ライフサイエンスコーパス: glutamyl-tRNA

1 ive mutant GSAT inhibited ALA formation from glutamyl-tRNA.

2 apicomplexans possess a unique heterodimeric glutamyl-tRNA amidotransferase consisting of GatA and Ga

3 acterial AspRS and the B subunit of archaeal glutamyl-tRNA amidotransferases, and another previously

4 tetrapyrrole biosynthesis and is formed from glutamyl-tRNA by two enzymatic steps.

5 ARLs as well as related enzymes, such as the glutamyl-tRNA-dependent dehydratases involved in the bio

6 linear peptide substrate through an unusual glutamyl-tRNA-dependent dehydration of Ser and Thr.

7 hat both wild-type and mutant GSAT stimulate glutamyl-tRNA-dependent NADPH oxidation by GTR.

8 LUCA by amidation of the mischarged species, glutamyl-tRNA(Gln) and aspartyl-tRNA(Asn), by tRNA-depen

9 nt amidation of the mischarged tRNA species, glutamyl-tRNA(Gln) or aspartyl-tRNA(Asn).

10 when it was incubated with Escherichia coli glutamyl-tRNA(Glu) and purified recombinant Chlamydomona

11 thesis of inert analogs that mimic substrate glutamyl-tRNA(Glu) and the glutamylated peptide intermed

12 Here we show that this process involves glutamyl-tRNA(Glu) to activate Ser/Thr residues.

13 verexpression of rHb1.1 and the hemA-encoded glutamyl-tRNA (GTR) reductase increased intracellular le

14 a mutation in hemA (the gene encoding gamma-glutamyl tRNA reductase).

15 ized from activated glutamate by the enzymes glutamyl-tRNA reductase (GluTR) and glutamate-1-semialde

16 Glutamyl-tRNA reductase (GluTR) as the first enzyme of A

17 Glutamyl-tRNA reductase (GluTR) is the first committed e

18 photosynthetic eukaryotes and many bacteria, glutamyl-tRNA reductase (GluTR) is the most tightly cont

19 In the first step, glutamyl-tRNA reductase (GluTR), converts glutamate of g

20 n translation, it serves as the substrate of glutamyl-tRNA reductase (GluTR), the enzyme catalyzing t

21 The enzyme glutamyl-tRNA reductase (GTR) catalyzes the first commit

22 erted to a glutamate 1-semialdehyde (GSA) by glutamyl-tRNA reductase (GTR) in an NADPH-dependent reac

23 A and tetrapyrrole synthesis is catalyzed by glutamyl-tRNA reductase (GTR) in plants.

24 The enzyme glutamyl-tRNA reductase (GTR), encoded by the hemA gene,

25 nverted to glutamate 1-semialdehyde (GSA) by glutamyl-tRNA reductase (GTR).

26 on is imposed on cultures of S. typhimurium, glutamyl-tRNA reductase (HemA) enzyme activity is increa

27 step is catalyzed by the hemA gene product, glutamyl-tRNA reductase (HemA).

28 E gene uncovered an unexpected inhibition of glutamyl-tRNA reductase by immature tRNA(Glu) We further

29 e genes complemented an E. coli hemA strain (glutamyl-tRNA reductase deficient).

30 e first enzyme committed to ALA synthesis is glutamyl-tRNA reductase encoded in Arabidopsis by a smal

31 However, glutamyl-tRNA reductase is also required for the synthes

32 of CHLH and HEMA1 encoding Mg chelatase and glutamyl-tRNA reductase were increased in rfd1 and the A

33 The HemA enzyme (glutamyl-tRNA reductase) catalyzes the first committed s

34 The first enzyme, glutamyl-tRNA reductase, and the second enzyme, glutamat

35 ression of the HEMA1 and Lhcb genes encoding glutamyl-tRNA reductase, the first committed enzyme of 5

36 eflected in an enhanced level of the encoded glutamyl-tRNA reductase, which catalyzes one of the rate

37 ichia coli, the hemA gene encodes the enzyme glutamyl-tRNA reductase, which catalyzes the first commi

38 ichia coli, the hemA gene encodes the enzyme glutamyl-tRNA reductase, which catalyzes the first commi

39 F, which can interact with the Clp substrate glutamyl-tRNA reductase.

40 persister protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX).

41 th the multisynthetase complex, E205G in the glutamyl-tRNA synthetase (ERS) region of EPRS is defecti

42 We identified three aaRSs, the glutamyl-tRNA synthetase (ERS), glutaminyl-tRNA syntheta

43 The glutamyl-tRNA synthetase (gltX) gene from Pseudomonas ae

44 ic screen reveals that the overexpression of glutamyl-tRNA synthetase (GltX) suppresses the toxicity

45 (Gln) is produced via an indirect pathway: a glutamyl-tRNA synthetase (GluRS) first attaches glutamat

46 To date, only glutamyl-tRNA synthetase (GluRS) has been found to conta

47 ort the characterization of a well conserved glutamyl-tRNA synthetase (GluRS) paralog (YadB in Escher

48 in early eukaryotes from a nondiscriminating glutamyl-tRNA synthetase (GluRS) that aminoacylates both

49 nsplanting a conserved arginine residue from glutamyl-tRNA synthetase (GluRS) to glutaminyl-tRNA synt

50 the presence of AsnRS and GlnRS, as well as glutamyl-tRNA synthetase (GluRS), a discriminating and a

51 ved from the archaeal-type nondiscriminating glutamyl-tRNA synthetase (GluRS), an enzyme with relaxed

52 oshii class I LysRS (LysRS1) and homology to glutamyl-tRNA synthetase (GluRS), residues implicated in

53 Gln) is initially acylated with glutamate by glutamyl-tRNA synthetase (GluRS), then the glutamate moi

54 netic analyses predict that GlnRS arose from glutamyl-tRNA synthetase (GluRS), via gene duplication w

55 first enzyme in this pathway, the apicoplast glutamyl-tRNA synthetase (GluRS).

56 ntaining the anchoring protein Arc1p and the glutamyl-tRNA synthetase (GluRS).

57 ced with the corresponding residues of human glutamyl-tRNA synthetase (GluRS).

58 ompare the signaling pathways in a bacterial glutamyl-tRNA synthetase (GluRS):tRNA(Glu) and an archae

59 ng protein that forms a ternary complex with glutamyl-tRNA synthetase (GluRSc) and methionyl-tRNA syn

60 in a two-step process; a non-discriminating glutamyl-tRNA synthetase (ND-GluRS) forms Glu-tRNA(Gln),

61 re of the chicken IARS1 UNE-I complexed with glutamyl-tRNA synthetase 1 (EARS1).

62 First, glutamyl-tRNA synthetase activates glutamate by ligating

63 e for essentially all of the glutaminyl- and glutamyl-tRNA synthetase activity detected in both the c

64 and asparaginyl-tRNA synthetase evolved from glutamyl-tRNA synthetase and aspartyl-tRNA synthetase, r

65 ase and utilize a two-step pathway involving glutamyl-tRNA synthetase and glutamine amidotransferase

66 n the linker region that joins the catalytic glutamyl-tRNA synthetase and prolyl-tRNA synthetase doma

67 t-transfer states with charged tRNA bound to glutamyl-tRNA synthetase from Thermus thermophilus (Glu-

68 E. coli HipA inactivates the glutamyl-tRNA synthetase GltX, which inhibits translatio

69 rk identifies genes encoding glutaminyl- and glutamyl-tRNA synthetase in the closely related organism

70 The glutamyl-tRNA synthetase is from the achaebacterium Pyro

71 lation pathway utilizes a non-discriminating glutamyl-tRNA synthetase to synthesize Glu-tRNA(Gln) and

72 C. trachomatis aspartyl-tRNA synthetase and glutamyl-tRNA synthetase were shown to be non-discrimina

73 glutamate is ligated to its cognate tRNA by glutamyl-tRNA synthetase.

74 d by a single eukaryotic-type discriminating glutamyl-tRNA synthetase.

75 kinase, sucrose-phosphate synthase (SPS) and glutamyl-tRNA synthetase.

76 tRNA is not a substrate for the H. volcanii glutamyl-tRNA synthetase.

77 inhibits translation via phosphorylation of glutamyl-tRNA synthetase.

78 m Helicobacter pylori utilizes two essential glutamyl-tRNA synthetases (GluRS1 and GluRS2).

79 Glutamyl-tRNA synthetases (GluRSs) occur in two types, t

80 f this enzyme from the eukaryotic lineage of glutamyl-tRNA synthetases.

81 5 putatively encodes an homolog of bacterial glutamyl-tRNA synthetases.

82 RNA synthetase (GlnRS) but has two divergent glutamyl-tRNA synthetases: GluRS1 and GluRS2.

83 RNA reductase (GluTR), converts glutamate of glutamyl-tRNA to glutamate 1-semialdehyde (GSA) which is

84 The chloroplast glutamyl-tRNA (tRNA(Glu)) is unique in that it has two e