ライフサイエンスコーパス: glucose homeostasis

1 latory responses whose purpose is to restore glucose homeostasis.

2 sfunction associated with disordered insulin-glucose homeostasis.

3 eficiency in body weight (BW) regulation and glucose homeostasis.

4 islet beta cells, which function to maintain glucose homeostasis.

5 t glucose production per se, is critical for glucose homeostasis.

6 chanisms governing such endocrine control of glucose homeostasis.

7 regulating beta-cell function and whole body glucose homeostasis.

8 selectively in SKM showed severe deficits in glucose homeostasis.

9 ere recently implicated in the regulation of glucose homeostasis.

10 ansport into adipocytes, regulate whole-body glucose homeostasis.

11 cretion in pancreatic beta-cells to maintain glucose homeostasis.

12 e involved in insulin-mediated regulation of glucose homeostasis.

13 The pancreatic islets of Langerhans maintain glucose homeostasis.

14 he development of obesity and disturbance in glucose homeostasis.

15 s, and an adiposity-dependent improvement in glucose homeostasis.

16 le of PU.1 in adipocyte biology, insulin and glucose homeostasis.

17 ation to extrapulmonary organs, and impaired glucose homeostasis.

18 tant mechanism for E(2) in the regulation of glucose homeostasis.

19 e and liver to maintain whole-body lipid and glucose homeostasis.

20 stand the consequences of this on whole-body glucose homeostasis.

21 ssure and cardiometabolic markers related to glucose homeostasis.

22 stalk between the adaptive immune system and glucose homeostasis.

23 s and were strongly associated with impaired glucose homeostasis.

24 d that IgA is a critical immune regulator of glucose homeostasis.

25 es in energy expenditure, thermogenesis, and glucose homeostasis.

26 ich controls stress and immune responses and glucose homeostasis.

27 in, and diabetes-like dysregulation of blood glucose homeostasis.

28 tic beta-cell glucose sensing and whole-body glucose homeostasis.

29 , storing, and releasing insulin to maintain glucose homeostasis.

30 n secretion is a determinant of postprandial glucose homeostasis.

31 but had no effect on blood pressure, HRV, or glucose homeostasis.

32 other metabolic tissues to regulate systemic glucose homeostasis.

33 source of serotonin is itself a regulator of glucose homeostasis.

34 he liver has an essential role in regulating glucose homeostasis.

35 ating lipogenesis, fatty acid oxidation, and glucose homeostasis.

36 and hepatic steatosis, and exhibit improved glucose homeostasis.

37 ole in how SH2B1 controls energy balance and glucose homeostasis.

38 ffect facultative cellular proliferation and glucose homeostasis.

39 regulation of energy metabolism and systemic glucose homeostasis.

40 The pancreatic islets of Langerhans regulate glucose homeostasis.

41 ocellular lipid (IHCL) concentrations and on glucose homeostasis.

42 ption of this alignment by shift work alters glucose homeostasis.

43 1), a critical incretin that regulates blood glucose homeostasis.

44 g physiological roles in insulin release and glucose homeostasis.

45 mechanism is essential for insulin-regulated glucose homeostasis.

46 as an important target of insulin action on glucose homeostasis.

47 y in hepatocytes did not show any changes in glucose homeostasis.

48 eta cells producing glucagon and insulin for glucose homeostasis.

49 r fat mass, but improved several measures of glucose homeostasis.

50 porter and characterized by altered glycogen/glucose homeostasis.

51 mselves by differential actions on lipid and glucose homeostasis.

52 re beta cells impaired insulin secretion and glucose homeostasis.

53 f alpha- and beta-cells in order to maintain glucose homeostasis.

54 have unfavorable consequences for whole-body glucose homeostasis.

55 ) signaling that results in dysregulation of glucose homeostasis.

56 ear hormone receptor that controls lipid and glucose homeostasis.

57 pancreatic beta-cell is required for normal glucose homeostasis.

58 ated with deregulation of systemic lipid and glucose homeostasis.

59 anase (hep-tg) was the discovery of improved glucose homeostasis.

60 ta-cell insulin secretion and helps maintain glucose homeostasis.

61 on, in vivo insulin sensitivity, and overall glucose homeostasis.

62 metabolic status is a fundamental aspect of glucose homeostasis.

63 ion on iron traits and their connection with glucose homeostasis.

64 on studies but without a clear connection to glucose homeostasis.

65 and disease processes, including cancer and glucose homeostasis.

66 tant for maintaining cellular and organismal glucose homeostasis.

67 paths of metabolites in type 2 diabetes and glucose homeostasis.

68 metabolic regulation of fat accumulation and glucose homeostasis.

69 ulator that plays major roles in maintaining glucose homeostasis.

70 secretion of insulin, which is essential for glucose homeostasis.

71 pha activation, leading to impaired systemic glucose homeostasis.

72 Targeted temperature management alters blood glucose homeostasis.

73 mportant regulators of bile acid, lipid, and glucose homeostasis.

74 suggests TFG to have an important role(s) in glucose homeostasis.

75 R signaling, leading to striking deficits in glucose homeostasis.

76 clocks are important regulators of GSIS and glucose homeostasis.

77 the potential of BMAT to influence systemic glucose homeostasis.

78 gRP)-expressing neurons, energy balance, and glucose homeostasis.

79 such drugs both diminish obesity and improve glucose homeostasis.

80 in lipid metabolism, insulin signaling, and glucose homeostasis.

81 tween liver and skeletal muscle is vital for glucose homeostasis.

82 uction (HGP) is pivotal to maintain systemic glucose homeostasis.

83 exogenously administered insulin to maintain glucose homeostasis.

84 tissue cross-talk is crucial for energy and glucose homeostasis.

85 ic beta-cells is essential to maintain blood glucose homeostasis.

86 and associated key target genes required for glucose homeostasis.

87 -sensitive K+ (KATP) channels in maintaining glucose homeostasis.

88 erum levels of aminotransferases and loss of glucose homeostasis.

89 uld have therapeutic utility in disorders of glucose homeostasis.

90 the transgenerational metabolic rewiring of glucose homeostasis.

91 n is essential for intact islet function and glucose homeostasis.

92 educed glucose uptake, resulting in impaired glucose homeostasis.

93 brain in the insulin-independent control of glucose homeostasis.

94 onmental risk factors, resulting in impaired glucose homeostasis.

95 study was to determine the role of FURIN in glucose homeostasis.

96 reduction of insulin content and compromised glucose homeostasis.

97 s as a key metabolic regulator that controls glucose homeostasis across the circadian cycle or under

98 nocortin neurons of ob/ob mice worsens their glucose homeostasis, adiposity, hyperphagia, and POMC ne

99 secretion and increased capacity to maintain glucose homeostasis after transplantation.

100 h as hyperphagia, hypermetabolism, disturbed glucose homeostasis, altered hematological parameters, i

101 nce has linked sleep duration and quality to glucose homeostasis, although the mechanistic pathways r

102 In examining iron variant associations with glucose homeostasis, an iron-raising variant of TMPRSS6

103 SR1a is an important regulator of energy and glucose homeostasis and a target for the treatment of ob

104 c enzyme inhibition, glucose uptake, hepatic glucose homeostasis and anti-glycation ability was analy

105 Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia a

106 We examined glucose homeostasis and beta-cell function of these mice

107 role for the translational factor eIF4G1 on glucose homeostasis and beta-cell function.

108 Insulin controls glucose homeostasis and cell growth through bifurcated s

109 ate that glycogen plays an important role in glucose homeostasis and contributes to key functions rel

110 in mitigating metabolic stress and improving glucose homeostasis and could therefore represent a nove

111 disrupts circulating hormone levels, impairs glucose homeostasis and fuel usage, and leads to the dev

112 Glucose homeostasis and growth essentially depend on the

113 t loss of liver glycogen impaired whole-body glucose homeostasis and increased hepatic expression of

114 bese SAT and an association between systemic glucose homeostasis and inflammatory parameters in obese

115 metabolism can strongly influence whole-body glucose homeostasis and insulin sensitivity.

116 that is central to the maintenance of normal glucose homeostasis and insulin sensitivity.

117 g selectively in adipocytes greatly improved glucose homeostasis and insulin signaling.

118 requirement for PAK1 and PAK2 in whole-body glucose homeostasis and insulin-stimulated muscle glucos

119 , whereas PAK1 is dispensable for whole-body glucose homeostasis and insulin-stimulated muscle glucos

120 Glycogen plays a central role in glucose homeostasis and is abundant in several types of

121 VMH) plays chief roles regulating energy and glucose homeostasis and is sexually dimorphic.

122 ciation between 9p21.3 and MI is modified by glucose homeostasis and lifestyle.

123 ype Ia (GSD-Ia) is characterized by impaired glucose homeostasis and long-term risks of hepatocellula

124 Disturbances in glucose homeostasis and low-grade chronic inflammation c

125 late supplementation might be beneficial for glucose homeostasis and lowering IR, but at present ther

126 n signaling governs many processes including glucose homeostasis and metabolism, and is therapeutical

127 r data demonstrate that VPS41 contributes to glucose homeostasis and metabolism.

128 carbohydrates, have been related to impaired glucose homeostasis and obesity.

129 rmones play an important role in controlling glucose homeostasis and pancreatic beta-cell function.

130 Atrial natriuretic peptide (ANP) influences glucose homeostasis and possibly acts as a link between

131 HIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced

132 substantial effects than LR on body mass and glucose homeostasis and reduced hepatic lipogenic gene e

133 factor (FGF) receptors regulates peripheral glucose homeostasis and reduces food intake in preclinic

134 ovalent analogues with respect to control of glucose homeostasis and suppression of food intake.

135 cells to produce a change in food intake and glucose homeostasis and that these effects depend on the

136 syndrome is characterized by disturbances in glucose homeostasis and the development of low-grade sys

137 ghlight the mechanisms by which BAs regulate glucose homeostasis and the settings in which endogenous

138 eatment with statins during MI can influence glucose homeostasis and thus the clinical outcome.

139 led receptor that plays an important role in glucose homeostasis and treatment of type 2 diabetes.

140 % of normal hepatic G6PT activity maintained glucose homeostasis and were protected against age-relat

141 to mass and function of these tissues impact glucose homeostasis and whole-body energy balance during

142 inhibits mTORC1 signaling without impairing glucose homeostasis and with substantially reduced or no

143 on beta-cell functional recovery by lowering glucose homeostasis and/or improving insulin sensitivity

144 on of EAT gene induces weight loss, improves glucose homeostasis, and attenuates hepatic steatosis.

145 ed cells, whereas adipose tissue morphology, glucose homeostasis, and beige-to-white adipocyte transi

146 t regulates gastric acid secretion, salt and glucose homeostasis, and heart rhythm.

147 Increased anxiety-like behavior, impaired glucose homeostasis, and higher body weight and abdomina

148 ipates in regulation of bile acid, lipid and glucose homeostasis, and liver protection.

149 Parameters of lipid metabolism, glucose homeostasis, and mitochondrial respiratory activ

150 ry for normal pancreatic beta-cell function, glucose homeostasis, and prevention of diabetes.

151 rm amelioration of body weight, food intake, glucose homeostasis, and pro-opiomelanocortin (POMC) pro

152 kers like Il6 in vascular tissue, normalized glucose homeostasis, and reduced circulating cholesterol

153 sary to lower glucose production and enhance glucose homeostasis, and thereby unveil a previously una

154 ore susceptible to HFD-induced impairment of glucose homeostasis, and these effects were mitigated by

155 (NOER) and membrane ERalpha (MOER) pools to glucose homeostasis are unknown.

156 119 agonists regulate metabolic hormones and glucose homeostasis as efficiently as human ligands, alt

157 roliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity

158 o be preserved, such as maintenance of blood glucose homeostasis, balancing the degradation of hepati

159 We evaluated metabolic regulators of glucose homeostasis before and after matched (approximat

160 gdala, affecting synaptic function, systemic glucose homeostasis, behavior, and cognition.

161 gon-containing alpha-cells potently regulate glucose homeostasis, but the developmental biology of al

162 nsulin from pancreatic islets is crucial for glucose homeostasis, but the mechanism behind coordinate

163 IF4G1 is critical for beta-cell function and glucose homeostasis by genetically ablating eIF4G1 speci

164 IF4G1 is critical for beta-cell function and glucose homeostasis by genetically ablating eIF4G1 speci

165 e that chronic hyperglucagonemia can improve glucose homeostasis by inducing glucagon resistance in t

166 trate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and im

167 the effects of chronic hyperglucagonemia on glucose homeostasis by inducing insulin secretion and re

168 Regulation of glucose homeostasis by insulin depends on beta-cell grow

169 factors are traditionally thought to control glucose homeostasis by modulating insulin levels, not in

170 that these glucose-sensing neurons maintain glucose homeostasis by promoting the secretion of dilp2

171 schizophrenia already exhibit alterations in glucose homeostasis compared with controls.

172 iture, resulting in a greater improvement in glucose homeostasis compared with food restricted mice.

173 Glucose homeostasis depends on signaling and allosteric

174 19498 that led to pronounced improvements in glucose homeostasis did not cause any significant side e

175 cate aPKC as a novel regulator of energy and glucose homeostasis downstream of the leptin-PI3K pathwa

176 as essential for the development of abnormal glucose homeostasis due to exposure to DEP.

177 agon plays a major role in the regulation of glucose homeostasis during fed and fasting states.

178 nts been shown to have protective effects on glucose homeostasis during high-fat overfeeding.

179 that the beneficial effects of a LP diet on glucose homeostasis, energy balance, and body compositio

180 ng the adequate insulin dose for maintaining glucose homeostasis following physical activity.

181 In addition to maintaining glucose homeostasis, glucagon participates in the regula

182 , a hypothalamic dysregulation of energy and glucose homeostasis has been hypothesized.

183 ategies limiting this lipid pressure improve glucose homeostasis; however, comprehensive cellular ada

184 mitochondrial fat entry predictably improves glucose homeostasis; however, remodeling of glucose meta

185 these NF-kappaB pathway components improves glucose homeostasis in a subset of patients with type 2

186 y searched for studies examining measures of glucose homeostasis in antipsychotic-naive individuals w

187 hat, surprisingly, parkin is dispensable for glucose homeostasis in both beta cells and adipocytes du

188 FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type 1 diabetes m

189 , upon transplantation, rapidly re-establish glucose homeostasis in diabetic NOD/SCID mice.

190 art with an AAV-shRNA (Grb14-shRNA) improves glucose homeostasis in diet-induced obese (DIO) mice.

191 es hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models

192 r the P2 isoform alone in the liver improves glucose homeostasis in dietary and genetic mouse models

193 suggests it may play a range of roles beyond glucose homeostasis in different cells and tissues.

194 to the hypothalamic regulation of energy and glucose homeostasis in divergent ways.

195 This first evaluation of glucose homeostasis in DKO pigs for two major xenoantige

196 rol AT-LSK improves both AT-inflammation and glucose homeostasis in HFD mice.

197 nografts such that they were able to restore glucose homeostasis in immune-competent diabetic mice fo

198 otentiator ivacaftor is suggested to improve glucose homeostasis in individuals with CF.

199 Here, we investigated the action of E(2) on glucose homeostasis in male and ovariectomized (OVX) fem

200 ly impairs growth and progressively disrupts glucose homeostasis in male mice.

201 effects of PCB-77 on weight gain or loss and glucose homeostasis in male vs. female mice.

202 id Fenretinide inhibits obesity and improves glucose homeostasis in mice and has pleotropic effects o

203 a gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans.

204 modulator (PAM) of M3R function can improve glucose homeostasis in mice by promoting insulin release

205 lpha signaling is predominant in maintaining glucose homeostasis in mice of both sexes.

206 e adipose tissue is associated with improved glucose homeostasis in mice.

207 prevent and reverse obesity and dysregulated glucose homeostasis in multiple mouse models, prolonging

208 nistration of resveratrol is able to improve glucose homeostasis in obese individuals.

209 e uptake into SKM and significantly improved glucose homeostasis in obese, glucose-intolerant mice.

210 substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans.

211 tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models, though

212 proteins play key roles in the regulation of glucose homeostasis in peripheral metabolic tissues.

213 resent a novel mechanism regulating maternal glucose homeostasis in pregnancy and we speculate that a

214 ate their distinct pathophysiologic roles in glucose homeostasis in pregnancy.

215 Hepatocytes help to maintain glucose homeostasis in response to a variety of signals,

216 TRs directly contribute to the regulation of glucose homeostasis in response to glucose ingestion is

217 , which is believed to be due alterations in glucose homeostasis in the skeletal muscle.

218 n osteocalcin, or its derivative (ucOC), and glucose homeostasis in this model.

219 classes of SKM GPCRs might lead to improved glucose homeostasis in type 2 diabetes.

220 ng may prove beneficial for restoring proper glucose homeostasis in type 2 diabetes.

221 whether mTOR in the small intestine affects glucose homeostasis in vivo remains unknown.

222 o show that increased hepatic PGC1A improves glucose homeostasis in vivo, revealing a counterregulato

223 ole of islet delta cells in regulating blood glucose homeostasis in vivo.

224 ge disappears after menopause with disrupted glucose homeostasis, in part owing to a reduction in cir

225 ne program enriched in factors important for glucose homeostasis, including members of the mammalian

226 n sham-operated ad libitum-fed mice impaired glucose homeostasis, increased body weight, and decrease

227 SGLT-2i combination therapies improved glucose homeostasis, independent of changes in body weig

228 In adult pdx1 (-/-) mutants, impaired glucose homeostasis induces increased hyperbranching and

229 We studied glucose homeostasis, insulin secretion, and insulin sens

230 We measured the temporal trends of glucose homeostasis, insulin secretion, beta cell morpho

231 e and control db/db mice were phenotyped for glucose homeostasis, insulin sensitivity, insulin secret

232 port that arsenite has effects on whole-body glucose homeostasis, insulin-stimulated glucose uptake,

233 Maintenance of glucose homeostasis is achieved via functional interacti

234 These findings show that glucose homeostasis is altered from illness onset in sch

235 Glucose homeostasis is coordinated by hormone-secreting

236 Maintenance of whole-body glucose homeostasis is critical to glycemic function.

237 Maintenance of glucose homeostasis is essential for normal physiology.

238 Glucose homeostasis is partly controlled by the energy s

239 Key to whole body glucose homeostasis is the ability of fat and muscle cel

240 The role of hepatitis virus infection in glucose homeostasis is uncertain.

241 gh p16 was recently shown to control hepatic glucose homeostasis, it is unknown whether p16 also cont

242 the OADH inhibition link the perturbation in glucose homeostasis, known in OADH mutants, to the nicot

243 etylase, in improved insulin sensitivity and glucose homeostasis, linking hyperglycaemia and SIRT1 do

244 nerating beta-cells to mitigate the aberrant glucose homeostasis manifested in the disease has remain

245 tered to 29 healthy, fasted male subjects on glucose homeostasis measured by means of an oral glucose

246 etwork involving carbohydrate metabolism and glucose homeostasis mediated by GLD4.

247 sporter (G6PT), is characterized by impaired glucose homeostasis, myeloid dysfunction, and long-term

248 revealed by epidemiological studies (altered glucose homeostasis, obesity, ethnicity, sex, etc.), the

249 differences in PCB-77-induced regulation of glucose homeostasis of mice.

250 chemical adrenalectomy rescued the impaired glucose homeostasis of obese male Dusp8-KO mice, respect

251 binding to the Mas receptor (MasR) improves glucose homeostasis, partly by enhancing glucose-stimula

252 Control of glucose homeostasis plays a critical role in health and

253 Estrogens favor glucose homeostasis primarily through the estrogen recep

254 or nutraceuticals aiming neuroprotection and glucose homeostasis regulation, with high relevance in A

255 NAD + dependent Sirtuin 6 (SIRT6) is a glucose homeostasis regulator in animals and humans and

256 upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepress

257 he molecular mechanisms linking the clock to glucose homeostasis remain largely unknown.

258 mechanistic links between these changes and glucose homeostasis remain to be defined.

259 in peripheral tissues regulating energy and glucose homeostasis remain unexplored.

260 ways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored.

261 eocalcin, which regulate kidney function and glucose homeostasis, respectively.

262 Dysregulation of glucose homeostasis result in hyperglycemia and pigmente

263 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin s

264 of activated, but not naive, ILC2s improves glucose homeostasis, resulting in both protection agains

265 Metabolic clamps and glucose homeostasis tests were undertaken in these obese

266 known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unkno

267 mmation markers, blood pressure, and insulin-glucose homeostasis.The results of our study suggest tha

268 atients, to control food intake and maintain glucose homeostasis.This trial was registered at trialre

269 siology, but these actions are entwined with glucose homeostasis through convergence with insulin sig

270 Pancreatic islets regulate glucose homeostasis through coordinated actions of hormo

271 rmined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serot

272 , a branched glucose polymer, helps regulate glucose homeostasis through immediate storage and releas

273 The pancreatic islets of Langerhans maintain glucose homeostasis through insulin secretion, where ins

274 Insulin action in the liver is critical for glucose homeostasis through regulation of glycogen synth

275 eserves oxidative mitochondrial function and glucose homeostasis, thus preventing death at the fetal-

276 in insulin resistance, resulting in impaired glucose homeostasis.TRIAL REGISTRATIONClinicalTrials.gov

277 PRMT1 modulates gluconeogenesis and mediates glucose homeostasis under physiological and pathological

278 an improve SKM glucose uptake and whole-body glucose homeostasis under physiological and pathophysiol

279 oncentrations were inversely associated with glucose homeostasis variables and inflammation variables

280 ch prevents developing strategies to improve glucose homeostasis via altering the brain-liver pathway

281 Bile diversion to the ileum improves glucose homeostasis via an intestinal Fxr-Glp-1 axis.

282 the hypothalamus (ARC) also regulate overall glucose homeostasis via insulin-dependent and -independe

283 The role of RR phenolics in regulating glucose homeostasis was deciphered using hepatic cell li

284 ed in all affected individuals, and abnormal glucose homeostasis was observed in the eldest affected

285 the central role of the liver in peripheral glucose homeostasis, we exposed mice to filtered air or

286 the role of Dipeptidyl Peptidase-4 (DPP4) in glucose homeostasis, we further demonstrate that DMAb-tr

287 ymatic activity in beta-cell development and glucose homeostasis, we generated mice overexpressing ei

288 Body composition, food intake and glucose homeostasis were measured throughout the study a

289 However, alterations in basic glucose homeostasis were not detectable following either

290 ermore, the adverse effects of ATB2 cells on glucose homeostasis were partially dependent upon T cell

291 t mice, evaluations of muscle physiology and glucose homeostasis were performed up to 16 wk of age.

292 months, and their inflammatory response and glucose homeostasis were then assessed.

293 Blood pressure, HRV, and glucose homeostasis were unaffected.

294 long-lasting transgenerational alteration in glucose homeostasis, which are all key hallmarks of gest

295 pair INSL5-RXFP4 that regulates appetite and glucose homeostasis, which likely relates to irregular f

296 rowth restriction (IUGR) and disturbances in glucose homeostasis with associated beta adrenergic rece

297 in adipose tissue is crucial for whole-body glucose homeostasis, with insulin resistance being a maj

298 r islet development, and hence for postnatal glucose homeostasis, with some functional redundancy.

299 ncreased subcutaneous adiposity and impaired glucose homeostasis without changes in food intake relat

300 ing variant of apelin-36 that could modulate glucose homeostasis without impacting blood pressure (or