ライフサイエンスコーパス: glutamine residue

1 whose methionine residue is replaced with a glutamine residue.

2 triplet within the coding region, encoding a glutamine residue.

3 ge interactions, one of which is braced by a glutamine residue.

4 itive residues but also on a conserved polar glutamine residue.

5 at its place in the DNA stack was taken by a glutamine residue.

6 xtended to peptides containing more than one glutamine residue.

7 ighly conserved histidine is replaced with a glutamine residue.

8 nvolved the gain or loss of an asparagine or glutamine residue.

9 also abrogated by a change in the Drosophila glutamine residue.

10 zide handles onto the side chain of internal glutamine residues.

11 eme-bound CO with the B10-tyrosine or the E7-glutamine residues.

12 mplicated in binding of hsp70s, PyJ contains glutamine residues.

13 active site causing hydrolysis of substrate glutamine residues.

14 huntingtin containing 20 (20Q) or 150 (150Q) glutamine residues.

15 35 (Q35-GFP), 56 (Q56-GFP), or 80 (Q80-GFP) glutamine residues.

16 in a region that contains clusters of serine-glutamine residues.

17 CAG/CAA repeats coding for a range of 25-300 glutamine residues.

18 transamidation of specific polypeptide-bound glutamine residues.

19 acids in length that is rich in proline and glutamine residues.

20 proteins containing abnormally long runs of glutamine residues.

21 -random blocks rich in alanine, glycine, and glutamine residues.

22 e SIVs exhibits an increase in the number of glutamine residues.

23 ngles and secondary structural motifs of the glutamine residues.

24 ndividually mutated to alanine, arginine, or glutamine residues.

25 paragine rich but, unexpectedly, contains no glutamine residues.

26 at expands above a critical threshold of ~35 glutamine residues.

27 epetitively anywhere within a stretch of ten glutamine residues.

28 while both release factors are methylated at glutamine residues.

29 old for fibril formation to approximately 15 glutamine residues.

30 glutamine expansion exceeds approximately 39 glutamine residues.

31 can occur at a threshold of approximately 40 glutamine residues.

32 the ester linkage formation used involucrin glutamine residues 107, 118, 122, 133, and 496 by conver

33 Substitution of the highly conserved glutamine residue 159 in the predicted ligand-binding po

34 , including one showing that substitution of glutamine residue 282 with arginine (Q282R) results in a

35 terminally derived 30-kDa fragment contains glutamine (residue 775) at the NH2-terminal end.

36 butions from tyrosine residues, we find that glutamine residues also participate in contacts leading

37 or the covalent crosslink reaction between a glutamine residue and a lysine residue.

38 rough mutational analysis, we identified two glutamine residues and a beta-hairpin within this putati

39 e, we synthesized poly(Q) peptides with 3-15 glutamine residues and a corresponding set of poly(Q) pe

40 e in length and rich in glycine, proline and glutamine residues and containing an unusual degenerate

41 ll Rho GTPases by deamidation of a conserved glutamine residue, and HlyA1 forms pores in eukaryotic c

42 corporate P1 lactam moieties in lieu of an L-glutamine residue are described.

43 resulting from expanded repeat sequences of glutamine residues are associated with the formation of

44 rspersed with acidic, proline, serine and/or glutamine residues are necessary for activation domain a

45 The results demonstrate that all three glutamine residues are very stable, with glutamine-50 un

46 Two N-terminal motifs, including a glutamine residue, are essential for conferring ACS acti

47 sequence from ACBF contains a long repeat of glutamine residues as found in well characterized transc

48 amine, serine and threonine, and proline and glutamine residues, as shown in transient transfection e

49 osphorylate Ser/Thr-containing motifs with a glutamine residue at position +1 and a hydrophobic resid

50 The essential glutamine residue at position 17 resided in the dimer in

51 The presence of a glutamine residue at the -3 position was found to be imp

52 zes a unique cleavage site, which features a glutamine residue at the P1 position and is not utilized

53 Similar motifs with glutamate or glutamine residues at that position are rare.

54 tamase containing non-canonical arginine and glutamine residues at the -3 position.

55 The glutamine residues at the reported in vivo deamidation s

56 lysine residues 5, 8, 12, and 16 changed to glutamine residues) background compared to the wild-type

57 between amino acids 7 and 74 and a group of glutamine residues between amino acids 75 and 84.

58 ngth and doubled with a difference of only 7 glutamine residues between equivalent amounts of purifie

59 pe distribution for a peptide containing one glutamine residue coincides with the first peak of the i

60 CheD not only deamidates receptor glutamine residues contained within a conserved structur

61 ic layer consisting of an arginine and three glutamine residues contributed from each of the four alp

62 Thus, the catalytic glutamine residue contributes to functions beyond GTP hy

63 In uveal melanoma, a conserved glutamine residue critical for GTP hydrolysis in the G p

64 only the longest poly(Q)-poly(P) peptide (15 glutamine residues) did so.

65 the htt(NT) sequence, with or without added glutamine residues, exists in solution as an equilibrium

66 owed that, while poly(Q) peptides with >or=6 glutamine residues formed beta-sheet-rich fibrils, only

67 A withdrawal of a phylogenetically invariant glutamine residue from contact with the gamma-phosphate

68 ith a chloride ion coordinated by one buried glutamine residue from each monomer.

69 Remarkably, the deletion of just one glutamine residue from the middle of the peptide leads t

70 In addition, a central, highly conserved glutamine residue (Gln-48) is buried within the interfac

71 GTPases and specifically deamidates a single glutamine residue (Gln-63 in RhoA) required for GTP hydr

72 inding sites, in part, by a highly conserved glutamine residue (Gln194 in Escherichia coli RecA) that

73 by catalyzing the deamidation of a specific glutamine residue (Gln40) in NEDD8 and the related prote

74 acement of an extracellular histidine with a glutamine residue (H508Q) abolished the slowing of recov

75 ric coiled coils, buried asparagine, but not glutamine, residues have been shown to confer specificit

76 Above a threshold of 37 glutamine residues, htt(e1) starts to aggregate in a nuc

77 erminal amino acids of TonEBP/OREBP, (ii) 17 glutamine residues, (iii) the TAD of c-Jun, or (iv) no T

78 s also synthesized by modifying a single key glutamine residue in A15.

79 ed that FXIIIa displays a preference for the glutamine residue in an xQAxBxPx sequence, where Q repre

80 The surrounding residues anchor the glutamine residue in different orientations for cAMP and

81 degree of regioselectivity for a particular glutamine residue in each peptide.

82 were suggested by the absence of a conserved glutamine residue in human S3 that usually resides at th

83 Mutation of histidine H452 to a glutamine residue in Kv1.5 yields a channel that no long

84 e hinge by the introduction of a hydrophilic glutamine residue in place of isoleucine 260 results in

85 as target substrates, both modify a specific glutamine residue in RhoA, Rac1 and Cdc42, which renders

86 oxins catalyze the deamidation of a specific glutamine residue in RhoA, Rac1, and Cdc42 and consist o

87 An exception is a glutamine residue in the AAA+ module (Gln 118) that is n

88 ling pathways via deamidation of a conserved glutamine residue in the alpha subunit of heterotrimeric

89 It has been proposed that a conserved glutamine residue in the first membrane-spanning region

90 transferase activity, and they methylate the glutamine residue in the GGQ motif of ribosomal translat

91 eric bacteria Shigella flexneri deamidates a glutamine residue in the host ubiquitin-conjugating enzy

92 nd to be approximately 50% methylated at the glutamine residue in the normal strain but completely un

93 We have placed a glutamine residue in the otherwise hydrophobic interior

94 Analysis of the cleavage sites identified a glutamine residue in the P2 position of all WDSV sites,

95 The glutamine residue in this segment, Gln102, is the site o

96 pentane) was used to study the reactivity of glutamine residues in acidic large and small proline-ric

97 transglutaminase 2 (TG2) to deamidate select glutamine residues in diet-derived gluten peptides.

98 nal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances st

99 es of huntingtin exon 1 (HDx1) containing 46 glutamine residues in its polyglutamine (polyQ) region.

100 e at greater lengths, our data indicate that glutamine residues in monomeric polyglutamine have a sig

101 almodulin (CaM) were individually changed to glutamine residues in order to investigate their roles i

102 ecent computational study suggested that the glutamine residues in polyglutamine tracts have a signif

103 ptide crosslinks between reactive lysine and glutamine residues in proteins.

104 his study, we investigated the role of these glutamine residues in SIVmac239 replication.

105 ence leading to an increase in the number of glutamine residues in the encoded protein.

106 that mutation of the equivalent arginine and glutamine residues in the Escherichia coli F1 gamma subu

107 preference for cleavage after glutamate and glutamine residues in the P1 position, which processes a

108 polyQ amyloid vary with the chirality of the glutamine residues in the polyQ.

109 Conserved arginine and glutamine residues in the tail are required for high aff

110 Arginine or glutamine residues in the tail were substituted by alani

111 ergy can be decreased by about 0.2 eV if two glutamine residues in the vicinity of the cofactor are m

112 t methylate lysine, arginine, histidine, and glutamine residues in various mitochondrial substrates.

113 came increasingly collapsed as the number of glutamine residues increased.

114 The glutamine residue is important both for decarboxylase ac

115 om the results that the primary role of this glutamine residue is in interdomain signal communication

116 o nonenzymatic deamidation of asparagine and glutamine residues may be an important determinant of pr

117 ructure-guided studies reveal the C-terminal glutamine residue of 2C as the primary determinant for T

118 tional methylation of release factors on the glutamine residue of a conserved GGQ motif is required f

119 A glutamine residue of Rab proteins (cis-glutamine) that i

120 of primary amines at selected peptide-bound glutamine residues of cytosolic proteins (including acti

121 Essentially only one lysine and two glutamine residues of involucrin and two glutamines of e

122 Conversion of the isoleucine and glutamine residues of the IQ motif to alanines in the ch

123 the possible replacement of the proline and glutamine residues of this lead compound were obtained b

124 TGM2), which selectively deamidates multiple glutamine residues on p21, stabilizing the protein and h

125 alyzes the posttranslational modification of glutamine residues on protein or peptide substrates.

126 uten T-cell epitopes by deamidating specific glutamine residues on the basis of their spacing to prol

127 Lys9 and an N-terminal lactam formed from a glutamine residue (Pca1), could also contribute to catal

128 g beta-strand/beta-turn structure with seven glutamine residues per beta-strand.

129 we use NMR spectroscopy to demonstrate that glutamine residues possess a high propensity to adopt th

130 presence of oligosaccharide structures on a glutamine residue present in the V(L) domain sequence of

131 also observed, but a maximum of only 14% of glutamine residues present in acidic PRPs and statherin

132 of a glutamate within VP3 (VP3-234E) with a glutamine residue (Q), conferred upon CB3-Nancy the capa

133 Previous studies found that a conserved glutamine residue [Q513 in the Avena sativa phototropin

134 ic differences, some of which are due to its glutamine residue rather than leucine at position 105.

135 licated in substrate binding and a conserved glutamine residue required for catalysis, demonstrating

136 d C-terminal regions are rich in proline and glutamine residues, respectively.

137 histidine residues 81, 90, 94, and 208 with glutamine residues resulted in a significant loss of cat

138 ous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible p

139 tingtin exon 1 fusion proteins with 16 to 46 glutamine residues reveal extended structures with rando

140 The glutamine residue serves as an essential hydrogen bond d

141 hile the longer poly(Q) peptides (nine or 15 glutamine residues) showed a beta-sheet conformation by

142 orter soluble poly(Q) peptides (three or six glutamine residues) showed polyproline type II-like (PPI

143 or threonines when positioned adjacent to a glutamine residue (SQ/TQ).

144 acing Trp-48 in the FRC active site with the glutamine residue that occupies an equivalent position i

145 The glutamine residue that serves as a substrate for activat

146 ng-lived proteins can contain asparagine and glutamine residues that are extremely resistant to in vi

147 hese basic residues and adjacent beta strand glutamine residues that may prevent assembly of intact v

148 Surprisingly, substitution of the glutamine residue to an arginine residue at position 132

149 We found that N-terminal cyclization of glutamine residues to pyroglutamate on the light and hea

150 d the structural and functional roles of the glutamine residue using site-directed mutagenesis, kinet

151 When a glutamine residue was introduced at the N terminus, whic

152 t from one allele of the LPL gene in which a glutamine residue was substituted for a glycine (gly 188

153 sines and also a mutant in which a conserved glutamine residue was substituted with an arginine to in

154 y terminus (aa 325 to 419), which is rich in glutamine residues, was dispensable for the EICP0 trans-

155 ic selection and the functional role of this glutamine residue, we analyzed all possible substitution

156 as amine nucleophile, substantial amounts of glutamine residues were converted in theanine residues.

157 ntingtin containing tracts of 2, 75, and 120 glutamine residues were expressed in photoreceptor neuro

158 lmimetics were created by mutating lysine to glutamine residues, which approximates size and charge o

159 imian immunodeficiency viruses use arrays of glutamine residues, which can form hydrogen bonds effici

160 e diseases are linked to expanded repeats of glutamine residues, which lead to the formation of amylo

161 ring by inclusion (or exclusion) of a single glutamine residue, whose relative levels of expression c

162 Four mutants were made: Q114P replaced the glutamine residue with proline; K115G replaced lysine wi

163 scherichia coli proteinases, were mutated to glutamine residues with the goal of producing more stabl

164 r site-specific IL-15 antagonist by mutating glutamine residues within the C terminus of IL-15 to asp

165 lent modifications of specific glutamate and glutamine residues within the cytoplasmic domains of met