ライフサイエンスコーパス: glutaminyl

1 This hydrolysis of glutaminyl adenylate represents a novel reaction that is

2 negative charge on the phosphorus center of glutaminyl-adenylate plays an important role in the tigh

3 l aldimine complexes, cysteinyl aldimine and glutaminyl aldimine.

4 Ks evolved from a common ancestor related to glutaminyl aminoacyl-tRNA synthetases, which may have be

5 for measurement of the deamidation rates of glutaminyl and asparaginyl residues in peptides and prot

6 The spontaneous nonenzymatic deamidation of glutaminyl and asparaginyl residues of peptides and prot

7 iscussed with respect to the hypothesis that glutaminyl and asparaginyl residues serve, through deami

8 constructed and evaluated as substrates for glutaminyl and cysteinyl-tRNA synthetases.

9 formation of amide bonds between endo-gamma-glutaminyl and endo-epsilon-lysyl residues of proteins,

10 transglutaminase-catalyzed reaction between glutaminyl and lysyl side-chains, leading to a covalent

11 y are responsible for essentially all of the glutaminyl- and glutamyl-tRNA synthetase activity detect

12 This work identifies genes encoding glutaminyl- and glutamyl-tRNA synthetase in the closely

13 of C73 brings about mischarging by glycyl-, glutaminyl-, and leucyl-tRNA synthetases.

14 Glutaminyl cyclase (hQC) has emerged as a new potential

15 e, we assess the antiarthritic efficiency of glutaminyl cyclase (QC) inhibitors.

16 ular ligation irreversible by coupling it to glutaminyl cyclase (QC)-catalyzed pyroglutamyl formation

17 Glutaminyl cyclase (QC, EC 2.3.2.5) catalyzes the format

18 ogic inhibition of CD47 interactions using a glutaminyl cyclase inhibitor.

19 nce that undergoes subsequent cyclization by glutaminyl cyclase, thereby yielding pyroGlu3-amyloid B.

20 monooxygenase (PAM), peptidase cleavage, and glutaminyl cyclase.

21 Glutaminyl cyclases (QCs) from the oral pathogens Porphy

22 Glutaminyl cyclases (QCs) from the oral pathogens Porphy

23 Mammalian glutaminyl cyclases may, therefore, have structural and

24 in vitro expanded polyglutamine repeats are glutaminyl-donor substrates of tissue transglutaminase (

25 ign and synthesis of dipeptidyl N,N-dimethyl glutaminyl fluoromethyl ketones (fmk) as severe acute re

26 terial peptidoglycan contains L-alanyl-D-iso-glutaminyl-meso-diaminopimelyl-D-alanyl-D-alanine peptid

27 An alternative approach of using glutaminyl-peptide cyclotransferase to convert the N-ter

28 at mouse monocyte migration was supported by glutaminyl-peptide cyclotransferase-like (QPCTL), an int

29 vacuolar SNAREs requires the wild-type three glutaminyl (Q) and one arginyl (R) residues for optimal

30 Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in cha

31 sopeptide bonds by transfer of an amine onto glutaminyl residues of a protein.

32 e can also form ester bonds between specific glutaminyl residues of human involucrin and a synthetic

33 CheD catalyzes amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptor

34 hylaminonaphthalene sulfonyl)diamidopentane (glutaminyl substrate) is cross-linked to dansyl cadaveri

35 is (glutamyl-prolyl-transfer RNA synthetase, glutaminyl-transfer RNA synthetase, elongation factor 2,

36 ombination of discriminating asparaginyl and glutaminyl tRNA synthetase (AARS) together with the amid

37 base frequencies for the seryl, aspartyl and glutaminyl tRNA-synthetase and U1 RNA-protein complexes.

38 Archaea make glutaminyl-tRNA (Gln-tRNA(Gln)) in a two-step process; a

39 Asparaginyl-tRNA (Asn-tRNA) and glutaminyl-tRNA (Gln-tRNA) are essential components of p

40 synthetase to synthesize Glu-tRNA(Gln) and a glutaminyl-tRNA amidotransferase to convert Glu-tRNA(Gln

41 alysis of the x-ray crystal structure of the glutaminyl-tRNA aminoacyl synthetase (GlnRS)-tRNA2Gln co

42 y prokaryotes form the amide aminoacyl-tRNAs glutaminyl-tRNA and asparaginyl-tRNA by tRNA-dependent a

43 "21st synthetase-tRNA pairs" include E. coli glutaminyl-tRNA synthetase (GlnRS) along with an amber s

44 ependent on coexpression of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) along with the E. col

45 e free state, and for tRNAGln complexed with glutaminyl-tRNA synthetase (GlnRS) are in good agreement

46 The crystal structure of E. coli glutaminyl-tRNA synthetase (GlnRS) bound to native tRNA1

47 Helicobacter pylori does not have a glutaminyl-tRNA synthetase (GlnRS) but has two divergent

48 alter amino acid specificities of TrpRS and glutaminyl-tRNA synthetase (GlnRS) by mutagenesis withou

49 Eukaryotic glutaminyl-tRNA synthetase (GlnRS) contains an appended

50 The glutaminyl-tRNA synthetase (GlnRS) enzyme, which pairs g

51 Glutaminyl-tRNA synthetase (GlnRS) evolved later and is

52 alysis of aminoacylation of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) has revealed that the

53 due from glutamyl-tRNA synthetase (GluRS) to glutaminyl-tRNA synthetase (GlnRS) improves the K(M) of

54 The structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) in complex with tRNAG

55 in the crystal structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) in complex with tRNAG

56 The N-terminal appended domain (NTD) of glutaminyl-tRNA synthetase (GlnRS) is intriguing since G

57 Glutaminyl-tRNA synthetase (GlnRS) is one noteworthy exc

58 Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzym

59 previously described mutant Escherichia coli glutaminyl-tRNA synthetase (GlnRS) proteins that incorre

60 eady-state and transient kinetic analyses of glutaminyl-tRNA synthetase (GlnRS) reveal that the enzym

61 rom the catalytic domain of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) were replaced with th

62 karyotes and some bacteria employ a specific glutaminyl-tRNA synthetase (GlnRS) which other Bacteria,

63 nthesis, which in eukaryotes is catalyzed by glutaminyl-tRNA synthetase (GlnRS), while most bacteria,

64 aminoacyl-tRNA synthetase, including E. coli glutaminyl-tRNA synthetase (GlnRS), yet functions with t

65 glutamine binding pocket in Escherichia coli glutaminyl-tRNA synthetase (GlnRS).

66 acent to the active site of Escherichia coli glutaminyl-tRNA synthetase (GlnRS).

67 on by asparaginyl-tRNA synthetase (AsnRS) or glutaminyl-tRNA synthetase (GlnRS).

68 Most bacteria and all archaea lack a glutaminyl-tRNA synthetase (GlnRS); instead, Gln-tRNA(Gl

69 Here we show for Escherichia coli glutaminyl-tRNA synthetase (GlnRS; EC 6.1.1.18) that the

70 e aaRSs, the glutamyl-tRNA synthetase (ERS), glutaminyl-tRNA synthetase (QRS), and methionyl-tRNA syn

71 dentification of mutations in QARS (encoding glutaminyl-tRNA synthetase [QARS]) as the causative vari

72 -tRNAGln, functionally replacing the lack of glutaminyl-tRNA synthetase activity in Gram-positive eub

73 However, it was previously shown that glutaminyl-tRNA synthetase activity is present in Leishm

74 Glutaminyl-tRNA synthetase and asparaginyl-tRNA syntheta

75 eria lack genes encoding asparaginyl- and/or glutaminyl-tRNA synthetase and consequently rely on an i

76 ecific interactions between Escherichia coli glutaminyl-tRNA synthetase and tRNA(Gln) have been shown

77 Archaebacteria lack glutaminyl-tRNA synthetase and utilize a two-step pathwa

78 as those for asparaginyl-tRNA synthetase and glutaminyl-tRNA synthetase are absent.

79 undwork for the acquisition of the canonical glutaminyl-tRNA synthetase by lateral gene transfer from

80 different from that reported for the tRNAGln-glutaminyl-tRNA synthetase complex.

81 dy-state kinetic studies of Escherichia coli glutaminyl-tRNA synthetase conclusively demonstrate the

82 d that residues Asp66, Tyr211, and Phe233 in glutaminyl-tRNA synthetase could potentially facilitate

83 either the cytoplasmic nor the mitochondrial glutaminyl-tRNA synthetase distinguishes between the imp

84 y perturb the enzyme-tRNA interface, E. coli glutaminyl-tRNA synthetase does not charge yeast tRNA.

85 Because glutaminyl-tRNA synthetase does not possess a spatially

86 The binding of glutaminyl-tRNA synthetase from Escherichia coli to seve

87 ells by regulating expression of the E. coli glutaminyl-tRNA synthetase gene in an inducible, cell-ty

88 Concomitant expression of the E. coli glutaminyl-tRNA synthetase gene results in aminoacylatio

89 Glutaminyl-tRNA synthetase generates Gln-tRNA(Gln) 10(7)

90 integrity, and translation, and identify the glutaminyl-tRNA synthetase Gln4 as the target of N-pyrim

91 2.5 A crystal structure of Escherichia coli glutaminyl-tRNA synthetase in a quaternary complex with

92 n) that may be preventing the acquisition of glutaminyl-tRNA synthetase in Archaea.

93 not dependent on arginyl-tRNA synthetase and glutaminyl-tRNA synthetase in the MSC.

94 Glutaminyl-tRNA synthetase is thought to be absent from

95 gical activity of an essential RNA.Bacterial glutaminyl-tRNA synthetase poorly aminoacylates yeast tR

96 structure of the complex between tRNAGln and glutaminyl-tRNA synthetase shows that the enzyme interac

97 gly, T. brucei uses the same eukaryotic-type glutaminyl-tRNA synthetase to form mitochondrial and cyt

98 dues were randomly mutated and the resulting glutaminyl-tRNA synthetase variants were screened in viv

99 ells in which arginyl-tRNA synthetase and/or glutaminyl-tRNA synthetase were absent from the MSC.

100 The cocrystal structure of the class I glutaminyl-tRNA synthetase with tRNAGln revealed an unco

101 A is dependent upon the expression of E.coli glutaminyl-tRNA synthetase, indicating that none of the

102 nsamidation, and the eukaryal cytoplasm uses glutaminyl-tRNA synthetase, it appears that the three do

103 The monomeric yeast Saccharomyces cerevisiae glutaminyl-tRNA synthetase, like several other class I e

104 catalysed by asparaginyl-tRNA synthetase and glutaminyl-tRNA synthetase, respectively.

105 inoacylated in vitro by the Escherichia coli glutaminyl-tRNA synthetase, suggesting that the lack of

106 Glutaminyl-tRNA(Gln) and asparaginyl-tRNA(Asn) were like

107 e and glutamine amidotransferase to generate glutaminyl-tRNA.