ライフサイエンスコーパス: glutamyl

1 Imaging was performed by injecting HP gamma-glutamyl-[1-(13)C]glycine and acquiring dynamic (13)C da

2 The signal-to-noise (SNR) ratios of gamma-glutamyl-[1-(13)C]glycine and its product [1-(13)C]glyci

3 ssess the value of hyperpolarized (HP) gamma-glutamyl-[1-(13)C]glycine for non-invasive imaging of gl

4 r-bearing rats showed no difference in gamma-glutamyl-[1-(13)C]glycine SNR, pointing to similar deliv

5 irst time, the feasibility of using HP gamma-glutamyl-[1-(13)C]glycine to monitor GGT expression in t

6 or drug activity was optimized in advance of glutamyl adduct prodrug design.

7 against spontaneous NO release by linkage to glutamyl adducts that could be cleaved by gamma-glutamyl

8 ut the subsequent elimination of the peptide-glutamyl adducts to afford dehydro amino acids.

9 mbinant GGCT2;1 converted both GSH and gamma-glutamyl Ala to 5-OP in vitro.

10 icted to specify activities related to gamma-glutamyl amide linkages and/or unusual peptide bonds.

11 Notably, levels of gamma-glutamyl amino acid, linked with glutathione metabolism

12 id, food component or plant, benzoate, gamma-glutamyl amino acid, methionine, and tryptophan).

13 bial, tryptophan, plant component, and gamma-glutamyl amino acid-related metabolites.

14 hione, with no activity against either gamma-glutamyl amino acids or oxidized glutathione.

15 copy, P = 0.046-0.002), including five gamma-glutamyl amino acids, beta-citryl-glutamate, N-acetyl-as

16 In contrast, nitrogen-rich and gamma-glutamyl amino acids, citrulline, and nucleotide catabol

17 ty acids and energy production, and 4) gamma-glutamyl amino acids, which represent an altered gamma-g

18 ster of differentiation 90)], and 6C3 [ENPEP glutamyl aminopeptidase (aminopeptidase A)].

19 A counter screen against glutamyl aminopeptidase (ENPEP), an enzyme with substrat

20 Homology modeling revealed glutamyl and aspartyl residues in close proximity (less

21 h contains beta-cyanoalanine (BCA) and gamma-glutamyl beta-cyanoalanine (gammaGBCA) is used for adult

22 uncertainties of beta-cyanoalanine and gamma-glutamyl-beta-cyanoalanine were obtained as 4.6% and 5.8

23 at acivicin is accommodated within the gamma-glutamyl binding pocket of the enzyme.

24 Residues that comprise the gamma-glutamyl binding site are primarily located in the 20 kD

25 hat compete with the substrate for the gamma-glutamyl binding site.

26 ic breakdown of GSH by cleavage of the gamma-glutamyl bond and release of cysteinylglycine.

27 hile hydrolase family that cleaves the gamma-glutamyl bond of glutathione and other gamma-glutamyl co

28 nds with two atoms of GSH spanning the gamma-glutamyl bond.

29 er mainly associated with mutations in gamma-glutamyl carboxylase (GGCX) that often has fatal outcome

30 gamma-Glutamyl carboxylase (GGCX), an approximately 94 kDa tra

31 based system for studying mutations in gamma-glutamyl carboxylase (GGCX), the enzyme responsible for

32 which were shown to result in reduced gamma-glutamyl carboxylase activity and in undercarboxylation

33 Thus, reduced gamma-glutamyl carboxylase activity in individuals either comp

34 The gamma-glutamyl carboxylase converts Glu to carboxylated Glu (G

35 As a result, activation of MGP by gamma-glutamyl carboxylase is diminished, allowing slow yet pr

36 GGCX encodes a gamma-glutamyl carboxylase necessary for activation of both co

37 The gamma-glutamyl carboxylase utilizes four substrates to catalyz

38 es 346-758) of the vitamin K-dependent gamma-glutamyl carboxylase, a glycoprotein located in the endo

39 Cellular gamma-glutamyl carboxylation also exhibited differential VKOR

40 that enables quantitative analysis of gamma-glutamyl carboxylation and its antagonism in live cells.

41 ctivity relationship for inhibition of gamma-glutamyl carboxylation by warfarin metabolites, observin

42 s, we demonstrate that PRGP2 undergoes gamma-glutamyl carboxylation in a manner that is both dependen

43 Maximal gamma-glutamyl carboxylation of F9CH required vitamin K supple

44 quinone, an essential cofactor for the gamma-glutamyl carboxylation of many clotting factors.

45 MGP requires to be activated by gamma-glutamyl carboxylation, a vitamin K-dependent reaction,

46 freeze-trapped acetylglutamyl anhydride and glutamyl-CoA thioester adducts.

47 We evaluated a series of gamma-glutamyl compounds as substrates for human GGT1 and huma

48 o cell surface enzymes that metabolize gamma-glutamyl compounds have been identified: gamma-glutamyl

49 Gamma-glutamyl compounds include antioxidants, inflammatory mo

50 ase that cleaves glutathione and other gamma-glutamyl compounds.

51 glutamyl bond of glutathione and other gamma-glutamyl compounds.

52 olism, and other pathways that involve gamma-glutamyl compounds.

53 of extracellular glutathione and other gamma-glutamyl-containing compounds.

54 n HUVECs, including impairments of the gamma-glutamyl cycle and methylglyoxal detoxification.

55 g to glutamine synthase (GLUL) and the gamma-glutamyl cycle as key regulators of CHD risk in diabetes

56 ed in glutamic acid metabolism and the gamma-glutamyl cycle in 62 HUVEC strains carrying different rs

57 m architecture through activity of the gamma-glutamyl cycle in the primary root tip.

58 creased ratio between plasma levels of gamma-glutamyl cycle intermediates pyroglutamic and glutamic a

59 glutamate, and ophthalmate-a marker of gamma-glutamyl cycle malfunction.

60 mino acids, which represent an altered gamma-glutamyl cycle of glutathione metabolism.

61 lack homologs of this enzyme (and the gamma-glutamyl cycle) but are predicted to have some way to di

62 zymatic intermediate in the eukaryotic gamma-glutamyl cycle, but it is also an unavoidable damage pro

63 We identified the gamma-glutamyl cycle, the production of glutathione, and the r

64 predominantly metabolized through the gamma-glutamyl cycle, where GSH is degraded by the sequential

65 GSH homeostasis is maintained by the gamma-glutamyl cycle, which involves GSH synthesis and degrada

66 nk between TDA/acid resistance and the gamma-glutamyl cycle.

67 rimary root tip where it activates the gamma-glutamyl cycle.

68 The enzyme gamma-glutamyl cyclotransferase (GGCT) is involved in Glu recy

69 then to Glu by the combined action of gamma-glutamyl cyclotransferase and 5-oxoprolinase in the cyto

70 Kinetics analysis suggests that gamma-glutamyl cyclotransferase is the major source of GSH deg

71 otransferase 1 (Chac1), a proapoptotic gamma-glutamyl cyclotransferase that depletes glutathione, was

72 f gamma-glutamyl transpeptidase (GGT), gamma-glutamyl cyclotransferase, and 5-oxoprolinase to yield g

73 r referred to as GGCT2;1, functions as gamma-glutamyl cyclotransferase.

74 stable-isotope labeled compound [GSX, gamma-glutamyl-cystein-glycin-(13)C2-(15)N] was used to trap r

75 ations, a mixture of glutathione [GSH, gamma-glutamyl-cystein-glycin] and the stable-isotope labeled

76 Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzy

77 nic mouse lines in which expression of gamma-glutamyl cysteine ligase, the rate-limiting enzyme in de

78 studies all used the structure of the gamma-glutamyl cysteine utilizing sulfoxide synthase, MthEgtB

79 etween N-alpha-trimethyl histidine and gamma-glutamyl cysteine, which is the key step in the biosynth

80 as the ACR-scavenging activity and the gamma-glutamyl-cysteine ligase (gamma-GCL) and acylase I activ

81 , including arsenate reductase (HAC1), gamma-glutamyl-cysteine synthetase (gamma-ECS), phytochelatin

82 Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is a major thiol-contai

83 n and characterization of glutathione (gamma-glutamyl-cysteinylglycine, GSH)-trapped reactive metabol

84 ta [g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic acid 1 (BGC 945, now known as ONX 08

85 m/z 272, corresponding to deprotonated gamma-glutamyl-dehydroalanyl-glycine originating from the glut

86 th hallmarks of hepatotoxicity such as gamma-glutamyl dipeptides, acylcarnitines, and proline derivat

87 2-hydroxybutyrate-related metabolites, gamma-glutamyl dipeptides, and lysophosphatidylcholines, which

88 ipid pathways and with lower levels of gamma-glutamyl dipeptides.

89 thway and positively associated with 5 gamma-glutamyl dipeptides.

90 Glutamyl endopeptidase (GE) from Alcalase 2.4 L was puri

91 uncompetitive inhibitors, binding the gamma-glutamyl enzyme complex.

92 in ligation, catalyzing formation of a gamma-glutamyl-epsilon-Lys (Gln40(Ub)-Lys92(Ube2N)) isopeptide

93 II (FXIIIa) catalyzes the formation of gamma-glutamyl-epsilon-lysyl cross-links within the fibrin blo

94 tor XIIIa (FXIIIa) introduces covalent gamma-glutamyl-epsilon-lysyl crosslinks into the blood clot ne

95 nation monitored by tritium release from the glutamyl gamma-carbon was dependent upon CO(2), and a pr

96 minantly the desired E-olefin isosteres of L-glutamyl-gamma-D-glutamate and L-glutamyl-gamma-L-glutam

97 ternally quenched fluorogenic derivatives of glutamyl-gamma-glutamate and (4,4-difluoro)glutamyl-gamm

98 f glutamyl-gamma-glutamate and (4,4-difluoro)glutamyl-gamma-glutamate to examine the effect of fluori

99 ontaining peptidomimetics of the isopeptide, glutamyl-gamma-glutamate, have been synthesized via a ro

100 steres of L-glutamyl-gamma-D-glutamate and L-glutamyl-gamma-L-glutamate, following which peracid-medi

101 e that was reacted with a suitably protected glutamyl-gamma-semialdehyde in a Julia-Kocienski olefina

102 k at the much harder N-terminus of the gamma-glutamyl (Glu) unit of GSH.

103 mma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate, refined at 1.50, 1.60, and 1.67 A re

104 competitive AMPA receptor-antagonist gamma-d-glutamyl-glycine (gamma-DGG), analysis of the coefficien

105 Using this method, we identified gamma-glutamyl hydrolase (GGH), emmprin, survivin, and diazepa

106 folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate red

107 ened or removed by the vacuolar enzyme gamma-glutamyl hydrolase (GGH).

108 The tail can be removed by gamma-glutamyl hydrolase (GGH; EC 3.4.19.9), a vacuolar enzyme

109 folylpolyglutamate synthase [FPGS] and gamma-glutamyl hydrolase [GGH]) evaluated in germline DNA (blo

110 amyltranspeptidase (HpGT) is a general gamma-glutamyl hydrolase and a demonstrated virulence factor.

111 cation in foods using the plant-origin gamma-glutamyl hydrolase as part of the extraction procedure.

112 Gamma-glutamyl hydrolase, a cysteine peptidase, catalyzes the

113 gamma-Glutamyl hydrolases (gammaGH) catalyze the hydrolysis of

114 rate recognition of zgammaGH and other gamma-glutamyl hydrolases.

115 We previously developed gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a

116 lidated a new fluorescent method using gamma-glutamyl hydroxymethyl rhodamine green to diagnose metas

117 ification of transglutaminase-mediated gamma-glutamyl isomers as intermediate products of transamidat

118 distinguished for the first time gamma/alpha-glutamyl isomers of deamidation, encountering a 1.7 gamm

119 S-4-mercapto-4-methylpentan-2-one-N-(l-gamma-glutamyl)-l-cysteine (gammaGluCys-4MMP) but at too low c

120 -weight thiol-containing tripeptide (l-gamma-glutamyl-l-cysteinyl-glycine) that can function as a rev

121 G) and a C-terminal NlpC/P60 domain (gamma-d-glutamyl-l-diamino acid endopeptidase) and is expected t

122 anine amidase, whereas Lc-Lys-2 is a gamma-D-glutamyl-L-lysyl endopeptidase.

123 denosine, and guanosine) and kokumi (gamma-l-glutamyl-l-valine) taste-related molecules was ascertain

124 ro-steroid monosulfate 2, uridine, and gamma-glutamyl-leucine, showed independent associations with a

125 mma-glutamyl transpeptidase (GGT1) and gamma-glutamyl leukotrienase (GGT5).

126 s homologous to CofE with an annotated gamma-glutamyl ligase activity, whereas the C-terminal domain

127 n the two domains is critical for full gamma-glutamyl ligase activity.

128 vertebrates, balanced activities of tubulin glutamyl ligase and cytoplasmic carboxypeptidase degluta

129 A gamma-glutamyl ligase catalyzes the final steps of the F420bio

130 llular localization or expression of tubulin glutamyl ligases (ttlls) and nonenzymatic proteins, incl

131 of TGM2, fibronectin (FN) and epsilon-(gamma-glutamyl) lysine (GGEL) proteins.

132 oscopy suggested formation of epsilon-(gamma-glutamyl) lysine cross-linkages by transglutaminase and

133 sponsible for the formation of epsilon(gamma-glutamyl)lysine crosslinks (transamidation).

134 a) catalyzes the formation of epsilon-(gamma-glutamyl)lysine isopeptide bonds between specific Gln an

135 Factor XIIIa-catalyzed epsilon-(gamma-glutamyl)-lysyl bonds between glutamine and lysine resid

136 Using N-acetylmuramyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alan ine as

137 on of Nod1 by its agonist, bacterial gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), in term trop

138 s induced by the bacterial dipeptide gamma-d-glutamyl-meso-diaminopimelic acid was intact in MyD88 de

139 dance of intestinal bacteria bearing gamma-d-glutamyl-meso-diaminopimelic acid, a ligand for the intr

140 derivative of the iE-DAP dipeptide [gamma-d-glutamyl-meso-diaminopimelic acid]) and the S Typhimuriu

141 fied in these SIP experiments used the gamma-glutamyl-methylamide pathway, found in both methylotroph

142 riched onion meals ( approximately 66% gamma-glutamyl-methylselenocysteine, providing the equivalent

143 The C-terminal glutamyl mimic was accessed by the stereospecific synthe

144 idase on the cell membrane cleaves the gamma-glutamyl moieties of the conjugate to generate positivel

145 nd hard reactive metabolites contain a gamma-glutamyl moiety and, thus, undergo a neutral loss of 129

146 ck of specific coordination beyond the gamma-glutamyl moiety may account for the substrate binding pe

147 stal structures identifies a Mg(2+) near the glutamyl moiety of the folate cofactor, providing the fi

148 abidopsis (Arabidopsis thaliana) chloroplast glutamyl peptidase (CGEP) is a homo-oligomeric stromal S

149 er GSH degradation or the diversion of gamma-glutamyl peptides to produce 5-oxoproline (5-OP).

150 ated lipid peroxidation products, MDA, gamma-glutamyl peptides, GGT, leukotriene B4 and 5-HETE.

151 were used to assess chymotrypsin-like, post-glutamyl peptidyl-hydrolyzing, and trypsin-like protease

152 ds are available to identify the gamma/alpha-glutamyl products of deamidation, none of these methods

153 Specificity is dictated by glutamyl-prolyl tRNA synthetase (EPRS) binding to a 3'UT

154 Agonist-inducible phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) by S6K1 in monocy

155 Glutamyl-prolyl tRNA synthetase (EPRS) is a component of

156 Importantly, the EN1-iPeps bound the glutamyl-prolyl tRNA synthetase (EPRS) target, which has

157 to the identification of a truncated form of glutamyl-prolyl tRNA synthetase (EPRS), a GAIT constitue

158 osphorylate Ser(886) in the linker domain of glutamyl-prolyl tRNA synthetase (EPRS), the initial even

159 and beta-actin) or in protein biosynthesis (glutamyl-prolyl-transfer RNA synthetase, glutaminyl-tran

160 Here we identify glutamyl-prolyl-tRNA synthetase (EPRS) as an mTORC1-S6K1

161 Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its func

162 oid cells is heterotetrameric, consisting of glutamyl-prolyl-tRNA synthetase (EPRS), NS1-associated p

163 Translation of the glutamyl-prolyl-tRNA synthetase gene EPRS is enhanced in

164 deamidation, encountering a 1.7 gamma/alpha-glutamyl ratio for most Gln deamidation products.

165 erhelical linker region around the conserved glutamyl residue Glu(49) of TatB from Escherichia coli F

166 t of a cofactor for the VKD carboxylation of glutamyl residues (Glus) to carboxylated Glus in VKD pro

167 o affected by reversible methylation of four glutamyl residues in the cytoplasmic domain of the recep

168 dehyde intermediates, and converts the gamma-glutamyl residues of GSSG to 5-hydroxybutyrolactam.

169 aining compounds, such as alliin and N-gamma-glutamyl-S-allyl cysteine, could notably be detected in

170 ommon vetch: ss-cyanoalanine (BCA) and gamma-glutamyl-ss-cyanoalanine (GCA).

171 the acceptor site while binding to the gamma-glutamyl substrate complex.

172 The interaction of Mg(2+) with the glutamyl tail of the folate cofactor and nonconserved re

173 (AST), alkaline phosphatase (ALP), and gamma-glutamyl transaminase (GGT) were measured.

174 The purified enzyme exhibited gamma-glutamyl transfer activity as well as iron reduction act

175 d and correlate with an increased content of glutamyl-transfer RNA reductase.

176 n 2-week-old ntrc seedlings, the contents of glutamyl-transfer RNA reductase1 (GluTR1) and CHLM are r

177 ction -21%; P = 0.029 versus placebo), gamma-glutamyl transferase (-30%; P < 0.001), alanine aminotra

178 ase (0.02 [0.01, 0.03]; P = 0.002) and gamma-glutamyl transferase (0.02 [0.01, 0.03]; P = 0.001).

179 artate aminotransferase (1251.76 U/L), gamma-glutamyl transferase (360.53 U/L), and alkaline phosphat

180 The patient's gamma-glutamyl transferase (77 U/L [1.28 mukat/L]; normal leve

181 (beta = 3.70; 95% CI: 1.78, 5.62), and gamma-glutamyl transferase (beta = 3.70; 95% CI: 0.80, 6.60) a

182 Increased gamma-glutamyl transferase (GGT) activity is associated with l

183 ociated phenotypes, including elevated gamma-glutamyl transferase (GGT) and alanine aminotransferase

184 aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at 52 weeks, for improvement

185 However, serum gamma-glutamyl transferase (GGT) concentrations were mildly el

186 docosahexaenoic acid) was catalyzed by gamma-glutamyl transferase (GGT) in human macrophages.

187 chromosome 22), one locus influencing gamma-glutamyl transferase (GGT) levels (HNF1A on chromosome 1

188 Elevated gamma-glutamyl transferase (GGT) levels are associated with hi

189 gamma-Glutamyl transferase (GGT) regulates glutathione metabol

190 ly detect urinary biomarkers including gamma-glutamyl transferase (GGT), alanine aminopeptidase (AAP)

191 ood for liver enzyme levels, including gamma-glutamyl transferase (GGT), alanine aminotransferase (AL

192 erum alanine aminotransferase (ALT) or gamma-glutamyl transferase (GGT), two markers of hepatic necro

193 waist circumference, triglyceride, and gamma-glutamyl transferase (GGT).

194 - 13 versus 27 +/- 10 IU/L (P = 0.81), gamma-glutamyl transferase 54 +/- 138 versus 49 +/- 35 IU/L (P

195 Optimal conditions for gamma-glutamyl transferase activity were found to be 35 degree

196 tasis-like phenotype with normal serum gamma-glutamyl transferase activity without intestinal disease

197 dent coagulopathy, low-to-normal serum gamma-glutamyl transferase activity, elevated serum alpha-feto

198 tasis-like phenotype with normal serum gamma-glutamyl transferase activity.

199 olangiocytes were functional, based on gamma glutamyl transferase and alkaline phosphatase activity a

200 Levels of gamma glutamyl transferase and alkaline phosphatase were measu

201 notransferase, hemoglobin A1C (P<.05), gamma-glutamyl transferase and development of type 2 diabetes

202 tion, serum levels of the liver enzyme gamma-glutamyl transferase and fecal virus shedding were signi

203 sis substantially through blocking the gamma-glutamyl transferase catalysis of the first breakdown st

204 Cholestasis with normal gamma glutamyl transferase characterizes functional deficienci

205 adults with Pi*MZ had lower levels of gamma-glutamyl transferase in serum and lower LSMs than adults

206 mpared with the vemurafenib group were gamma-glutamyl transferase increase (36 [15%] in the cobimetin

207 se, CD4(+) T-cell count, HCV genotype, gamma-glutamyl transferase level, and baseline APRI.

208 using the kidney-specific podocin and gamma-glutamyl transferase promoters, but found expression pri

209 Increasing level of gamma-glutamyl transferase was also associated with reduced od

210 aminotransferase, total bilirubin, and gamma glutamyl transferase were higher in DSA-positive patient

211 d nausea and asymptomatic increases in gamma-glutamyl transferase were observed in some patients rece

212 and serum levels of aminotransferase, gamma-glutamyl transferase, and bilirubin.

213 oved: compared with placebo, levels of gamma-glutamyl transferase, aspartate transaminase, and solubl

214 known cholangiocyte markers including gamma glutamyl transferase, cytokeratin 19, epithelial cellula

215 nalysis, younger age, higher levels of gamma-glutamyl transferase, lower pretherapeutic hemoglobin, a

216 ansferase, aspartate aminotransferase, gamma-glutamyl transferase, tissue inhibitor of metalloprotein

217 vation of alanine aminotransferase and gamma-glutamyl transferase, two markers of fatty liver disease

218 transferase, alkaline phosphatase, and gamma-glutamyl transferase: - 27.2, - 7.2, - 39.2, and - 16.3

219 ferase, aspartate aminotransferase, or gamma-glutamyl transferase; and low numbers of platelets were

220 gamma-glutamyl-transferase (GGT) is a key enzyme in GSH homeos

221 cell damage (P=0.02), higher values of gamma-glutamyl-transferase (gGT) resembling tubulus injury (P=

222 with fasting alanine aminotransferase, gamma-glutamyl-transferase, LDL cholesterol, A1C, and systolic

223 for measurements of triglycerides and gamma-glutamyl-transferase.

224 is, alanine aminotransferase, AST, and gamma-glutamyl transpeptase) and fructose or sucrose intake ap

225 39.9 +/- 28.6U/L vs 23.8 +/- 14.1U/L), gamma-glutamyl transpeptidase (34.3 +/- 16.6 vs 24.5 +/- 16.8U

226 otransferase (14 of 44, 32%), elevated gamma-glutamyl transpeptidase (eight of 44, 18%), hyperbilirub

227 tamyl adducts that could be cleaved by gamma-glutamyl transpeptidase (gamma-GT), found predominantly

228 ate markers of NAFLD, such as elevated gamma glutamyl transpeptidase (GGT) and alanine aminotransfera

229 Plasma levels of gamma-glutamyl transpeptidase (GGT) are associated with risk f

230 her CagA, VacA, lipopolysaccharide, or gamma-glutamyl transpeptidase (GGT) implicated the latter in H

231 Expression of gamma-glutamyl transpeptidase (GGT) in tumors contributes to r

232 gamma-Glutamyl transpeptidase (GGT) is a heterodimeric membran

233 gamma-Glutamyl transpeptidase (GGT) is an enzyme located on th

234 Both the presence of gamma-glutamyl transpeptidase (GGT) on the apical brush-border

235 The cell surface glycoprotein gamma-glutamyl transpeptidase (GGT) was isolated from healthy

236 and H. pylori These include flagellin, gamma-glutamyl transpeptidase (ggt), collagenase, the secreted

237 degraded by the sequential reaction of gamma-glutamyl transpeptidase (GGT), gamma-glutamyl cyclotrans

238 ase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), or total bilirubin.

239 utamyl compounds have been identified: gamma-glutamyl transpeptidase (GGT1) and gamma-glutamyl leukot

240 Overexpression of gamma-glutamyl transpeptidase (GGT1) has been implicated in an

241 dverse events were increased levels of gamma-glutamyl transpeptidase (two [4%]), a reduction in the n

242 gamma-Glutamyl transpeptidase 1 (GGT1) is a cell surface, N-te

243 LT], aspartate aminotransferase [AST], gamma-glutamyl transpeptidase [GGT], alkaline phosphatase [ALP

244 1.87; 95% CI, 1.10; 3.18; P = 0.021); gamma-glutamyl transpeptidase above the upper limit of normal

245 erum bile acid (BA) levels, and normal gamma-glutamyl transpeptidase activity.

246 ss than 30 kg/m(2), genotype 2, normal gamma-glutamyl transpeptidase and increased alanine aminotrans

247 wer concentrations of the liver enzyme gamma-glutamyl transpeptidase and lower scores on a measure of

248 Among secondary end points, levels of gamma-glutamyl transpeptidase decreased 48%-63%, on average, a

249 (BSEP) disease, and 4 others with low gamma-glutamyl transpeptidase disease (levels <100 U/L), were

250 5 days liver histology was normal, but gamma-glutamyl transpeptidase expression was observed, with al

251 H. pylori virulence determinants, the gamma-glutamyl transpeptidase GGT and the vacuolating cytotoxi

252 kaline phosphatase of 75.6%; P<0.0001; gamma-glutamyl transpeptidase of 117.9%, P<0.0001; bilirubin o

253 tumour interstitium, the overexpressed gamma-glutamyl transpeptidase on the cell membrane cleaves the

254 , significantly reduced levels of ALP, gamma-glutamyl transpeptidase, and alanine aminotransferase, c

255 ntrations of alanine aminotransferase, gamma-glutamyl transpeptidase, and alkaline phosphatase.

256 inotransferases, alkaline phosphatase, gamma glutamyl transpeptidase, and homeostasis model assessmen

257 oncentrations of alkaline phosphatase, gamma-glutamyl transpeptidase, cystatin C, neutrophil gelatina

258 rgery, urinary protein and creatinine, gamma-glutamyl transpeptidase, lactate dehydrogenase, histolog

259 higher body mass index, triglycerides, gamma-glutamyl transpeptidase, maximum alanine aminotransferas

260 or ferritin) and fibrosis (P<.0001 for gamma-glutamyl transpeptidase, P=.01 for alkaline phosphatase,

261 resence of excess CapD, a B. anthracis gamma-glutamyl transpeptidase, the protective capsule is degra

262 wed that pretreatment body mass index, gamma-glutamyl transpeptidase, triglyceride, IL-28B TT genotyp

263 Here, we present a gamma-glutamyl transpeptidase-responsive camptothecin-polymer

264 We found that inhibition of gamma-glutamyl-transpeptidase (gamma-GT) protects human acute

265 rthermore, serial sections stained for gamma-glutamyl-transpeptidase (GGT, a marker of fetal hepatobl

266 ansfer, alkaline phosphatase activity, gamma-glutamyl-transpeptidase activity and physiological respo

267 . pylori persistence determinants, the gamma-glutamyl-transpeptidase GGT and the vacuolating cytotoxi

268 s Dug1, Dug2, and Dug3) but not by the gamma-glutamyl-transpeptidase, raising the question of the rol

269 persister protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX).

270 The chloroplast glutamyl-tRNA (tRNA(Glu)) is unique in that it has two e

271 apicomplexans possess a unique heterodimeric glutamyl-tRNA amidotransferase consisting of GatA and Ga

272 tetrapyrrole biosynthesis and is formed from glutamyl-tRNA by two enzymatic steps.

273 Glutamyl-tRNA reductase (GluTR) as the first enzyme of A

274 photosynthetic eukaryotes and many bacteria, glutamyl-tRNA reductase (GluTR) is the most tightly cont

275 n translation, it serves as the substrate of glutamyl-tRNA reductase (GluTR), the enzyme catalyzing t

276 E gene uncovered an unexpected inhibition of glutamyl-tRNA reductase by immature tRNA(Glu) We further

277 of CHLH and HEMA1 encoding Mg chelatase and glutamyl-tRNA reductase were increased in rfd1 and the A

278 eflected in an enhanced level of the encoded glutamyl-tRNA reductase, which catalyzes one of the rate

279 F, which can interact with the Clp substrate glutamyl-tRNA reductase.

280 ic screen reveals that the overexpression of glutamyl-tRNA synthetase (GltX) suppresses the toxicity

281 (Gln) is produced via an indirect pathway: a glutamyl-tRNA synthetase (GluRS) first attaches glutamat

282 in early eukaryotes from a nondiscriminating glutamyl-tRNA synthetase (GluRS) that aminoacylates both

283 nsplanting a conserved arginine residue from glutamyl-tRNA synthetase (GluRS) to glutaminyl-tRNA synt

284 ved from the archaeal-type nondiscriminating glutamyl-tRNA synthetase (GluRS), an enzyme with relaxed

285 first enzyme in this pathway, the apicoplast glutamyl-tRNA synthetase (GluRS).

286 ntaining the anchoring protein Arc1p and the glutamyl-tRNA synthetase (GluRS).

287 ced with the corresponding residues of human glutamyl-tRNA synthetase (GluRS).

288 ompare the signaling pathways in a bacterial glutamyl-tRNA synthetase (GluRS):tRNA(Glu) and an archae

289 ng protein that forms a ternary complex with glutamyl-tRNA synthetase (GluRSc) and methionyl-tRNA syn

290 in a two-step process; a non-discriminating glutamyl-tRNA synthetase (ND-GluRS) forms Glu-tRNA(Gln),

291 and asparaginyl-tRNA synthetase evolved from glutamyl-tRNA synthetase and aspartyl-tRNA synthetase, r

292 t-transfer states with charged tRNA bound to glutamyl-tRNA synthetase from Thermus thermophilus (Glu-

293 E. coli HipA inactivates the glutamyl-tRNA synthetase GltX, which inhibits translatio

294 lation pathway utilizes a non-discriminating glutamyl-tRNA synthetase to synthesize Glu-tRNA(Gln) and

295 RNA synthetase (GlnRS) but has two divergent glutamyl-tRNA synthetases: GluRS1 and GluRS2.

296 LUCA by amidation of the mischarged species, glutamyl-tRNA(Gln) and aspartyl-tRNA(Asn), by tRNA-depen

297 nt amidation of the mischarged tRNA species, glutamyl-tRNA(Gln) or aspartyl-tRNA(Asn).

298 thesis of inert analogs that mimic substrate glutamyl-tRNA(Glu) and the glutamylated peptide intermed

299 Here we show that this process involves glutamyl-tRNA(Glu) to activate Ser/Thr residues.

300 linear peptide substrate through an unusual glutamyl-tRNA-dependent dehydration of Ser and Thr.