ライフサイエンスコーパス: glycolate

1 h as dihydroxyacetone phosphate, malate, and glycolate.

2 ted against the interleukin-2 receptor, with glycolate.

3 late reductase 1 that converts glyoxylate to glycolate.

4 s accompanied with lesser ability to process glycolate.

5 photorespiratory intermediates, glycine and glycolate.

6 way evolved to prevent accumulation of toxic glycolate.

7 Low concentrations of glycolate (12-48 nmol/g) and PG (4-17 nmol/g) were detec

8 mediate stage in method development, 1 pg of glycolate-2,2,-d(2) could be detected by subjecting it t

9 ing the following sequence of steps: (1) add glycolate-2,2-d(2) as an internal standard and exchange

10 The pathway recycles glycolate-2-phosphate, the most abundant byproduct of Ru

11 analytes for oxidative sugar damage to DNA: glycolate, 3-hydroxy-2-butanone, 3-phenylbutyraldehyde,

12 glycolate levels were 12 times, and urinary glycolate 6 times, the upper limit of normal observed in

13 s with a complex composition [Zn(12)(tdc)(6)(glycolate)(6)(dabco)(3)] where glycolate is a deprotonat

14 e inhibitor also caused the cells to excrete glycolate, a photorespiratory intermediate, but did not

15 ed an additive growth defect, an increase in glycolate accumulation, and reductions in photosynthetic

16 ochemical outcome of the Lewis acid-mediated glycolate addition of the titanium enolates from protect

17 carboxylic acids derived from the asymmetric glycolate aldol addition reaction with p-nitrobenzenesul

18 iated oxazolidine-2-thione-guided asymmetric glycolate aldol addition reaction.

19 ct with enolates and enones to afford either glycolate aldol or Michael adducts.

20 es, arylboronic acids, and aldehydes to give glycolate aldol products.

21 A glycolate aldol reaction provided a diene useful for rin

22 ropyran, a dinuclear Zn-catalyzed asymmetric glycolate aldol reaction to prepare the syn 1,2-diol, an

23 include the use of two new asymmetric boron glycolate aldol reactions.

24 low for the preparation of cross-benzoin and glycolate-aldol products in high yield and with exceptio

25 a novel asymmetric phase-transfer-catalyzed glycolate alkylation reaction.

26 c decision to rely heavily on the asymmetric glycolate alkylation to construct both the C1-C14 fragme

27 arpless kinetic resolution and an asymmetric glycolate alkylation to establish the stereogenic center

28 Asymmetric glycolate alkylation using a protected acetophenone surr

29 oxypropionic acid 26 that was made using PTC glycolate alkylation.

30 n hydrogen/deuterium isotope effect and that glycolate alpha-deprotonation itself was only partially

31 We found that exogenous glycolate also rescued photoheterotrophic growth of CT01

32 erevisiae Tdp1, catalyzed similar removal of glycolate, although less efficiently than removal of tyr

33 Glycolate and 2-phosphoglycolate (PG) are 2-carbon monoc

34 Labeling cells with 14C-glycolate and chromatographic analyses indicated that de

35 latter results in the ubiquitous metabolites glycolate and glucosamine 6-phosphate.

36 The mutant accumulates glycolate and glycerate, leading to the hypothesis that

37 is paper reports an additional pathway for P-glycolate and glycolate metabolism in the chloroplasts.

38 It is a key player in plant glycolate and glyoxylate accumulation pathways.

39 ultimately prove to be useful for decreasing glycolate and glyoxylate levels in primary hyperoxaluria

40 Glycolate and P-glycolate were oxidized about equally we

41 s spectrometry (IC-MS) to quantify levels of glycolate and PG in tissue.

42 s of the origin, function, and metabolism of glycolate and PG in tissues.

43 ation is essential for the detoxification of glycolate and recycling of carbon to the Calvin Benson B

44 ylase, increased accumulation of glycine and glycolate and reduced levels of sucrose.

45 1)H chemical shifts of our reporter ligands, glycolate and sulfoacetate, and is easily implemented us

46 D-glycerate, the reduction of glyoxylate to glycolate and the oxidation of D-glycerate to hydroxypyr

47 The plasma concentration of glycolate and the urinary excretion of oxalate, the majo

48 ansporting copolymers with varying ratios of glycolated and alkylated repeat units.

49 constant for capture of glycolate (k(cat)/K(glycolate)) and the K(d)((app)) for the formation of the

50 ry pathway intermediates 2-phosphoglycolate, glycolate, and glycine, suggest that the deregulation of

51 Isotopic enrichments of plasma oxalate, glycolate, and glyoxylate were measured on a gas chromat

52 rk in roots with C(1) units originating from glycolate, and that these units are then used mainly for

53 e unstable 3,3-difluorocyclopropenylcarbinyl glycolates arising from the difluorocyclopropenation.

54 nce in glycolate using natural or deuterated glycolate as a substrate.

55 shed thylakoids from spinach leaves oxidized glycolate at a rate of 22 mol per mg of chlorophyll per

56 is most active on the two-carbon substrate, glycolate, but is also active on 2-hydroxy fatty acids.

57 nnosamine and N-glycolylglucosamine (but not glycolate) can serve as precursors for biosynthesis of e

58 e involvement of only one oxygen atom of the glycolate carboxylate and the product DDP tetrahedral ph

59 The ability of glycolate, CO2, or DMSO to support photoheterotrophic gr

60 Method precision was good for oxalate and glycolate (coefficients of variation [CV] were <6.3% and

61 Versus inactive Y6 and Y11, all of the new glycolated compounds exhibit mixed ion-electron transpor

62 concentrations and markedly elevated plasma glycolate concentrations (> or =97.7 mg per deciliter [1

63 l injury during treatment; all 10 had plasma glycolate concentrations at or below 76.8 mg per decilit

64 carbon cycle in the ocean where significant glycolate concentrations have been found.

65 ALN-GO1 also increased urinary glycolate concentrations in normal nonhuman primates and

66 coding glycolate oxidase and increased serum glycolate concentrations in wild-type mice, rats, and no

67 However, heavily glycolated conjugated polymer films have been observed t

68 For example, background contamination by glycolate could increase rather than decrease when the m

69 metabolic pathway, we developed an indirect glycolate cytotoxicity assay in a 1,536-well plate forma

70 ed levels of RNA for genes encoding putative glycolate degradation functions.

71 ion, (ii.) glycolate excretion together with glycolate dehydrogenase down-regulation prevents the tox

72 Particularly, the pivaloyl protected glycolate derivative provides the reluctant anti adducts

73 wide array of beta-stereogenic tertiary aryl glycolate derivatives with high levels of diastereo- and

74 de catalyst is effective for the addition of glycolate-derived silyl ketene acetals to aldehydes.

75 ified." The work extends the sensitivity for glycolate detection by approximately 100-fold and provid

76 SHAM stimulated severalfold glycolate excretion by algal cells, Dunaliella or Chlamy

77 By monitoring growth and glycolate excretion in mutants deficient in either CCM o

78 n does not depend on photorespiration, (ii.) glycolate excretion together with glycolate dehydrogenas

79 ata indicate that BASS6 and PLGG1 partner in glycolate export from the chloroplast, whereas PLGG1 alo

80 nthetic pathways was maximized by inhibiting glycolate export from the chloroplast.

81 ways into crop chloroplasts while inhibiting glycolate export into the native pathway can drive incre

82 ribution, pharmacokinetics and catabolism of glycolated Fab (glyco-Fab) were evaluated at two differe

83 with various numbers of glycolate molecules [glycolated Fab fragments (glyco-Fabs)] and separated the

84 required in C(3) plants to metabolize toxic glycolate formed when ribulose-1,5-bisphosphate carboxyl

85 nvolvement in the photorespiratory export of glycolate from Arabidopsis chloroplasts.

86 n the presence of EDTA, catalyzed removal of glycolate from phosphoglycolate at a single-stranded 3'

87 Tdp1 has also been shown to remove glycolate from single-stranded DNA containing a 3'-phosp

88 ase activities together with accumulation of glycolate further implied that SHR deficiency impacts th

89 expression analyses, we identified Plastidal glycolate glycerate translocator 1 (PLGG1) as a candidat

90 s double knockout line of both BASS6 and the glycolate/glycerate transporter PLGG1 (bass6, plgg1) sho

91 s indicate that PLGG1 is the chloroplastidic glycolate/glycerate transporter, which is required for t

92 e, leading to the hypothesis that PLGG1 is a glycolate/glycerate transporter.

93 The kinetic parameters for the oxidation of glycolate, glyoxylate, and 2-hydroxy octanoate indicate

94 LO genes and characterizing other members of glycolate/glyoxylate biosynthesis pathway in various pla

95 P-glycolate has been considered to be metabolized exclusiv

96 Incubation of these cells with glycolate has revealed that a pathway may function to sy

97 ine, creatine, creatinine, formate, glycine, glycolate, histidine, 2-hydroxybutyrate, lysine, threoni

98 icle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by el

99 ion protocol of (13)C(2)-oxalate and 1-(13)C-glycolate in both healthy individuals and PH patients.

100 isotope effects using natural and deuterated glycolate in either natural or deuterated solvent.

101 examines pathways of oxalate synthesis from glycolate in Hep G2 cells, a human hepatoma cell line.

102 te, succinate and tartrate by irradiation of glycolate in the presence of sulfite was also revealed.

103 ccompanied with the depletion of formate and glycolate, in roots of the transgenic Arabidopsis plants

104 uses l-lactate with a similar efficiency to glycolate; in contrast, the photorespiratory isoforms GO

105 d to identify compounds that reduce indirect glycolate-induced cytotoxicity by either enhancing AGT a

106 safety and antiviral effects of polyethylene glycolated interleukin-2 (PEG-IL-2) and thymosin alpha 1

107 eing produced during a complete oxidation of glycolate into CO(2) catalyzed by three rice-self-origin

108 n glycine revealed significant conversion of glycolate into glycine in pyridoxine responsive, but not

109 n(12)(tdc)(6)(glycolate)(6)(dabco)(3)] where glycolate is a deprotonated polyatomic alcohol (ethylene

110 which accepts electrons from glycolate or P-glycolate is a quinone after the DCMU site but before th

111 in which X(-) is a sacrificial anion such as glycolate, isethionate, or nitrate.

112 he second-order rate constant for capture of glycolate (k(cat)/K(glycolate)) and the K(d)((app)) for

113 k(cat)/K(m) = 4 x 10(2) M(-1) s(-1)), acetyl glycolate (k(cat)/K(m) = 1.3 x 10(4) M(-1) s(-1)), and u

114 hree polar residues for interaction with the glycolate leaving group.

115 Her plasma glycolate levels were 12 times, and urinary glycolate 6

116 logue of the existing {Pd84 }(Ac) wheel with glycolate ligands, {Pd84 }(Gly) , and the next in a magi

117 m high CO2 to air in light, they accumulated glycolate linearly for 6 h to levels 7-fold higher than

118 se results show that engineering alternative glycolate metabolic pathways into crop chloroplasts whil

119 nstalled into tobacco chloroplasts synthetic glycolate metabolic pathways that are thought to be more

120 leading us to propose that CO2 produced from glycolate metabolism can be used by the Calvin cycle to

121 ts an additional pathway for P-glycolate and glycolate metabolism in the chloroplasts.

122 A detailed examination of glycolate metabolism in these cells should help clarify

123 H16) by characterizing the proxy process of glycolate metabolism, performing comparative transcripto

124 Antibacterial assays revealed this simple glycolate modification enhanced inhibition 4-8-fold rela

125 One 2-phosphoglycolate (P-glycolate) molecule is produced for each O2 molecule fix

126 ti-Tac Fab fragments with various numbers of glycolate molecules [glycolated Fab fragments (glyco-Fab

127 nd PLGG1 therefore balance the export of two glycolate molecules with the import of one glycerate mol

128 e possible site which accepts electrons from glycolate or P-glycolate is a quinone after the DCMU sit

129 Light-dependent glycolate or P-glycolate oxidation by osmotically shocke

130 A replaced the N-terminal 43 amino acids of glycolate oxidase (a peroxisomal protein) was affinity p

131 Glycolate oxidase (GLO) is an FMN-containing enzyme loca

132 nctioning independently from NADPH oxidases, glycolate oxidase (GLO) was recently demonstrated as an

133 rotein, and the leaf-type peroxisomal enzyme glycolate oxidase (GLO) were transported into pumpkin (C

134 Glycolate oxidase (GO) and alanine:glyoxylate aminotrans

135 Human glycolate oxidase (GO) catalyzes the FMN-dependent oxida

136 wed further clustering into two groups i.e., glycolate oxidase (GOX) and hydroxyacid oxidase (HAOX).

137 characterized family members, e.g., spinach glycolate oxidase (GOX) and the electron transferases ye

138 miana, and identified the peroxisomal enzyme glycolate oxidase (GOX) as an essential component of non

139 zed members of this protein family including glycolate oxidase (GOX) from spinach.

140 As an exception, glycolate oxidase (GOX) mutants with a photorespiratory

141 Here, we identify the Arabidopsis glycolate oxidase (GOX) paralogs GOX1, GOX2, and GOX3 as

142 -residue segment from its soluble homologue, glycolate oxidase (GOX).

143 al trial data suggested she has <2% residual glycolate oxidase activity.

144 Decreased glycolate oxidase and catalase activities together with

145 tructural studies of two homologous enzymes, glycolate oxidase and flavocytochrome b(2), indicated th

146 , and durable silencing of the mRNA encoding glycolate oxidase and increased serum glycolate concentr

147 ogenase alone as well as in combination with glycolate oxidase could determine EG in raw materials an

148 of the mechanism and possible differences in glycolate oxidase enzyme chemistry from C3 and C4 plant

149 High levels of active glycolate oxidase from spinach (GO) and active catalase

150 ound MDH are replaced by residues 176-195 of glycolate oxidase from spinach.

151 Glycolate oxidase is a flavin-dependent, peroxisomal enz

152 In plants, glycolate oxidase is involved in the photorespiratory cy

153 effect was also investigated for each plant glycolate oxidase protein by measuring the (13)C natural

154 HAO1 (glycolate oxidase) silencing is the mechanism of lumasir

155 lpha-hydroxy acid oxidases including spinach glycolate oxidase, a loop region, known as loop 4, is co

156 ith significant sequence similarity to plant glycolate oxidase, a prototypical 2-hydroxy acid oxidase

157 in situ production by chloroplast-localized glycolate oxidase, implying that H2O2 can activate CEF e

158 y three rice-self-originating enzymes, i.e., glycolate oxidase, oxalate oxidase, and catalase.

159 NA interference (RNAi) therapeutic targeting glycolate oxidase, to deplete the substrate for oxalate

160 t is mainly focused on inhibiting the enzyme glycolate oxidase, which plays a pivotal role in the pro

161 the oxidation of glycolate to glyoxylate by glycolate oxidase.

162 uces hepatic oxalate production by targeting glycolate oxidase.

163 ic steps of the catalytic mechanism of human glycolate oxidase.

164 A mutant in the maize (Zea mays) Glycolate Oxidase1 (GO1) gene was characterized to inves

165 d a second-site loss-of-function mutation in GLYCOLATE OXIDASE1 (GOX1) that attenuated the photorespi

166 Light-dependent glycolate or P-glycolate oxidation by osmotically shocked chloroplasts

167 This glycolate oxidation is a light-dependent, SHAM-sensitive

168 Glycolate oxidation was assayed with 3-(3,4)-dichlorophe

169 oup acting as a base in the chemical step of glycolate oxidation.

170 ometry of photorespiratory CO2 formation per glycolate oxidized normally increases at higher temperat

171 All three glycolate oxygens coordinate the two Mn(2+) atoms.

172 ng induction of malic enzymes, ppsA, and the glycolate pathway and repression of glycolytic and gluco

173 ction of GLO genes with other members of the glycolate pathway and the activity of GLO genes in vario

174 (PPSB) with the photorespiration-associated glycolate pathway of Ser biosynthesis (GPSB) using Arabi

175 a pharmacologically optimized, polyethylene-glycolated (PEG)-leptin analog in combination with exend

176 sociated structural relaxation slows down in glycolated polymers (5 ps vs. 1.25 ps for alkylated), co

177 A series of glycolated polythiophenes for use in organic electrochem

178 l emphasis is given to sol-gel processes via glycolated precursor molecules as well as the miniemulsi

179 mate:glyoxylate aminotransferase 1 re-routed glycolate processing to the chloroplast, resulting in ph

180 dation is a light-dependent, SHAM-sensitive, glycolate-quinone oxidoreductase system that is associat

181 Moreover, glycolate-removing activity could be immunodepleted from

182 rol polymer film swelling is to copolymerize glycolated repeat units with a fraction of monomers bear

183 reogenic centers, including a highly unusual glycolate residue.

184 nd releases repaired proteins and lactate or glycolate, respectively.

185 Feeding of butyrate, isobutyrate and glycolate results in the production of 3-hydroxyhexanoat

186 Two new glycolated semiconducting polymers PgBT(F)2gT and PgBT(F

187 Here, we show that the use of glycolated side chains on a thiophene backbone can resul

188 Pretreating arterioles with polyethylene glycolated--SOD (PEG-SOD) improved vasodilation to ACh a

189 Concurrent administration of polyethylene-glycolated superoxide dismutase (SOD), l-nitroarginine m

190 hway may function to synthesize oxalate from glycolate that does not depend on the oxidation of glyco

191 enolate derived from O-Boc protected methyl glycolate then formed the remaining C(1) and C(2) stereo

192 thylenetriamines with the triflate of benzyl glycolate, thereby minimizing competitive lactamization,

193 el, CHK-336 inhibited conversion of (13)C(2)-glycolate to (13)C(2)-oxalate in a dose-dependent manner

194 alate synthesis rate and the contribution of glycolate to both oxalate and glycine synthesis in vivo

195 GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key

196 ate that does not depend on the oxidation of glycolate to glyoxylate by glycolate oxidase.

197 ation biocatalyst used for the conversion of glycolate to glyoxylate in the presence of a reaction co

198 oxy octanoate indicate that the oxidation of glycolate to glyoxylate is the primary reaction catalyze

199 Providing [1-14C]glycolate to leaf tissue of go1 mutants in darkness conf

200 Mean (SD) contribution of glycolate to oxalate production was 47.3% (12.8) in pati

201 ng for enzymes involved in the conversion of glycolate to ribulose-1,5-bisphosphate.

202 Using the incorporation of [1- 13 C]glycolate tracer in glycine revealed significant convers

203 lite analysis and genetic complementation of glycolate transport in yeast showed that BASS6 was capab

204 rt in yeast showed that BASS6 was capable of glycolate transport.

205 continuous infusion of intravenous [1- 13 C]glycolate, [U- 13 C 2 ]oxalate, and, in a subgroup, [D 5

206 /kg TCDD; other urinary metabolites, such as glycolate, urocanate, and 3-hydroxyisovalerate, were onl

207 by measuring the (13)C natural abundance in glycolate using natural or deuterated glycolate as a sub

208 o fully overcome background contamination by glycolate was unsuccessful.

209 uence applied to readily available propargyl glycolates was developed as a route toward functionalize

210 s little as 10 pg of standard glycolic acid (glycolate) was detected in a method comprising the follo

211 where replacing Bpin with Beg (eg = ethylene glycolate) was predicted to significantly improve ortho

212 topic enrichment of 13 C-labeled oxalate and glycolate were measured using a new gas chromatography-t

213 Glycolate and P-glycolate were oxidized about equally well to glyoxylate

214 ely established but is suggestive of a bound glycolate, which is isosteric with a glycine (Xaa) produ

215 hich share similar enzymatic properties, use glycolate with much higher efficiencies than l-lactate.

216 thylsilyl ketene acetals derived from methyl glycolates with a large protecting group on the alpha-ox

217 e ketal developed by Ley provided alpha-aryl glycolates with excellent diastereoselectivities (90 to