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1 hibiting also butyrylcholinesterase and beta-glucosidase.
2 g predicted a high affinity of CGA for alpha-glucosidase.
3 chanism-based covalent inhibitor of an alpha-glucosidase.
4 .2 nM) of the Thermotoga maritima TmGH1 beta-glucosidase.
5 coincubated with the recombinant human alpha-glucosidase.
6 l) displayed strong inhibition towards alpha-glucosidase.
7 e aglycones produced by hydrolysis with beta-glucosidase.
8 potent inhibitors of alpha-amylase and alpha-glucosidase.
9 tural inhibitors for alpha-amylase and alpha-glucosidase.
10 obioside as the strongest inhibitor of alpha-glucosidase.
11 od covalent inhibitors of a GH13 yeast alpha-glucosidase.
12 luble beta-glucosidase and GPI-anchored beta-glucosidase.
13 ding endoglucanases, exoglucanases, and beta-glucosidases.
14 interpret the glucose dependence of GH1 beta-glucosidases.
15 the beetle myrosinase from other insect beta-glucosidases.
16 up to 76% sequence similarity to other beta-glucosidases.
17 for other glycoside hydrolase family 3 beta-glucosidases.
18 tly modify the nucleophile of retaining beta-glucosidases.
19 understand the glucose tolerance in GH3 beta-glucosidases.
20 he C-ring was related to inhibition of alpha-glucosidases.
21 so has soluble and membrane-bound xyloglucan glucosidases.
22 dase (3.42), beta-xylosidase (0.07) and beta-glucosidase (0.28) on low-cost copra meal (CM) in SSF.
23 n-degrading extracellular enzymes (beta-1, 4-glucosidase, 1, 4-beta-cellobiosidase, beta-D-xylosidase
26 Anthocyanin-rich extracts inhibited alpha-glucosidase (37.8%), alpha-amylase (35.6%), dipeptidyl p
30 ect in inhibiting i) alpha-amylase and alpha-glucosidase activities and ii) colorectal cancer cell li
35 -) mice, pharmacological inhibition of alpha-glucosidase activity almost completely abolished residua
37 noterpenes inhibited alpha-amylase and alpha-glucosidase activity and stimulated glucose uptake and l
38 al DeltaSPD0247 strain had reduced 6-phospho-glucosidase activity and was attenuated in growth on cel
40 he inhibition of the alpha-amylase and alpha-glucosidase activity facilitates the maintenance of circ
43 nd 17 muM, and also inhibited lysosomal beta-glucosidase activity in live cells at low-micromolar con
44 resulting in deficient lysosomal acid-alpha-glucosidase activity in patients, and a progressive decl
46 We then used HPLC-MS/MS to assess the beta-glucosidase activity of purified enzymes on p-nitropheny
49 ential inhibition of alpha-amylase and alpha-glucosidase activity was observed in response to polarit
51 Ectomycorrhizal fungal richness and beta-glucosidase activity were strongly reduced by burning an
53 CWEN, and enzyme activities especially beta-Glucosidase activity were the key determinants of MCC.
54 he strongest inhibitory effect against alpha-glucosidase activity with IC(50) 0.08 +/- 0.002 mg/mL.
55 glucosidase enzymes (Delta3betaG) lacks beta-glucosidase activity, but efficiently induces cellulase
58 lycosidase activity (GA) by 13.0%, alpha-1,4-glucosidase (AG) by 19.6%, beta-1,4-glucosidase (BG) by
59 vities of the three lysosomal enzymes (alpha-glucosidase (AG), beta-galactosidase (B-GAL) and beta-N-
61 dehydrogenase (DHA) and extracellular alpha-glucosidase (alpha-Glu) and protease (PRO) enzymes were
62 toprostanes (PhytoPs) on four enzymes: alpha-glucosidase, alpha-amylase, acetylcholinesterase, and bu
66 ted with metabolic syndrome, including alpha-glucosidase, amylase and lipase and exhibited antioxidan
68 rpm), significantly (p < 0.05) higher alpha-glucosidase and acetylcholinesterase inhibition activiti
69 dant activities for free fraction, and alpha-glucosidase and acetylcholinesterase inhibition for whol
70 scavenging activity and alpha-amylase, alpha-glucosidase and aldose reductase inhibitory activity wer
74 th evaluation of in vitro antioxidant, alpha-glucosidase and alpha-amylase inhibitory activities of v
75 rdolino extracts exhibited the highest alpha-glucosidase and alpha-amylase inhibitory activity with I
76 h can be counteracted by inhibition of alpha-glucosidase and alpha-amylase, both involved in the carb
77 antioxidant activities, inhibition of alpha-glucosidase and alpha-amylase, inhibition of angiotensin
78 as selective competitive inhibitors of beta-glucosidase and are promising candidates as pharmacologi
79 al design to optimise the production of beta-glucosidase and convert glycosidic isoflavones in aglyco
80 green olives is due to the activity of beta-glucosidase and esterase during the first months of stor
85 e highest inhibition of alpha-amylase, alpha-glucosidase and lipase (IC50: 0.38mg/mL, 0.87mug/mL and
86 L-cholesterol peroxidation, as well as alpha-glucosidase and lipase activities were demonstrated, the
89 pinnatifida has a potential to inhibit alpha-glucosidase and may be used as a bioactive food ingredie
92 1 genes co-localize with genes encoding beta-glucosidases and ATP-binding cassette transporters, high
93 ) crystal structures, we determine that most glucosidases and beta-mannosidases preferentially bind t
95 study was to monitor olive hydrolytic (beta-glucosidase) and oxidative (peroxydase, POX, and polyphe
96 in glucocerebrosidase (GBA, a retaining beta-glucosidase), and deficiency in GBA constitutes the larg
97 nzyme, enzyme type (cellulase, pectinase, ss-glucosidase), and hydrolysis time (1, 4, 8, 24 h) on the
98 t activity, and greater alpha-amylase, alpha-glucosidase, and ACE inhibitory activity than the pasteu
99 inhibitory potential of alpha-amylase, alpha-glucosidase, and dipeptidyl peptidase III (DPP III) enzy
100 ritol B epoxide is an inhibitor of acid beta-glucosidase, and lowers glucosylceramide degradation.
102 stinct for antioxidant activity, ACE-, alpha-glucosidase-, and Kunitz trypsin-inhibitory activity.
107 ribes novel preparations of immobilized beta-glucosidase as highly stable and active catalysts for in
108 y-2-fluoro-beta-glucosides react with a beta-glucosidase at rates differing by 10(6)-fold, despite th
111 ur) are both produced by E. coli, while beta-glucosidase (beta-gluco) is produced by Enterococcus spp
112 aucher disease is caused by mutations in the glucosidase, beta, acid gene that encodes glucocerebrosi
114 ll wall metabolism (beta-galactosidase, beta-glucosidase, beta-amylase, chitinase, pectate lyase (PL)
117 lpha-1,4-glucosidase (AG) by 19.6%, beta-1,4-glucosidase (BG) by 11.1%, beta-1,4-xylosidase (BX) by 2
118 r glycosidases, alpha-glucosidase (AG), beta-glucosidase (BG), beta-xylosidase (BX), cellobiohydrolas
119 potential activities of cellulase (CL), beta-glucosidase (BG), lignin peroxidase (LiP), and manganese
120 ize a family 3 glycosyl hydrolase (GH3) beta-glucosidase (Bgl) produced by Malbranchea pulchella (MpB
122 be in an operon with a putative phospho-beta-glucosidase (bglB) downstream and a predicted antitermin
124 primarily of stereochemistry-retaining beta-glucosidases but also contains a subfamily of beta-N-ace
125 tural basis of glucose tolerance in GH1 beta-glucosidases but also demonstrate a strategy to improve
126 opsis thaliana contain large amounts of beta-glucosidases, but the physiological functions of ER bodi
127 fy both catalytic residues of retaining beta-glucosidases by the combined use of cyclophellitol beta-
128 zymes of intact heterotrophic biofilms, beta-glucosidase (carbon-cycling) and l-leucin aminopeptidase
130 to non-homologous (putative) retaining beta-glucosidases categorized in GH1 and GH116: GBA2, GBA3, a
132 on of both enzymes, as a membrane-bound beta-glucosidase could specifically digest soluble xyloglucan
133 D) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive gl
134 A is, thus, preferable as an industrial beta-glucosidase despite its lower activity caused by transgl
135 iated uptake of recombinant human acid-alpha-glucosidase during ERT in mice with Pompe disease follow
137 the beta-glucoside permease (bglP) and beta-glucosidase enzyme (bglB) in 5448, we showed that bglB,
138 ntrations were associated with enhanced beta-glucosidase enzyme activities (V max ) but short-term dr
139 showed more than 80% inhibition of the alpha-glucosidase enzyme at a concentration of 40mg/mL (dry sa
140 matic activities, results show that the beta-glucosidase enzyme is the key enzyme responsible for the
142 assa mutant carrying deletions of three beta-glucosidase enzymes (Delta3betaG) lacks beta-glucosidase
143 mutant lacking genes encoding both the beta-glucosidase enzymes and cellodextrin transporters (Delta
144 -4B is an iminosugar that inhibits the alpha-glucosidase family of enzymes and subsequently the foldi
147 me and the immobilised cells containing beta-glucosidase, for 2h at 40 degrees C, promoted efficient
148 most potent (IC50: 0.25mug/mL) against alpha-glucosidase; Fraction IV from black turtle bean was the
150 to be low micromolar inhibitors of the alpha-glucosidase from baker's yeast with Ki's near to 2 muM.
153 expressed OeGLU, an oleuropein-specific beta-glucosidase from olive (Olea europaea), had enzymatic ki
154 i-casuarine is a strong inhibitor of alpha-d-glucosidase from rice and of rat intestinal sucrase.
156 y of the industrially relevant family 3 beta-glucosidases from Hypocrea jecorina, HjCel3A and HjCel3B
157 somal glycogen-hydrolyzing enzyme acid alpha-glucosidase (GAA) activity, which results in lysosomal g
158 arily the liver and kidney, while acid alpha-glucosidase (GAA) deficiency in GSD II causes primarily
159 or gene replacement therapy with acid alpha-glucosidase (GAA) has achieved only partial efficacy in
160 d to and degraded in lysosomes by acid alpha-glucosidase (GAA) in mammals, but it is unclear why and
161 disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glyc
162 caused by mutations in lysosomal acid alpha-glucosidase (Gaa), manifests rapidly progressive fatal c
165 dated the method by using the retaining beta-glucosidase GBA (CAZy glycosylhydrolase family GH30) and
167 -glucosidase GBA1 and the non-lysosomal beta-glucosidase GBA2 degrade glucosylceramide (GlcCer) to gl
168 xide (CBE), as well as the nonlysosomal beta-glucosidase (GBA2) inhibitor N-butyldeoxygalactonojirimy
170 caused by insufficient activity of acid beta-glucosidase (GCase) and the resultant glucosylceramide (
172 CBE-N2a) was created by inhibiting acid beta-glucosidase (GCase) in N2a cells with conduritol B epoxi
176 erococcus faecalis, encodes a 6-phospho-beta-glucosidase (GenA) and a phosphotransferase system perme
179 confirmed their high affinity towards alpha-glucosidase, highlighting a static quenching mechanism.
180 oved the functional properties of a GH1 beta-glucosidase highly expressed by Trichoderma harzianum (T
181 lings with a rare genetic defect in ER alpha-glucosidase I (ER Glu I) who showed resistance to viral
182 lacking Erv41-Erv46 function, the ER enzyme glucosidase I (Gls1) was mislocalized and degraded in th
183 ic that inhibits endoplasmic reticulum alpha-glucosidase I and II enzymes resulting in improper glyco
185 was particularly active against yeast alpha-glucosidase (IC(50) = 1.53 mug/mL), acting through a non
186 on (alpha-amylase: IC(50)-42.34 ug/mL; alpha-glucosidase: IC(50):63.89 ug/mL), basal uptake of glucos
187 pea showed inhibitory activity against alpha-glucosidase (IC50 6967 +/- 343 and 2885 +/- 85.4 mug/ml,
188 (bran) and 148.23 mug/ml (hulls)] and alpha-glucosidase [IC50, 62.1 mug/ml (bran) and 68.14 mug/ml (
190 structures of the main ERQC enzyme, ER alpha-glucosidase II (alpha-GluII; from mouse), alone and in c
191 and genetic approaches, we demonstrate that glucosidase II (GII) mediates glycan trimming of TRPP2.
193 sylation of N-glycans, and oppositely acting glucosidase II (GlucII), and that vIL-6 can promote prot
196 unctions as the noncatalytic beta subunit of Glucosidase II, an endoplasmic reticulum (ER)-resident e
197 e we show that PYK10, the most abundant beta-glucosidase in A. thaliana root ER bodies, hydrolyzes in
198 ell as a decrease in the inhibition of alpha-glucosidase in both extracts, when compared to undigeste
201 Interestingly, expression of individual beta-glucosidases in Escherichia coli K-12 enabled this non-c
203 garding the in vitro alpha-amylase and alpha-glucosidase inhibition activities of extracts derived fr
208 ing, beta-carotene bleaching activity, alpha-glucosidase inhibition and the highest total phenolic co
209 one extracts of seaweeds were used for alpha-glucosidase inhibition assay hyphenated with high perfor
210 variate data analysis, high-resolution alpha-glucosidase inhibition assays and HPLC-HRMS-SPE-NMR with
213 ore investigated using high-resolution alpha-glucosidase inhibition profiling combined with high-perf
214 ) activity, however, a 10% increase in alpha-glucosidase inhibition was observed in irradiated (2.5 k
216 ved on antidiabetic (alpha-amylase and alpha-glucosidase inhibition) activity, however, a 10% increas
217 tyrylcholinesterase, tyrosinase, amylase and glucosidase inhibition) were used for screening of peppe
218 anticancer activity, alpha-amylase and alpha-glucosidase inhibition, angiotensin-converting-enzyme (A
219 stigated, as well as alpha-amylase and alpha-glucosidase inhibition, antihypertensive, antioxidant an
220 lified roasting-induced differences in alpha-glucosidase inhibition, CGA showed a decreasing trend up
221 were in vitro digested and tested for alpha-glucosidase inhibition, to explore their antidiabetic po
223 ter fraction (WF) of ME was a stronger alpha-glucosidase inhibitor (EC50 2.9 mug/mL) than quercetin,
224 SMD, 0.33 [95% CI, 0.13 to 0.52]), and alpha-glucosidase inhibitor (SMD, 0.35 [95% CI, 0.12 to 0.58])
226 l" analogue would be a potent retaining beta-glucosidase inhibitor for those enzymes reacting through
227 tive synthesis of nectrisine, a potent alpha-glucosidase inhibitor, was carried out starting from but
231 rily by adding or adjusting metformin, alpha-glucosidase inhibitors, thiazolidinediones, or insulin,
232 litol aziridine-both covalent retaining beta-glucosidase inhibitors-we postulated that the correspond
235 lues following fermentation, while the alpha-glucosidase inhibitory activities ranged from 95.2 to 19
236 X2C gave a subfraction, with enhanced alpha-glucosidase inhibitory activity (IC50=6.15mug/mL), with
237 -bioassay/HPLC-HRMS-SPE-NMR showed the alpha-glucosidase inhibitory activity of A. nodosum, F. vesocu
239 oside-A showed concentration-dependent alpha-glucosidase inhibitory activity with IC50=35.01 mug/ml.
240 identification of three analytes with alpha-glucosidase inhibitory activity, and subsequent HPLC-HRM
245 ibly due to the presence of intestinal alpha-glucosidase inhibitory and augmenting cellular glucose u
249 In the present work Aspergillus niger beta-glucosidase is immobilized within nanoscale polymeric ma
250 s found that only one of four predicted beta-glucosidases is required in a physiological context.
251 abetes framework, the extract inhibits alpha-glucosidase (K(i) = 166.9 ug/mL) and aldose reductase (K
252 rological legacy alters the response of beta-glucosidase kinetics (i.e. type of inhibition) to short-
253 l-NBDNJ is able to enhance lysosomal alpha-glucosidase levels in Pompe disease fibroblasts, either
254 lic syndrome, including alpha-amylase, alpha-glucosidase, lipase and hydroxyl methyl glutaryl CoA red
255 compounds did not affect inhibition of alpha-glucosidase (maltase) activity, which remained relativel
256 In vitro digested coffee inhibited alpha-glucosidase more effectively, compared to undigested sam
258 and biallelic MOGS (mannosyl-oligosaccharide glucosidase) mutations (GenBank: NM_006302.2; c.[65C>A;
260 screen, and the Exg1 gene (coding for a beta-glucosidase) of D. bruxellensis was cloned and purified.
261 ct and its inhibiting activity against alpha-glucosidase, pancreatic lipase and hyaluronidase were de
262 enzymatic in vitro inhibition tests of alpha-glucosidase, pancreatic lipase, acetylcholinesterase and
263 ), anti-diabetic (anti-alpha-amylase, -alpha-glucosidase, -pancreatic lipase) and antioxidant potenti
264 e insect but can be cleaved by a spruce beta-glucosidase, PgbetaGLU-1, which releases the active agly
265 surfaces with OM inputs had the highest beta-glucosidase, phosphatase, NAGase and cellobiohydrolase a
266 yl acetate fraction inhibited in vitro alpha-glucosidase (pIC(50) = 4.8 +/- 0.1), an enzyme involved
268 The ability of olive endogenous enzymes beta-glucosidase, polyphenol oxidase (PPO) and peroxidase (PO
270 kdown of beta-1, 4-glycosidic linkages, beta-glucosidases produce free fermentable glucose and allevi
272 f the full-length GAA transcript, acid-alpha-glucosidase protein, and enzyme activity in all patients
273 -bound drug for recombinant human alpha acid glucosidase (rhGAA) in plasma from patients suffering fr
274 this benefit, most characterised fungal beta-glucosidases show weak activity at high glucose concentr
275 lpha-amylase, but potent inhibitors of alpha-glucosidase, showing low-micromolar IC(50) values, far l
276 n properties against alpha-amylase and alpha-glucosidases, showing different inhibition constants (K(
278 o-component defense system comprising a beta-glucosidase that activates oleuropein into a toxic gluta
279 ) is an intestinal membrane-associated alpha-glucosidase that breaks down di- and oligosaccharides to
280 ta-glucanase, BT3312, and a periplasmic beta-glucosidase that targets primarily 1,6-beta-glucans.
281 rients involves the action of 6-phospho-beta-glucosidase to convert them into usable monosaccharaides
282 ion of ICHO and ICOOH derivative pools after glucosidase treatment revealed that, in response to AgNO
283 resence of active polyphenoloxidase and beta-glucosidase was determined by HPLC and UV-Visible spectr
284 activity of pectin methyl esterase and beta-glucosidase was enhanced in ET-treated berry skins, sugg
286 looxygenase 1 and -2, as well as amylase and glucosidase was recorded for the breads enriched with th
291 mutation(s) in GBA, which encodes acid beta-glucosidase, were recruited at the SZMC Gaucher Clinic.
292 osomal acid maltase, two major hepatic alpha-glucosidases, were unaltered in L-G6pc(-/-) mice, pharma
293 rated uncompetitive inhibitors against alpha-glucosidase, while EAEP, AEP, and HEX-AEP (used as contr
294 se tolerance and stimulation of the GH1 beta-glucosidases will be crucial to improve their applicatio
295 lted in the thermo-stabilization of the beta-glucosidase with an increase in optimum temperature and
296 of fucoxanthin significantly inhibited alpha-glucosidase with IC(50) value 0.047 +/- 0.001 mg/mL.
298 mary and tertiary structures of two GH1 beta-glucosidases with distinct glucose dependence, some puta
299 ractions X1C and X2C notably inhibited alpha-glucosidase, with IC50=9.89 and 8.05mug/mL, respectively
300 HjCel3A and other structurally similar beta-glucosidases would have a significant economic effect on