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1 ), Bach1, cystine/glutamate transporter, and glutamate cysteine ligase.
2 ough an increase in the rate-limiting enzyme glutamate cysteine ligase.
3 tase (NQO1), glutathione S-transferases, and glutamate-cysteine ligase.
4  in its de novo biosynthesis is catalyzed by glutamate cysteine ligase, a broadly expressed enzyme fo
5 ed that loss of MLK3 increased expression of glutamate cysteine ligase, accelerated hepatic GSH recov
6                             We conclude that glutamate-cysteine ligase activity is an important facto
7    Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also
8 us thermophilus (GshF), which possesses both glutamate-cysteine ligase and glutathione synthase activ
9  suggest that Nrf2, through up-regulation of glutamate-cysteine ligase and increase of GSH levels, pr
10  C57Bl/6 mice that conditionally overexpress glutamate-cysteine ligase, and report here their resista
11                                              Glutamate-cysteine ligase carries out the rate-limiting
12  and those that were stably transfected with glutamate cysteine ligase catalytic subunit (GCLC), a ra
13 , and upregulation of Nrf2-regultated genes, glutamate cysteine ligase catalytic subunit (GCLC), and
14 otypic Nrf2-regulated enzymes, including the glutamate-cysteine ligase catalytic and modifier subunit
15  of genes encoding heme oxygenase 1 (Hmox1), glutamate-cysteine ligase catalytic subunit (Gclc) and p
16 A of key glutathione biosynthesis regulators glutamate-cysteine ligase catalytic subunit (GCLC) and s
17 O-1), as well as restoring the expression of glutamate-cysteine ligase catalytic subunit (GCLC) back
18 disease and a functional polymorphism in the glutamate-cysteine ligase catalytic subunit (GCLC) gene.
19                                              Glutamate-cysteine ligase catalytic subunit (GCLC) is re
20                                              Glutamate-cysteine ligase catalytic subunit (GCLC), glut
21 -cysteine ligase modifier subunit (GCLM) and glutamate-cysteine ligase catalytic subunit (GCLC).
22  of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC).
23 quinone exposure as well as the induction of glutamate-cysteine ligase catalytic subunit and 14-3-3si
24 e levels reveal that the expression of GCLC (glutamate-cysteine ligase catalytic subunit), a key comp
25 drogenase, quinone 1, glutathione reductase, glutamate-cysteine ligase catalytic subunit, ABCC1, pero
26 2-dependent genes, such as heme oxygenase-1, glutamate-cysteine ligase catalytic subunit, and NAD(P)H
27              Livers from hepatocyte-specific glutamate-cysteine ligase catalytic subunit-null mice ha
28 enase-1, NADPH quinone oxidoreductase 1, and glutamate-cysteine ligase catalytic subunit.
29 so induced the oxidant stress response genes glutamate-cysteine ligase, catalytic subunit, and NAD(P)
30  Male transgenic mice induced to overexpress glutamate-cysteine ligase exhibited resistance to acetam
31 y cathepsin L (CTSL), resulting in decreased glutamate-cysteine ligase expression and increased react
32  H9c2 cells, or overexpression of either the glutamate cysteine ligase (GCL) catalytic subunit (GCLC)
33                                              Glutamate cysteine ligase (GCL) catalyzes the rate-limit
34                                              Glutamate cysteine ligase (GCL) deficiency is a rare aut
35 of manganese superoxide dismutase (MnSOD) or glutamate cysteine ligase (GCL) expression.
36                            The mRNA level of glutamate cysteine ligase (GCL) was quantified by real-t
37 ovo GSH biosynthesis pathway is catalyzed by glutamate cysteine ligase (GCL), a heterodimer, composed
38               Structural characterization of glutamate cysteine ligase (GCL), the enzyme that catalyz
39  further demonstrate a rhythm in activity of glutamate cysteine ligase (GCL), the rate-limiting enzym
40 roach (i.e. post-translational activation of glutamate cysteine ligase (GCL), the rate-limiting enzym
41 ncrease cellular GSH levels, the activity of glutamate cysteine ligase (GCL), the rate-limiting enzym
42                                              Glutamate cysteine ligase (GCL), which synthesizes gamma
43 is catalyzed by the heterodimeric holoenzyme glutamate cysteine ligase (GCL).
44 enzyme in the glutathione synthetic pathway [glutamate cysteine ligase (GCL)] were found to be induce
45 reatment was observed to promote the loss of glutamate cysteine ligase (GCL, rate-limiting enzyme in
46 ssion of genes downstream of Nrf2, including glutamate-cysteine ligase (GCL) and glutathione S-transf
47           GSH is synthesized sequentially by glutamate-cysteine ligase (GCL) and GSH synthase and def
48                                              Glutamate-cysteine ligase (GCL) expression was measured
49                                              Glutamate-cysteine ligase (GCL) expression was measured
50                                              Glutamate-cysteine ligase (GCL) has a key influence on g
51                                              Glutamate-cysteine ligase (GCL) is the rate-limiting enz
52                                              Glutamate-cysteine ligase (GCL) is the rate-limiting enz
53 ly, boosting neuronal glutathione levels via glutamate-cysteine ligase (Gcl) overexpression is suffic
54                    The hepatic expression of glutamate-cysteine ligase (GCL) subunits and GSH synthas
55 xamined the response of Arabidopsis thaliana glutamate-cysteine ligase (GCL) to changes in redox envi
56 ymes for glutathione synthesis, particularly glutamate-cysteine ligase (GCL), and metabolism as well
57 se in glutathione S-transferase-P1 (GST-P1), glutamate-cysteine ligase (GCL), and NAD(P)H:quinone oxi
58  on the activity of the rate-limiting enzyme glutamate-cysteine ligase (GCL), consisting of a catalyt
59                                   Inhibiting glutamate-cysteine ligase (GCL), the enzyme that catalys
60        The hypothesis that overexpression of glutamate-cysteine ligase (GCL), which catalyzes the rat
61 e (GSH) and its de novo rate-limiting enzyme glutamate-cysteine ligase (GCL), which consists of a cat
62 dant, whose synthesis is mainly regulated by glutamate-cysteine ligase (GCL).
63 )-dependent transcriptional up-regulation of glutamate-cysteine ligase (GCL).
64  occurs via two enzymatic steps catalyzed by glutamate-cysteine ligase (GCL, made up of two subunits)
65                                              Glutamate-cysteine ligase (GCL; also known as gamma-glut
66 l gene targeting of the catalytic subunit of glutamate cysteine ligase (Gclc) blocked GSH production
67 very that combining inhibitors of mTORC1 and glutamate cysteine ligase (GCLC) can selectively and eff
68 pecific ablation of the catalytic subunit of glutamate cysteine ligase (Gclc), that glutathione synth
69 ls exhibit markedly diminished expression of glutamate-cysteine ligase (GCLC) and reduced glutathione
70 , due to deletion of the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzy
71 ransporter xCT and the regulatory subunit of glutamate-cysteine ligase (GCLM) in a hypoxia-inducible
72 s) from mice lacking the modifier subunit of glutamate-cysteine ligase (Gclm).
73  of epoxide hydrolase, heme oxygenase-1, and glutamate cysteine ligase gene expression.
74                                              Glutamate-cysteine ligase (Glc) catalyzes the first and
75 encoding the glutathione biosynthesis enzyme glutamate cysteine ligase (GSH1).
76 nobacteria, we generated deletion mutants of glutamate-cysteine ligase (gshA) and glutathione synthet
77 logy model of the catalytic subunit of human glutamate cysteine ligase (hGCLC).
78 ional response and an increased formation of glutamate cysteine ligase holoenzyme, as shown using a h
79 ergistic lethality with heme oxygenase-1 and glutamate-cysteine ligase inhibitors against CLL cells.
80                                        Human glutamate cysteine ligase is a heterodimer comprised of
81 /c-Myc phosphorylation, nuclear Nrf2 levels, glutamate cysteine ligase levels, GSH concentration and
82 ng to the upregulation of gene expression of glutamate-cysteine ligase modifier subunit (GCLM) and gl
83  library screen, we observe that the loss of glutamate-cysteine ligase modifier subunit (GCLM), a rat
84 nding protein (YTHDF2)-mediated decay of the glutamate-cysteine ligase modifier subunit (GCLM).
85 f glutathione through knock-out of the GCLM (glutamate-cysteine ligase modifier subunit) also did not
86                   The cluster included HO-1, glutamate-cysteine ligase modifier subunit, aldo-keto re
87               Among these, we identified the glutamate-cysteine ligase modifier subunit, GCLM, as a r
88 defense because basal levels of glutathione, glutamate cysteine ligase modulatory subunit, catalase,
89 out (KO) of the key GSH-synthesizing enzyme, glutamate-cysteine ligase modulatory subunit (GCLM).
90 evels of odorant-binding protein 2b (OBP2B), glutamate-cysteine ligase regulatory subunit (GCLM) and
91 d the structures of Saccharomyces cerevisiae glutamate cysteine ligase (ScGCL) in the presence of glu
92            GCLC and GCLM, the genes encoding glutamate cysteine ligase subunits, are induced by indol
93  (Nrf2) that down-regulate the expression of glutamate cysteine ligase, the rate limiting enzyme for
94                                              Glutamate cysteine ligase, the rate-limiting enzyme for
95 eated male mice carrying, but not expressing glutamate-cysteine ligase transgenes, or to female gluta
96 ate-cysteine ligase transgenes, or to female glutamate-cysteine ligase transgenic mice.
97 amma-glutamylcysteine synthetase (gamma-GCS, glutamate-cysteine ligase), which catalyzes the first an
98 e-(S,R)-sulfoximine, a specific inhibitor of glutamate-cysteine ligase, which is a rate-limiting enzy