ライフサイエンスコーパス: glycosylation

1 a molecular basis of the site-specific nMPO glycosylation.

2 fluence of natural variants on ACE2 receptor glycosylation.

3 they had potential for both N- and O-linked glycosylation.

4 unicamycin-mediated inhibition of ER protein glycosylation.

5 sphorylation step into an orthogonal one-pot glycosylation.

6 ned with the use of tunicamycin to prevent N-glycosylation.

7 fragment and the 6C domain mutant to prevent glycosylation.

8 y of a major type of cancer-relevant protein glycosylation.

9 d for the in-depth characterization of rhEPO glycosylation.

10 une response through mutation and increasing glycosylation.

11 d directs initiation of mucin-type protein O-glycosylation.

12 hreiner's thiourea in catalyzing dehydrative glycosylation.

13 I LacNAc oligosaccharides by chemoselective glycosylation.

14 uman cancer cell lines defective in O-linked glycosylation.

15 tical method to study site-specific isomeric glycosylation.

16 h weak nucleophiles for the explanation of O-glycosylation.

17 cific proteins were selected for analysis of glycosylation.

18 ulation, likely caused by varying degrees of glycosylation.

19 eatures in protein sequence but not N-linked glycosylation.

20 e st3gal2, two enzymes involved in protein N-glycosylation.

21 eomics data and illuminate the many roles of glycosylation.

22 also showed distinct structural features and glycosylation.

23 lycoproteins and 604 unique protein sites of glycosylation.

24 er the influence of site- and stereospecific glycosylations.

25 n 3 of 3 patients tested), corrected protein glycosylation (2 of 2), and normal neutrophil chemotaxis

26 other mucin which has a much lower degree of glycosylation (~60%) - bovine submaxillary mucin - a wea

27 In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse

28 Overall, our data reveal how organisation of glycosylation across class I viral fusion proteins influ

29 Core-2 O-glycosylation also reported Notch signaling in CD8(+) T

30 is widely established for the site-specific glycosylation analysis of rhEPO.

31 cific sites in parallel to the site-specific glycosylation analysis of rhEPO.

32 g and robust tool would greatly facilitate O-glycosylation analysis on single proteins in tumor bioma

33 Anthocyanin glycosylation and acylation affected PACN formation to a

34 y demonstrates that TMTC3 regulates O-linked glycosylation and cadherin-mediated adherence, providing

35 Here, we demonstrate that SEZ6 controls glycosylation and cell surface localization of kainate r

36 ted our understanding of the significance of glycosylation and development of carbohydrate-derived me

37 tereoselective reactions, including chemical glycosylation and enantioselective catalysis.

38 The interaction is independent of glycosylation and is not inhibitory toward endoRNase act

39 d that whereas PrP(C) is predisposed to full glycosylation and is therefore refractory to PRC7 detect

40 ent knowledge on flavivirus envelope protein glycosylation and its impact on viral infection and path

41 Protein glycosylation and phosphorylation are two important prot

42 lymphocytes with MAGT1 mRNA restored both N-glycosylation and receptor function.

43 the secreted form of ACLP contains N-linked glycosylation and that inhibition of glycosylation resul

44 ngs reveal the biological significance of HA glycosylation and therapeutic potential of targeting the

45 in-Hammett fast-exchange assumption for most glycosylations and highlight the distinct reactivity pro

46 ms of size, charge, conformation, absence of glycosylation, and containing proper disulfide bond pair

47 ation, thermal or photochemical cyclization, glycosylation, and final functionalization at position 6

48 through control of lipid metabolism, protein glycosylation, and organization of microvilli in the nod

49 Pivotal mutations conferring loss-of-glycosylation, and repeat vaccination with unchanged ant

50 Together, these results establish IgE glycosylation, and specifically sialylation, as an impor

51 layers, allowing chemical control of length, glycosylation, and surface density of a model glycocalyx

52 gA effector functions depend on subclass and glycosylation, and that disturbances in subclass balance

53 dification, including Pro hydroxylation, Hyp glycosylation, and/or Tyr sulfation.

54 ntents; the gamma/gamma' chains ratio; the N-glycosylation; and the post-translational modifications.

55 d metabolism, carotenoid metabolism, protein glycosylation, antibiotics and cytotoxins biosynthesis,

56 s been chemically synthesized using a linear glycosylation approach.

57 ddition, alterations in mucin expression and glycosylation are common in a variety of human diseases,

58 demonstrate that Cosmc and its effects on O-glycosylation are important for controlling B cell homin

59 Pyranylation and glycosylation are pivotal for accessing a myriad of natu

60 Using core-2 O-glycosylation as a marker of Notch signaling, we identif

61 t of viral evolution and divergence on Spike glycosylation, as well as the influence of natural varia

62 tion of NLGN4 protein by inhibiting N-linked glycosylation at an adjacent residue (N102), which is co

63 prion infection leads to diminished PrP(Sc) glycosylation at Asn-196, resulting in an unshielded PRC

64 ed disaccharide motif and its regioselective glycosylation at O3.

65 oup 2 viruses, due in part to differences in glycosylation between group 1 and 2 stems.

66 low assessment of differences in FcgammaRIII glycosylation between individuals, cell types, subcellul

67 discovered the existence of an artificial "S-glycosylation" between protein cysteines and per-O-acety

68 e.g., esterification) and hydrophilic (e.g., glycosylation) bioderivatization strategies on the biosy

69 GalNAzMe enters O-GalNAc glycosylation but does not enter other major cell surfac

70 by chemical (periodate) oxidation of gTSSA-I glycosylation but retained after heat-denaturation of co

71 Glycosylation can impact virus interactions with cell su

72 These results reveal that N-glycosylation can modulate GPCR function by altering rec

73 ess pathways following inhibition of protein glycosylation can promote EC proliferation and angiogene

74 (POMGnT1), an enzyme involved in O-mannosyl glycosylation, cause retinitis pigmentosa (RP), RP25 and

75 Increased protein glycosylation causes the inhibition of a nuclear ubiquit

76 istically, PGM3 inhibition, reducing protein glycosylation, causes a sustained Unfolded Protein Respo

77 the equatorial selectivity between C- and O-glycosylation cautions against the extrapolation of mode

78 manganese (Mn) and a Congenital Disorder of Glycosylation (CDG) due to the exquisite sensitivity of

79 Cases of congenital disorders of glycosylation (CDG) have been associated with specific m

80 in the regulation of energy taxis, flagellar glycosylation, cellular communication via quorum sensing

81 carbenium ion intermediates formed under the glycosylation conditions.

82 ability to reduce friction is related to its glycosylation consisting of sialylated and unsialylated

83 Protein glycosylation contributes to essential biological proces

84 tified a gap-junction-like structure using a glycosylation-deficient mutant, N255A.

85 CD43 core-2 O-glycosylation depended on cell-intrinsic canonical Notch

86 ferent mechanisms, including those involving glycosylation-dependent programs that influence the biol

87 ogeneous, studies suggest that levels of IgG glycosylation differ between disease states.

88 Of note, loss of SIRT1 glycosylation discomposed these interactions resulting i

89 erapeutics, and the etiology of a congenital glycosylation disorder.

90 tanding of the mechanisms regulating protein glycosylation during neutrophil granulopoiesis and a mor

91 antify mast cells and expression of advanced glycosylation end-product specific receptor (AGER).

92 However, the resulting lack of glycosylation enhances beta1 integrin signaling leading

93 ermore, variants near several genes encoding glycosylation enzymes are unambiguously associated with

94 erase SECRET AGENT (SEC) are two prominent O-glycosylation enzymes in higher plants, with both overla

95 bilization that restricts access to N-linked glycosylation enzymes.

96 glycans correspond to the protein levels of glycosylation enzymes.

97 This study identified 3144 unique glycosylation events belonging to 378 glycoproteins and

98 Protein glycosylation events that happen early in the secretory

99 biochemicals related to methylation, protein glycosylation, extracellular matrix structure, sugars, K

100 its kind, highlights novel granule-specific glycosylation features and is a crucial first step towar

101 Quantitative data on 12 Fc-glycosylation features of 23 mAb-Ds (12 clones, 5 produc

102 which consequently explained the outcome of glycosylations for the synthesis of type I LacNAc hexasa

103 se significant increases in transcription of glycosylation genes, which may reflect the substantial c

104 Aberrant glycosylation has been shown to associate with disease p

105 However, the large-scale profiling of Ig glycosylation in a biomedical setting is challenged by t

106 Delta-like Notch ligands abrogated core-2 O-glycosylation in a dose-dependent manner after allogenei

107 , which are both required for proper protein glycosylation in cells.

108 ManN inhibits glycosylation in ECs and induces significant changes in

109 y suggest that mutations and variations in N-glycosylation in HA caused antigenic variations in H1N1

110 dent variation and suggesting a role for IgG glycosylation in immunocompetence.

111 rain samples have found evidence of aberrant glycosylation in individuals with schizophrenia.

112 tebrates and confirm the high diversity of N-glycosylation in lower organisms.

113 (+) T cells, and IgG fraction crystallizable glycosylation in murine epidermolysis bullosa acquisita

114 complexes, and discuss the role of S protein glycosylation in potentially modulating the innate and a

115 The importance of post-translational glycosylation in protein structure and function has gain

116 We review the effects of protein glycosylation in regulation of gastrointestinal and live

117 ogical theme emerging from GWAS: the role of glycosylation in schizophrenia.

118 84) that examined the mechanisms of chemical glycosylation in the absence of stereodirecting particip

119 Our study highlights the importance of O-glycosylation in the biology of peptide hormones, and ou

120 To investigate the roles of protein glycosylation in the heterogeneity of high-grade serous

121 We suggest that any role of glycosylation in the pathobiology of SARS-CoV-2 will lie

122 a-associated proteins critically modified by glycosylation including glutamate receptors, voltage-gat

123 These changes due to N-glycosylation increased the ligand on-rate and decreased

124 at the receptor-binding area suggested that glycosylation interferes with APOE's attraction to recep

125 Glycosylation is a common post-translational modificatio

126 phalopathy uncovered that incomplete PrP(Sc) glycosylation is a consistent feature of prion pathogene

127 is an important biopharmaceutical for which glycosylation is a critical quality attribute.

128 Glycosylation is a key modification that contributes to

129 Mucin-type O-glycosylation is an essential post-translational modific

130 Mammalian protein N-linked glycosylation is critical for glycoprotein folding, qual

131 Glycosylation is critical to megakaryocyte (MK) and thro

132 Protein glycosylation is essential to trafficking and immune fun

133 O-Glycosylation is initiated by a large family of enzymes

134 IL-22-mediated host N-glycosylation is likely impaired in patients with ulcera

135 Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a conserved feature o

136 st-translational modification of proteins by glycosylation is poorly understood, especially for O-lin

137 peratures in a neutral environment much less glycosylation is present for Pyrobaculum than for Sulfol

138 Immunoglobulin (Ig) glycosylation is recognized for its influence on Ig turn

139 biogenesis, and that alpha(1D)-AR N-terminal glycosylation is required for complete translation of na

140 ion with the matriglycan and that O-mannosyl glycosylation is required for photoreceptor survival in

141 sylating the aggrecan, we show that aggrecan glycosylation is the structural feature that causes HA s

142 i complex fragmentation, and reduced protein glycosylation, leading to reduced secretion of cancer-pr

143 istically, we show that the altered antibody glycosylation leads to increased ROS release from neutro

144 apparatus, but the relationships among their glycosylation levels, processing, and functionalities ar

145 sequence, they will be exposed to the host's glycosylation machinery, and, if their amino acid sequen

146 Overall, chemical inhibitors of glycosylation may be evaluated for COVID-19.

147 APOE glycosylation may contribute to the atherogenicity of L5

148 n pairs even at the S(N)1 end of the general glycosylation mechanism.

149 ing the circadian clock and implicate that O-glycosylation might play an evolutionarily conserved rol

150 is expands Woerpel's "inside/outside attack" glycosylation model by considering the stereoelectronic

151 terogeneous entities, it remains unclear how glycosylation modulates the protein structure and functi

152 While the mutation of the N-linked glycosylation motif (T168A) is primarily responsible for

153 he interaction surface, in the asparagine 90-glycosylation motif and at buried sites.

154 e have shown that the absence of an N-linked glycosylation motif in the subunit G1 of the glycoprotei

155 nsity fractionation assays revealed the dual glycosylation mutant alpha(1D)-AR is widely distributed

156 henyl)formamide (MPF), is introduced for the glycosylation of 2-azido-2-deoxyglucose building blocks.

157 The glycosylation of 7 was attempted by three different meth

158 indings highlight the importance of N-linked glycosylation of ACLP for its secretion and contribute t

159 ycosyltransferase involved in the functional glycosylation of alpha-dystroglycan (DG), a key componen

160 All patients showed loss of O-glycosylation of apolipoprotein C-III, a non-redundant s

161 ite-directed mutagenesis, we determined that glycosylation of Asn-471 and Asn-1030 is necessary for A

162 N-glycosylation of asparagine 130 in its extracellular dom

163 ost-translational modifications, including N-glycosylation of asparagine residues.

164 These data revealed that O-linked glycosylation of chromatin factors is essential for the

165 es, overexpression of TMTC3 rescued O-linked glycosylation of E-cadherin and cell adherence.

166 Extensive glycosylation of Env is an important feature that both p

167 NleB-mediated glycosylation of GshB resulted in enhanced GshB activity

168 analysis and observed differential N-linked glycosylation of human MOR N40D.

169 It is well-established that glycosylation of IgG dictates its effector function and

170 rmined by both protein sequence and N-linked glycosylation of influenza glycoproteins, especially hem

171 his interaction in CD81 impairs the accurate glycosylation of its CD19 partner, the target for leukem

172 n of these outer domain interactions through glycosylation of key residues.

173 hey also showed that MAGT1 is required for N-glycosylation of key T cell and NK cell receptors that c

174 Little is known about HA head glycosylation of low-pathogenicity avian influenza virus

175 Glycosylation of mAb-Ds from human B-lymphoblastoid cell

176 The missense mutation severely limits the glycosylation of NCSTN to its mature form and impairs th

177 Thus, we establish that nutrient-dependent glycosylation of SIRT1 is essential to gate its function

178 te that during a fasted-to-refed transition, glycosylation of SIRT1 modulates its interactions with v

179 Glycosylation of the antigenic protein targets therefore

180 Here, we show that GALA induces the glycosylation of the ER-resident calnexin (Cnx) in breas

181 improved mitochondrial density, and enhanced glycosylation of the extracellular matrix protein, alpha

182 Glycosylation of the Fc region of alpha-GA(1) is importa

183 N-Glycosylation of the major structural proteins (archaell

184 essed counterpart, due to contributions from glycosylation of the N terminus and palmitoylation of th

185 N-Glycosylation of the TBEV envelope (E) glycoprotein is c

186 that acts as a substrate for enzymatic mono-glycosylation of various nuclear, cytosolic, and mitocho

187 es, and has been used to study the impact of glycosylation on backbone proton exchange.

188 Glycosylation on both IgG and FcgammaR impacts their int

189 intensity of the six states of N-glycan type glycosylation on each site provides a new avenue to inve

190 se and automated analysis of site-specific O-glycosylation on single proteins is crucial for comprehe

191 In plants, the effects of O-glycosylation on the circadian clock and the underlying

192 ycosylation pointed to enhanced differential glycosylation on the Fc domain.

193 lie beyond its immediate impact of receptor glycosylation on virus binding.

194 affords an easy way to discover additional O-glycosylations on a multiply glycosylated peptide by vir

195 o the number, the position and the nature of glycosylations on the hydroxyl groups in C-13 and C-19 o

196 diprotomeric nMPO arising from heterogeneous glycosylation, oxidation, chlorination and polypeptide t

197 e specificity underpinning the cytoplasmic O-glycosylation pathway that modifies all six flagellins,

198 ame heptameric glycan, suggesting a common N-glycosylation pathway.

199 roinflammatory IgG fraction crystallizable N-glycosylation pattern and provide a mechanistic link to

200 Herein, we analyze the glycosylation pattern of three SLPs, SLP-8348, SLP-8321,

201 (3D-HPLC/MS) approach for the monitoring of glycosylation patterns at the middle-up level.

202 accurate and comprehensive profiling of mAb glycosylation patterns at the reduced level, a 3D-LC/MS

203 er SLC39A8, which is associated with altered glycosylation patterns in humans.

204 Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals wit

205 ) could provide the insight into the altered glycosylation patterns that relate to disease progressio

206 These characteristics enable a wide array of glycosylation patterns to be accessed, including all C1-

207 cluding primary sequence, disulfide bonding, glycosylation patterns, biotransformation, and more.

208 ffect regardless of the differences in their glycosylation patterns.

209 ed stability and folding of the TCRs reduces glycosylation, perhaps through conformational stabilizat

210 luten can be mainly conducted via acylation, glycosylation, phosphorylation, and deamidation.

211 nal modifications of ECM proteins, including glycosylation, phosphorylation, and hydroxylation, were

212 complex, and influenza hemagglutinin, where glycosylation plays a known role in shielding immunogeni

213 Protein glycosylation plays essential roles in protein structure

214 ng of whole, Fc, and Fab domain-specific IgG glycosylation pointed to enhanced differential glycosyla

215 We suggest that extensive glycosylation previously observed in T4P of Sulfolobus i

216 thesis, and the development of glycan array, glycosylation probes, and inhibitors of carbohydrate-ass

217 Deeper understanding of the glycosylation process and glycosylation production in di

218 aturation that can be used to understand the glycosylation process during granulopoiesis.

219 derstanding of the glycosylation process and glycosylation production in different subtypes of HGSC m

220 The glycosylation profile of these IgGs was consistent with

221 Alterations in glycosylation profiles have been detected in diseases ra

222 Here, we present glycosylation profiles of recombinant gp120 proteins fro

223 hensive mass spectrometric analysis of the N-glycosylation profiles of the SARS-CoV-2 spike proteins

224 Glycosylations promoted by triflate-generating reagents

225 flexion points concerns the mechanism of the glycosylation reaction and the role of protecting groups

226 The glycosylation reaction, which is key for the studies on

227 n are first examined from the perspective of glycosylation reactions and then more broadly in the con

228 support of stereodirecting participation in glycosylation reactions by esters from either the vicina

229 Mechanistic understanding of glycosylation reactions is advancing to a stage at which

230 C-Glycosylation reactions of glycosyl picolinates with all

231 imolecular S(N)2-like mechanisms for typical glycosylation reactions over unimolecular ones involving

232 Glycosylation reactions were performed on a series of bi

233 Glycosylation reactions with 7 gave >80% yields, and onl

234 and acceptor used, can affect the outcome of glycosylation reactions.

235 ll for various glycosyltransferase-catalyzed glycosylation reactions.

236 ensively studied, their metabolism including glycosylation remains poorly understood.

237 idized LDL receptor-1 (LOX-1) signaling, and glycosylation removal from L5 attenuated L5-induced apop

238 SALSA), a large glycoprotein with multiple O-glycosylation repeats.

239 y-dependent affinity trend and site-specific glycosylation requirements for high affinity binding to

240 For these reasons, glycosylation requires characterization and close monito

241 oduction, so the inactivation of ecdysone by glycosylation results in a failure of host larvae to mol

242 -linked glycosylation and that inhibition of glycosylation results in its intracellular retention.

243 nd order-specific aspects of this species' N-glycosylation reveal both invertebrate- and vertebrate-l

244 and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors,

245 igns of an immunogenic region to add a new N-glycosylation site and mask it from antibody binding.

246 To determine whether this glycosylation site may be the binding region for EphA2,

247 nity for EphA2, indicating that the EBV gL N-glycosylation site might be responsible for inhibiting t

248 L is at least in part proximal to the EBV gL glycosylation site, which in part accounts for differenc

249 subclasses and heterogeneities at each head glycosylation site.

250 All of the three N-linked glycosylation sites (i.e. sequons NCSV at HA 54, NHTV at

251 Primarily, the pattern of glycosylation sites and residues in the Sa antigenic reg

252 Occlusion of the Asn355/Asn391-glycosylation sites and the Asn323-/Asn483-glycans, loca

253 ested that mutations and changes in N-linked glycosylation sites are associated with the rise of anti

254 NA head domain of H1N1 IAVs, three N-linked glycosylation sites are conserved and that a fourth site

255 of 25, 22, and 34 glycopeptides covering all glycosylation sites are enriched by the modified tips fr

256 SHM introduces DNA sequences encoding N-glycosylation sites asparagine-X-serine/threonine (N-gly

257 sylated trimer that lacks potential N-linked glycosylation sites at positions 230, 241, and 289.

258 dentification and orthogonal validation of N-glycosylation sites based on alternating sequential samp

259 ddition to antigenicity, changes in N-linked glycosylation sites can alter other properties of viral

260 carrying key hemagglutinin (HA) head region glycosylation sites can be removed from the lung by pulm

261 Vs of human origin, where the number of head glycosylation sites first increased over time and then d

262 expose the CD4bs by selective elimination of glycosylation sites flanking the CD4bs, and 2) minimize

263 The presence of these extra glycosylation sites in the variable region of the molecu

264 dentification, delineating multiple N- and O-glycosylation sites on single glycopeptides, and derivin

265 rimental analyses verified that the N-linked glycosylation sites on the NA head domain contribute to

266 Additionally, human-adapted HAs gain glycosylation sites over time, although their biological

267 concentrations, and the presence of multiple glycosylation sites per Ig.

268 By sequentially introducing O-glycosylation sites to ST6GAL1, we demonstrated that O-g

269 Almost all potential N-linked glycosylation sites were at least partially occupied in

270 ous system function - contain two putative N-glycosylation sites within the large N-terminal domain a

271 uence coverage, including seven of the eight glycosylation sites, and has been used to study the impa

272 y of previously unobserved putative N-linked glycosylation sites, as well as codons that evolve under

273 HDX changes focused around the N221 and N255 glycosylation sites, which contain mannose-6-phosphate m

274 cale mapping of Tn-glycosylated proteins and glycosylation sites.

275 SIGN is better correlated with the number of glycosylation sites.

276 molecular dynamics simulations revealed that glycosylation stabilized a beta-sheet adjacent to the N1

277 therefore sought to investigate whether the glycosylation state of ACE2 impacts the interaction with

278 The glycosylation stereoselectivities for a series of bicycl

279 isolate and analyze factors that control the glycosylation stereoselectivities observed in carbohydra

280 The glycosylation stereoselectivity is then governed by the

281 ng mass spectrometry experiments to identify glycosylation substrates of NleB orthologs, we unexpecte

282 ecoration process involves a three-component glycosylation system (TGS) represented by an undecapreny

283 s poorly understood, especially for O-linked glycosylation systems.

284 VMA21 in male patients with abnormal protein glycosylation that result in mild cholestasis, chronic e

285 Glycosylation, the enzymatic attachment of carbohydrates

286 Glycosylation, therefore, is a promising target of thera

287 ences contain consensus sequons for N-linked glycosylation, they may become glycosylated.

288 tracyclic aglycon scaffold and gold-promoted glycosylations to install the synthetically challenging

289 aped glycoproteins to bypass the classical N-glycosylation trimming pathway involving ER glucosidases

290 Differential glycosylation was observed across antigen-specific antib

291 While similar global MPO glycosylation was observed across conditions, the conser

292 charide donors and acceptors, chemoselective glycosylations were investigated to obtain optimal condi

293 The glycosylations were operated under mild neutral conditio

294 IL-22 signaling in HMA mice regulated host glycosylation, which enabled the growth of succinate-con

295 , previously reported associations of IgG Fc glycosylation with age in healthy individuals were confi

296 Glycosylation with O-linked beta-N-acetylglucosamine (O-

297 was conducted for the notoriously difficult glycosylation with the most unreactive axial 4-OH of the

298 t the extrapolation of models for S(N)1-type glycosylation with weak nucleophiles for the explanation

299 Glycosylation within the human host plays a critical rol

300 The patterns of N-glycosylation within the recombinant ectodomain and S1 s