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1 r to that obtained with cyanoacrylate "Krazy Glue".
2 s surface attachment by acting as 'molecular glue'.
3 r: enlarged ulcer, perforation or transplant/glue).
4 nein regulation by the dynactin subunit p150(Glued).
5 and interacts with the Dynactin subunit p150(Glued).
6 sidues 10-44, is sufficient for binding p150(Glued).
7 rdered and becomes ordered upon binding p150(Glued).
8 re in solution, IC preferentially binds p150(Glued).
9 ed regulation of binding between IC and p150(Glued).
10 s association with the dynactin subunit p150(Glued).
11 protein PCM-1 and the dynactin subunit p150(Glued).
12 binding to MTs and the dynactin subunit p150(Glued).
13 association and does not interact with p150(Glued).
14 nalling endosomes require both Lis1 and p150(Glued).
15 olization with N-butyl-cyano-acrylate (NBCA) glue.
16 treatment with N-butyl-cyano-acrylate (NBCA) glue.
17 with a 1:2 dilution of N-butyl cyanoacrylate glue.
18 cent donors and secured in place with fibrin glue.
19 ss or risk of viral transmission from fibrin glue.
20 ricoceles using n-butyl cyanoacrylate (NBCA) glue.
21 mniotic membrane graft placement with fibrin glue.
22 SUN domains, effectively acting as molecular glue.
23 nd RF were applied between corneal strips as glue.
24 tures, Evicel fibrin glue, or Tisseel fibrin glue.
25 seel fibrin glue compared with Evicel fibrin glue.
26 ng an amniotic membrane scaffold with fibrin glue.
27 (digits 2 and 3) were adjoined with surgical glue.
28 molecules could be converted into molecular glues.
29 o overcome major challenges of technical wet glues.
30 y offering advanced coatings, adhesives, and glues.
31 n what chemical traits give rise to the best glues.
32 one cements, dental composites, and surgical glues.
33 se approximation with commercially available glues.
34 taken from horses and other animals to make glues.
36 bolising agents adopted were microcoils 57%, glue 14%, microplug 7%, particles 14%, and covered stent
38 ), stromal patching (10 cases; 9.9%), fibrin glue (8 cases; 7.9%), and suturing of the defect (1 case
39 i-segmental binding region reported for p150(Glued), a subunit of the dynein activator protein dynact
41 oagulation, endosuturing with application of glue after 36.1 +/- 19.07 days of failed conservative tr
42 eated by embolization of the lesion with 20% glue, after which he showed mild improvement of symptoms
47 evidence for the use of intralesional fibrin glue and intralesional sclerosant, and describe using bo
48 N3 or proteins known to disrupt dynein, p150/Glued and 50/dynamitin, resulted in decreased FMDV repli
50 surgical intervention in the form of corneal gluing and therapeutic corneal transplantation compared
51 ed only for centrosomal localization of p150(Glued) and does not affect its microtubule-organizing pr
52 lope during prophase, the exact role of p150(Glued) and its regulation during NEBD are largely elusiv
54 e stabilizing protein, tau, which binds p150(Glued) and similarly affects EC lumen formation by contr
55 complex proteins, end binding 1 (EB1), p150(Glued), and Clasp1, control human EC tube formation by (
56 ta reveal that Vpr interacted with EB1, p150(Glued), and dynein heavy chain and was sufficient to cri
58 strengths from scotch tape to hot-melt wood-glue, and adheres to metal, glass, wood, and Teflon(R) s
59 ected eyes, cultured on 3T3 cells and fibrin glue, and transplanted to the patient's injured eye.
67 rformance was benchmarked against commercial glues as well as the genuine material produced by live m
69 inding affinity for growing MT ends and p150(Glued) as compared with nonmutated protein, whereas a ph
71 antly, Plk1-mediated phosphorylation of p150(Glued) at Ser-179 positively regulates its accumulation
73 A new structural approach, the cluster-plus-glue-atom model, is introduced, which suits specifically
74 leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and
78 ammasome components by acting as a molecular glue between danger-signal sensors and procaspase-1.
82 The long disordered linker between the p150(Glued) binding segments and the dynein light chain conse
86 thyl 2-cyanoacrylate), commonly called Super Glue, can easily assemble into long and well defined fib
93 sis that the total amount of adhesive energy gluing cisternae dictates Golgi cisternal stacking, irre
94 the formation and motility of a dynein-p150(Glued) co-complex using dual-colour total internal refle
96 eatment such as endoscopic ultrasound-guided glue-coiling combination therapy and the emergence of hi
101 Understanding the function of individual glue components and the role of the droplet's macro-stru
102 a bona fide PROTAC degrader into a molecular glue compound, which has a completely different mechanis
104 nt enhancement of adhesion over nanoparticle glues comprised of spherical or cylindrical micelles.
105 on regeneration was enhanced when the fibrin glue contained dilutions of 500-nM solution of either sm
108 The largest subunit of dynactin, the p150(Glued), contains an N-terminus segment that is responsib
109 e length determination, whereas CLIP-190 and Glued contribute only to Dynein-dependent myonuclear pos
110 demonstrates that the CAP-Gly domain of p150(Glued) decreases the detachment rate of the dynein-dynac
113 aditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the
114 k1-independent dynein was reduced after p150(Glued) depletion, consistent with the binding of dephosp
115 of disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss
117 ydrogel cuboids displaying face-specific DNA glues, diverse structures are achieved in aqueous and in
122 Modern orb-weaving spiders use micron-sized glue droplets on their viscid silk to retain prey in web
124 a pair of axial silk fibres as micron-sized glue droplets that are composed of an aqueous coat of sa
125 orb web's prey capture thread relies on its glue droplets to retain insects until a spider can subdu
127 ariable for two isoforms (1A and 1B) of p150(Glued) expressed in cultured fibroblast-like cells (isof
128 ed: 4 cyanoacrylate adhesives (CA), 2 fibrin glues (FG), 3 polyethylene glycol (PEG) adhesives, and 3
132 methods we show residues 381 to 530 of p150(Glued) form a minimal fragment that binds to the dynein
133 the IC binding domains of both NudE and p150(Glued) form dimeric coiled-coils and bind IC at a common
134 (NDE1) and dynactin (as represented by p150(Glued)) form mutually exclusive complexes with dynein, e
135 silk glands, the expression profiles of the glue-forming aggregate glands were divergent from fiber-
139 genetic analyses show that kinesin and p150(Glued) function cooperatively at TBs to coordinate trans
140 Arfaptin and the Drosophila DCTN1 homologue, Glued, function in the same pathway during synapse growt
141 ctival autograft plus suturing versus tissue glue), graft alterations (misapposition, granuloma, haem
143 nucleotide array of the human transcriptome [Glue Grant human transcriptome (GG-H array)] has been de
144 Inflammation and the Host Response to Injury Glue Grant studies and other representative studies in G
145 ospective analysis of clinical data from the Glue Grant trauma database demonstrated that despite a s
148 Inflammation and the Host Response to Injury Glue Grant with the following inclusion criteria: 0 to 8
150 Inflammation and the Host Response to Injury Glue Grant, with the following inclusion criteria: 0-99
151 hila salivary gland cells undergo a burst of glue granule secretion to attach the forming pupa to a s
152 ve day was significantly lower in the fibrin glue groups compared with the suture group (P = 0.047).
153 ime) was significantly shorter in the fibrin glue groups compared with the Vicryl group: 5.46 minutes
156 tubule plus end localization of EB1 and p150(Glued), hence altering the centripetal movement of phago
157 randomized to receive either a cyanoacrylate glue (Histoacryl, n = 216), self-gripping mesh (Parietex
158 sions may serve as both a molecular-specific glue, holding defined populations of cells together, and
160 ntermediate chain (IC) and the dynactin p150(Glued); however, the interface and mechanism that regula
163 tic duct occlusion (PDO) with neoprene-based glue in selected patients undergoing pancreatoduodenecto
167 icrotubule dynamics, while depletion of p150(Glued) in neurons leads to a dramatic increase in microt
169 ing alone, with or without tissue sealant or glue, in reducing the incidence and duration of air leak
170 M2 degrader but instead works as a molecular glue, inducing degradation of a translation termination
171 g-term endoscopic variceal ligation (EVL) or glue injection + beta-blocker treatment was compared wit
172 eyes and in the capsular bag for 3 eyes, and glued intrascleral fixation of IOL was performed in 3 ey
175 Forty-one eyes of 33 children who underwent glued IOL implantation were retrospectively evaluated.
183 y neurons using live-cell imaging, that p150(Glued) is a potent anti-catastrophe factor for microtubu
185 a, indicating that Kif3a recruitment of p150(Glued) is critical for subdistal appendage formation.
187 up the voids between particles and act as a "glue", joining grains in hot-pressed pellets or solution
191 pact behavior of polyQ is mainly due to the "glue-like" behavior of glutamine's side chains with sign
193 ated mutation introduced into the Drosophila Glued locus generates a partial loss-of-function allele
194 odel, we investigated the effects of a 24 hr gluing manipulation in which the right index and right m
195 ed microtubule-associated proteins like p150(Glued) may also modulate the dynamics of microtubules, w
196 s of microtubules, we hypothesized that p150(Glued) might promote cargo initiation by stabilizing the
197 dentify covalent interactions between tissue glue molecules and corneal ECM molecules in either the p
200 stoma only (n = 27; 9%), plug (n = 15; 5%), glue (n = 13; 5%), or others (n = 8, 3%)]; and 69 major
201 erize the structure and dynamics of the p150(Glued) N-terminal region, both free and in complex with
203 Vicryl sutures (Ethicon, NJ), Evicel fibrin glue (Omrix Biopharmaceuticals Ltd, Ramat-Gan, Israel),
204 l wet cells, that featured an optical window glued on top of the electrode system and a very limited
205 lorimetry that the binding footprint of p150(Glued) on IC involves two noncontiguous recognition regi
207 f split GFPs as versatile sensors, molecular glues, optogenetic tools, and platforms for photophysica
208 FM protocol that does not rely on the use of glue or chemical agents for muscle and tendon fiber immo
212 d protein glycine-rich domain of Nip100/p150(glued) Our results support a model in which dynein desta
214 with VIII and core protein V, which together glue peripentonal hexons beneath the vertex region and c
215 m Greek gammalambdaomicroniotaalpha meaning 'glue') pertains to non-neuronal cells in the central (CN
217 lobe was significantly higher in the fibrin glue, polyvinyl alcohol particles with coils, and n-buty
218 using saline (sham), gelatin sponge, fibrin glue, polyvinyl alcohol particles with coils, n-butyl cy
219 The prospective discovery of 'molecular glue' presented here provides a paradigm for the develop
220 useum conservation work, such as addition of glues, preservatives, and fumigants to "protect" archaeo
221 differ chemically from those shown for other glue-producing terrestrial or marine species and thus re
222 exposed moieties can confer gain-of-function glue properties to an inhibitor, and we propose this as
224 molecular and structural features of spider glue proteins, in particular bioadhesives that interconn
228 iameter) to show that for La(2)CuO(4+y), the glue regions contain incommensurate modulated local latt
229 n by heterobifunctional ligands or molecular glues represents a new modality in drug development, all
230 studies that compared surgical time, fibrin glue required 1 to 5 minutes less time than suturing in
231 nding footprint of p150(Glued), whereas p150(Glued) requires regions 1 and 2 to match the binding aff
232 atic embolization with n-butyl cyanoacrylate glue resulted in sustained improvement of the serum albu
233 trochemically inactive, working as an ideal "glue" robustly bridging tin and copper to survive harsh
236 /- 13, 32 +/- 9, and 38 +/- 9 minutes in the glue, self-gripping, and suture groups, respectively (P
237 sing DNA as programmable, sequence-specific 'glues', shape-controlled hydrogel units are self-assembl
238 acid (Asp), wool, parchment, and rabbit skin glue showed a significant increase in Asp racemization u
239 increasing irradiation time with rabbit skin glue showing the greatest increase in d-Asp formation.
244 points) were treated with PDO using neoprene glue (study cohort); patients with FRS <=15% (<=5 points
245 ions that were initially closed using fibrin glue subsequently developed a wound gap that required su
246 dynamitin displaces the dynein-binding p150(Glued) subunit from the cargo-binding Arp1 filament.
247 rate that SLK (LOSK) phosphorylates the p150(Glued) subunit of dynactin and thus targets it to the ce
249 e localization of dynein, NuMA, and the p150(Glued) subunit of dynactin to the spindle pole and cell
251 ations within the CAP-gly domain of the p150(Glued) subunit of the dynactin complex have been identif
252 actin binds both dynein and MTs via its p150(Glued) subunit, but little is known about the 'pointed-e
256 he peptide-HLA with the viral Ag as the main glue, such that neighboring TCR-MHC interactions are rec
257 osphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizin
259 imple Transection (ST), Simple Transection & Glue (TG), Stepwise Transection and Sutures (SU), and St
261 vation by providing a unique type of protein glue that boosts multiple protein interactions along the
262 Therefore Slk19 likely acts as kinetochore glue that clusters kinetochores to facilitate efficient
264 onsite symmetries alone, and connectors are glues that complete the open edges shared by two or mult
265 _Quad, where the ligand serves as molecular "glue" that bridges the S4-S5 linker to the S1-S4 domain
266 e the dream of understanding the biological "glue" that sustains life at a molecular and cellular lev
267 ically and biochemically interacts with both Glued (the regulator of dynein-dependent transport) and
268 l contacts of the nanoparticles efficiently "glued" the structural elements of microfibrils together,
269 Although it has been described that p150(Glued), the major component of the dynein/dynactin compl
270 to the coiled-coil 1B (CC1B) domain of p150(Glued), thus explaining why H2 is necessary for tight bi
271 dhesive strength between corneal strips, the glue-tissue interface was subjected to a constant force
272 s discussing the use of intralesional fibrin glue to aid dissection and intralesional sclerosant to s
273 ure suggest that the off-label use of fibrin glue to close limbal conjunctival incisions in strabismu
276 howed the transition from the protein sizing glue to starch sizing; also the employment of kaolin var
277 the adhesion energy between a silica colloid glued to AFM cantilever and the studied surfaces increas
278 language-learning mechanisms might have been glued to phylogenetically older subcortical reward syste
281 s tend to show that internal cations act as "glue" to maintain the POM units connected through the co
282 direct binding of the dynactin subunit p150(Glued) to JIP1 competitively inhibits KHC activation in
284 ficial targeting of nonphosphorylatable p150(Glued) to the centrosome restores microtubule radial arr
285 to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles,
286 m Rubiscos from higher plants where LSus are glued together by small subunits (SSu) into hexadecameri
287 s ubiquitous near relative, the horse, to be glued together with a bespoke matrix of regenerated silk
290 ong-term assessment of the optic position of glued transscleral fixated intraocular lens (IOL) with o
292 olecular weight salts and proteins makes the glue viscoelastic and humidity responsive in a way not e
295 ch as silk, wool, parchment, and rabbit skin glue were irradiated; (2) synchrotron X-ray energy; (3)
296 f the bi-segmental binding footprint of p150(Glued), whereas p150(Glued) requires regions 1 and 2 to
299 ion in the non-manipulated fingers following gluing, with the representation of the ring finger (digi
300 osal barriers, intermolecular (lattice-like) gluing within the extracellular meshwork or synaptogenes