ライフサイエンスコーパス: glycosphingolipid

1 of membrane traffic when loaded with excess glycosphingolipid.

2 lipid-binding domains specific for PI4P and glycosphingolipids.

3 ed as novel mimics of glycoglycerolipids and glycosphingolipids.

4 e diseases involves the lysosomal storage of glycosphingolipids.

5 h results in the progressive accumulation of glycosphingolipids.

6 ese types of strains to a panel of different glycosphingolipids.

7 s partition, are enriched in cholesterol and glycosphingolipids.

8 howed enlarged lysosomes and accumulation of glycosphingolipids.

9 in CDT binding, including glycoproteins, and glycosphingolipids.

10 ized by lysosomal storage of cholesterol and glycosphingolipids.

11 cultured with GM2 or GM3 alone or with other glycosphingolipids.

12 icking defect with secondary accumulation of glycosphingolipids.

13 ve lysosomal accumulation of cholesterol and glycosphingolipids.

14 ternalization, and infection are mediated by glycosphingolipids.

15 production, as well as various phospho- and glycosphingolipids.

16 reduced the accumulation of cholesterol and glycosphingolipids.

17 is the precursor for all of the more complex glycosphingolipids.

18 from glycoproteins, and glycan nitriles from glycosphingolipids.

19 The mechanism through which glycosphingolipid accumulation causes these manifestatio

20 elated to myocardial iron overload states or glycosphingolipid accumulation in Anderson-Fabry disease

21 iency of alpha-galactosidase A, resulting in glycosphingolipid accumulation in organs and tissues, in

22 a-galactosidase A enzyme activity leading to glycosphingolipid accumulation, mainly globotriaosylcera

23 -stimulate interleukin (IL)-13 production by glycosphingolipid-activated NKT cells.

24 like molecule that presents phospholipid and glycosphingolipid Ags to a subset of CD1d-restricted T c

25 Unexpectedly, the third compound was the glycosphingolipid alpha-galactosylceramide (alpha-GalCer

26 lipid Ags, such as the marine sponge-derived glycosphingolipid alpha-galactosylceramide (alphaGalCer)

27 he synthesis of specific glioma cell-surface glycosphingolipids alters invasivity in a manner that ma

28 We have previously shown that glycosphingolipid analogs are internalized primarily via

29 ypically, 40-60% of the cellular pool of GM1 glycosphingolipid and 10-20% of the total cellular chole

30 ablish an unexpected connection between this glycosphingolipid and the fungal responses to physiologi

31 We found that 1) the glycosphingolipids and cholesterol components of lipid r

32 of secondary storage compounds (e.g., small glycosphingolipids and cholesterol in Niemann-Pick disea

33 rotein involved in the cellular transport of glycosphingolipids and cholesterol that is mutated in a

34 ha-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of

35 o characterize the structures of amphiphilic glycosphingolipids and gangliosides in comparison to col

36 s not only corroborate the critical role for glycosphingolipids and programmed cell death in regulati

37 n is a viable option for analysis of neutral glycosphingolipids and that Gb4Cer may play a role in th

38 ceptors: beta1-linked galactosyl residues in glycosphingolipids and the phosphocholine group in phosp

39 Herein, the ability of glycosphingolipids (and their sphingolipid metabolites)

40 urated lipids (the lipid analog diI-C(18) or glycosphingolipids)) and lipid-anchored proteins coredis

41 luding N- and O-glycans, glycosaminoglycans, glycosphingolipids, and glycophosphatidylinositol anchor

42 was used to characterize and quantify ocular glycosphingolipids, and histology and electron microscop

43 ophilic polymorphonuclear leukocytes contain glycosphingolipid- and cholesterol-enriched lipid raft m

44 Glycosphingolipids are a subgroup of glycolipids that co

45 Glycosphingolipids are abundant in the kidney, have role

46 s are strongly associated with emphysema and glycosphingolipids are associated with COPD exacerbation

47 Glycosphingolipids are cell-type-specific components of

48 Sphingolipids and glycosphingolipids are emerging as major regulators of t

49 These glycosphingolipids are found in Toll-like receptor-stimu

50 Glycosphingolipids are found on all vertebrate cells and

51 Glycosphingolipids are important structural constituents

52 Our results suggest that glycosphingolipids are likely important participants in

53 Most glycosphingolipids are synthesized by the sequential add

54 Glycosphingolipids are ubiquitous components of mammalia

55 Glycosphingolipids are ubiquitous constituents of eukary

56 Gangliosides, sialic acid-containing glycosphingolipids, are especially enriched on neuronal

57 rate that sulfatides, highly charged anionic glycosphingolipids, are important for maintaining high p

58 phoglycerolipids to alpha- and beta-anomeric glycosphingolipids, as well as microbial alpha-glycosyl

59 ptors, we found that an A. fumigatus-derived glycosphingolipid, asperamide B, directly activates inva

60 ulfated galactosylceramides (sulfatides) are glycosphingolipids associated with cholesterol- and sphi

61 also of endogenous ligands, such as the self-glycosphingolipid beta-glucopyranosylceramide, up-regula

62 HET-C2 is a fungal protein that transfers glycosphingolipids between membranes and has limited seq

63 We identified a consensus glycosphingolipid-binding motif in the extracellular jux

64 fficiency was observed unexpectedly with the glycosphingolipid-binding mutant protein.

65 e have shown that FAPP2, a PI4P effector and glycosphingolipid-binding protein, is recruited to the H

66 ose metabolism, prostaglandin synthesis, and glycosphingolipid biology that may either play an adapti

67 and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and

68 Biochemical profiling of glycosphingolipid biosynthesis confirmed a lack of GM2 i

69 Blocking glycosphingolipid biosynthesis in cultured human neutrop

70 Additionally, when oral glycosphingolipid biosynthesis inhibitors (beta-hexosami

71 The glycosphingolipid biosynthesis is initiated by monoglyco

72 atment of cells with a chemical inhibitor of glycosphingolipid biosynthesis, which suppresses the exp

73 GlcCer is a main precursor for higher order glycosphingolipids but might also serve as intracellular

74 The metabolism of glycosphingolipids by the malaria-causing parasite Plasm

75 GM2-synthase produces sialic acid-containing glycosphingolipids called gangliosides, and its mRNA ove

76 ial cells and support the idea that specific glycosphingolipids can be harnessed as molecular vehicle

77 Previous reports have shown that glycosphingolipids can modulate the activity of the insu

78 Although many glycosphingolipid catabolic defects have been defined, o

79 Gangliosides are a family of glycosphingolipids characterized by mono- or polysialic

80 Consequently, unique viral glycosphingolipids, composed of unusual hydroxylated C17

81 sted evolutionary adaptation for the simpler glycosphingolipid compositions of filamentous fungi.

82 a fluidizing effect is seen that varies with glycosphingolipid concentration, but results do not dire

83 nteraction studies of Sydney GII.4 VLPs with glycosphingolipid-containing HIE membranes, both binding

84 Binding to artificial glycosphingolipid-containing vesicles, human saliva, and

85 To explore whether HBGAs of glycosphingolipids contribute to HuNoV infection, we obt

86 glucosylceramide, and possibly higher-order glycosphingolipids, could contribute to the pathogenesis

87 This glycosphingolipid, DB06-1, is similar in chemical struct

88 in peptides that are essential for lysosomal glycosphingolipid degradation.

89 was resistant to neuraminidase treatment and glycosphingolipid depletion.

90 ngomyelin were actively sequestered, whereas glycosphingolipids diffused freely.

91 However, it is unknown whether glycosphingolipids directly take part in the membrane in

92 to the cell surface, whereas cholesterol and glycosphingolipids drive caveolae scission from the PM.

93 been attributed to this family of sialylated glycosphingolipids, e.g. in modulation of ion channels a

94 nocytosis, clathrin-mediated endocytosis, or glycosphingolipid-enriched carriers.

95 lls induced the formation of cholesterol and glycosphingolipid-enriched Golgi domains that contained

96 Lipid rafts are small cholesterol- and glycosphingolipid-enriched membrane subdomains.

97 osidosis, GM1-ganglioside accumulates in the glycosphingolipid-enriched microdomain (GEM) fractions o

98 ptor known as phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG).

99 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) is a tr

100 ese proteins, phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) was ide

101 regulation of phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding prot

102 ds, we found that treatment with B. fragilis glycosphingolipids-exemplified by an isolated peak (MW =

103 Glycosphingolipid expression differs between human breas

104 of cell death, cancer stem cell percent and glycosphingolipid expression on CSC and non-CSC after tr

105 mammospheres, and its influence upon several glycosphingolipid expressions, it can be concluded that

106 Whereas glycosphingolipid formation is catalyzed by membrane-bou

107 Globotriaosylceramide (Gb3), a glycosphingolipid found in the plasma membrane of animal

108 Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and ti

109 The total non-acid glycosphingolipid fractions were characterized by antibo

110 In the present study, total non-acid glycosphingolipid fractions were isolated from two human

111 Glcbeta1Cer), and a mixture of three complex glycosphingolipids (Fucalpha2Galbeta4GlcNAcbeta6(Fucalph

112 s; little is known, however, about how these glycosphingolipids function in neural stem cell (NSC) fa

113 tures each containing a long-chain saturated glycosphingolipid, galactosylceramide (GalCer), and chol

114 imental evidence that sialic acid-containing glycosphingolipids (gangliosides) are also ligands for h

115 Platelets were engaged by the sialated glycosphingolipids (gangliosides) integrated in the rigi

116 e lectin LecA and its cellular receptor, the glycosphingolipid Gb3, triggers plasma membrane bending

117 x binding with the more abundantly expressed glycosphingolipid Gb4.

118 ive to Stx2 because they lacked the receptor glycosphingolipid globotriaosylceramide (Gb(3)) in vitro

119 Stx2 binds to the glycosphingolipid globotriaosylceramide receptor, expres

120 xin, which uses a plasma membrane-associated glycosphingolipid, globotriaosylceramide (Gb3), for its

121 tant strain lacking the cell wall-associated glycosphingolipid glucosylceramide (Delta gcs1), previou

122 igh IgM and IgG levels against O-glycans and glycosphingolipid glycans of cercariae were observed.

123 sent the first analysis of the N- and O- and glycosphingolipid-glycans from total human lungs, along

124 The glycosphingolipid GM1 binds cholera toxin (CT) on host c

125 A tetramethylrhodamine-labeled glycosphingolipid (GM1-TMR) was used as a substrate.

126 D movements were modulated by binding of the glycosphingolipid GM3.

127 unt of intracellular CMP-Neu5Ac consumed for glycosphingolipid (GSL) biosynthesis, we can increase th

128 he view that saposin C has multiple roles in glycosphingolipid (GSL) catabolism as well as a prominen

129 Unlike disorders of glycosphingolipid (GSL) degradation, very little is know

130 Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide sy

131 s) is mediated by an interaction between the glycosphingolipid (GSL) GM3 on virus particles and CD169

132 e approximately 80 amino acid stimulators of glycosphingolipid (GSL) hydrolases that derive from a si

133 unctions as an activity enhancer for several glycosphingolipid (GSL) hydrolases.

134 -mediated recognition of GM3, a host-derived glycosphingolipid (GSL) incorporated into the virus part

135 e outer membrane of S. paucimobilis contains glycosphingolipid (GSL) instead of lipopolysaccharide (L

136 s in Bbs2-/- cilia, indicating impairment of glycosphingolipid (GSL) metabolism in BBS.

137 by altered transcriptome and methylome, but glycosphingolipid (GSL) profiles in naive human embryoni

138 screens, we uncovered that the cell surface glycosphingolipid (GSL) repertoire determines effective

139 It has been shown previously that inhibiting glycosphingolipid (GSL) synthesis increases insulin sens

140 Mutations in glycosphingolipid (GSL)-degrading glucocerebrosidase are

141 In addition, we observed large glycosphingolipid (GSL)-glycans, which also consists of

142 ronment, suitable for screening libraries of glycosphingolipids (GSL) against proteins to identify sp

143 e possible contribution of Sphingomonas spp. glycosphingolipids (GSL) and its extracellular polymeric

144 Glycosphingolipids (GSL) have been associated with a var

145 Glycosphingolipids (GSL) on the surface of cells are imp

146 most potent NKT cell antigens identified are glycosphingolipids (GSL).

147 Glycosphingolipids (GSLs) are a family of highly diverse

148 Glycosphingolipids (GSLs) are essential constituents of

149 Previous studies demonstrated that certain glycosphingolipids (GSLs) are involved in various cell f

150 Glycosphingolipids (GSLs) are of fundamental importance

151 Glycosphingolipids (GSLs) at the cell surface membrane a

152 an altered profile of lipid raft-associated glycosphingolipids (GSLs) compared with that of healthy

153 Glycosphingolipids (GSLs) constitute major components of

154 nstrate a crucial role for host cell-derived glycosphingolipids (GSLs) for the initial interactions o

155 Glycan head-groups attached to glycosphingolipids (GSLs) found in the cell membrane bil

156 ellular ceramide levels and the synthesis of glycosphingolipids (GSLs) in cellular membranes.

157 ceed in detection and structural analysis of glycosphingolipids (GSLs) in crude lipid extracts, which

158 Accumulation of glycosphingolipids (GSLs) in lysosomal storage diseases

159 ontributions of the N-glycans, O-glycans and glycosphingolipids (GSLs) in regulating complex biologic

160 d increased amounts of GlcCer and downstream glycosphingolipids (GSLs) in SOD1(G86R) muscle compared

161 he present study demonstrates involvement of glycosphingolipids (GSLs) in the EMT process by using no

162 lation may exist between increased levels of glycosphingolipids (GSLs) in the lipid rafts of T cells

163 s between glycan-binding proteins (GBPs) and glycosphingolipids (GSLs) in the membranes of cells are

164 ently, we showed that the expression of some glycosphingolipids (GSLs) is down-regulated during EMT i

165 The biological function of glycosphingolipids (GSLs) is largely determined by their

166 Interactions between glycosphingolipids (GSLs) on the surfaces of cells and g

167 not known, however, whether other structural glycosphingolipids (GSLs) or bioactive signaling sphingo

168 The globo-series glycosphingolipids (GSLs) SSEA3, SSEA4, and Globo-H spec

169 The ability of different glycosphingolipids (GSLs) to activate type I natural kil

170 Coccolithoviruses employ a suite of glycosphingolipids (GSLs) to successfully infect the glo

171 oside GM2, suggesting a close association of glycosphingolipids (GSLs) with EMT.

172 e, which we found to be comprised largely of glycosphingolipids (GSLs) with lesser amounts of polar g

173 We focus on glycosphingolipids (GSLs), a class of glycoconjugates th

174 like particles (noroVLPs) with H or B type 1 glycosphingolipids (GSLs), embedded in a supported phosp

175 eceptors of Shiga toxins (Stxs), the neutral glycosphingolipids (GSLs), globotriaosylceramide (Gb3Cer

176 Glycosphingolipids (GSLs), including lyso-glycosphingoli

177 that homeostasis of a subset of lipids, the glycosphingolipids (GSLs), is severely perturbed in the

178 t is widely believed that these self-Ags are glycosphingolipids (GSLs), molecules that contain cerami

179 Glycosphingolipids (GSLs), particularly globo-series GSL

180 ngolipids included HBGA-related type 1 chain glycosphingolipids (GSLs), with HBGA epitopes correspond

181 tegrin signaling are stimulated by exogenous glycosphingolipids (GSLs).

182 orrelation between emphysema and circulating glycosphingolipids (GSLs).

183 y insufficient degradation of myelin-related glycosphingolipids (GSLs): galactosylceramide and galact

184 Depletion of glycosphingolipids (GSLs; a subgroup of SLs) selectively

185 an increase in expression of the sialylated glycosphingolipid, GT1b.

186 Galactosyl ceramide, a glycosphingolipid, has been postulated to be a receptor

187 ngliosides, which are sialic acid-containing glycosphingolipids highly enriched in the mammalian nerv

188 ctosidase, and beta-galactosidase) mediating glycosphingolipid hydrolysis were also elevated up to th

189 Here, we report that ganglioside GD2 (a glycosphingolipid) identifies a small fraction of cells

190 lts demonstrate the caveolar accumulation of glycosphingolipids in an in vitro model of a lysosomal s

191 e cycle and suggests a link between PI4P and glycosphingolipids in HCV genome replication.

192 ation, further arguing for the importance of glycosphingolipids in HCV RNA synthesis.

193 ly sensitive method to monitor the uptake of glycosphingolipids in infected red blood cells (iRBCs).

194 leads to the accumulation of cholesterol and glycosphingolipids in late endosomes and early lysosomes

195 s to massive accumulation of cholesterol and glycosphingolipids in late endosomes and lysosomes.

196 ntracellular accumulation of cholesterol and glycosphingolipids in many tissues, including the brain.

197 Our study sheds new light on the impact of glycosphingolipids in the cellular invasion of bacterial

198 tes, for the first time, the crucial role of glycosphingolipids in the HCV life cycle and suggests a

199 tructural characterization of membrane-bound glycosphingolipids include their high internal dynamic m

200 contain large quantities of cholesterol and glycosphingolipids, including glucosylceramide synthase

201 Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human

202 tor studies, pharmacological accumulation of glycosphingolipids increased activation of the endoplasm

203 Purified glycosphingolipids induced biochemical hallmarks of prog

204 Glycosphingolipid inhibitors augmented insulin-stimulate

205 Glycosphingolipids, integral components of the cell memb

206 he recruitment of PI(4,5)P2, cholesterol and glycosphingolipids into larger clusters.

207 The x2 glycosphingolipid is expressed on erythrocytes from indi

208 sting that fine specificity for alpha-linked glycosphingolipids is influenced by Valpha-encoded TCR r

209 Lysosomal degradation of glycosphingolipids is mediated by the consecutive action

210 While the accumulation of cholesterol and glycosphingolipids is seen as a primary hallmark of NPC1

211 Galactosylceramide (GalCer), a glycosphingolipid, is believed to exist in the extracell

212 d mass spectrometry characterization of acid glycosphingolipids isolated from a large number (1 x 10(

213 Glycosphingolipids IV(6)Neu5Ac-nLc(4)Cer and GalNAc-GM1b

214 urther work we found that application of the glycosphingolipid lactosylceramide to CLN3-deficient cel

215 minidase 1 expression, and the levels of the glycosphingolipid lactosylceramide.

216 ncy results in intracellular accumulation of glycosphingolipids, leading to a variety of clinical man

217 XCR3, reducing renal T cell infiltration and glycosphingolipid levels.

218 allowed identification of several novel acid glycosphingolipids, like the gangliosides sialyl-lactote

219 Glycosphingolipids (GSLs), including lyso-glycosphingolipids (lyso-GSLs) and cerebrosides (HexCer)

220 rate conformation has broad implications for glycosphingolipid macromolecule recognition and ligand b

221 s a major role in the formation of 2-hydroxy glycosphingolipids, main components of myelin.

222 lactosidase A and subsequent accumulation of glycosphingolipids (mainly globotriaosylceramide, Gb3),

223 how early and significant dysfunction of the glycosphingolipid metabolic pathway in the kidneys of lu

224 d vestibular neurons suggests that alternate glycosphingolipid metabolic pathways predominate in thes

225 used to quantify cell-to-cell variability in glycosphingolipid metabolism as a function of cellular l

226 Here, we show dysfunctional glycosphingolipid metabolism in patients with lupus neph

227 We report a method for the analysis of glycosphingolipid metabolism in single cells.

228 Here, we investigated whether altered glycosphingolipid metabolism is a modulator of disease c

229 cent genetic evidence suggests that aberrant glycosphingolipid metabolism plays an important role in

230 Glycosphingolipid metabolism relies on selective recruit

231 t glycolysis, glutaminolysis, fatty acid and glycosphingolipid metabolism, mitochondrial hyperpolariz

232 of cell-to-cell diversity and regulation of glycosphingolipid metabolism.

233 5) and neuraminidase 1, enzymes that mediate glycosphingolipid metabolism.

234 The endogenous glycosphingolipid metabolite, isoglobotrihexosylceramide

235 Here we show that the glycosphingolipid metabolizing enzyme glucosylceramidase

236 ht to evaluate the therapeutic potential for glycosphingolipid modulation as a new approach to treat

237 Sialic acid glycosphingolipids, molecules thought to mediate EhV inf

238 ic stem cells, a number of type 2 core chain glycosphingolipids (neo-lactotetraosylceramide, the H ty

239 the conclusion that on human neutrophils the glycosphingolipid NeuAcalpha2-3Galbeta1-4GlcNAcbeta1-3[G

240 ailable crystal structures of alpha-anomeric glycosphingolipids now sheds light on the structural bas

241 ons in association with lysosomal storage of glycosphingolipids occurs in patients with this disease,

242 It is the most abundant non-acid glycosphingolipid on erythrocytes and displays the same

243 d weak agonist, galacturonic acid-containing glycosphingolipid, or a synthetic agonist, alpha-galacto

244 metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and glucosylce

245 Here, we provide evidence that glycosphingolipids play an important role in muscle inne

246 ucosylceramide (GlcCer), one of the simplest glycosphingolipids, plays key roles in physiology and pa

247 ed sugar, mammalian self Ags are beta-linked glycosphingolipids, posing the interesting question of h

248 Gangliosides, sialic acid-containing glycosphingolipids present in the outer leaflet of plasm

249 on to the globo-series and type 1 core chain glycosphingolipids previously described in human embryon

250 Deletion of genes controlling later steps of glycosphingolipid production also perturb GlcCer transpo

251 phingomonas spp.) known to express antigenic glycosphingolipid products.

252 toxin, gains entry into human cells via the glycosphingolipid receptor Gb3.

253 re only when bound to multiple copies of its glycosphingolipid receptor, GM1, and the ceramide struct

254 e pentameric B subunit to multiple copies of glycosphingolipid receptors.

255 Three glycosphingolipids recognized by both specialist and gen

256 Previously defined foreign glycosphingolipids recognized by NKT cells are uniquely

257 We show that viral glycosphingolipids regulate infection of Emiliania huxle

258 ateral motion of ganglioside GM1, which is a glycosphingolipid residing on the outer leaflet of the p

259 The consequent abnormal accumulation of glycosphingolipids results in several clinical signs and

260 The addition of cholesterol disrupts the glycosphingolipid selectively but perturbs the di-satura

261 These glycosphingolipid species have been shown to play variou

262 Multiple glycosphingolipid species were also detected.

263 , but when it is dysfunctional, sphingosine, glycosphingolipids, sphingomyelin and cholesterol accumu

264 may be important for understanding lysosomal glycosphingolipid storage disorders.

265 n resulted in cholesterol, sphingomyelin and glycosphingolipid storage in these compartments.

266 tron microscopy revealed the location of the glycosphingolipid storage.

267 pha-galactosidase A (alpha-GalA) activities, glycosphingolipid substrate levels, and in vitro mutatio

268 y incubated with three fluorescently labeled glycosphingolipid substrates, GM3-BODIPY-FL, GM1-BODIPY-

269 yme contributes to the cellular recycling of glycosphingolipids such as galabiosylceramide (Ga2), glo

270 lyl-globotetraosylceramide, and the sulfated glycosphingolipids sulfatide, sulf-lactosylceramide, and

271 Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis

272 eramide metabolism that results in increased glycosphingolipid synthesis and efflux of Cav-1-sphingol

273 Thus inhibiting glycosphingolipid synthesis can be a bonafide target to

274 Here, we show that an inhibitor of glycosphingolipid synthesis can improve glucose control

275 These results suggest that inhibiting glycosphingolipid synthesis can significantly improve in

276 Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atheroscler

277 Targeting glycosphingolipid synthesis has emerged as a novel appro

278 Thus, inhibition of glycosphingolipid synthesis may be a novel approach to a

279 By linking glycosphingolipid synthesis with tumor growth, renal can

280 ce were fed 5 or 10 mg/kg of an inhibitor of glycosphingolipid synthesis, D-threo-1-phenyl-2-decanoyl

281 r not ceramide glycosylation, which controls glycosphingolipid synthesis, plays a role in modulating

282 ace by a lipid flippase in order to nucleate glycosphingolipid synthesis.

283 which catalyses the first committed step of glycosphingolipid synthesis.

284 abolic products of the fluorescently labeled glycosphingolipid tetramethylrhodamine labeled GM1 (GM1-

285 GM1 ganglioside is a glycosphingolipid that has been reported to be beneficia

286 B pentamer (CTxB) that binds up to five GM1 glycosphingolipids to enter host cells.

287 (HCPs), and the carbohydrate content of CHO glycosphingolipids to estimate the demand of NSs towards

288 ll AB(5) toxins and polyomaviruses that bind glycosphingolipids to invade host cells.

289 Here, we test if the properties of glycosphingolipid trafficking in epithelial cells can be

290 rm of NPC2, suggesting a unique mechanism of glycosphingolipid transfer by NPC2.

291 irus genome replication via PI4P binding and glycosphingolipid transport to the HCV RC.

292 esponse to the accumulation of virus-derived glycosphingolipids upon infection of natural E. huxleyi

293 Virally-encoded glycosphingolipids (vGSLs) are virulence factors that ar

294 particular, levels of lactosylceramides and glycosphingolipids were decreased in CLN3-defective cell

295 y, and electron microscopy, whereas sulfated glycosphingolipids were only found in intracellular comp

296 CV significantly increases the level of some glycosphingolipids, whereas adding these lipids to FAPP2

297 hat regulate the metabolism of ceramides and glycosphingolipids, which are important members of the S

298 We report here that sialylated glycosphingolipids with 5 N-acetyllactosamine (LacNAc, G

299 Quantitatively minor terminally sialylated glycosphingolipids with 5 to 6 LacNAc repeats and 2 to 3

300 a class of biologically active cell surface glycosphingolipids with known immunosuppressive properti