ライフサイエンスコーパス: glucuronide

1 ide) and total NNAL (the sum of NNAL and its glucuronide).

2 otinate and quinate) and alcohol (with ethyl glucuronide).

3 ls of quercetin-3-rhamnoside and quercetin-3-glucuronide.

4 y of urinary GTC metabolite epigallocatechin glucuronide.

5 ings with the endogenous compound, bilirubin glucuronide.

6 reference standard, JWH-018 5-hydroxypentyl glucuronide.

7 ithin glucuronides, and indole-3-acetic acid glucuronide.

8 TCC in human urine was largely the N- or N'-glucuronide.

9 that was not induced by 4-nitrophenyl-beta-D-glucuronide.

10 de, p-cresol glucuronide, and pregnanediol-3-glucuronide.

11 L), NNAL-N-beta-glucuronide, and NNAL-O-beta-glucuronide.

12 a metabolite expressed in human sweat, Ethyl Glucuronide.

13 es of CYP2C8 that allow potential binding to glucuronides.

14 thocyanins reached the circulation mainly as glucuronides.

15 d forms (79.4% +/- 3.9%) and as sulfates and glucuronides.

16 the mechanisms of hepatic uptake of androgen glucuronides.

17 aluronan (HA), proteoglycans, and xenobiotic glucuronides.

18 environmental toxicants to highly excretable glucuronides.

19 unambiguously differentiate acyl-, N-, and O-glucuronides.

20 nsport rate toward AG as compared with other glucuronides.

21 can reactivate estrogens from their inactive glucuronides.

22 y in the case of deprotonated, migrated acyl-glucuronides.

23 able the differentiation of acyl-, N-, and O-glucuronides.

24 ucuronides and unmigrated, deprotonated acyl-glucuronides.

25 individual OATPs in hepatic uptake of these glucuronides.

26 tic uptake of major circulating testosterone glucuronides.

27 GUS expression in response to small-molecule glucuronides.

28 ts binding to anionic and bulky ligands like glucuronides.

29 1-hydroxypyrene (1-pyOH) and 1-hydroxypyrene-glucuronide (1-pyOglu) in phosphate buffer and artificia

30 a 5.1 mM solution of a synthetic model drug glucuronide, 1-beta-O-acyl (S)-alpha-methyl phenylacetyl

31 c acid (21.83 mg/g extract) and apigenin-7-O-glucuronide (10.6 mg/g extract) were the most abundant.

32 MS fragmentation matching with the synthetic glucuronide 26.

33 caftaric acid (12.24 mg/100 g), quercetin 3-glucuronide (29.66 mg/100 g), cyanidin 3-O-galactoside (

34 In addition, luteolin 7-O-glucuronide 3-O-glucoside was identified for the first t

35 metabolite, 3'-O-methyl-epicatechin-5-O-beta-glucuronide (3'-O-Me-EC-Gluc), one of the PAC metabolite

36 esent as the metabolite 4-methylumbelliferyl glucuronide (4-MUG), which makes it remarkable that 4-MU

37 yl sulfamethoxazole, sulfamethoxazole beta-D-glucuronide, 4-nitroso sulfamethoxazole, and 4-nitro sul

38 o other common opiates, morphine, morphine-3-glucuronide, 6-acetyl morphine, demonstrates an advantag

39 id (an omega-3-fatty acid) and quercetin-3-O-glucuronide (a polyphenol metabolite) do not undergo sen

40 ng intensity and duration: cotinine plus its glucuronide, a biomarker of nicotine uptake; 4-(methylni

41 Conjugation of the MAC beta-glucuronide AE drug linker to the anti-CD30 antibody cAC

42 two T metabolites which remain conjugated as glucuronides after an enzymatic hydrolysis of the urine.

43 de, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against acridin were 21.8%, 22.4% and 23.6%,

44 de, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against ethyl methanesulfonate were 57.6%, 5

45 al acyl migration reactions of 1-beta-O-acyl glucuronides (AGs), which rearrange at neutral or slight

46 s, namely, indole-3-acetic acid and p-cresyl glucuronide, an increase in blood flow rate is advantage

47 llow-back method and monitored by hair ethyl glucuronide analysis.

48 onide, cortolone-3-glucuronide, testosterone-glucuronide and 17-hydroxyprogesterone), which belonged

49 he glucuronide conjugates ethinylestradiol-3-glucuronide and 17beta-estradiol-17-glucuronide stimulat

50 androstan-17-one (6beta-hydroxyandrosterone) glucuronide and 3alpha,6beta-dihydroxy-5beta-androstan-1

51 r selectivity of OATP1B3 toward testosterone glucuronide and androsterone glucuronide can be leverage

52 and two predominant metabolic conjugates-BPA glucuronide and BPA sulfate-in umbilical cord serum coll

53 to morphine and related opioids (morphine-6-glucuronide and buprenorphine) was blocked by JNK inhibi

54 nicotine metabolites, the levels of nicotine-glucuronide and cotinine-glucuronide were 42% (P < 0.000

55 wo distinct estrogen glucuronides, estrone-3-glucuronide and estradiol-17-glucuronide, to estrone and

56 Along with ethyl glucuronide and ethyl sulfate, N-acetyltaurine (NAT) was

57 ransport was inhibited by estradiol 17beta-d-glucuronide and fumitremorgin C.

58 ucose (UDP-Glc), leading to the formation of glucuronide and glucoside conjugates.

59 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-sulphate were also detected.

60 ity monitors that measured urinary estrone-3-glucuronide and luteinizing hormone (LH).

61 rphine, the two main metabolites, morphine-3-glucuronide and morphine-6-glucuronide, were quantified

62 ed three metabolites RV 3-O-sulphate, RV 3-O-glucuronide and RV 4'-O-glucuronide, and studied their e

63 Flavonoids are conjugated with glucuronide and sulfate and are excreted in urine and bi

64 We measured serum enterolactone glucuronide and sulfate concentrations by liquid chromat

65 er had significant lower serum enterolactone glucuronide and sulfate concentrations than controls (gl

66 S-MS) has been developed for the analysis of glucuronide and sulfate metabolites of seven anabolic-an

67 olic catabolites are included with flavanone glucuronide and sulfate metabolites, orange juice (poly)

68 Hesperetin-3'-O-glucuronide and the colonic microbiota-derived catabolit

69 Interestingly, the endobiotic estradiol-17-glucuronide and the xenobiotic indomethacin-acyl-glucuro

70 noside, luteolin 7-O-glucoside, apigenin 7-O-glucuronide and tricin 7-O-diglucuronide have been isola

71 We tentatively identified 1-methylpyrene glucuronides and 1-carbonylpyrene glycine as phase II me

72 Only deprotonated N-glucuronides and deprotonated, migrated acyl-glucuronide

73 the mechanism of hepatic uptake of androgen glucuronides and estimate the fractional contribution of

74 thoroughly investigated for a wide range of glucuronides and for the reference standard, JWH-018 5-h

75 EG can be produced similarly to other simple glucuronides and should therefore be no more expensive.

76 nditions for enzyme hydrolysis of polyphenol glucuronides and sulfate esters, extraction, and dansyla

77 beled metabolites, namely, (14)C- and (13)C6-glucuronides and sulfates.

78 ct ions were not observed for deprotonated O-glucuronides and unmigrated, deprotonated acyl-glucuroni

79 morphine-like compounds (morphine and/or its glucuronides and/or codeine) in the adult mouse spinal c

80 ansport of [(3)H]17beta-estradiol-17-beta-(D-glucuronide) and doxorubicin efflux in AAV-293 cells.

81 total cotinine (the sum of cotinine and its glucuronide) and total NNAL (the sum of NNAL and its glu

82 (ii) dill: neochlorogenic acid and quercetin glucuronide, and (iii) parsley: apigenin-7-apiosylglucos

83 man (alpha-CEHC) glycine, alpha-CEHC glycine glucuronide, and alpha-CEHC taurine.

84 d circulating levels of APAP, APAP-GSH, APAP-glucuronide, and APAP-sulfate.

85 Morphine, codeine, morphine-6-glucuronide, and morphine-3-glucuronide are synthesized

86 -1-(3-pyridyl)-1-butanol (NNAL), NNAL-N-beta-glucuronide, and NNAL-O-beta-glucuronide.

87 in CSF (major chlorogenicacid, quercetin 3-O-glucuronide, and p-coumaric acid).

88 indole-3-acetic-acid-O-glucuronide, p-cresol glucuronide, and pregnanediol-3-glucuronide.

89 1-hydroxypyrene, pyrene-1-sulfate, pyrene-1-glucuronide, and pyrene glucoside sulfate, with pyrene-1

90 esveratrol-4'-O-sulfate, resveratrol sulfate glucuronide, and resveratrol disulfate were identified b

91 hydroepiandrosterone sulfate, androstanediol glucuronide, and sex hormone binding globulin).

92 trone, 5alpha-androstane-3alpha, 17beta-diol-glucuronide, and sex hormone-binding globulin.

93 3-O-sulphate, RV 3-O-glucuronide and RV 4'-O-glucuronide, and studied their effects on cell growth in

94 the levels of nicotine-glucuronide, cotinine-glucuronide, and trans-3'-hydroxycotinine (3HC)-glucuron

95 ude acyl glucuronides, ether glucuronides, N-glucuronides, and carbamoyl glucuronides, have been show

96 Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main

97 yphenyl-gamma-valerolactone, three urolithin glucuronides, and indole-3-acetic acid glucuronide.

98 tion of Gli1 reduced UGT1As, eliminated drug glucuronides, and renewed sensitivity to ribavirin and A

99 teers were glucuronides, sulfates, and sulfo-glucuronides, and the total excretion of flavanones incr

100 uronide and the xenobiotic indomethacin-acyl-glucuronide are found to exhibit markedly differential b

101 eine, morphine-6-glucuronide, and morphine-3-glucuronide are synthesized de novo in mammalian cells a

102 We previously established that androgen glucuronides are effluxed by multidrug resistance-associ

103 ect methods for the determination of steroid glucuronides are employed.

104 However, it was found that glucuronides are not stable, particularly in the case of

105 t Km values of >130 microM), suggesting that glucuronides are the preferred substrates for this trans

106 egrees C and pH 6 using 4-nitrophenyl beta-D-glucuronide as an indicator.

107 and pyrene glucoside sulfate, with pyrene-1-glucuronide as the most prominent metabolite.

108 This review summarizes glucuronides as CYP2C8 ligands and the active-site struc

109 transfer E. coli GusR's preferential DNA and glucuronide binding affinity to S. enterica GusR.

110 ravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and

111 de, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using a eukaryotic cell system, Saccharo

112 Apigenin-7-O-beta-d-glucuronide, caffeic and carnosic acids were quantitativ

113 re to NNN--the sum of NNN and its pyridine-N-glucuronide, called total NNN--was quantified in the uri

114 nt mouse models, we show here that sorafenib-glucuronide can be extruded from hepatocytes into the bi

115 rd testosterone glucuronide and androsterone glucuronide can be leveraged for establishing these meta

116 cording to this model, hepatocytic bilirubin glucuronide can follow a liver-to-blood shuttling loop v

117 r, there is growing evidence to suggest that glucuronides can be ligands of human CYP2C8, making CYP2

118 Although the structures of CYP2C8-glucuronide complexes have not been determined, the stru

119 L) at 10 mg/kg was due to the formation of O-glucuronide conjugate by phase 2 metabolism.

120 ughput method to directly analyze the intact glucuronide conjugate of HP (HP-G) in human urine after

121 ent glucuronidation to form a novel O-linked glucuronide conjugate, O-(beta-D-glucosidurony1)-2-hydro

122 ty is expected to reduce the reactivation of glucuronide-conjugated drugs in the intestine, thereby r

123 The glucuronide conjugates ethinylestradiol-3-glucuronide an

124 rase (UGT) enzymes catalyze the formation of glucuronide conjugates of phase II metabolism.

125 We hypothesized that glucuronide conjugates of xenobiotics, such as the antic

126 Several classes of glucuronide conjugates, which include acyl glucuronides,

127 over-the-counter drugs as their sulfate and glucuronide conjugates.

128 metabolites and the corresponding sulfo and glucuronide conjugates.

129 a significant factor in renal elimination of glucuronide conjugates.

130 endocrine compounds (tetrahydroaldosterone-3-glucuronide, cortolone-3-glucuronide, testosterone-glucu

131 3'-hydroxycotinine (OH-COT), cotinine-N-beta-glucuronide (COT-GLUC), and trans-3'-hydroxycotinine-O-b

132 o significantly alter the levels of nicotine-glucuronide, cotinine-glucuronide, and trans-3'-hydroxyc

133 ble concentrations of COT, OH-COT, and their glucuronides, depending on sampling and storage time or

134 differentiation of isomeric acyl-, N-, and O-glucuronide derivatives of drugs is challenging.

135 analysis showed that DHT was converted to a glucuronide, DHT-G, at a 6-fold higher level in androgen

136 educe conjugated steroids such as Dht-17beta-glucuronide (DhtG), Dht-17beta-sulfate (DhtS), and Tib-1

137 three previously unknown metabolites (2-DAMP glucuronide, didesethyl PM, and hydroxy-2-DAMP glucuroni

138 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-

139 disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 defici

140 CC10 transport substrates estrogen estradiol-glucuronide (E(2)17betaG) and leukotriene C4 (LTC(4)) si

141 f E2-3G and its oxidized metabolite, estrone glucuronide (E1-3G), both of which were transformed into

142 fferent molecular weights: estradiol-17-beta-glucuronide (E17betaG), prostaglandin E2 (PGE2), cholecy

143 Estradiol-17ss-D-glucuronide (E17G) activates different signaling pathway

144 strogen levels, by measuring urinary estrone glucuronide (E1G) in the periovulatory and luteal phases

145 ects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an association b

146 eled prototype conjugate, 17beta-estradiol-3-glucuronide (E2-3G).

147 ites (SREM), particularly (-)-epicatechin-3'-glucuronide, (-)-epicatechin-3'-sulfate and 3'-O-methyl-

148 estosterone, androstenedione, androstanediol glucuronide, estradiol, and sex hormone-binding globulin

149 enzymes to reactivate two distinct estrogen glucuronides, estrone-3-glucuronide and estradiol-17-glu

150 ency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increase

151 tification of a metabolite of ethanol, ethyl glucuronide (EtG).

152 f glucuronide conjugates, which include acyl glucuronides, ether glucuronides, N-glucuronides, and ca

153 We further demonstrate that sorafenib-glucuronide excreted into the gut lumen can be cleaved b

154 Urinary pregnanediol glucuronide excretion was not significantly affected.

155 glucuronides and deprotonated, migrated acyl-glucuronides form the two diagnostic product ions: a BF(

156 hich influenced the rate of ezetimibe beta-D-glucuronide formation as determined in microsomes treate

157 eta-acyl-glucuronides from the isomeric acyl-glucuronides formed upon acyl migration.

158 he differentiation of unmigrated 1-beta-acyl-glucuronides from the isomeric acyl-glucuronides formed

159 : BPA (GM 0.16, range <LOD-52.26 ng/mL), BPA glucuronide (GM 0.14, range <LOD-5.41 ng/mL) and BPA sul

160 ut severely impaired by the presence of a 17-glucuronide group for AKR1C1-3 isoforms.

161 glucuronides, N-glucuronides, and carbamoyl glucuronides, have been shown to be substrates or time-d

162 lavanone metabolites, mainly hesperetin-3'-O-glucuronide, hesperetin-3'-sulfate, naringenin-4'-O-gluc

163 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-sulphate were also

164 curonide, and trans-3'-hydroxycotinine (3HC)-glucuronide in human liver microsomes in vitro.

165 acid, 5-O-caffeoylquinic acid, apigenin 7-O-glucuronide in primary heads as well 1,5-di-O-caffeoylqu

166 pendent transport of [(3)H]estradiol-beta-17-glucuronide in vitro as compared with wild-type Ycf1p.

167 e presence of morphine, codeine, or morphine glucuronides in gamma-aminobutyric acid (GABA)-ergic neu

168 of morphine in case of fragmentation of the glucuronides in the atmospheric-to-vacuum interface of t

169 Here, we focus on glucuronides in the gut and the microbial proteins that

170 an methods for the open detection of steroid glucuronides in urine samples.

171 , lamotrigine, and its major metabolite (2-N-glucuronide), in environmental water samples using a new

172 MRP1-mediated uptake of tritiated estradiol glucuronide into inside-out membrane vesicles, their aff

173 t of leukotriene C(4) and estradiol-17beta-d-glucuronide into vesicles derived from MRP1 CK2alpha(-)

174 tate is an effective prodrug, and the O-aryl glucuronide is a major metabolite.

175 ICUP) technique, we found that quercetin-3-O-glucuronide is also capable of interfering with the init

176 We propose curcumin glucuronide is an inflammation-responsive natural prodru

177 The low SN-38 glucuronide is attributed to low hepatic uptake of SN-38

178 de, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide) isolated from Mentha longifolia (L.) Huds.

179 Urinary pregnanediol glucuronide levels were measured weekly for two 3-month

180 d (RA), lithospermic acid (LA), luteolin-7-O-glucuronide (Lgr), luteolin-7-O-rutinoside (Lr), eriodic

181 and Salmonella enterica in complexes with a glucuronide ligand.

182 d that its human metabolite lamotrigine-N(2)-glucuronide (LMG-N2-G) is the actual source of OXO-LMG i

183 Among them, apigenin-glucuronide, lucenin-2 and lithospermic acid were tentat

184 -glucoside (cosmosiin), luteolin 3'-O-beta-d-glucuronide, luteolin, apigenin, cirsimaritin, isokaempf

185 on, the morphine metabolite morphine-3beta-D-glucuronide (M3G) elicited hyperalgesia in WT but not in

186 es due to TLR4 active metabolite, morphine-3-glucuronide (M3G) exposure in vivo.

187 e for the residual heroin and morphine-6beta-glucuronide (M6G) analgesia in the exon 1 knockout mice.

188 e concentrations for morphine and morphine-6-glucuronide (M6G) were observed in stable expression cel

189 ntified apigenin-7-O-glucoside, luteolin-3-O-glucuronide, malonyl caffeoylquinic acid, trans-resverat

190 Brain-targeted quercetin-3-O-glucuronide may simultaneously modulate multiple indepen

191 de and sulfate concentrations than controls (glucuronide: median 3.14 nM vs. 6.32 nM, P < 0.001; sulf

192 ad similar enterolactone levels as controls (glucuronide: median 5.39 nM vs. 6.32 nM, P = 0.357; sulf

193 response and cytokine release syndrome, and glucuronide metabolite AUC correlated with tumor lysis s

194 The structure of the glucuronide metabolite was confirmed by retention time a

195 samples analyzed and lamotrigine and its 2-N-glucuronide metabolite were mostly detected in both wast

196 on for propranolol and its hydroxyproranolol glucuronide metabolite within specific organs of the tis

197 s dapagliflozin's major systemic circulating glucuronide metabolite, BMS-801576, concentrations in hu

198 g from extensive metabolism of PT2385 to its glucuronide metabolite.

199 ion-molecule reactions between deprotonated glucuronide metabolites and BF(3) followed by collision-

200 was enzymatically hydrolyzed to convert the glucuronide metabolites into the original pharmaceutical

201 olam metabolite) hydroxyl, and the 1' and 4' glucuronide metabolites were measured.

202 the relative abundance of hydroxypropranolol glucuronide metabolites were recorded and found to be co

203 ne transaminase and a lower clearance of the glucuronide metabolites with a renal dysfunction.

204 r an amino group to form acyl-, O-, and/or N-glucuronide metabolites, respectively.

205 DMS also separates morphine from its glucuronide metabolites, which allows for preventing the

206 e patients to receive morphine with 3- and 6-glucuronide metabolites, which are known to be neurotoxi

207 a lower probability of forming reactive acyl-glucuronide metabolites.

208 r magnetic resonance using the acetaminophen glucuronide method.

209 A series of MAC beta-glucuronide model constructs were prepared to evaluate s

210 fenac, it has been shown that removal of the glucuronide moieties from drug metabolites by bacterial

211 (FITC)], by utilizing a difluoromethylphenol-glucuronide moiety (TrapG) to trap the fluorochromes in

212 1-beta-O-acyl (S)-alpha-methyl phenylacetyl glucuronide (MPG) in 0.1 M sodium phosphate buffer in D2

213 min E metabolites (gamma-CEHC and gamma-CEHC glucuronide); MR analysis showed that genetically high l

214 ydroflavonol derivatives; myricetin hexoside-glucuronide, myricetin O-di-hexoside, syringetin O-di-he

215 tosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) i

216 ates, which include acyl glucuronides, ether glucuronides, N-glucuronides, and carbamoyl glucuronides

217 nide, hesperetin-3'-sulfate, naringenin-4'-O-glucuronide, naringenin-7-O-glucuronide, was equivalent

218 Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-

219 a unique biomarker, N-acetyltyramine-O,beta-glucuronide (NATOG), a neurotransmitter-derived secretio

220 It is also the first report of a glucuronide of an antidepressant surviving wastewater tr

221 res of 36 phenolic conjugates, including the glucuronides of 3',4'-di- and 3',4',5'-trihydroxyphenyl-

222 As interaction perpetrators with CYP2C8, glucuronides of gemfibrozil and clopidogrel showed marke

223 The results of this study suggest that glucuronides of pharmaceuticals might also be sources of

224 Glucuronides of syringetin and laricitrin, and rhamnosyl

225 rters and characterize transport kinetics of glucuronides of testosterone (TG), dihydrotestosterone (

226 er hydrolysis of the conjugated form (mainly glucuronide) of quercetin found in human plasma, the pha

227 T-GLUC), and trans-3'-hydroxycotinine-O-beta-glucuronide (OH-COT-GLUC) are excreted in urine followin

228 de, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide on TA1537 strain were 84.03%, 87.63% and 67.

229 In this study, free, conjugated (BPA glucuronide or BPAG and BPA disulfate or BPADS), and sub

230 nd animals, conjugation of BPA molecule with glucuronide or sulfate is considered as a mechanism for

231 chroman (CEHC) and CEHC conjugates (sulfate, glucuronide, or glucoside).

232 etrahydropentoxyline, indole-3-acetic-acid-O-glucuronide, p-cresol glucuronide, and pregnanediol-3-gl

233 acetyl-l-glutamine, 5-hydroxyindole, indoxyl glucuronide, p-cresol sulfate, and indoxyl sulfate.

234 is of propranolol and its hydroxypropranolol glucuronide phase II metabolites from a rat thin tissue

235 uronide substrates like p-nitrophenol-beta-D-glucuronide (pNPG), the GUS orthologs that are most effi

236 However, NIR glucuronide probes are not yet available.

237 We then compare the pNPG and diclofenac glucuronide processing abilities of a panel of twelve st

238 of reporter expression and for personalized glucuronide prodrug cancer therapy in preclinical studie

239 y in mice compared to HMR 1826, a well-known glucuronide prodrug of doxorubicin that cannot bind cova

240 tin metabolites in human plasma, quercetin 3-glucuronide (Q3G), quercetin 3'-sulphate (Q3'S) and isor

241 its derivatives, caffeoyl hexoside, luteolin glucuronide, quercetin derivatives and myristin, while A

242 tradiol levels, and testosterone:17beta-diol-glucuronide ratio are associated with reduced BPH risk,

243 one, estradiol, and testosterone:17beta-diol-glucuronide ratio were 0.64 (95% confidence interval (CI

244 ites of (epi)catechin and (epi)gallocatechin glucuronide reach peak nanomolar per liter plasma concen

245 However, some acyl-glucuronides react with biomolecules in vivo, which may

246 t the residues essential for DNA binding and glucuronide recognition.

247 tive chromogenic substrate, resorufin beta-d-glucuronide (REG), which is exceptionally sensitive and

248 s that are most efficient at processing drug-glucuronides remain unclear.

249 peron under the transcriptional control of a glucuronide repressor, GusR.

250 Intravenous administration of the glucuronide resulted in the formation of curcumin in the

251 absorbed compound is metabolized to inactive glucuronides, resulting in poor bioavailability (<1%).

252 esveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, resveratrol-3-O-sulfate, resveratrol-4'-O-s

253 ompound plus its metabolites resveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, resveratrol-3

254 r time scale to yield a series of positional glucuronide ring isomers and alpha/beta anomers from the

255 (-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.8

256 de, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide showed antimutagenic effects on TA1537 and T

257 rgeted polyphenol metabolites, quercetin-3-O-glucuronide, significantly reduced the generation of bet

258 ation in APC (a metabolite of CPT-11), SN-38 glucuronide (SN-38G), and SN-38G/SN-38 AUCs, respectivel

259 radiol-3-glucuronide and 17beta-estradiol-17-glucuronide stimulated the ATPase with relatively high a

260 viors were observed depending on the steroid glucuronide structure.

261 eatures necessary for the processing of drug-glucuronide substrates and the inhibition of such proces

262 L1 GUS enzymes presented here process small glucuronide substrates inefficiently compared to previou

263 al GUS enzymes have been examined with model glucuronide substrates like p-nitrophenol-beta-D-glucuro

264 s of the inactive metabolite buprenorphine-3-glucuronide suggested that darunavir-ritonavir and fosam

265 and experimental CCS obtained for mycotoxin glucuronides suggested the potential of the CCS matching

266 Glucuronide, sulfate, and methyl metabolites of (epi)cat

267 anthocyanins and 12 metabolites (methylated, glucuronided, sulfated).

268 etabolites in both groups of volunteers were glucuronides, sulfates, and sulfo-glucuronides, and the

269 mino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is denoted as total NNAL) are

270 od, with abstinence confirmed by urine ethyl glucuronide testing.

271 ahydroaldosterone-3-glucuronide, cortolone-3-glucuronide, testosterone-glucuronide and 17-hydroxyprog

272 -nor-9-carboxy-Delta(9)-tetrahydrocannabinol glucuronide (THC-COO-glu).

273 xtended periods, and forms very little SN-38 glucuronide (the precursor of enterotoxic SN-38).

274 idases, and by understanding which substrate glucuronides they process, molecular insights into mamma

275 yloside, dihydroquercetin, and quercetin 3-O-glucuronide to be discriminant in the detection of the o

276 nzyme that hydrolyzes the glycosidic bond of glucuronides to generate the parent compound, in human b

277 ides, estrone-3-glucuronide and estradiol-17-glucuronide, to estrone and estradiol, respectively.

278 curonides (total NNAL), and cotinine and its glucuronides (total cotinine), validated biomarkers of u

279 nitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), a biomarker of the tobacco ca

280 nitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine and its glucuron

281 Lastly, we found that quercetin-3-O-glucuronide treatment, compared to vehicle-control treat

282 behavior of thirteen representative steroid glucuronides, used as model compounds, was studied.

283 ramework toward understanding the control of glucuronide utilization by opportunistic pathogens in th

284 d to its metabolite 3alpha-androstanediol-17-glucuronide via the previously unrecognized "conjugation

285 The level of 3HC-glucuronide was 42% (P < 0.001) lower in the urine from

286 Only one flavonoid, luteolin-3'-O-glucuronide was found in all the samples, ranging from 8

287 ing the disposition of BPA and BPS and their glucuronides was built from these data to estimate the k

288 naringenin-4'-O-glucuronide, naringenin-7-O-glucuronide, was equivalent to 4.2% of OJ flavanone inta

289 levels of nicotine-glucuronide and cotinine-glucuronide were 42% (P < 0.0005) and 48% (P < 0.0001),

290 ntration and urinary excretion of naringenin glucuronide were both significantly higher after the con

291 tions of protein unbound, total RAL, and RAL glucuronide were determined by liquid chromatography-tan

292 rostan-17-one (6beta-hydroxyetiocholanolone) glucuronide were established as the structures for these

293 metabolites, except sulfamethoxazole beta-D-glucuronide were found to be more photostable than SMX u

294 Serum free-BPA and BPA-glucuronide were quantitated in sera of individual PND 3

295 Resveratrol and resveratrol-3-O-glucuronide were recovered from tissues at maximal mean

296 In contrast, epicatechin glucuronides were dominant in plasma, bile, and urine.

297 bin was reduced by 40% +/- 5%, and bilirubin glucuronides were excreted into bile.

298 transport screening assays revealed that the glucuronides were primarily taken up by OATP1B1 and OATP

299 onalized 2-acetamido-2-deoxy-Delta(4)-beta-D-glucuronides were synthesized to explore noncharge inter

300 ucuronide, didesethyl PM, and hydroxy-2-DAMP glucuronide) were tentatively identified in different ma

301 hormone binding globulin, and androstenediol glucuronide, were analyzed.

302 lites, morphine-3-glucuronide and morphine-6-glucuronide, were quantified by high-performance liquid