ライフサイエンスコーパス: glutarate

1 ot find evidence of peroxisomal oxidation of glutarate.

2 abbit (rb) differ in their ability to handle glutarate.

3 and was stimulated in oocytes preloaded with glutarate.

4 s trans-stimulated in oocytes preloaded with glutarate.

5 m-coupled transport of proline, glucose, and glutarate.

6 either bis(3,5-dibromosalicyl)-succinate or -glutarate.

7 H pocket inhibit the production of 2-Hydroxy glutarate.

8 ersus NADH, indicating the formation of a E:(glutarate)2 complex as a result of occupying both the ly

9 with methoxypolyethylene glycol succinimidyl glutarate 5000 (MEGC-PEG).

10 d to methoxypolyethylene glycol succinimidyl glutarate-5000 in order to prolong the half-life of rMET

11 with methoxypolyethylene glycol succinimidyl glutarate-5000 with a molar ratio of PEG:rMETase of 15:1

12 omobifunctional cross-linker, disuccinimidyl glutarate (7.7 A).

13 In addition, OAA and glutarate also bind to free enzyme as does lysine at hig

14 esigned to explore sustainable production of glutarate, an attractive C5 building block of polyesters

15 ng dual-label competitive uptakes with (14)C-glutarate and (3)H-succinate to calculate the transport

16 External glutarate and alpha-ketoglutarate (1 mM), both counterio

17 an activatable bond in this manner, such as glutarate and citrate, are excluded from catalysis and a

18 wo-electrode voltage clamp, were similar for glutarate and succinate in Xenopus oocytes expressing mN

19 which catalyzes glutaryl-CoA synthesis from glutarate and succinyl-CoA.

20 , fumarate, and the inhibitors oxaloacetate, glutarate, and 3-nitropropionate.

21 2,3,4-butanetetracarboxylate, tricarballate, glutarate, and acetate to a C(3)(v) symmetric metallo-ho

22 angeable dicarboxylates alpha-ketoglutarate, glutarate, and adipate, but not by succinate, a nonexcha

23 h of P. aeruginosa PAO1 on both alpha-KG and glutarate (another C5-dicarboxylate).

24 ve state and as a complex with the inhibitor glutarate at 1.85 A and 2.4 A resolution, respectively.

25 wo isoreticular three-dimensional copper(II) glutarate-based pillared-layered metal-organic framework

26 Oxaloacetate (OAA), pyruvate, and glutarate behave as dead-end analogues of lysine, which

27 driving force to maximize carbon flux toward glutarate biosynthesis by replenishing glutamate and NAD

28 . coli native lysine catabolic machinery for glutarate biosynthesis.

29 tation, which could be replaced by alfa-keto glutarate but not glucose.

30 ulated when oocytes were preloaded with 2 mM glutarate but not glutamate.

31 hippurate and the dicarboxylates adipate and glutarate (but not succinate or malonate) inhibited indi

32 he NAC-Hg(2+) conjugate was cis-inhibited by glutarate, but not by methylsuccinate, paralleling their

33 for reactivation by the enzyme succinyl-CoA:glutarate-CoA transferase (SUGCT) and become substrate f

34 e addition of RP(OTMS)(2) to alpha-methylene glutarate containing a chiral auxiliary resulted in only

35 e high and low DHTKD1 expression, adipate or glutarate, correspondingly, are the most affected metabo

36 xo-acid dehydrogenase (BCOADC-E2), and 2-oxo-glutarate dehydrogenase (OGDC-E2).

37 drogenase complex (BCOADC-E2), and the 2-oxo-glutarate dehydrogenase complex (OGDC-E2).

38 drogenase complex, the E2 subunit of the oxo-glutarate dehydrogenase complex, four additional inner m

39 phogluconate dehydrogenase, 2-(hydroxymethyl)glutarate dehydrogenase, and phenylserine dehydrogenase,

40 ed chain 2-oxo-acid dehydrogenase, and 2-oxo-glutarate dehydrogenase.

41 The iron(II)- and 2-(oxo)glutarate-dependent (Fe/2OG) oxygenases catalyze an arra

42 ing protein) enzymes are iron(II)- and 2-oxo-glutarate-dependent dioxygenases that are found in all k

43 udy of FtmOx1, a fungal iron(II)- and 2-(oxo)glutarate-dependent oxygenase that installs the endopero

44 Iron(II)- and 2-(oxo)-glutarate-dependent oxygenases catalyze diverse oxidativ

45 valuated: the palmitate (C16), the octadecyl glutarate diester (C18-C5) and the decyl carbamate (CB10

46 Glutarate exerts its effects either by directly inhibiti

47 apenem synthase (CarC), an Fe(II) and 2-(oxo)glutarate (Fe/2OG)-dependent oxygenase, then inverts the

48 Glutarate gives S-parabolic noncompetitive inhibition ve

49 of dianions from succinate (suc(2-)) through glutarate (glu(2-)), alpha-ketoglutarate (kglu(2-)), adi

50 )), malonate (mal(2-)), succinate (suc(2-)), glutarate (glu(2-)), maleate (male(2-)) and fumarate (fu

51 es in the presence of either pyruvate, 3-oxo-glutarate, glutamate, isocitrate, dihydroorotate, alpha-

52 with this interpretation, an imposed outward glutarate gradient stimulated 2,4-D uptake in the absenc

53 olism of dodecanedioate (DODA), azelate, and glutarate in perfused rat livers, using a combination of

54 In contrast, currents evoked by glutarate in rbNaDC1 were only about 5% of the succinate

55 s tissue in vitro was stimulated by external glutarate in the presence of sodium.

56 sodium gradient but only in the presence of glutarate, indicating the presence of apical dicarboxyla

57 Glutarate is an intermediate of amino acid catabolism an

58 Poly(dimethyltin glutarate) is presented as the first organometallic poly

59 H-preferring, phosphonate mostly affects the glutarate level.

60 ryostatin's A- and B-rings are replaced by a glutarate linker.

61 d to methoxypolyethylene glycol succinimidyl glutarate (MEGC-PEG-5000).

62 e-gauche enantiomeric interconversion of the glutarate moieties.

63 All ligands demonstrate an invariant glutarate moiety within the S1' pocket of the enzyme.

64 bic functions as substituents of a canonical glutarate moiety.

65 ented binding mode in which the putative P1' glutarate occupies the spacious entrance funnel rather t

66 f TM 3-4 from mNaDC1, had a decreased K(0.5)(glutarate) of 4 mM compared with 15 mM in wild-type rbNa

67 or ophthalmic acid (a GSH analog) but not by glutarate or N-acetylcysteine, suggesting that GSH deriv

68 A number of brefeldin A succinates, glutarates, oxidation products, and sulfone derivatives

69 1-expressing oocytes was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a me

70 res of synthetic discrete mass poly(butylene glutarate) (PBG) oligomers of known structure having deg

71 and high yield (0.54 mol mol(-1) glucose) of glutarate production are achieved under fed-batch condit

72 the formation of sodium malonate and sodium glutarate salts resulted by HCl evaporation from dehydra

73 xy HbA modified with bis(3,5-dibromosalicyl)-glutarate showed that cross-linking only occurred betwee

74 sing rat CP tissue, which showed both sodium/glutarate-stimulated 2,4-D (tissue/medium (T/M) approxim

75 Glutarate stimulation was abolished by 5 mM LiCl.

76 e desired homoallylic derivative, a putative glutarate surrogate.

77 in cross-linking studies with disuccinimidyl glutarate this subunit's most reactive neighbor, and (4)

78 ion modes of citrate, acetate, succinate and glutarate to AuNPs is obtained by (13)C and (23)Na solid

79 affected individuals, urine molar ratios of glutarate to its derivatives (3-hydroxyglutarate, glutar

80 le transmembrane helices (TM) participate in glutarate transport, the most important contribution is

81 To identify domains involved in glutarate transport, we constructed a series of chimeric

82 and F, as well as E and G by disuccinimidyl glutarate was obtained, while in the free V(1) domain, c

83 s trans-stimulated in oocytes preloaded with glutarate, whereas the dicarboxylate methylsuccinate, wh