ライフサイエンスコーパス: glycyl

1 Vmax for apical uptake of [14C]glycyl-[14C]sarcosine was increased 1.64 (+/- 0.34)-fold

2 N-Substituted-glycyl-2-cyanopyrrolidide compounds, typified by NVP-DPP

3 ed and characterized two new (4-quinolinoyl)-glycyl-2-cyanopyrrolidine-based small molecules for imag

4 a new DPP-IV inhibitor class, N-substituted-glycyl-2-cyanopyrrolidines, are described as well as the

5 pha-subunit in the complex with an analog of glycyl adenylate at 2.8 A resolution presents a conforma

6 A glycyl-adenylate analogue, glycine sulfamoyl adenosine (

7 The mutation is at the site for synthesis of glycyl-adenylate, but the rest of the two structures are

8 ine (gly-gly), alalyl-alanine (ala-ala), and glycyl-alanine (gly-ala) show that upon photoexcitation

9 alyzes the stereospecific hydroxylation of a glycyl alpha-carbon in a reaction that requires O(2) and

10 aminolyzes acyclic D-alanyl substrates than glycyl analogues, in contrast to the wild-type beta-lact

11 In addition, both the glycyl and alanyl residues of the GXXXG or GXXXA motifs

12 ntained a constant acyl group, (phenylacetyl)glycyl, and chemically different leaving groups, m-carbo

13 Active-site labeling with dansyl-glutamyl-glycyl-arginyl chloromethyl ketone or immunoblot analysi

14 he adhesion of H10 cells to vitronectin and (glycyl-arginyl-glycyl-aspartyl-serine)4 and significant

15 y higher rates to the polymeric RGD peptide (glycyl-arginyl-glycyl-aspartyl-serine)4 than to monomeri

16 Glycyl aspartate and D-erythro-imidazole-glycerol-phosph

17 s significantly increases their RGD (arginyl-glycyl-aspartate)-dependent interaction with endothelial

18 o 142 of the pre-pro-protein form an arginyl-glycyl-aspartic (RGD) sequence, a motif involved in the

19 Arginyl-glycyl-aspartic acid (RGD), a cell adhesion tripeptide m

20 DF4(C16)) tagged with the tripeptide arginyl-glycyl-aspartic acid cell adhesion motif RGD, which can

21 [c(RGDfk)](2) = glutamic acid-[cyclo(arginyl-glycyl-aspartic acid-D-phenylalanine-lysine)], both in s

22 H10 cells to vitronectin and (glycyl-arginyl-glycyl-aspartyl-serine)4 and significant inhibition of t

23 to the polymeric RGD peptide (glycyl-arginyl-glycyl-aspartyl-serine)4 than to monomeric RGD peptides.

24 measurements indicate that the peptidoglycan glycyl bridges are complete (five units long) and form c

25 glyoxylate and the oxidative cleavage of the glycyl Calpha-N bond in N-benzoylglycine (hippurate) by

26 tivity induces ribosome stalling at all four glycyl codons but does not evoke a stringent response.

27 singly, the yields are lower (< 50%) for non-glycyl couplings due to an aza-Wittig reaction that dive

28 the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2

29 tate by the aminolysis product (phenylacetyl)glycyl-D-phenylalanine indicated that the second binding

30 D-alanyl-D-phenylalanine and N-(phenylacetyl)glycyl-D-phenylalanine were used as a test pair against

31 nhibiton of the hydrolysis of (phenylacetyl)-glycyl-D-thiolactate by the aminolysis product (phenylac

32 , RGD-hirudin, and Nalpha-2-naphthylsulfonyl-glycyl-DL-4-amidinophenylalanyl-piperidide acetate salt

33 dyl (Jo-1), threonyl (PL-7), alanyl (PL-12), glycyl (EJ), and isoleucyl (OJ), are closely associated

34 yanate, were removed from partially purified glycyl endopeptidase (PPGE).

35 11(Delta181-381), revealed that the D-alanyl-glycyl endopeptidase activity is contained within the N-

36 ults show that the phi11 enzyme has D-alanyl-glycyl endopeptidase as well as N-acetylmuramyl-L-alanyl

37 O4) precipitation was applied to fractionate glycyl endopeptidase from the papaya latex of Red Lady a

38 Glycyl endopeptidase with high purification fold (PF) an

39 us cysteine proteases papain, actinidin, and glycyl endopeptidase, folding into two distinct domains

40 rolytic activity toward valacyclovir, the 5'-glycyl ester of acyclovir, and the 5'-valyl ester of zid

41 ered proteins (IDPs) containing phenylalanyl-glycyl (FG)-rich repeats line the pore and interact with

42 ged to arginyl-alanyl-aspartic or to arginyl-glycyl-glutamic, were expressed in Escherichia coli.

43 Glycyl-glutamine (3 nmol) also prevented the rise in bod

44 Glycyl-glutamine (3 nmol) co-injection into the mPOA inh

45 In this study, we investigated whether glycyl-glutamine (beta-endorphin(30-31)), an inhibitory

46 Opioid peptides and glycyl-glutamine (Gly-Gln) have been implicated in the c

47 Glycyl-glutamine had no effect on body temperature when

48 stitution of C73 brings about mischarging by glycyl-, glutaminyl-, and leucyl-tRNA synthetases.

49 mor activities of these compounds and their [glycyl,glutamyl] diethyl ester prodrug forms (1(Et)2-3(E

50 ndirectly delivered into tumor cells as the [glycyl,glutamyl] diethyl or dicyclopentyl esters.

51 the fungus, but the control peptide arginyl-glycyl-glutamyl-serine provided no protection.

52 , N(alpha)-acetyl lysine amide, and N(alpha)-glycyl glycine amide are investigated by combined densit

53 y photodynamics of the aqueous dipeptides of glycyl-glycine (gly-gly), alalyl-alanine (ala-ala), and

54 ntified based on the inability to use prolyl-glycyl-glycine as a proline source and were defective in

55 , which also serves as the substrate for its glycyl-glycine endopeptidase domain.

56 Using sequential digestion with the glycyl-glycine endopeptidase lysostaphin followed by the

57 is removed by treatment with lysostaphin, a glycyl-glycine endopeptidase that separates the cell wal

58 e show that while lysostaphin is genuinely a glycyl-glycine hydrolase, LytM can also act as a D-alany

59 ny of these M23 family members can hydrolyse glycyl-glycine peptide bonds and show lytic activity aga

60 ine, L-alanyl-glycine, glycyl-L-alanine, and glycyl-glycine, in which we attempt to isolate structura

61 shown to catalyze the prebiotic synthesis of glycyl-glycine, we expect this work will stimulate furth

62 t is a competitive inhibitor of the acceptor glycyl-glycine, which indicates that OU749 occupies the

63 The phenylalanyl-glycyl-glycyl-alanyl-prolyl (FG-GAP) domain plays an imp

64 onstrated that the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (de

65 drug-like inhibitors, such as TGX-221, and S-Glycyl-H-1152 span both the L-Histidine and AdoMet bindi

66 ns containing the photo-tag: 4-benzoylbenzyl-glycyl-hexahistidine.

67 odulate polyfunctional thiol stability using glycyl histidine (Gly-His) as a model dipeptide.

68 lycemia were 3-hydroxykynurenine, serotonin, glycyl-histidine, and nicotinic acid.

69 ibitor N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid.

70 reveals two architectural elements unique to glycyl initiases and critical for their activity.

71 thetase (HisRS) or to alanyl-, asparaginyl-, glycyl-, isoleucyl-, or threonyl-tRNA synthetase occur i

72 Certain glycyl-l(but not d)-amino acids, such as glycyl-l-alanin

73 ain glycyl-l(but not d)-amino acids, such as glycyl-l-alanine and glycyl-l-phenylalanine, are also go

74 tides, L-alanyl-L-alanine, L-alanyl-glycine, glycyl-L-alanine, and glycyl-glycine, in which we attemp

75 n-pimelyl-D-alanyl-D-alanine, 1, contain the glycyl-L-alpha-amino-epsilon-pimelyl side chain.

76 The first is a penicillin having the glycyl-L-alpha-amino-epsilon-pimelyl side-chain of Strep

77 y complexed with a highly specific fragment (glycyl-L-alpha-amino-epsilon-pimelyl-D-Ala-D-Ala) of the

78 , where the enzyme catalyzes transfer of the glycyl-l-alpha-amino-epsilon-pimelyl-d-alanyl moiety to

79 , a peptidoglycan-mimetic peptide substrate, glycyl-l-alpha-amino-epsilon-pimelyl-d-alanyl-d-alanine,

80 hown that the peptidoglycan-mimetic peptide, glycyl-l-alpha-amino-epsilon-pimelyl-d-alanyl-d-alanine,

81 f the Streptomyces R61 dd-peptidase, such as glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine,

82 peptidase substrate yielded a new substrate, glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine.

83 t overlap with the peptide carbonyl group of glycyl-l-amino acids.

84 es of protonated and alkali metal-cationized glycyl-L-arginine (GlyArg) and L-arginylglycine (ArgGly)

85 c cerebral arteries via binding to L-arginyl-glycyl-L-aspartate-dependent integrin receptors and prev

86 n of an analogous thiolester substrate, 3-(N-glycyl-l-cysteinyl)-propanoyl-d-alanyl-d-thiolactate, th

87 ed by studying the response to the substrate glycyl-L-glutamine (Gly-Gln) of the proton-coupled pepti

88 Glycyl-L-glutamine (Gly-Gln; beta-endorphin 30-31) is an

89 moiety was investigated employing N-benzoyl-glycyl-L-lysine (Bz-Gly-Lys) as a model compound of Lys

90 carboxyethyl) -alpha-(S)-(4-phenyl-3-butynyl)glycyl-L-O-methyltyrosine, N-methylamide), a potent inhi

91 mine acute effects of the osmotic disruptant glycyl-L-phenylalanine 2-naphthylamide (GPN).

92 d)-amino acids, such as glycyl-l-alanine and glycyl-l-phenylalanine, are also good acceptors.

93 Glycyl-L-phenylalanine-beta-naphthylamide (GPN) was used

94 -glycine cross-linking/covalent labeling and glycyl-l-proline cross-linking/covalent labeling with to

95 e by AsPc-1 and Capan-2 cells was similar to glycyl-L-sarcosine absorption by Caco-2 cells and a Chin

96 Absorption of the model dipeptide glycyl-L-sarcosine by AsPc-1 and Capan-2 cells was simil

97 -3-((13-methyltetradecanoyl)oxy)hexadecanoyl)glycyl-l-serine, abbreviated as l-serine-(R+S)-Lipid 654

98 ential UV-Vis spectroscopy, and bioassays, L-glycyl-L-tryptophan (Gly-Trp) was found to be the only d

99 y titrating a mixture of model fluorophores, glycyl-L-tryptophan and L-tryptophan with Cu2+ at pH 6.

100 I molecules, and we find that the dipeptide glycyl-leucine efficiently supports the folding of HLA-A

101 Treatment of cells with glycyl-leucine induces accumulation of peptide-receptive

102 joined at the normal N and C termini by a di-glycyl linker.

103 ent of (1)H/(2)H exchange into methionine, N-glycyl-methionine, and methionine sulfoxide suggests tha

104 of methionine sulfoxide that is absent for N-glycyl-methionine.

105 AIPPMER), 18-O-[N-(3'-iodo-4'-azidophenethyl)glycyl]methyl reserpate (IAPEGlyMER), and 2-N-[(3'-iodo-

106 tituent that better stabilizes the analogous glycyl moiety.

107 trogen and carbon atoms coming from the same glycyl moiety.

108 Gly-Lys and was then identified as N-benzoyl-glycyl-Nepsilon-(hexanonyl)lysine.

109 s between hypoxanthine and all standard, non-glycyl/non-prolyl amino acid side chain analogs as deriv

110 de investigated has either a central pyridyl glycyl or a pyridyl alanyl residue between two terminall

111 th one substrate, however, m-[[(phenylacetyl)glycyl]oxy]benzoic acid, isotope effects on V/K of very

112 a depsipeptide substrate, m-[[(phenylacetyl)glycyl]-oxy]benzoic acid, and of a beta-lactam substrate

113 pounds using electronic tongue assay; leucyl-glycyl-proline exhibited synergism with monosodium gluta

114 ated with a mixture containing the dipeptide glycyl-proline in Tris-HCl supplemented with manganese a

115 ermined by the complete disappearance of the glycyl-proline peak with the concomitant appearance of t

116 beneath the proline to the area beneath the glycyl-proline peak.

117 acid, trigonelline, alanyl-tyrosine, leucyl-glycyl-proline, and leucyl-aspartyl-glutamine) and three

118 activity of the chromogenic substrate tosyl-glycyl-prolyl-argly-4-nitroanilide acetate was present a

119 A post-translationally installed glycyl radical (G(734). in Escherichia coli) is essentia

120 ass III ribonucleotide reductases (RNRs) are glycyl radical (G*) enzymes that provide the balanced po

121 of an intermediate, tentatively ascribed to glycyl radical and acrylate.

122 e PFL contains a novel alpha-carbon centered glycyl radical at G734 that is required for its catalyti

123 tranded beta/alpha-barrel that surrounds the glycyl radical cofactor and active site.

124 radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical r

125 Such damage occurs at the glycyl radical cofactor, resulting in cleaved PFL (cPFL)

126 The glycyl radical cofactor, which is posttranslationally in

127 tivity regulation in anaerobic or class III (glycyl radical containing) RNRs, we determine cryo-elect

128 benzylsuccinate synthase complex lacking the glycyl radical could be purified as an alpha(2)beta(2)ga

129 hat the toluene synthase reaction involves a glycyl radical decarboxylase.

130 copri NrdD is active and has a fully ordered glycyl radical domain (GRD) in one monomer of the dimer.

131 In contrast, the position of the glycyl radical domain is unaffected by the cone domain c

132 alphagamma complex center around the crucial glycyl radical domain, thus suggesting a role for BSSbet

133 activity, as evidenced by the characteristic glycyl radical electron paramagnetic resonance signal ob

134 nzymes, including the evolutionarily ancient glycyl radical enzyme (GRE) family, catalyze chemically

135 The glycyl radical enzyme (GRE) indoleacetate decarboxylase

136 The glycyl radical enzyme (GRE) superfamily utilizes a glycy

137 imethylamine-lyase is an anaerobic bacterial glycyl radical enzyme (GRE) that cleaves choline to prod

138 Pyruvate formate-lyase (PFL) is a glycyl radical enzyme (GRE) that converts pyruvate and c

139 acetaldehyde by a previously uncharacterized glycyl radical enzyme (GRE), isethionate sulfite-lyase (

140 s, we investigate the catalytic cycle of the glycyl radical enzyme 4-hydroxyphenylacetate decarboxyla

141 Glycyl radical enzyme activating enzymes (GRE-AEs) are a

142 The class III ribonucleotide reductase (RNR) glycyl radical enzyme and its corresponding RNR-AE are a

143 mental pollutant toluene is initiated by the glycyl radical enzyme benzylsuccinate synthase (BSS), wh

144 te an immunological role of NO in inhibiting glycyl radical enzyme chemistry in the gut.

145 BSS belongs to the glycyl radical enzyme family and catalyzes the fumarate

146 We find that BSSalpha has the common glycyl radical enzyme fold, a 10-stranded beta/alpha-bar

147 ealed the involvement of a C-N bond cleaving glycyl radical enzyme in TMA production, which is unprec

148 re, we demonstrate that the Escherichia coli glycyl radical enzyme pyruvate formate lyase (PFL), whic

149 nt (sFUT) encapsulating the oxygen-sensitive glycyl radical enzyme pyruvate formate lyase and a phosp

150 nd distribution of individual members of the glycyl radical enzyme superfamily among the microbiomes

151 e determined x-ray crystal structures of the glycyl radical enzyme that catalyzes the addition of tol

152 Benzylsuccinate synthase is a glycyl radical enzyme that initiates anaerobic toluene m

153 zylsuccinate synthase was speculated to be a glycyl radical enzyme.

154 Activation of glycyl radical enzymes (GREs) by S-adenosylmethonine (Ad

155 Glycyl radical enzymes (GREs) catalyze mechanistically d

156 Glycyl radical enzymes (GREs) represent a diverse superf

157 X-succinate synthases (XSSs) are glycyl radical enzymes (GREs) that catalyze the addition

158 Recently, BMCs associated with glycyl radical enzymes (GREs) were discovered; these are

159 It is becoming increasingly apparent that glycyl radical enzymes are more prevalent than previousl

160 The glycyl radical enzymes include pyruvate formate-lyase, a

161 primarily on its sequence similarity to the glycyl radical enzymes, pyruvate formate-lyase and anaer

162 cysteine residues that are conserved in all glycyl radical enzymes.

163 Benzylsuccinate synthase is a member of the glycyl radical family of enzymes.

164 trate RVSG(734)YAV, which mimics the site of glycyl radical formation on the native substrate, pyruva

165 sed mechanism in which dioxygen quenches the glycyl radical in the active enzyme and the resulting pe

166 erminal region of YfiD is important for YfiD glycyl radical installation but not for catalysis, and t

167 late the conformational changes required for glycyl radical installation.

168 ytic cleavage, resulting in the formation of glycyl radical ions and loss of CH2SO.

169 uced capability to stabilize the thus-formed glycyl radical ions via the captodative effect.

170 cal ions, the stability of the product ions (glycyl radical ions) and the location of the charge (pro

171 The glycyl radical is formed even in the dATP-bound form, bu

172 eals that the conversion of Omega to peptide glycyl radical is not concerted.

173 e open conformation of PFL in which: (i) the glycyl radical is significantly less stable; (ii) the ac

174 obic RNRs, on the other hand, store a stable glycyl radical next to the active site and the basis for

175 for radical intermediates generated from the glycyl radical of activated pyruvate formate-lyase (PFL)

176 es that generate the catalytically essential glycyl radical of GREs, which in turn catalyze essential

177 ted mutagenesis we show that NO destroys the glycyl radical of PFL.

178 nerates a stable and catalytically essential glycyl radical on G(734) of pyruvate formate-lyase via t

179 me (PFL-AE) involves formation of a specific glycyl radical on PFL by the PFL-AE in a reaction requir

180 onversion of the [4Fe-4S](1+) cluster to the glycyl radical on PFL; however, 3.7-fold less activation

181 the generation of a catalytically essential glycyl radical on pyruvate formate-lyase (PFL).

182 zyme that installs a catalytically essential glycyl radical on pyruvate formate-lyase.

183 aradigm, we demonstrate that generation of a glycyl radical on the B(12)-independent glycerol dehydra

184 edominantly affected by the stability of the glycyl radical product through the captodative effect, r

185 reveals the formation of the peptide G(734)* glycyl radical product.

186 nfortunately, the extreme sensitivity of the glycyl radical to oxygen has hampered the structural and

187 -terminal region of BSSalpha that houses the glycyl radical to shift within the barrel toward an exit

188 exhibits lower catalytic activity; (iii) the glycyl radical undergoes less H/D exchange with solvent;

189 he active site of PFL and harboring a stable glycyl radical, or an open conformation, with Gly-734 mo

190 rements for growth in reactions activated by glycyl radical-containing enzymes.

191 Benzylsuccinate synthase is a member of the glycyl radical-containing family of enzymes, and the rea

192 from the ethanolamine utilization (Eut) and glycyl radical-generating protein MCPs are able to targe

193 m from an enzymatic glycyl residue to form a glycyl radical.

194 ts activity with the concomitant loss of the glycyl radical.

195 PFL is a glycyl-radical enzyme whose vulnerability to oxygen is a

196 of MCPs have been identified, including the glycyl-radical propanediol (Grp) MCP.

197 en tolerance by jettisoning enzymes that use glycyl radicals and exposed low-potential iron-sulfur cl

198 Glycyl radicals are important bioorganic radical species

199 ylsuccinate synthase radical and that of the glycyl radicals of pyruvate formate-lyase and anaerobic

200 collagen degradation can occur via transient glycyl radicals, the formation of which is enhanced in A

201 the bridging segment was reduced to a single glycyl residue 1.0 +/- 0.1 (FemA), the level of cross-li

202 model dipeptides, each of which contained a glycyl residue and a variable residue.

203 ngly, position 14 of h-alpha-CGRP contains a glycyl residue and is part of an alpha-helix spanning re

204 ontains an organic free radical located on a glycyl residue in the C-terminal portion of the polypept

205 the estimated pKa (approximately 8.0) of the glycyl residue in the high-affinity substrate 1a.

206 lattice, the carbonyl oxygen of the central glycyl residue in two gly-gly-gly polymorphs form interm

207 physiological conditions principally when a glycyl residue is at the carboxyl side of Asn and leads

208 ar to stabilize the Rossmann fold: the first glycyl residue of either the GXXXG or GXXXA motif contac

209 incorporation of this isotope label into the glycyl residue of glutathione at 44.2 ppm can be detecte

210 glycyl residue of these motifs and the third glycyl residue of the GX(1-2)GXXG motif are the same res

211 acts the carbonyl oxygen atom from the first glycyl residue of the GX(1-2)GXXG motif consistent with

212 ither GXXXG or GXXXA motifs, where the first glycyl residue of these motifs and the third glycyl resi

213 bstracting a hydrogen atom from an enzymatic glycyl residue to form a glycyl radical.

214 ent hydroxylation of the alpha-carbon of the glycyl residue, producing an alpha-hydroxyglycine-extend

215 s much more efficient than the transfer of a glycyl residue.

216 The bridging segment length changed from 5.0 glycyl residues (wild-type strain) to 2.5 +/- 0.1 (FemB)

217 hielding parameters are reported for central glycyl residues in crystallographically characterized tr

218 ns), the excess glycine is used primarily as glycyl residues in protein.

219 iction scheme for the 2 degrees structure of glycyl residues in proteins based on shielding parameter

220 decarboxylated or inserted as (13)C-labeled glycyl residues in proteins.

221 ysine (for a direct measure of the number of glycyl residues in the bridging segment), [1-(13)C]glyci

222 termining step in the Staudinger ligation of glycyl residues mediated by (diphenylphosphino)methaneth

223 cross-bridges containing one, three, or five glycyl residues, but not to the epsilon-amino of lysyl i

224 isolated yields for the ligation of two non-glycyl residues.

225 he order: ryanodol > ryanodine > C(10)-O(eq)-glycyl-ryanodine > C(10)-O(eq)-beta-alanyl-ryanodol.

226 he order: ryanodol < ryanodine < C(10)-O(eq)-glycyl-ryanodine < C(10)-O(eq)-beta-alanyl-ryanodol, imp

227 The currents evoked by 20 mM glycyl-sarcosine (Gly-Sar) at pH 5.0 were dependent upon

228 L296C-, and F297C-hPepT1) showed negligible glycyl-sarcosine (gly-sar) uptake activity and may play

229 g in a high concentration of open N-terminal glycyl segments.

230 Here we report a MOF that consists of glycyl-serine dipeptides coordinated to metal centres, a

231 lpha-hydroxy acids act as acyl acceptors for glycyl substrates but not for more specific d-alanyl sub

232 sidue of desmethylsalinamide E with acylated glycyl thioesters yields desmethylsalinamide C.

233 he activated enzyme and may participate in a glycyl/thiyl radical equilibrium.

234 Evidence for AlmG glycyl to lipid substrate transferase activity is demons

235 , encoding the ubiquitously expressed enzyme glycyl-transfer RNA (tRNA) synthetase (GlyRS).

236 Glycyl tRNA synthetase (GlyRS) provides a unique case am

237 t point mutations in the gene GARS, encoding glycyl tRNA synthetase (GlyRS).

238 disease-associated missense mutations in the glycyl tRNA synthetase gene in families with CMT2D and d

239 ase) toxin that specifically targets charged glycyl tRNA.

240 peptide bond formation between the incoming glycyl-tRNA and a nascent peptide that otherwise is cond

241 inding of CHL to a ribosome complex carrying glycyl-tRNA does not affect the positions of the reactin

242 Here we report a pathway that features glycyl-tRNA instead.

243 itochondrial forms of Caenorhabditis elegans glycyl-tRNA synthetase (CeGlyRS) are encoded by the same

244 ly implicated mutations in the gene encoding glycyl-tRNA synthetase (GARS) as the cause of CMT2D and

245 a unique disease caused by mutations in the glycyl-tRNA synthetase (GARS) gene.

246 2D (CMT2D), caused by dominant mutations in glycyl-tRNA synthetase (GARS).

247 throughout the primary sequence of the human glycyl-tRNA synthetase (GARS).

248 a Drosophila model for CMT with mutations in glycyl-tRNA synthetase (GARS).

249 axonal neuropathy, is caused by mutations in glycyl-tRNA synthetase (GARS).

250 ctions may explain why dominant mutations in glycyl-tRNA synthetase (GlyRS) and tyrosyl-tRNA syntheta

251 The (alphabeta)(2) glycyl-tRNA synthetase (GlyRS) in many bacteria is an or

252 res and biochemical analyses show that human glycyl-tRNA synthetase (GlyRS) produces Ap4A by direct c

253 Here we focus on mutations in glycyl-tRNA synthetase (GlyRS) that cause an axonal form

254 e gene GARS, encoding the ubiquitous enzyme, glycyl-tRNA synthetase (GlyRS), cause peripheral nerve d

255 in the housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective periph

256 bunit of bacterial heterotetrameric Class II glycyl-tRNA synthetase (GlyRS-B) enzymes.

257 cerevisiae, two genes (GRS1 and GRS2) encode glycyl-tRNA synthetase (GlyRS1 and GlyRS2, respectively)

258 SR1 glycyl-tRNA synthetase acylates tRNA(Gly)UCA with glycin

259 Pol gamma B shows high similarity to glycyl-tRNA synthetase and dimerizes through an unusual

260 Coexpression of SR1 glycyl-tRNA synthetase and tRNA(Gly)UCA in Escherichia c

261 h a significant conformational transition in glycyl-tRNA synthetase coupled to the binding of GSAd.

262 of horizontal transfer of the gene encoding glycyl-tRNA synthetase from a bacterium of the Thermus-D

263 by the expression of the only known gene for glycyl-tRNA synthetase in Schizosaccharomyces pombe.

264 Unfolding of glycyl-tRNA synthetase is complex with a native state, a

265 erential scanning calorimetry indicated that glycyl-tRNA synthetase is stabilized by nucleotides.

266 Thus, a single gene for glycyl-tRNA synthetase likely encodes both cytoplasmic a

267 ATP and nonsubstrate ATP analogues render glycyl-tRNA synthetase more resistant to digestion by a

268 Unfolding of Bombyx mori glycyl-tRNA synthetase was examined by multiple spectros

269 The interaction of adenine nucleotides with glycyl-tRNA synthetase was examined by several experimen

270 f the Bacillus subtilis glyQS gene (encoding glycyl-tRNA synthetase) can be reproduced in a purified

271 fferent mutant alleles of GARS (the gene for glycyl-tRNA synthetase) have been reported to cause a do

272 mutation in Aats-gly (also known as gars or glycyl-tRNA synthetase), the Drosophila melanogaster ort

273 f the Bacillus subtilis glyQS gene, encoding glycyl-tRNA synthetase, depends on stabilization of an a

274 GARS encodes glycyl-tRNA synthetase, the enzyme that couples glycine

275 AMPPNP and AMPPCP were not substrates for glycyl-tRNA synthetase.

276 ied as GRS1, which encodes the S. cerevisiae glycyl-tRNA synthetase.

277 ved in flies expressing a neuropathy-causing glycyl-tRNA synthetase.

278 We found that CMT mutant glycyl-tRNA synthetases bound tRNA(Gly) but failed to re

279 Interestingly, significant homology to glycyl-tRNA synthetases from prokaryotic organisms revea

280 ular tRNA(Gly) pool, leading to insufficient glycyl-tRNA(Gly) supply to the ribosome.

281 tylates the aminoacyl moiety of isoaccepting glycyl tRNAs, thus precluding their participation in tra

282 This fragmentation produces a glycyl-type radical upon losing CH2 SO, and the degree o

283 Herein, we demonstrate that the stability of glycyl-type radicals (X-(.) CH-Y) can be tuned on a mole

284 9), sumatriptan, serotonin-5-O-carboxymethyl-glycyl -tyrosinamide (GTI), 5-methylaminosulfonylmethyl-

285 In the case of glycyl-tyrosine, a stable 3-(1-hydroperoxy-4-oxocyclohex

286 against D-alanyl substrates with respect to glycyl was observed.