ライフサイエンスコーパス: glutathionylation

1 e to cysteine residues in target proteins (S-glutathionylation).

2 differentiation increased ROS and protein S-glutathionylation.

3 ntracellular GSH:GSSG ratio and cause eNOS S-glutathionylation.

4 otting and the direct determination of total glutathionylation.

5 esults confirm that Grx2 deactivates UCP3 by glutathionylation.

6 ted neutrophils via driving reversible actin glutathionylation.

7 release (CICR) via the IP(3)R is enhanced by glutathionylation.

8 nts pyridine disulfides (PDSs), suggesting S-glutathionylation.

9 in-glutathione (P-SSG) mixed disulfide, i.e. glutathionylation.

10 annel is inhibited in oxidative stress via S-glutathionylation.

11 to post-translational modification through S-glutathionylation.

12 e stress could alter eNOS activity through S-glutathionylation.

13 utathione S-transferase A4 (GSTA4) dependent glutathionylation.

14 ecific reducing agents, which reverse this S-glutathionylation.

15 mass increase [+305.3 Da] consistent with S-glutathionylation.

16 steine-dependent activities are modulated by glutathionylation.

17 as operating as a thiol donor with minimal S-glutathionylation.

18 proximal DNA-binding domain, as the sites of glutathionylation.

19 attached to the E2 subunit, was the site of glutathionylation.

20 quences of alpha-ketoglutarate dehydrogenase glutathionylation.

21 cysteine residue, Cys(90), was involved in S-glutathionylation.

22 get for oxidative inactivation by means of S-glutathionylation.

23 so major sites of both S-nitrosylation and S-glutathionylation.

24 reactive thiol in human MCU that undergoes S-glutathionylation.

25 C91A mutation, presumably by preventing C91 glutathionylation.

26 s, revealed that the channel is activated by glutathionylation.

27 oxin 1 in patch pipette solutions to reverse glutathionylation.

28 the yeast glutathione S-transferase Gtt1p in glutathionylation.

29 r cysteine S-nitrosation, sulfenylation, and glutathionylation.

30 eins, most of which are novel candidates for glutathionylation.

31 yn, were then confirmed to be susceptible to glutathionylation.

32 xidative modification of cysteine known as S-glutathionylation.

33 viding a versatile handle for characterizing glutathionylation.

34 athione, or certain metals, NO can lead to S-glutathionylation, a post-translational modification pot

35 iated proton leak is modulated by reversible glutathionylation, a process responsive to small changes

36 sulfenic acid-dependent switch, leading to S-glutathionylation, a protein modification that protects

37 Protein thiols can undergo S-glutathionylation, a reversible protein modification inv

38 ced hypertension was associated with Sirt3 S-glutathionylation, acetylation of vascular SOD2, and red

39 s of the 19 S regulatory particle, undergo S-glutathionylation after exposure of purified 26 S protea

40 ion, intramolecular disulfide formation, and glutathionylation, allowing accumulation of its substrat

41 r than oxidation to sulfonic acid, such as S-glutathionylation, also decreased aconitase activity, th

42 ound to trigger both GAPDH nitrosylation and glutathionylation, although nitrosylation was widely pro

43 hat eNOS uncoupling can also be induced by S-glutathionylation, although the functional relationships

44 Titin has been identified as a target of S-glutathionylation, an end product of the nitric-oxide-si

45 hese cysteines to alanine leads to a loss in glutathionylation and a concomitant loss in calcium chan

46 The C91A mutation limits MAL glutathionylation and acts as a dominant negative, block

47 ed technique to identify proteins undergoing glutathionylation and apply it to the secretome and the

48 We found that oxidant-induced increased S-glutathionylation and calcium-independent puncta formati

49 ngly suggest that oxidative damage-induced S-glutathionylation and degradation of TK2 have significan

50 We further investigated the mechanism of glutathionylation and demonstrate a role for the yeast g

51 t Glrx knockout mice had increased protein S-glutathionylation and developed obesity by an unknown me

52 In vitro studies have shown that S-glutathionylation and disulfide bonding of titin fragmen

53 ed LysM(iDTR) transgenic mice prevented eNOS glutathionylation and eNOS-derived N(omega)-nitro-L-argi

54 Thus, the decreasing S-glutathionylation and ETA in mitochondrial complex II ar

55 steine residues are identified as sites of S-glutathionylation and found to be critical for redox-reg

56 We measured beta1 subunit glutathionylation and function of Na(+)-K(+)-ATPase in m

57 tions were due, in large part, to reversible glutathionylation and inhibition of the Krebs cycle enzy

58 first enzyme identified to regulate UCP3 by glutathionylation and is the first study on the role of

59 ow evidence for the molecular basis of the S-glutathionylation and its structural impact on channel g

60 Glrx ablation elevated protein S-glutathionylation and lipid content in 3T3L1 cells.

61 ion in MCs requires calcium rise mediated by glutathionylation and membrane translocation of LVDCCs,

62 production, hypoxia caused the ROS-dependent glutathionylation and membrane translocation of the alph

63 d search for protein modifications, cysteine glutathionylation and O-linked glycosylation featured pr

64 increased levels of GSNO caused increased S-glutathionylation and partial dimerization of hBCATc, su

65 Glutathionylation and phosphorylation of SOD1 is omnipre

66 double-mutant C/EBPbeta prevented protein S-glutathionylation and preserved the interaction with PIA

67 eficiency in endothelial cells promoted eNOS glutathionylation and reduced its enzymatic activity, wh

68 lization of the protein S-thiolation forms S-glutathionylation and S-cysteinylation in response to in

69 ase function and 3 Ox-PTM: disulfide bond, S-glutathionylation and S-nitrosation were assessed.

70 thiol groups of cysteine residues undergo S-glutathionylation and S-nitrosylation and form non-nativ

71 O(2)(.-), only XOR inhibition reduced eNOS S-glutathionylation and Ser-1177 phosphorylation and resto

72 eNOS S-glutathionylation and Ser-1177 phosphorylation were sign

73 show that monocyte priming results in the S-glutathionylation and subsequent inactivation and degrad

74 in completely resistant to inactivation by S-glutathionylation, and a mutant expressing this mutation

75 Cys(43) had only a modest contribution to S-glutathionylation, and Cys(120) was modulated by extrace

76 ave been described, including sulfenylation, glutathionylation, and disulfide formation.

77 susceptible to reversible S-nitrosylation, S-glutathionylation, and disulfide oxidation.

78 c mechanism for inhibition of BAK1 by C408 S-glutathionylation, and more generally, support the notio

79 to shift the poise toward E2 species reduced glutathionylation, and ouabain eliminated a ONOO(-)-indu

80 rent redox modifications (S-nitrosylation, S-glutathionylation, and oxidation to disulfides).

81 Cysteine targets for S-palmitoylation, S-glutathionylation, and S-nitrosylation show little corre

82 use post-translational modifications such as glutathionylation are often induced by oxidative stress,

83 ally, support the notion of protein kinase S-glutathionylation as a means of redox signaling in plant

84 lar, we have identified irreversible protein glutathionylation as a process associated with cellular

85 vidence supports the importance of protein S-glutathionylation as a regulatory post-translational mod

86 d, we identified increased endothelial NOS s-glutathionylation as the main mechanism for NOS uncoupli

87 H2O2 induces reversible S-glutathionylation at conserved cysteine residues within

88 thione leads to TRPC5 activation via TRPC5 S-glutathionylation at Cys176/Cys178 residues.

89 Catalysis of S-glutathionylation at low pK cysteines in proteins is a n

90 genes, was posttranslationally modified by S-glutathionylation at this conserved cysteine residue and

91 s actin deglutathionylation, increased actin glutathionylation, attenuated actin polymerization, and

92 ulatory cysteines made them inaccessible for glutathionylation but had no profound effect on the enzy

93 vel findings indicate that increased TRPC5 S-glutathionylation by oxidative stress and decreased TRPC

94 ective and versatile approach to identifying glutathionylation by using a mutant of glutathione synth

95 These effects were reversed using diamide, a glutathionylation catalyst.

96 antiproliferative activity and extents of S-glutathionylation correlated well with levels of intrace

97 in fresh kidney slices, the increased AQP2 S-glutathionylation correlated with tert-butyl hydroperoxi

98 that a frequent GSTO1-1 polymorphism affects glutathionylation cycle reactions reveals a common mecha

99 rase GSTO1-1 plays a significant role in the glutathionylation cycle.

100 Similar to sulfenylation, we observe glutathionylation decouples BiP ATPase and peptide bindi

101 Protein S-glutathionylation decreased the interaction of C/EBPbeta

102 We have examined whether glutathionylation depends on the conformational changes

103 that susceptibility of the beta1 subunit to glutathionylation depends on the conformational poise of

104 Susceptibility of the beta1 subunit to glutathionylation depends on the conformational poise of

105 low methods demonstrated that although actin glutathionylation did not significantly alter the rate c

106 peroxide scavenger ebselen, reduced Sirt3 S-glutathionylation, diminished SOD2 acetylation, and redu

107 tion was associated with increased complex I glutathionylation diminishing its activity.

108 redox protein, is shown to rescue eNOS from glutathionylation during ischemia-reperfusion in a GSH-i

109 We show glutathionylation enhances cell proliferation during oxi

110 , thus confirming the protective effect of S-glutathionylation from the oxidative damage of nitration

111 ) is a small cytosolic enzyme that removes S-glutathionylation, glutathione adducts of protein cystei

112 nstrate the physiological relevance of the S-glutathionylation-GRX redox module in controlling the ma

113 Glutathionylation has emerged as a key modification requ

114 es of redox-state-dependent protein kinase S-glutathionylation have fueled discussion of redox-sensit

115 is treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cycle

116 Loss of SDHA glutathionylation impairs ETC II activity, thereby inhib

117 ) leukocytes and up-regulated levels of eNOS glutathionylation in aortas of C57BL/6 mice.

118 er WT or mutant eNOS rendered resistant to S-glutathionylation in cells with Tet-regulated expression

119 Ouabain further reduced glutathionylation in E2 and eliminated an increase seen

120 We show that eNOS S-glutathionylation in endothelial cells, with loss of NO

121 r the first time that AQP2 is subjected to S-glutathionylation in kidney and in HEK-293 cells stably

122 ass spectrometry revealed that C91 undergoes glutathionylation in macrophages activated with the TLR4

123 Preventing MKP-1 S-glutathionylation in metabolically stressed monocytes by

124 ostasis in mice, and we identify basal TAZ S-glutathionylation in murine kidney lysates, which is ele

125 Signals for glutathionylation in Na(+)-K(+)-ATPase-enriched membrane

126 utaredoxin and ROS- induced reversible actin glutathionylation in regulation of actin dynamics in neu

127 SG formation and, consequently, ATP synthase glutathionylation in response to H(2)O(2) challenges.

128 Protein glutathionylation in response to oxidative stress can af

129 le posttranslational modification, namely, S-glutathionylation in stressed states, including DNA dama

130 Diabetes promotes the S-glutathionylation, inactivation and subsequent degradati

131 Furthermore, the extent of S-glutathionylation increased in response to oxidative str

132 iously published experimental evidence for S-glutathionylation induced deactivation of the Arabidopsi

133 To address a possible role for BH4 in S-glutathionylation-induced eNOS uncoupling, we expressed

134 he first evidence that BH4 deficiency- and S-glutathionylation-induced mechanisms of eNOS uncoupling,

135 Glutathionylation involves reversible protein cysteine m

136 ent a novel mechanism for peptide or protein glutathionylation involving a carbon-sulfur cross-link b

137 We conclude that Prx2 glutathionylation is a favorable reaction that can occur

138 Protein S-glutathionylation is a posttranslational modification th

139 S-Glutathionylation is a redox-dependent post-translationa

140 Protein S-glutathionylation is a reversible redox-dependent post-t

141 These results suggest that S-glutathionylation is an important mechanism for the vasc

142 Because protein glutathionylation is associated with redox regulation, o

143 We further demonstrate that TAZ S-glutathionylation is critical for reactive oxygen specie

144 In hypertensive vessels, eNOS S-glutathionylation is increased with impaired endothelium

145 However, whether or not UCP3 glutathionylation is mediated enzymatically has remained

146 The relationship between AQP2 and S-glutathionylation is of potential interest because react

147 ROS levels, we resolved to determine whether glutathionylation is required for UCP2 regulation of GSI

148 ues by disulfide formation with glutathione (glutathionylation) is a reversible posttranslational mod

149 GSTO1-1 resulted in a 50% reduction in total glutathionylation levels.

150 sed aconitase activity, thus indicating that glutathionylation may be an important means of modulatin

151 These results suggest that actin glutathionylation may play a limited but defined role in

152 We hypothesized that actin glutathionylation may play a role in the multifactorial

153 However, it is unknown how S-glutathionylation may regulate the elasticity of titin a

154 Ca(2+), i.e. enhanced CICR, and suggest that glutathionylation may represent a fundamental mechanism

155 ion model in vivo This study suggests that S-glutathionylation may represent a mechanism by which CDC

156 sed CFTR function by oxidative modification (glutathionylation) may now be explained by high concentr

157 inactivated hBCATm, neither S-nitrosation, S-glutathionylation, nor dimerization could be detected, s

158 tic islets, we demonstrate that induction of glutathionylation not only deactivates UCP2-mediated pro

159 of conformation-dependent beta1 pump subunit glutathionylation, not restricted subsarcolemmal diffusi

160 he ratio of GSH:GSSG decreased significant S-glutathionylation occurred (with a further loss of 20% B

161 Post-translational S-glutathionylation occurs through the reversible addition

162 Under oxidative stress, S-glutathionylation occurs through thiol-disulphide exchan

163 H) to PRDX2 cysteine residues (i.e., protein glutathionylation) occurs before or during PRDX2 release

164 and GST pi harboring bound GSH, followed by glutathionylation of 1-Cys Prx and then formation of an

165 Rapid glutathionylation of 1-Cys Prx in the heterodimer is det

166 lutathione (GSSG), induce isoform-specific S-glutathionylation of 6-phosphofructo-2-kinase/fructose-2

167 However, S-glutathionylation of ACS2 and ACS6 proteins was not dete

168 hondria with hydrogen peroxide resulted in S-glutathionylation of added recombinant TK2.

169 Glutathionylation of alpha-ketoglutarate dehydrogenase c

170 Glutathionylation of alpha-ketoglutarate dehydrogenase p

171 rotective mechanism against overoxidation, S-glutathionylation of AtGAPC1 triggers an unexpected aggr

172 S-glutathionylation of ATP synthase alpha subunit occurred

173 ion and adipogenesis via increased protein S-glutathionylation of C/EBPbeta, stabilizing and increasi

174 s throughout the BAK1 kinase domain, whereas glutathionylation of C353 in the N-lobe and C374 near th

175 We found that glutathionylation of C408 allosterically destabilizes th

176 Glutathionylation of C408 also has structural consequenc

177 ll, MAL is not disulfide-bonded and requires glutathionylation of C91 for signaling.

178 these improvements to a downregulation of S-glutathionylation of cardiac myosin binding protein-C in

179 at this was associated with an increase in S-glutathionylation of cell proteins, particularly actin.

180 induced substantially increased levels of S-glutathionylation of cellular proteins in comparison wit

181 nd that GSTO1-1 is associated with the rapid glutathionylation of cellular proteins when the cells ar

182 f reactive oxygen species, carbonylation and glutathionylation of cellular proteins, inhibition of IK

183 To gain further insights into protein S-glutathionylation of complex I, we used two peptides of

184 S-glutathionylation of cryptic cysteines greatly decreases

185 Furthermore, we demonstrate that S-glutathionylation of cryptic cysteines in titin mediates

186 s spectrometry analysis identified protein S-glutathionylation of Cys201 and Cys296 in the LIP region

187 ontent (Fas-SH) and resultant increases in S-glutathionylation of Cys294, leading to increases of sur

188 Glutathionylation of cysteine 46 of the beta1 subunit of

189 Numerous studies of S-glutathionylation of cysteine thiols indicate that this

190 141 at the dimer interface of p53 and showed glutathionylation of either residue would inhibit p53-DN

191 ndogenous TNT-active GSTs catalyse excessive glutathionylation of endogenous substrates, depleting gl

192 Thus, S-glutathionylation of eNOS is a pivotal switch providing

193 Here we show that S-glutathionylation of eNOS reversibly decreases NOS activ

194 We reveal that S-glutathionylation of eNOS, by exposure to either 1,3-bis

195 d (FasL)-induced apoptosis is augmented by S-glutathionylation of Fas (Fas-SSG), which can be reverse

196 versely, overexpression of Grx1 attenuates S-glutathionylation of Fas and partially protects against

197 stimulation with Fas ligand (FasL) induces S-glutathionylation of Fas at cysteine 294 independently o

198 These results suggest that S-glutathionylation of Fas within the lung epithelium enha

199 ased FasL-induced oxidative processing and S-glutathionylation of Fas, resulting in decreased death-i

200 d interactions between Fas-ERp57-GSTP1 and S-glutathionylation of Fas.

201 S-glutathionylation of IKK-beta Cys-179 is reversed by glu

202 centrations of NAC and mito-Q instead caused glutathionylation of IKKalpha, thereby inhibiting its ac

203 The glutathionylation of intracellular protein thiols can pr

204 Glutathionylation of intracellular proteins is an establ

205 s primed to form insoluble aggregates by the glutathionylation of its catalytic cysteine (Cys149).

206 levels and high GSSG levels and significant glutathionylation of mitochondrial proteins as well as b

207 Glutathionylation of mitochondrial proteins is a major c

208 Metabolic stress promoted the S-glutathionylation of MKP-1, targeting MKP-1 for proteaso

209 ncreased myofilament response to Ca(2+) with glutathionylation of myosin binding protein C.

210 Lastly, biochemical studies showed that glutathionylation of native IP(3)R(1) is increased in ce

211 The results indicate that GRx-dependent S-glutathionylation of p65-NFkappaB is most likely respons

212 Thus, it appears that S-glutathionylation of PDI is an upstream signaling event

213 Circular dichroism confirmed that S-glutathionylation of PDI results in alterations in the a

214 was undetectable, PABA/NO treatment caused S-glutathionylation of PDI.

215 Reversible S-glutathionylation of proteins is a focal point of redox

216 S-Glutathionylation of proteins is critical to cellular st

217 and in the case of 13 inducing cross-linking glutathionylation of proteins.

218 However, glutathionylation of Prx V, not known to bind to Srx, wa

219 ROS exerts its effect through glutathionylation of PTEN (phosphatase and tensin homolo

220 Furthermore, in vitro S-glutathionylation of purified SQR resulted in enhanced S

221 Glutathionylation of reactive cysteines represents an ox

222 These findings identify S-glutathionylation of Rpn2 as a contributory mechanism fo

223 t, increased oxidative stress results in the glutathionylation of sarcomeric actin.

224 d enhanced ER Ca(2+) uptake, likely due to S-glutathionylation of SERCA pumps.

225 ecreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in an increase in

226 ne synthesis is impaired, leading to reduced glutathionylation of succinate dehydrogenase A (SDHA), a

227 o increased protein expression and protein S-glutathionylation of the adipogenic transcription factor

228 Regulatory S-glutathionylation of the alpha subunit was induced in ra

229 oxidative modification of AMPK, including S-glutathionylation of the AMPKalpha and AMPKbeta subunits

230 O(2)-treated HEK 293 cells, activation and S-glutathionylation of the AMPKalpha subunit were present

231 urrents might be accounted for by changes in glutathionylation of the beta1 Na(+)-K(+) pump subunit,

232 have explored the possible involvement of S-glutathionylation of the catalytic alpha subunit in redo

233 Our findings imply that regulatory S-glutathionylation of the catalytic subunit plays a key r

234 oxygen species, along with carbonylation and glutathionylation of the cellular proteins.

235 The enzyme inhibition concurred with S-glutathionylation of the Cys-454, -458, -459, and -244.

236 We recently demonstrated that S-glutathionylation of the death receptor Fas (Fas-SSG) am

237 Camalexin biosynthesis involves glutathionylation of the intermediary indole-3-cyanohydr

238 quires glutaredoxin 2-dependent reversible S-glutathionylation of the NAD(+)-dependent protein deacet

239 ubunit) were extensively glutathionylated; S-glutathionylation of these proteins resulted in a substa

240 eatments with redox active drugs, relative S-glutathionylation of these serpins was higher in plasma

241 ons support a role of Grx6 in regulating the glutathionylation of thiols of endoplasmic reticulum/Gol

242 ddition of dithiothreitol, suggesting that S-glutathionylation of TK2 is reversible.

243 K2 activity and protein levels, as well as S-glutathionylation of TK2.

244 We also observed S-glutathionylation of Trx1 and localized that redox modif

245 in intracellular nitric oxide that caused S-glutathionylation of various proteins.

246 S-Glutathionylation on Cys-189 was responsible for the obs

247 S-Glutathionylation on Cys47 and Cys101 autoregulates GSTp

248 ding did not suggest a large impact of actin glutathionylation on the binding to myosin-S1.

249 BAK1), we investigated the consequences of S-glutathionylation on the equilibrium conformational ense

250 cies-regulated effects on polymerization and glutathionylation on the one hand and the Grx1-mediated

251 s expressing T338C CFTR to CuCl2, but not by glutathionylation or nitrosylation of the thiol or by ox

252 We propose that uncoupling of eNOS by S-glutathionylation- or by BH4-dependent mechanisms exempl

253 the isolated SQR was subjected to in vitro S-glutathionylation, oxidative modification and impairment

254 The identification of novel targets of glutathionylation, particularly in the secretome where t

255 PTP1B is known to be regulated by oxidation, glutathionylation, phosphorylation, and SUMOlyation, and

256 Reversible glutathionylation plays a critical role in protecting pr

257 Reversible protein glutathionylation plays a key role in cellular regulatio

258 ated with redox regulation, our finding that glutathionylation promotes SOD1 monomer formation suppor

259 Cysteine 111 glutathionylation promotes SOD1 monomer formation, a nec

260 anslational modification of SOD1, especially glutathionylation, promotes dimer dissociation.

261 Here the intrinsic protein S-glutathionylation (PrSSG) at the 70-kDa FAD-binding subu

262 Protein S-glutathionylation (PSSG) is a posttranslational modifica

263 Our findings suggest that NOS s-glutathionylation, rather than BH4 depletion, accounts f

264 Our results show that GSTpi potentiates S-glutathionylation reactions following oxidative and nitr

265 kinetics of both the deglutathionylation and glutathionylation reactions.

266 and it also mediates GS transfer (protein S-glutathionylation) reactions, where GS (*) serves as a s

267 e functional relationships between BH4 and S-glutathionylation remain unknown.

268 rotein disulfide isomerase and catalyst of S-glutathionylation, respectively, in the ER.

269 s to functional inactivation of caspase 8 by glutathionylation, resulting in necroptosis, which occur

270 -N124K) had a significant decrease in AQP2 S-glutathionylation secondary to reduced ROS levels and re

271 d 5 mol/mol, respectively, and at least four glutathionylation sites were identified in the GS-DSDO-t

272 lfide formation, S-nitrosylation (SNO) and S-glutathionylation (SSG), have been recognized for their

273 Recently, we showed that the glutathionylation state of uncoupling protein-3 (UCP3) m

274 l agents, such as diamide, to alter the UCP3 glutathionylation state.

275 Collectively, our findings indicate that the glutathionylation status of UCP2 contributes to the regu

276 Consistent with S-glutathionylation, streptavidin pull-down assays with bi

277 Simulation modeling of Kir6.1 S-glutathionylation suggested that after incorporation to

278 human APE1 as the critical residue for the S-glutathionylation that leads to reduced AP endonuclease

279 roteins to form glutathione (GSH) adducts, S-glutathionylation, that are selectively removed by gluta

280 not the homomeric Kir4.1 is subject to the S-glutathionylation thus suggests a novel Kir4.1-Kir5.1 ch

281 Here we show that Kir5.1 also enables S-glutathionylation to the heteromeric channel.

282 These results link S-glutathionylation to vertebrate development and successf

283 This finding of a S-glutathionylation-to-S-cysteinylation switch in a condit

284 -transferase proteins and enhanced protein S-glutathionylation, uncovering a previously unexplored va

285 endogenous GRx1, which also promotes protein glutathionylation under hypoxic radical generating condi

286 Here, we demonstrated that S-glutathionylation was a modulation mechanism underlying

287 Increase in S-glutathionylation was associated with dose- and time-dep

288 h an antibody against glutathione, protein S-glutathionylation was enhanced in post-ischemic myocardi

289 S-Glutathionylation was followed by suppression of the Na,

290 Glutathionylation was reversed by glutaredoxin 1 (Grx1),

291 To facilitate the study of protein S-glutathionylation, we developed a synthesis and purifica

292 Increased levels of endogenous TRPC5 S-glutathionylation were observed in the striatum in both

293 sulfhydryls that had undergone H2O2 mediated glutathionylation were specifically derivatized with N-e

294 ne with either disulfide bond formation or S-glutathionylation, which induces eNOS uncoupling.

295 ified the ACO1 protein to be a subject for S-glutathionylation, which is consistent with our in silic

296 duces ROS elevation and, subsequently, TAZ S-glutathionylation, which promotes TAZ-mediated target ge

297 e TM2 helix of Kir5.1 was critical for the S-glutathionylation, which was accessible to intracellular

298 Reversing NOS s-glutathionylation with dithiothreitol (100 mumol/L) comp

299 ormational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformati

300 residues via sequential sulfenylation and S-glutathionylation within EGFR and the non-receptor-tyros