogenesis are mostly unknown.

131 ltiple genes/proteins involved in glycolysis/gluconeogenesis are upregulated, whereas those involved

132 the effects of various signaling pathways on gluconeogenesis are well established, the downstream sig

133 Collectively, our results implicate gluconeogenesis as the key mechanism behind organophosph

134 and hyperglucagonemia and stimulate hepatic gluconeogenesis as well as their beneficial effects in c

135 e had reduced expression of liver markers of gluconeogenesis associated with increased glucose tolera

136 nto insulin resistance and increased hepatic gluconeogenesis associated with obesity and type 2 diabe

137 tformin (dimethylbiguanide) inhibits hepatic gluconeogenesis at concentrations relevant for type 2 di

138 kinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90.

139 nt with the inhibitory role of bile acids on gluconeogenesis, bile diversions promote a blunting in h

140 role of TGF-beta1/Smad3 signaling in hepatic gluconeogenesis, both in normal physiology and in the pa

141 ta1/Smad3 signaling pathway promotes hepatic gluconeogenesis, both upon prolonged fasting and during

142 mass, and increased hepatic ureagenesis and gluconeogenesis but decreased glycolysis.

143 icarboxylic acid (TCA) cycle, glycolysis and gluconeogenesis by conversion of mitochondrial oxaloacet

144 ), and pyruvate phosphate dikinase (PPDK) in gluconeogenesis by generating the respective Leishmania

145 ere we show that glucagon stimulates hepatic gluconeogenesis by increasing the activity of hepatic ad

146 ease in hepatic NADH, which inhibits hepatic gluconeogenesis by reducing the conversion of lactate to

147 e, which is likely due to the suppression of gluconeogenesis by salidroside as the protein levels of

148 nhibiting phosphofructokinase-1 and activate gluconeogenesis by stimulating fructose-1,6-bisphophatas

149 Mechanistically, CS and SULT2B1b inhibited gluconeogenesis by suppressing the expression of acetyl

150 hepatic glycogenolysis but similar rates of gluconeogenesis compared to those on the mixed diet.

151 understanding of the role of mitochondria in gluconeogenesis control.Hepatic gluconeogenesis is tight

152 emical modification known to inhibit hepatic gluconeogenesis, could be potentially used for treatment

153 turnover), hepatic glucose production (HGP), gluconeogenesis (deuterium incorporation from body water

154 h fat (LCHF) diet would have higher rates of gluconeogenesis during exercise compared to those who fo

155 in response to stress by increasing hepatic gluconeogenesis during fasting.

156 gy-deficiency in any tissue had no effect on gluconeogenesis during starvation.

157 ich PGC1A plays dual roles in the control of gluconeogenesis during the fasting-to-fed transition thr

158 a key transcriptional coactivator regulating gluconeogenesis, enhancing its activity via arginine met

159 sugar as well as metabolites associated with gluconeogenesis, entailing a critical nodal role of PEPC

160 tasis outcomes, reveal the exploitation of a gluconeogenesis enzyme for pyrimidine biosynthesis under

161 n gluconeogenic organs and reexpression of a gluconeogenesis enzyme, fructose-1,6-bisphosphatase (FBP

162 ndent carboxylases catalyze key reactions in gluconeogenesis, fatty acid synthesis, and amino acid ca

163 The low metformin dose inhibited gluconeogenesis from both oxidized (dihydroxyacetone) an

164 ructose conversion into blood (13)C glucose (gluconeogenesis from fructose), blood VLDL-(13)C palmita

165 cited by HFD feeding is linked with enhanced gluconeogenesis from glycerol and with alterations in BA

166 ase (G6pc) expression in liver and increased gluconeogenesis from glycerol.

167 of enhanced glycolysis, but it also enhances gluconeogenesis from lactate in the liver that contribut

168 nous glucose production, glycogenolysis, and gluconeogenesis from phosphoenolpyruvate.

169 vate ratio and redox-dependent inhibition of gluconeogenesis from reduced but not oxidized substrates

170 -(13)C3]glucose in equal proportions through gluconeogenesis from the level of trioses.

171 ate that Tup11/12 repress transcription of a gluconeogenesis gene, fbp1(+), by three distinct mechani

172 cortisol led to stronger upregulation of the gluconeogenesis genes g6pca and pepck1.

173 ealed that transcriptional regulation of the gluconeogenesis genes PCK1 and G6PC and the fatty acid s

174 The expression of gluconeogenesis genes was evaluated in both the liver an

175 Both the expression of two gluconeogenesis genes, G6PC and PCK1, and the inhibitory

176 iRNAs encoded by the Dlk1-Dio3 locus reduced gluconeogenesis, glucose intolerance, and fasting blood

177 including amino acid metabolism, TCA cycle, gluconeogenesis, glutathione metabolism, pantothenate an

178 xidation, cellular redox and ATP production, gluconeogenesis, glycerolipid synthesis, and fatty acid

179 activation of the cytoskeletal motility and gluconeogenesis/glycolysis pathways was most prominent i

180 eferential carbohydrate metabolism including gluconeogenesis, glyoxylate cycle and succinate producti

181 occurs via hepatic glycogenolysis (GLY) and gluconeogenesis (GNG) and plays an important role in mai

182 Gluconeogenesis (GNG) is de novo production of glucose f

183 degradation of hepatic glycogen stores, and gluconeogenesis (GNG).

184 egulating the balance between glycolysis and gluconeogenesis; however, in vivo regulation of PK flux

185 improved insulin sensitivity and suppressed gluconeogenesis; however, these effects of E(2) were abo

186 ional changes of biomarker genes involved in gluconeogenesis, immune response and circadian rhythm in

187 e, a single oral dose of shizukaol F reduced gluconeogenesis in C57BL/6 J mice.

188 Still, the role of gluconeogenesis in cancer is unknown.

189 ed hepatic miR-22-3p expression and impaired gluconeogenesis in diabetic db/db mice via the regulatio

190 primary hepatocytes, E(2) suppressed HGP and gluconeogenesis in hepatocytes from control mice but fai

191 revious data suggest that adropin suppresses gluconeogenesis in hepatocytes.

192 uantitate the contribution and regulation of gluconeogenesis in humans.

193 Glucagon receptor signaling and gluconeogenesis in Mgat5(-/-) cultured hepatocytes was i

194 nt in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.

195 Our work affirms a role for gluconeogenesis in Mtb virulence and reveals previously

196 ether, our analysis reveals a novel role for gluconeogenesis in neuronal signaling.

197 c nutrients and needs the ability to perform gluconeogenesis in order to colonize mice precolonized w

198 levels during fasting, and decreased hepatic gluconeogenesis in response to a pyruvate challenge.

199 oposed to inhibit anabolic processes such as gluconeogenesis in response to cellular energy stress.

200 was essential for suppression of hepatocyte gluconeogenesis in response to insulin in vitro.

201 tive FBPase (GPM2, Rv3214) that can maintain gluconeogenesis in the absence of GLPX.

202 pathways, including fatty acid oxidation and gluconeogenesis in the fasted state and lipogenesis and

203 d the expression levels of genes involved in gluconeogenesis in the liver and the kidney and signific

204 hat otherwise induce free radicals impacting gluconeogenesis in the liver.

205 riant 2 (PRMT1V2), is critical in regulating gluconeogenesis in the liver.

206 ific Ddb1 deletion leads to impaired hepatic gluconeogenesis in the mouse liver but protects mice fro

207 a transcriptome signature of more pronounced gluconeogenesis in tolerant accessions, a response that

208 ects of sirtinol, a SIRT2 inhibitor, on cell gluconeogenesis in vivo and in vitro.

209 only used stable isotopes methods to measure gluconeogenesis in vivo.

210 ependent transcriptional defects and blunted gluconeogenesis in Vps15 mutant cells.

211 to suppress expression of genes involved in gluconeogenesis, in the process improving glucose handli

212 ptake, although all genes for glycolysis and gluconeogenesis, including bifunctional unidirectional f

213 rate-limiting enzymes for glycogenolysis and gluconeogenesis, including liver glycogen phosphorylase

214 the current understanding of carbon flux in gluconeogenesis, including substrate contribution of var

215 Hepatic gluconeogenesis increased by 70%, and net glycogenolysis

216 ch from lactate to glycerol as substrate for gluconeogenesis, indicating an intricate balance of exac

217 rated significant upregulation of glycolysis/gluconeogenesis intermediates (e.g., glucose/fructose, C

218 The chronic effects of metformin on liver gluconeogenesis involve repression of the G6pc gene, whi

219 Gluconeogenesis is a complex metabolic process that invo

220 Gluconeogenesis is a fundamental metabolic process that

221 Increased gluconeogenesis is a major contributor to the hyperglyce

222 Failure to inhibit hepatic gluconeogenesis is a major mechanism contributing to fas

223 Gluconeogenesis is a well-established metabolic process

224 However, enhanced gluconeogenesis is also a signature feature of type 2 di

225 Gluconeogenesis is also increased in primary cultured he

226 most widely accepted technique to determine gluconeogenesis is by measuring the incorporation of deu

227 Gluconeogenesis is critical to fuel the transition from

228 Gluconeogenesis is essential for the conversion of fatty

229 Appropriate control of hepatic gluconeogenesis is essential for the organismal survival

230 Gluconeogenesis is frequently suppressed in tumors arisi

231 patic glucose production, whereas intestinal gluconeogenesis is increased in the gut segments devoid

232 that under fasting conditions, when hepatic gluconeogenesis is stimulated, pyruvate recycling is rel

233 A rate-limiting step in gluconeogenesis is the conversion of fructose 1,6-bispho

234 Inhibition of hepatic gluconeogenesis is the primary contributor to its anti-d

235 ochondria in gluconeogenesis control.Hepatic gluconeogenesis is tightly regulated at transcriptional

236 ncluding metabolites involved in glycolysis, gluconeogenesis, lipid metabolism, citric acid cycle, an

237 Transcripts of key pathways of gluconeogenesis, lipogenesis, and inflammatory cytokines

238 es often target biochemical pathways such as gluconeogenesis, lipogenesis, or the metabolic response

239 Hepatic gluconeogenesis makes a significant contribution to the

240 Revealing that gluconeogenesis may be of nonenzymatic origin, our resul

241 A comprehensive analysis of gluconeogenesis may enable a better understanding of T2D

242 brain metastasis and suggest that targeting gluconeogenesis may help eradicate this deadly feature i

243 the existing trunk pathway of glycolysis and gluconeogenesis may represent a maximal flux solution.

244 ne pathways controlling lipid metabolism and gluconeogenesis.METHODSCross-sectional study of severe r

245 Further, alterations in glycolysis/gluconeogenesis, mitochondrial function and lipid biosyn

246 to fuel Glu and glutathione synthesis while gluconeogenesis occurs in the PDTX.

247 tives to the trunk pathway of glycolysis and gluconeogenesis, one of the most highly conserved pathwa

248 lance by slowing down glycolysis, activating gluconeogenesis or depleting oxygen enables L-form growt

249 rol in the tricarboxylic acid cycle prior to gluconeogenesis or glyceroneogenesis.

250 rack the conversion of metabolites along the gluconeogenesis pathway, lung cancer cell lines were inc

251 ression of the rate-limiting enzymes in both gluconeogenesis (Pck1) and glycogenesis (Gys2), consiste

252 data suggest that RDN downregulated hepatic gluconeogenesis primarily by upregulating liver X recept

253 Lastly, we observe that neuronal gluconeogenesis promotes anterograde neuropeptide distri

254 nduced WAT lipolysis also stimulates hepatic gluconeogenesis, promoting fasting and postprandial hype

255 a the targeting of key regulators of hepatic gluconeogenesis, protein phosphatase 2A (PP2A), AMP-acti

256 Hepatic gluconeogenesis provides fuel during starvation, and is

257 vate and its major determinants (glycolysis, gluconeogenesis, pyruvate dehydrogenase [PDH], and H2O2

258 In receptor-level IR, FFA oxidation drives gluconeogenesis rather than being reesterified to trigly

259 ondrial (Pgc1a, Cox5b and Cox7a) and hepatic gluconeogenesis related genes (Pepck) in liver.

260 ition of IRS-1 mRNA levels and activation of gluconeogenesis-related gene expression.

261 We identified a panel of glycolysis/gluconeogenesis-related metabolites that was significant

262 ion of circulating fatty acids, amino acids, gluconeogenesis-related metabolites, and many other mole

263 MT2-specific pathways include glycolysis and gluconeogenesis-related processes, while HSP-specific pa

264 Gluconeogenesis results in the generation of glucose fro

265 e metabolism and PGC-1alpha-mediated hepatic gluconeogenesis, suggesting that influencing methionine

266 rate-limiting enzymes in both glycolysis and gluconeogenesis, supporting the formation of multienzyme

267 hydroxyisobutyrylation, including glycolysis/gluconeogenesis, TCA cycle, starch biosynthesis, lipid m

268 ars to be involved in suppression of hepatic gluconeogenesis, the molecular mechanism is not thorough

269 al metabolic pathways, including glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, and

270 in the levels of intermediates of glycolysis/gluconeogenesis, the tricarboxylic acid cycle, and monos

271 atic beta-cell function and enhanced hepatic gluconeogenesis, thereby resulting in hyperglycemia and

272 er demonstrated that E(2) suppresses hepatic gluconeogenesis through activation of estrogen receptor

273 that insulin-activated SREBP1c downregulates gluconeogenesis through CRY1-mediated FOXO1 degradation

274 ed GRalpha's function and attenuated hepatic gluconeogenesis through downregulation of phosphoenolpyr

275 nsulin-induced SREBP1c and decreases hepatic gluconeogenesis through FOXO1 degradation, at least, at

276 mediating the switch between glycolysis and gluconeogenesis through the conversion of glucose 1-phos

277 fication, the pentose phosphate pathway, and gluconeogenesis through the tricarboxylic acid cycle.

278 ased glycemia, and hampered glucagon-induced gluconeogenesis, thus preventing a proper and complete a

279 technique, and the relative contribution of gluconeogenesis to EGP was quantitated using deuterated

280 INSR subjects had a higher contribution of gluconeogenesis to HGP, approximately 77%, versus 52% to

281 cer cells may utilize at least some steps of gluconeogenesis to overcome the detrimental metabolic si

282 rboxylic acid (TCA) cycle and early steps of gluconeogenesis to promote glucose-independent cell prol

283 energetically demanding processes, including gluconeogenesis, translation, and lipid synthesis.

284 r several decades have offered insights into gluconeogenesis under euglycemic and diabetic conditions

285 Although Pck is associated with gluconeogenesis under standard growth conditions, the en

286 elucidate a mechanism by which GCs regulate gluconeogenesis utilizing the transcription factor Krupp

287 pyruvate and that their metabolism requires gluconeogenesis, valine metabolism, the Krebs cycle, the

288 rstand the mechanism by which E(2) regulates gluconeogenesis via an interaction with hepatic Foxo1.

289 bolism, enhancing glycolysis, and inhibiting gluconeogenesis via elevated translation of the transcri

290 rboxylase, which catalyzes the first step of gluconeogenesis, was also downregulated by hypoxia with

291 ity, FoxO1 phosphorylation, which diminishes gluconeogenesis, was impaired; in contrast, Akt-dependen

292 , the effects of GCG neuronal stimulation on gluconeogenesis were lost, while the food intake-lowerin

293 timulatory effects of PRMT1V2 in controlling gluconeogenesis were observed in human HepG2 cells.

294 ynthesis, ribosome biogenesis and glycolysis/gluconeogenesis were significantly associated with the c

295 ic acid cycle and by concurrently activating gluconeogenesis, which guarantee a continued biogenesis

296 for mediating hyperglycemia through hepatic gluconeogenesis, which is necessary for anticipating and

297 amino acids and a switch from glycolysis to gluconeogenesis while those of cells carrying the missen

298 es fasting glucose levels and blunts hepatic gluconeogenesis without affecting systemic glucose toler

299 sulin resistance due to unrestrained hepatic gluconeogenesis, without alterations in glucose-stimulat

300 the signaling pathways that regulate hepatic gluconeogenesis would allow better insight into the proc