ライフサイエンスコーパス: glycerate

1 ry metabolites l-serine and 1,3-bisphospho-d-glycerate.

2 elevated urinary excretion of oxalate and L-glycerate.

3 ts for the substrates and the activator, 3-P-glycerate.

4 amic acid mutant enzyme was inhibited by 3-P-glycerate.

5 chemistry was assessed by using [14C-methyl]glycerate.

6 ereas PLGG1 alone accounts for the import of glycerate.

7 at position 382 influence the binding of 3-P-glycerate.

8 idues are not involved in the binding of 3-P-glycerate.

9 Six PDI-related metabolites (glycerate, 1,5-anhydroglucitol, gamma-glutamylalanine, g

10 ant enzymes with apparent affinities for 3-P-glycerate 10-160-fold lower than that of the wild-type e

11 and in vivo application of sodium [1-(13)C]-glycerate ([(13)C]-Glyc) as a novel probe for evaluating

12 of yeast enolase with substrate, 2-phospho-D-glycerate (2-PGA), and product, phosphoenolpyruvate (P-e

13 These include the racemization of glycerate, 2-hydroxybutyrate, 2,4-dihydroxybutyrate, 2-h

14 Members of a novel glycerate-2-kinase (GK-II) family were tentatively ident

15 midodiphosphate (Mg-AMP-PNP) and 3-phospho-D-glycerate (3-PG) has been determined by X-ray crystallog

16 starting with methyl 2,3-O-isopropylidene-d-glycerate (4) and D-ribo-phytosphingosine (3), respectiv

17 haelis constants (K(m)) for both 3-phospho-D-glycerate and ATP are increased only by three or fourfol

18 bolism as well as mineral nutrition and that glycerate and glutamine are the main metabolites respond

19 catalyzes the interconversion of 2-phospho-D-glycerate and phosphoenolpyruvate.

20 e formation of proteins and metabolites with glycerate and phosphoglycerate modifications on amino gr

21 atalyzed the NAD(+)-dependent oxidation of d-glycerate and the NADH-dependent reduction of tartronate

22 bolism, as well as decreases in pyruvate and glycerate as CodY activity decreased.

23 , CoMn-S spheres were synthesized using CoMn-glycerate as the precursor, followed by a sulfidation re

24 The sensing outcomes revealed that glycerate-assisted CoMn-S spheres have impressive electr

25 The performance characteristics of the glycerate-assisted CoMn-S spheres were compared with CoM

26 zed using an ion-exchange process to prepare glycerate-assisted CoMn-S spheres with many nanoparticle

27 , producing an operon clearly designed for d-glycerate biosynthesis from tartronate semialdehyde.

28 exchange of the alpha-proton of 2-phospho-D-glycerate but not the complete dehydration, was assayed

29 atalyzed the NAD(+)-dependent oxidation of d-glycerate but was significantly more efficient in the ox

30 sphosphate carboxylase [Rubisco; 3-phospho-D-glycerate carboxy-lyase (dimerizing), EC 4.1.1.39].

31 The reduction of hydroxypyruvate to glycerate catalyzed by hydroxypyruvate reductase (HPR) i

32 ruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.

33 The glycerate-derived design provides an efficient and effec

34 achment, and intramolecular cyclization of a glycerate-derived three-carbon unit, which forms the cor

35 but forms pyruvate, rather than 3-phospho-D-glycerate, due to incapacity in protonation of the termi

36 rom inactivation most effectively, while 3-P-glycerate, fructose-1,6-P2, pyridoxal-P, and ATP plus ma

37 yed in the dehydration reaction (2-phospho-D-glycerate --> phosphoenolpyruvate + H(2)O) at different

38 (i.e. glycine not part of the production of glycerate in support of photosynthesis) is either fully

39 the progressive identification of acetyl-(R)-glycerate (k(cat)/K(m) = 4 x 10(2) M(-1) s(-1)), acetyl

40 allelic differences in 5 core genes encoding glycerate kinase (glxK), valine-pyruvate transaminase (a

41 gckA and ttuD might be structural genes for glycerate kinase and that the serine cycle and the tartr

42 gene (gckA) responsible for the activity of glycerate kinase has been identified within a chromosoma

43 Mn.ATP bound to the active site of yeast 3-P-glycerate kinase is presented.

44 dolase, tartronate semialdehyde reductase, a glycerate kinase that generates 2-phosphoglycerate as pr

45 (HCO(2)(-)) by 1,2-hydroxyl-functionalized l-glycerate (l-gly, l-HOCH(2)(HO)CHCO(2)(-)) was investiga

46 The mutant accumulates glycolate and glycerate, leading to the hypothesis that PLGG1 is a gly

47 t reactions in the mitochondrion that supply glycerate may support TAG synthesis.

48 e is transferred from the enzyme back to the glycerate moiety.

49 o glycolate molecules with the import of one glycerate molecule during photorespiration.

50 The apparent affinity for 3-P-glycerate of this double-mutant enzyme was 104-fold lowe

51 ome members showing high specificity towards glycerate or 2-hydroxybutyrate.

52 s bacterium, and instead, the bacterial-like glycerate pathway is the main route for phosphoglycolate

53 Upon disruption of the glycerate pathway, we find that an oxidative pathway, wh

54 ncoding the enzymes of the d-glucarate and d-glycerate pathways (gudT, gudD, garR, garL, garK) are si

55 hat catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to form phosphoenolpyruvate (PEP), is a

56 group of the substrate/product, 2-phospho-D-glycerate/phosphoenolpyruvate, and induces binding of th

57 phosphate, in the absence or presence of 3-P-glycerate, respectively.

58 First, glycerate spheres were prepared by solvothermal treatmen

59 osphate in the absence of the activator, 3-P-glycerate, than that of the wild-type enzyme.

60 sphorylase is involved in the binding of 3-P-glycerate, the allosteric activator.

61 alyzes the reduction of hydroxypyruvate to D-glycerate, the reduction of glyoxylate to glycolate and

62 then transformed through hydroxypyruvate and glycerate to enter central metabolism at phosphoglycerat

63 yoxylate to glycolate and the oxidation of D-glycerate to hydroxypyruvate.

64 to the O2 or O3 positions of the reoriented glycerate to yield the PGA product.

65 talyzes the conversion of hydroxypyruvate to glycerate together with the oxidation of a pyridine nucl

66 analyses, we identified Plastidal glycolate glycerate translocator 1 (PLGG1) as a candidate core pho

67 nockout line of both BASS6 and the glycolate/glycerate transporter PLGG1 (bass6, plgg1) showed an add

68 that PLGG1 is the chloroplastidic glycolate/glycerate transporter, which is required for the functio

69 to the hypothesis that PLGG1 is a glycolate/glycerate transporter.

70 ays that lead to GK-II-driven utilization of glycerate via a glycolysis/gluconeogenesis route.

71 M1401, respectively), that convert serine to glycerate via hydroxypyruvate.

72 Then, CoMn-glycerate was solvothermally sulfidized using an ion-exc

73 uses CTP and phosphoglycerate to produce CDP-glycerate, which we hypothesize is the phosphoglycerate

74 he exchange of the C-2 proton of 2-phospho-D-glycerate with deuterium in D2O, whereas both the E211Q