ライフサイエンスコーパス: glutaminase

1 GLS2 isoforms (glutaminase B and liver-type glutaminase).

2 as 2 orders of magnitude higher than that of glutaminase.

3 ly, they are more sensitive to inhibition of glutaminase.

4 t cancer at baseline and after inhibition of glutaminase.

5 thereby decreasing the flux through GDH and glutaminase.

6 t human airway epithelium could also express glutaminase.

7 s characterization of Glu-AdT as a Ser-based glutaminase.

8 an increased synthesis of the mitochondrial glutaminase.

9 r cell lines with differential expression of glutaminase.

10 ed through the pharmacological inhibition of glutaminase.

11 ort survival and growth, a process linked to glutaminase 1 (GLS) isoforms.

12 hat depriving ECs of glutamine or inhibiting glutaminase 1 (GLS1) caused vessel sprouting defects due

13 Aberrant glutaminase 1 (GLS1) expression enables malignant cells

14 Glutaminase 1 (GLS1) inhibitors depleted pyrimidines and

15 utamine metabolism and how the inhibition of glutaminase 1 (GLS1) reverses pulmonary fibrosis.

16 he activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively.

17 tamine transporter ASCT2 and the activity of glutaminase 1 (GLS1).

18 SCC cells to combined treatment with CB-839 (glutaminase 1 inhibitor) plus metformin/phenformin.

19 Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor

20 analysis and in vitro experiments confirmed glutaminase 2 (GLS2) as a key gene associated with the f

21 Here, we identify glutaminase 2 (GLS2) as a previously uncharacterized p53

22 Additionally, we found that glutaminase 2 (GLS2), a modulator of p73-dependent antio

23 s, including two involved in metabolism:Gls2(glutaminase 2) and Sco2 We also show that human and mous

24 lly controls a key enzyme of glutaminolysis, glutaminase-2 (GLS-2).

25 o Glu-AdT, none of the ATP analogues induced glutaminase activation except ATP-gammaS, which stimulat

26 has long been the accepted mechanism for the glutaminase activation.

27 midotransferase, which produces ammonia in a glutaminase active site and channels it through a 30-A i

28 The N-terminal domain lacks the glutaminase active site found in AS-B, and an extended l

29 channel indicate that NaAD(+) stimulates the glutaminase active site in the k(cat) term by a synergis

30 The glutaminase active site is stimulated by NaAD(+) more th

31 Upregulation of the glutaminase active site occurs when these competitive in

32 (alphaS,5R) diastereomer were modeled in the glutaminase active site of GMPS and CPS to confirm that

33 structure of a ternary complex in which the glutaminase active site was inactivated by a glutamine a

34 eading from the effector binding site to the glutaminase active site, forming conserved communication

35 PS with a Michaelis-like intermediate in the glutaminase active site, the first covalent intermediate

36 ein-protein interface, and ultimately at the glutaminase active site.

37 lase domain to the substrate analogue in the glutaminase active site.

38 with engagement of a Ser nucleophile in the glutaminase active site.

39 uncoupling between ATP-gammaS hydrolysis and glutaminase activities suggests that the activation of g

40 nal enzyme couples the NAD(+) synthetase and glutaminase activities through an ammonia tunnel but fre

41 were twofold greater and phosphate-activated glutaminase activities were fourfold greater in the schi

42 shows completely preserved asparaginase and glutaminase activities, long-term storage stability, imp

43 in part because of its dual asparaginase and glutaminase activities.

44 esence of Asp-tRNA(Asn) and ATP enhances the glutaminase activity about 22-fold.

45 e hydrolysis were examined: (a) an enzymatic glutaminase activity and (b) a non-enzymatic mechanism.

46 dues (Lys(52), Ser(128), Ser(152)) abolished glutaminase activity and consequently the amidotransfera

47 cells in vitro have biochemical evidence for glutaminase activity and express mRNA for two glutaminas

48 Pdx2 has been shown to have glutaminase activity and most likely channels ammonia to

49 Therefore, l-asparaginases with reduced l-glutaminase activity are predicted to be safer.

50 transfer reaction while fully activating the glutaminase activity at the hydrolase domain.

51 the synthase activity without inhibiting the glutaminase activity at the hydrolase domain.

52 e activities suggests that the activation of glutaminase activity by ATP or ATP-gammaS, together with

53 e, interface mutations controlling secondary glutaminase activity demonstrated the importance of this

54 position 121 (WoA-P121) was found to have L-glutaminase activity in contrast to Uniprot entry P50286

55 ent of spectroscopic approaches that measure glutaminase activity in real time.

56 enzymes and serves to explain the lack of L-glutaminase activity in the guinea pig enzyme.

57 ayed as PLP synthase, whereas PdxT exhibited glutaminase activity in vitro.

58 Glutaminase activity increased in response to acidic str

59 Glutaminase activity is impaired in the resting enzyme,

60 Here, we show that L-ASP's glutaminase activity is not always required for the enzy

61 re a common glutaminase domain for which the glutaminase activity is tightly regulated by an acceptor

62 d that this inhibition correlates with their glutaminase activity levels and produces a strong apopto

63 consequence, combined targeting of eIF4A and glutaminase activity more effectively inhibits PDA cell

64 PurQ had a glutaminase activity of 0.002 s(-1), and smPurL had an a

65 NA(Gln) but not tRNA(Gln) could activate the glutaminase activity of GatD suggests that glutamine hyd

66 ibition of the Glu-tRNA(Gln)/ATP-independent glutaminase activity of Glu-AdT by gamma-Glu boronic aci

67 Those observations indicate that the glutaminase activity of L-ASP is necessary for anticance

68 However, Glu-tRNA(Gln) activates the glutaminase activity of the enzyme about 10-fold; additi

69 The essential glutaminase activity of the enzyme is a property of the

70 By diminishing the l-glutaminase activity of these highly active l-asparagina

71 Pharmacologic inhibition of glutaminase activity reduced tumor growth in both ephrin

72 In analogy to the conditional glutaminase activity seen in IGPS and GMPS, the rates of

73 JHU-083 normalized CSDS-induced increases in glutaminase activity specifically in microglia-enriched

74 WoA-S121 was confirmed to have much lower L-glutaminase activity than WoA-P121, yet both showed comp

75 cceptor, Glu-tRNA(Gln), the enzyme has basal glutaminase activity that is unaffected by ATP.

76 ATP-gammaS stimulates the glutaminase activity to an extent similar to that with A

77 tivation except ATP-gammaS, which stimulates glutaminase activity to the same level as ATP, but witho

78 generated through increased small intestinal glutaminase activity with concomitantly reduced intestin

79 ssay method that measures the stimulation of glutaminase activity, a K(d) of 2 microm was measured fo

80 glial activation), serum ammonia, intestinal glutaminase activity, and cecal glutamine content were c

81 BPTES inhibited glutaminase activity, lowered glutamate and alpha-KG lev

82 oxicity of L-ASP is thought to stem from its glutaminase activity, these findings suggest the hypothe

83 Y176F and Y176S exhibited greatly decreased glutaminase activity, whereas K288S/Y176F, a variant mut

84 d l-asparaginases also possess significant l-glutaminase activity, which correlates with many of the

85 Ser254(ErA), may correlate with significant glutaminase activity, while their substitution by Gln an

86 were attributed to increased RhoA-dependent glutaminase activity.

87 ng leads to elevated GLS gene expression and glutaminase activity.

88 asparaginase activity but shows undetectable glutaminase activity.

89 l-ase) is an anticancer agent also harboring glutaminase activity.

90 tructure has not been reported, contains the glutaminase activity.

91 raphy and apparently form a complex that has glutaminase activity.

92 tro, whereas the latter mutants retain basal glutaminase activity.

93 or their ability to stimulate tRNA-dependent glutaminase activity.

94 and Asn, respectively, may lead to minimal L-glutaminase activity.

95 nases have been related to their secondary L-glutaminase activity.

96 glutarate dehydrogenase, phosphate-activated glutaminase, alanine aminotransferase, aspartate aminotr

97 cle intermediate alpha-ketoglutarate through glutaminase and alanine aminotransferase is essential fo

98 An up-regulation of two key enzymes (glutaminase and alanine aminotransferase) provided a mec

99 -AT is proposed to channel ammonia between a glutaminase and AT domain.

100 bound ammonia to urea (through mitochondrial glutaminase and carbamoylphosphate synthetase) depends o

101 further identified that increased levels of glutaminase and connexin 32 in Mecp2-null microglia are

102 We propose that dual targeting of glutaminase and CPT1 activities may have therapeutic rel

103 Moreover, chemical inhibition of both glutaminase and CPT1 decreased cell proliferation and mi

104 Glutamine is converted to glutamate by glutaminase and further metabolized to alpha-KG.

105 High glucose inhibited both glutaminase and GDH flux, and leucine could not override

106 High glucose inhibited flux through both glutaminase and GDH, and leucine was unable to override

107 augmenting glutaminolysis through activating glutaminase and GDH.

108 ected replacement of Ser176 by Ala abolishes glutaminase and Gln-dependent transamidase activities of

109 in infected cells, as did the activities of glutaminase and glutamate dehydrogenase, the enzymes nee

110 Differences in phosphate-activated glutaminase and glutamic acid decarboxylase activities i

111 Greater phosphate-activated glutaminase and glutamic acid decarboxylase activities,

112 In IGP synthase the glutaminase and PRFAR binding sites are separated by 30

113 needed to (i) coordinate, albeit weakly, the glutaminase and synthetase activities of the enzyme and

114 nitoring of ATP or ATP-gammaS hydrolysis and glutaminase and transamidase activities reveals tight co

115 ree proteins: PurS (10 kDa), PurQ (25 kDa, a glutaminase), and smPurL (80 kDa, an AT).

116 on of vascular endothelial growth factor and glutaminase, and is likely mediated by reduced expressio

117 tissue pH, inhibition of phosphate-activated glutaminase, and medication effects could not account fo

118 ns the ATP and FGAR binding sites, PurQ is a glutaminase, and the function of PurS is just now becomi

119 We found that the glutaminase ANK repeats form unique intramolecular conta

120 In conclusion, these findings support glutaminase as a potential component of the HAND pathoge

121 Pseudomonas 7A glutaminase-asparaginase (PGA) catalyzes the hydrolysis

122 The mechanism of catalysis by the L-glutaminase-asparaginase from Pseudomonas 7A (PGA) was i

123 learly show that the reaction catalyzed by L-glutaminase-asparaginases proceeds through formation of

124 AC) for GLS, and the liver isoform (LGA) and glutaminase B (GAB) for GLS2.

125 ey-type glutaminase (KGA) and GLS2 isoforms (glutaminase B and liver-type glutaminase).

126 tifs employed in our interaction studies are glutaminase, beta-catenin and FAS.

127 ermobacter thermautotrophicus GatD acts as a glutaminase but only in the presence of both Glu-tRNA(Gl

128 pathways, including effective inhibition of glutaminase by nanoparticle drug delivery, holds promise

129 neous repression of pyruvate carboxylase and glutaminase by selecting all seed matches shared by thei

130 domain interface is proposed to activate the glutaminase by unblocking the oxyanion hole.

131 The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamin

132 ve transcripts: the kidney isoform (KGA) and glutaminase C (GAC) for GLS, and the liver isoform (LGA)

133 Glutaminase C (GAC) is the GA isoform that is most abund

134 The glutaminase C (GAC) isoform of mitochondrial glutaminase

135 Here, we demonstrate that activated glutaminase C (GAC) self-assembles into a helical, fiber

136 enzyme glutaminase, with a specific isoform, glutaminase C (GAC), being highly expressed in cancer ce

137 ied splice variant of the gene gls, known as Glutaminase C (GAC), is important for tumor metabolism.

138 ppearance of the most active enzyme isoform, glutaminase C (GAC), which is expressed in many cancers,

139 tamate-generating enzyme glutaminase isoform glutaminase C in HIV-1-infected microglia.

140 The glutaminase C levels in the brain tissues of HIV dementi

141 zole-4-carboxamide ribonucleotide) activates glutaminase catalysis at a distance of 25 A from the glu

142 GLS2 encodes a mitochondrial glutaminase catalyzing the hydrolysis of glutamine to gl

143 Glutaminase converts glutamine to glutamate, which is fu

144 The glutaminase, CPS.A, and CPS.B homologs from A. aeolicus

145 mulated during the reaction catalyzed by the glutaminase-deficient mutants or by GatE alone.

146 nt determinants of glutamine anaplerosis and glutaminase dependence in cancer.

147 sition states during catalysis, and validate glutaminase-directed inhibition of Glu-AdT as a route fo

148 Targeting glutaminase disturbs redox homeostasis and nucleotide sy

149 classes of Qns1 mutants that fall within the glutaminase domain and the synthetase domain selectively

150 tamylthioester intermediate was found in the glutaminase domain at Cys1135.

151 onia and displays a modest activation of the glutaminase domain compared to tbNadE.

152 of the enzymes in this family share a common glutaminase domain for which the glutaminase activity is

153 osphorylation of this site may influence the glutaminase domain of hCTPS2.

154 hannel through which ammonia passes from the glutaminase domain to the FGAM synthetase domain.

155 esence of a partially structured loop in the glutaminase domain, whose sequence is present in eukaryo

156 domain, the FGAM synthetase domain, and the glutaminase domain, with a putative ammonia channel loca

157 leotide synthetase (PurM) dimer, and a triad glutaminase domain.

158 de of the cyclase domain in signaling to the glutaminase domain.

159 The HisH (glutaminase) domain of imidazole glycerol phosphate synt

160 lution, is organized as a hexamer, where the glutaminase domains adopt an inactive conformation.

161 s of the two complexes are superimposed, the glutaminase domains are rotated by about 180 degrees wit

162 Distinctions in the glutaminase domains of IGPS from E. coli, the bifunction

163 udy 4-13 wk after initiation of therapy with glutaminase, dual TORC1/2, or programmed death-1 inhibit

164 tilize glutamine and possess the appropriate glutaminase enzyme for metabolizing glutamine.

165 related to glutamine metabolism through the glutaminase enzyme.

166 Significantly, an ultra-low l-glutaminase ErA variant maintained its cell killing abil

167 Correlation between glutaminase expression and axonal damage was confirmed e

168 Active MS lesions showed high-level glutaminase expression in macrophages and microglia in c

169 ncentrations partly as a result of decreased glutaminase expression.

170 asparaginase (WoA) has been reported to be L-glutaminase free, suggesting it would have fewer side ef

171 ally used) or Wolinella succinogenes (novel, glutaminase-free form).

172 of the frog enzyme, K258L, yields a gain of glutaminase function.

173 Glutaminase (GA) catalyzes the first step in mitochondri

174 lism involves its conversion to glutamate by glutaminase (GA).

175 , we targeted the glutamate-recycling enzyme glutaminase (gene Gls1).

176 Humans have two glutaminase genes, GLS (GLS1) and GLS2, each of which ha

177 nd the ammonium-evolving periplasmic enzymes glutaminase (Ggt) and asparaginase (AsnB).

178 mal inhibition lowered the expression of the glutaminases GLS and GLS2, which support glutamine metab

179 High glutaminase (GLS) activity in TNBC tumors resulted in lo

180 ective enzymes producing glutamate and GABA, glutaminase (Gls) and glutamate decarboxylase 1 and 2 (G

181 tabolomic studies in GBM cells revealed that glutaminase (GLS) and glutamate levels are elevated foll

182 screen has revealed that the combination of glutaminase (GLS) and heat shock protein 90 (Hsp90) inhi

183 We identify glutaminase (GLS) as a critical enzyme for optimal adeno

184 mplex fine-tunes the alternative splicing of Glutaminase (GLS) by selecting the poly(A) site in intro

185 r Genome Atlas project) with low versus high glutaminase (GLS) gene expression.

186 The cancer target glutaminase (GLS) has proven to be a fascinating protein

187 The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated during tumo

188 ted with TGF-beta1-induced expression of the glutaminase (GLS) isoform, GLS1, which converts Gln into

189 STS subtypes expressing elevated glutaminase (GLS) levels are highly sensitive to glutami

190 ene JUN, is a key regulator of mitochondrial glutaminase (GLS) levels.

191 a panel of 19 GBM BTSC lines, inhibition of glutaminase (GLS) showed a variable response from comple

192 elective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a molecular probe t

193 5' untranslated region of the gene encoding glutaminase (GLS) that was identified through detailed c

194 o deamination reactions, the first requiring glutaminase (GLS) to generate glutamate and the second o

195 void microRNA-mediated repression, including glutaminase (GLS), a key metabolic enzyme for tumour pro

196 ort that ovarian cancer cells overexpressing glutaminase (GLS), a target of MYC and a key enzyme in g

197 Loss-of-function mutations in glutaminase (GLS), the enzyme converting glutamine into

198 Kidney-type glutaminase (GLS), the first enzyme in the glutaminolysi

199 Silencing of glutaminase (GLS), which catalyzes the first step in glu

200 ibited significantly increased expression of glutaminase (GLS), which catalyzes the first step in the

201 Glutaminase (GLS), which converts glutamine to glutamate

202 est whether recently developed inhibitors of glutaminase (GLS), which mediates an early step in Gln m

203 yzed by GAC, a splice variant of kidney-type glutaminase (GLS).

204 ration of cancer cells through up-regulating glutaminase (GLS).

205 tumor sensitivity to inhibitors of SIRT1 and glutaminase GLS1.

206 Interestingly, HMCLs expressed glutaminase (GLS1) and were sensitive to its inhibition,

207 ation modulated metabolic enzymes, including glutaminase (GLS1), to coordinate glutaminolysis and gly

208 atter with markers for glutamate production (glutaminase), glutamate transport (GLAST, GLT-1 and EAAT

209 t strain, Ty21a-AR-Ss, by inserting Shigella glutaminase-glutamate decarboxylase systems coexpressed

210 the thioester intermediate formed during the glutaminase half-reaction by accessing the N-terminal ac

211 metabolism via pharmacological inhibition of glutaminase has been translated into clinical trials as

212 monstrate that, of the three major mammalian glutaminases identified to date, the lesser studied spli

213 rget engagement, and should robustly inhibit glutaminase in humans.

214 ies observed in the CSDS model, and identify glutaminase in microglia-enriched CD11b(+) cells as a ph

215 GP synthase shows a 4900-fold stimulation of glutaminase in the presence of the substrate acceptor PR

216 first demonstrated the existence of multiple glutaminases in mammals.

217 ssion of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 pro

218 on, whereas pharmacologic and siRNA-mediated glutaminase inhibition reduced 2HG levels.

219 the HypoxCR reporter in vivo, we found that glutaminase inhibition reduced tumor growth by specifica

220 Changes in V(D) with glutaminase inhibition support the ability to assess res

221 evealed that surviving tumor cells following glutaminase inhibition were reliant on glycolysis and gl

222 Upon glutaminase inhibition with CB-839 or BPTES, the RCC cel

223 2-mutant lung tumors as likely to respond to glutaminase inhibition.

224 U-083, our recently developed prodrug of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine (DON) a

225 ckage of microglial glutamate synthesis by a glutaminase inhibitor abolished the neurotoxic activity,

226 ministration of a KV1.3 channel blocker or a glutaminase inhibitor ameliorated disability in experime

227 Here we report that the glutaminase inhibitor CB-839 preferentially inhibits xen

228 Treatment with glutaminase inhibitor CB-839 substantially reduced the g

229 effect and glutamine dependence, making the glutaminase inhibitor CB-839 therapeutically promising f

230 subline that led directly to sensitivity to glutaminase inhibitor CB-839.

231 ormed at baseline and after treatment with a glutaminase inhibitor or a vehicle solution for 4 mouse

232 Treatment of cells with a glutaminase inhibitor phenocopies glutamine restriction,

233 In contrast, a glutaminase inhibitor reduced conversion of (13)C-pyruva

234 ls of liver enzymes in contrast to CB-839, a glutaminase inhibitor that is currently in clinical tria

235 As a result, glutamine deprivation or glutaminase inhibitor treatment triggers DNA damage accu

236 1,3,4-thiadiazol-2-yl)ethyl sulfide, a known glutaminase inhibitor, completely disrupted the higher o

237 BPTES), a selective but relatively insoluble glutaminase inhibitor, in nanoparticles.

238 igms will lead to new treatment options with glutaminase inhibitors and the utility of PET to identif

239 Known glutaminase inhibitors have potential limitations, and i

240 ents with ccRCC who are likely to respond to glutaminase inhibitors in the clinic.

241 d-deprived cells with exogenous glutamine or glutaminase inhibitors restores tRNA(Gln) charging and t

242 Glutaminase inhibitors sensitized chemoresistant pancrea

243 Importantly, we show that glutaminase inhibitors, 6-Diazo-5-oxo-L-norleucine (DON)

244 at may aid in the design of isoform-specific glutaminase inhibitors.

245 Human glutaminase interacting protein (GIP), also known as tax

246 Glutaminase interacting protein (GIP), also known as Tax

247 YaaE shows similarity to HisH, a glutaminase involved in histidine biosynthesis.

248 These data demonstrate that glutaminase is expressed and active in the human airway

249 glutaminase C (GAC) isoform of mitochondrial glutaminase is overexpressed in many cancer cells and th

250 catalyzing glutaminolysis, human kidney-type glutaminase isoform (KGA) is becoming an attractive targ

251 egulation of the glutamate-generating enzyme glutaminase isoform glutaminase C in HIV-1-infected micr

252 lutaminase activity and express mRNA for two glutaminase isoforms (KGA and GAC).

253 uman genes are known to encode at least four glutaminase isoforms.

254 d the activity levels of the three mammalian glutaminase isozymes was established, with GAC being the

255 eat-containing C termini of both kidney-type glutaminase (KGA) and GLS2 isoforms (glutaminase B and l

256 ng is confirmed by significant reductions in glutaminase kinetic activity and allosteric ligand bindi

257 siveness, and they were able to adjust their glutaminase level to suit glutamine availability.

258 This interdomain contact modulates the glutaminase loop containing the histidine and glutamic a

259 ce within the 3'-nontranslated region of the glutaminase mRNA binds a unique protein with high affini

260 art, by a cell-specific stabilization of the glutaminase mRNA that leads to an increased synthesis of

261 , these findings suggest the hypothesis that glutaminase-negative variants of L-ASP would provide lar

262 retion could be blocked by inhibiting either glutaminase or KV1.3 channels, which are known to be lin

263 epletion or pharmacologic inhibition of Rho, glutaminase, or fatty acid synthase abrogated the increa

264 The brain/kidney phosphate-activated glutaminase (PAG), the product of the GLS1 gene, produce

265 te early gene c-fos) and phosphate activated glutaminase (PAG; the rate-limiting enzyme in the synthe

266 Analysis of the glutaminase partial reaction demonstrated that the hydro

267 r was used to predict a docking site for the glutaminase partner, PdxT.

268 ng pyridoxine synthase (PDX1) and pyridoxine glutaminase (PDX2).

269 raction and enzymatic deamidation by protein-glutaminase (PG) on evening primrose seed cake (EPSC) pr

270 ture, glutamine deprivation or inhibition of glutaminase prevents EC proliferation, but does not prev

271 In renal tubular epithelium, glutaminase produces ammonia to buffer urinary acid excr

272 ty MCEM(2) to data from the endogenous mouse glutaminase promoter reveals nearly deterministic promot

273 understanding how this residue impacts the L-glutaminase property, kinetic analysis was coupled with

274 Glutaminase protein was expressed in the human airway in

275 r inflammatory neurologic diseases displayed glutaminase reactivity, whereas normals and noninflammat

276 Using prokaryotic and eukaryotic glutaminase sequences, we built a phylogenetic tree whos

277 Binding of PRPP is required to activate the glutaminase site (termed interdomain signaling) to preve

278 ely accepted view that ammonia released in a glutaminase site is channeled efficiently into a separat

279 ase is that the transfer of ammonia from the glutaminase site occurs through the (beta/alpha)(8) core

280 or Gln hydrolysis, as is common in all other glutaminases: some Glu-AdT lack Cys, but all contain a c

281 In a novel finding using glutaminase-specific antibodies in combination with flow

282 rms a stable and functional complex with the glutaminase subunit (HisH) of an extant ImGP-S.

283 The glutaminase subunit is a glutamine amidotransferase that

284 The inclusion of the glutaminase subunit resulted in the formation of a 171-k

285 S and PdxT appear to encode the synthase and glutaminase subunits, respectively, of a glutamine amido

286 he intact enzyme includes 12 synthase and 12 glutaminase subunits.

287 iptional signature and tended to overexpress glutaminase, suggestive of a functional relationship bet

288 h in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermedi

289 ely, these results provide information about glutaminases that may aid in the design of isoform-speci

290 EC-specific deletion in mice of glutaminase, the initial enzyme in glutamine catabolism,

291 ects neutrophil function at rest and whether glutaminase, the major enzyme that metabolizes glutamine

292 ic fuel that is catabolized by mitochondrial glutaminase to support tumor growth.

293 redness, drug prescriptions and tissue-Trans-Glutaminase (tTG) serum levels.

294 The unique means by which Myc regulates glutaminase uncovers a previously unsuspected link betwe

295 with flow cytometry and confocal microscopy, glutaminase was shown to be present on the surface of hu

296 When glutaminase was subsequently inhibited by siRNA or by a

297 The fluxes via GDH and glutaminase were measured by tracing 15N flux from [2-15

298 The ankyrin (ANK) repeats in the glutaminases were acquired early in their evolution.

299 Therefore, we inhibited glutaminase with siRNA or the small molecule inhibitor b

300 ism is catalysis by the mitochondrial enzyme glutaminase, with a specific isoform, glutaminase C (GAC