ライフサイエンスコーパス: gonococcal

1 entous phage can induce antibodies with anti-gonococcal activity and that phage proteins may be a can

2 ATCC 33323, or L. gasseri ATCC 9857 reduced gonococcal adherence by nearly 50%.

3 s subsequently produced and shown to inhibit gonococcal adherence to epithelial cells in a dose-depen

4 the healthy human vaginal tract, can inhibit gonococcal adherence to epithelial cells in culture.

5 dition, methanol-fixed L. jensenii inhibited gonococcal adherence to live epithelial cells, indicatin

6 ound no evidence that C. muridarum increases gonococcal adherence to, or invasion of, immortalized mu

7 of L. jensenii involved in the inhibition of gonococcal adherence.

8 t antibiotics and the limited number of anti-gonococcal agents currently in clinical trials.

9 t of lead compounds for optimization of anti-gonococcal agents.

10 Members of the clade continue to acquire gonococcal alleles, including one allele associated with

11 xpress a capsule, and acquisition of several gonococcal alleles, including one allele encoding a high

12 Here, we demonstrated that gonococcal AmiC can act on macromolecular PG to liberate

13 ion to displaying high basal activity on PG, gonococcal AmiC can utilize metal ions other than the zi

14 Thus gonococcal AmiC has distinct differences from related en

15 is partly due to ampG, since replacement of gonococcal ampG with the meningococcal allele reduced PG

16 n, suggesting that the chemistry involved in gonococcal anaerobic UFA synthesis is distinct from that

17 in which methods for the diagnosis of rectal gonococcal and chlamydial infection are optimal.

18 dered to be acceptable for identification of gonococcal and chlamydial infections from urine samples,

19 Over 60% and 80% of gonococcal and chlamydial infections, respectively, amon

20 and identify interactions of NHBA with both gonococcal and host cells.

21 ntial to offer broad protection against both gonococcal and meningococcal infections.

22 and the maintenance of variant GGIs in some gonococcal and meningococcal isolates.

23 rd ratios for the comparison of trichomonal, gonococcal, and chlamydial infection incidence in partic

24 Rates of chlamydial, gonococcal, and syphilis infection continue to increase

25 ssed by Gram stain and incident trichomonal, gonococcal, and/or chlamydial genital infection.

26 levated risk for acquisition of trichomonal, gonococcal, and/or chlamydial genital infection.

27 old increased risk for incident trichomonal, gonococcal, and/or chlamydial infection (adjusted hazard

28 with a positive test result for trichomonal, gonococcal, and/or chlamydial infection.

29 13.3% by positive detection of trichomonal, gonococcal, and/or chlamydial infection.

30 The rise in gonococcal antibiotic resistance and the threat of untre

31 The anti-gonococcal antibodies induced by MeNZB-like OMV proteins

32 eviously shown to regulate the expression of gonococcal antimicrobial efflux systems.

33 The rise of gonococcal antimicrobial resistance highlights the need

34 could be used to expand the availability of gonococcal antimicrobial resistance testing for both cli

35 nce typing, and challenges posed by emerging gonococcal antimicrobial resistance.

36 ility data from 24 countries in the European Gonococcal Antimicrobial Surveillance Programme and anti

37 erapy, prescribers should consider trends in gonococcal antimicrobial susceptibility due to emerging

38 could bridge bacteria to CR3 and facilitate gonococcal association with host cells.

39 To further study the mechanism of gonococcal biofilm formation, we compared transcriptiona

40 on occurs predominantly in the substratum of gonococcal biofilms and that expression of aniA is induc

41 xtends to its ability to disrupt established gonococcal biofilms through degradation of the DNA in th

42 (LOS) epitope recognized mAb 2C7 attenuates gonococcal burden in the mouse vaginal colonization mode

43 We show that only gonococcal, but not meningococcal, LNT LOS sialylation e

44 Here we showed that a gonococcal catalase (kat) mutant in strain MS11 was more

45 respiratory burst during infection and that gonococcal catalase and the MntC protein confer an unide

46 Here we assessed the importance of gonococcal catalase in a surrogate model of female genit

47 A gonococcal catalase mutant and a catalase, cytochrome C

48 Mutagenized TbpAs were expressed on the gonococcal cell surface and maintained wild-type transfe

49 However, >40% of the gonococcal cell wall is cross-linked, where the peptide

50 crease in T-cell populations observed during gonococcal cervicitis.

51 tment of mice with IL-12 microspheres during gonococcal challenge led to faster clearance of infectio

52 veral predictions of the polyploidy model of gonococcal chromosome organization.

53 difA and difB, is not readily lost from the gonococcal chromosome, the substitution of difB with ano

54 pendent bactericidal activity and attenuates gonococcal colonization in mice, recognizes an epitope c

55 ation of CMP-Kdn or CMP-Leg5,7Ac2 attenuates gonococcal colonization of mouse vaginas.

56 ork, we show that deletion of ng1686 affects gonococcal colony morphology but not cell morphology and

57 arms of ocular topical medication to prevent gonococcal conjunctival infection in newborns.

58 tion, 8 participants had positive pharyngeal gonococcal cultures, and 4 had positive rectal cultures.

59 had acquired by gene conversion the complete gonococcal denitrification norB-aniA gene cassette, and

60 tion tests (NAATs) for rectal chlamydial and gonococcal diagnosis.

61 sting sequelae, prompting the reemergence of gonococcal disease as a leading global health concern.

62 hormones potentially modulate the course of gonococcal disease in women.

63 seria, the epidemiology of meningococcal and gonococcal disease, and mechanisms of Neisseria pathogen

64 severe restriction of treatment options for gonococcal disease.

65 e female genital tract mediate the course of gonococcal disease.

66 ected to be important in the pathogenesis of gonococcal disease.

67 gonococcal Fur- and iron-regulated genes in gonococcal disease.

68 Evolving gonococcal epidemiology and clinical trial design constr

69 pressures compete with antibiotics to shape gonococcal evolution.

70 Gonococcal fatty acid profiles confirmed that NGO1024 wa

71 This study demonstrated that the gonococcal FbpABC transport system is required for utili

72 s of resistance mechanisms that may increase gonococcal fitness and therefore the potential for sprea

73 in humans; loss of HepII lactose compromises gonococcal fitness in mice.

74 isolated gyrA(91/95) and parC86 mutations on gonococcal fitness.

75 Gonococcal fluoroquinolone resistance emerged more rapid

76 lectively, our studies have established that gonococcal Fur functions as an activator of gene transcr

77 study we have demonstrated expression of the gonococcal fur gene in vitro, in human cervical epitheli

78 studies confirmed that the expression of the gonococcal fur gene was repressed during growth under ir

79 e genes exhibited reduced transcription in a gonococcal fur mutant strain.

80 itro findings and point toward a key role of gonococcal Fur- and iron-regulated genes in gonococcal d

81 The gonococcal Fur-activated genes displayed variable transc

82 f its four intrinsic 16S rRNA genes with the gonococcal gene.

83 indicate that transcriptional regulation of gonococcal genes by MtrR is centrally involved in determ

84 er MtrR can exert regulatory action on other gonococcal genes, we performed a whole-genome microarray

85 The 57-kb gonococcal genetic island (GGI) encodes a type IV secret

86 FA1090, however, lacks the gonococcal genetic island (GGI) that is present in the m

87 ins of Neisseria gonorrhoeae carry the 57-kb gonococcal genetic island (GGI), as do a few strains of

88 -MtrE efflux-pump system during experimental gonococcal genital-tract infection and also illustrate a

89 of 1668 loci were identified as core to the gonococcal genome.

90 b 2C7 showed functional activity against all gonococcal HepI LOS structures defined by various lgtA/C

91 A unique gonococcal immune evasion strategy involves capping of l

92 Neisseria gonorrhoeae can cause disseminated gonococcal infection (DGI).

93 ensitive for the detection of chlamydial and gonococcal infection at the rectal site than is culture.

94 ined from female subjects with uncomplicated gonococcal infection corroborated our in vitro findings

95 n with the same serovar can occur, and prior gonococcal infection does not alter the Ig response upon

96 of participants with a laboratory-confirmed gonococcal infection during the 36-month follow-up.

97 of ocular prophylaxis, transmission rates of gonococcal infection from mother to newborn are 30% to 5

98 ted bacterial growth and was able to treat a gonococcal infection in a human cervical epithelial cell

99 the contributions of MisR and MisS (CpxA) to gonococcal infection in a murine model of cervicovaginal

100 cific antibiotic susceptibility profile of a gonococcal infection in a patient.

101 d genes are expressed in vivo during mucosal gonococcal infection in men, which suggests that this or

102 not constitutive activation is required for gonococcal infection in mice.

103 erefore the potential for spread, (b) use of gonococcal infection in the animal model system to study

104 Gonococcal infection induced a significant increase in s

105 The role of autolysis during gonococcal infection is not known, but possible advantag

106 Although gonococcal infection of B cells produced small amounts o

107 that an intact MisRS system is required for gonococcal infection of mice.

108 irectly influences B cells, we observed that gonococcal infection prolonged viability of primary huma

109 Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist t

110 In this work, a cell culture model of gonococcal infection was adapted to examine the effects

111 inal pH, positive whiff test, and concurrent gonococcal infection were positively associated with TV

112 Symptomatic gonococcal infection, caused exclusively by the human-sp

113 immune responses in a mouse model of genital gonococcal infection.

114 sion of IgD(+)CD27(+) B cells in response to gonococcal infection.

115 oluble 17beta-estradiol to promote long-term gonococcal infection.

116 rations in host innate responses may enhance gonococcal infection.

117 ffects of H(2)O(2)-producing lactobacilli on gonococcal infection.

118 lain species-specific restriction of natural gonococcal infection.

119 mens from female subjects with uncomplicated gonococcal infection.

120 a key arm of innate immune defenses against gonococcal infection.

121 ge of nucleic acid amplification testing for gonococcal infection.

122 al potent treatment for antibiotic-resistant gonococcal infection.

123 erapeutic and prophylactic compounds against gonococcal infection.

124 play a role in tubal scarring in response to gonococcal infection.

125 o = 0.50; 95% CI, 0.28 to 0.88; P = .02) and gonococcal infections (48 vs 54 participants, respective

126 and public health strategy for management of gonococcal infections and antimicrobial resistance.

127 ceiving eculizumab on their risk for serious gonococcal infections and perform screening for sexually

128 her insights into the species specificity of gonococcal infections and proof-of-concept of a novel th

129 ay have resulted in decreased chlamydial and gonococcal infections at the population level.

130 Gonococcal infections cause significant morbidity, parti

131 Gonococcal infections do not elicit protective immunity,

132 ariable pathophysiology of meningococcal and gonococcal infections given that after an initial exposu

133 Here, we demonstrate that women with gonococcal infections have levels of sialidases present

134 and Prevention STD treatment guidelines for gonococcal infections in adolescents and adults.

135 the evidence on screening for chlamydial and gonococcal infections in asymptomatic patients from stud

136 rnative treatment regimen, and management of gonococcal infections in persons with severe cephalospor

137 Specificity for gonococcal infections was >/= 99.8%.

138 es were evaluated, and 281 chlamydial and 69 gonococcal infections were identified.

139 To better understand the role of Opa in gonococcal infections, we created and characterized a de

140 96.9 to 100% using LCA for the detection of gonococcal infections.

141 et for beta-lactam antibiotics used to treat gonococcal infections.

142 G, which for over 40 years was used to treat gonococcal infections.

143 standard that defines AZI susceptibility for gonococcal infections.

144 arynx, possibly modulating meningococcal and gonococcal infections.

145 ed to examine the effects of lactobacilli on gonococcal interactions with endometrial epithelial cell

146 nii uses a constitutive component to inhibit gonococcal interactions with epithelial cells.

147 Lactobacilli also inhibited gonococcal invasion of epithelial cells by more than 60%

148 Centers for Disease Control and Prevention's Gonococcal Isolate Surveillance Project (GISP) from sent

149 approximately 60 clinics associated with the Gonococcal Isolate Surveillance Project (GISP), enhanced

150 f a combination of routine isolates from the Gonococcal Isolate Surveillance Project and isolates col

151 smitted disease clinic, a participant in the Gonococcal Isolate Surveillance Project, during 2009.

152 Centers for Disease Control and Prevention's Gonococcal Isolate Surveillance Project.

153 enomes of 649 isolates collected through the Gonococcal Isolate Surveillance Project.

154 thromycin using detailed genomic analyses of gonococcal isolates collected in the United States, 2014

155 ic susceptibility, and patient data from 897 gonococcal isolates cultured at the NYC Public Health La

156 smids are widespread in a collection of 3724 gonococcal isolates from 56 countries, and characterized

157 nome-based phylogeographical analysis of 419 gonococcal isolates from across the globe.

158 mary outcome measures included percentage of gonococcal isolates resistant to antimicrobials used to

159 This cluster of genetically related gonococcal isolates with decreased ceftriaxone susceptib

160 Both BamD and BamE are expressed in diverse gonococcal isolates, under host-relevant conditions, and

161 identified globally distributed, persistent, gonococcal lineages improving understanding of the popul

162 ressing TEM-135 are associated with distinct gonococcal lineages.

163 Sialylation of gonococcal lipo-oligosaccharide, or expression of porin

164 A gonococcal lipooligosaccharide epitope defined by the mA

165 Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed

166 Although gonococcal LNT LOS sialylation enhances binding of the a

167 and function of MAb 2C7 in vitro Here, four gonococcal LOS mutants, each with lactose from HepII but

168 can result in desialylation of (sialylated) gonococcal LOS.

169 were substrates for Lst, further elucidating gonococcal Lst specificity.

170 ellular DNA is an essential component of the gonococcal matrix.

171 found in the FA1090 genome, suggesting that gonococcal MMC is not methyl directed.

172 These results show that gonococcal MMC repairs mismatches and small insertion/de

173 Gonococcal mutants deficient in MtrA, an activator of th

174 Isogenic gonococcal mutants in which the lgt required for mAb 2C7

175 imilar complement-dependent killing of three gonococcal mutants with glycan extensions beyond lactose

176 The high level of human anti-gonococcal NHBA antibodies generated by Bexsero vaccinat

177 These data indicate that the gonococcal NHBA contributes to several aspects of the co

178 Furthermore, we report that a gonococcal nhba mutant displays decreased cell aggregati

179 uding one allele encoding a highly efficient gonococcal nitrite reductase.

180 The gonococcal OmpA protein was previously identified as a p

181 ework for understanding the transcription of gonococcal ompA through a regulatory system known to be

182 Estimates were similar for trichomonal-only, gonococcal-only, and chlamydial-only infection outcomes.

183 cular prophylaxis is effective in preventing gonococcal ophthalmia neonatorum and related ocular cond

184 Gonococcal ophthalmia neonatorum can cause corneal scarr

185 endation Statement on ocular prophylaxis for gonococcal ophthalmia neonatorum summarizes published ev

186 In the United States, the rate of gonococcal ophthalmia neonatorum was an estimated 0.4 ca

187 pical medication for all newborns to prevent gonococcal ophthalmia neonatorum.

188 The secondary end point was newly acquired gonococcal or chlamydial infection.

189 in vitro, which is facilitated by either the gonococcal or E. coli RecA proteins or high pH, and auto

190 istant N gonorrhoeae through augmentation of gonococcal outbreak surveillance and identification of p

191 tigating the contribution of Opa proteins to gonococcal pathogenesis is complicated by high-frequency

192 The purified endopeptidase degraded gonococcal peptidoglycan in vitro, cutting the peptide c

193 gococcal PG recycling is more efficient than gonococcal PG recycling.

194 terone functioned in an additive manner with gonococcal phospholipase D to augment Akt kinase activit

195 The NYC gonococcal phylogeny reflected global diversity with iso

196 We reconstructed the gonococcal phylogeny, defined transmission clusters usin

197 The dynamics of gonococcal population biology have been poorly defined d

198 We provide evidence that the modern gonococcal population has been shaped by antimicrobial t

199 can be used to improve our understanding of gonococcal population structure compared with current ty

200 resistant gonococcal strains by identifying gonococcal populations containing mutations of concern.

201 actor H binding to meningococci that express gonococcal Por.

202 sialylated) that did not bind factor H with gonococcal Por1B augmented factor H binding.

203 Gonococcal Por1B introduced in the background of an unsi

204 o unsialylated meningococci transfected with gonococcal Por1B was similar to the sialylated counterpa

205 lylated meningococcal mutants that possessed gonococcal Por1B were resistant to complement-mediated k

206 Conversely, replacing gonococcal Por1B with meningococcal PorB abrogated facto

207 se effects of lipid A PEA on C4BP binding to gonococcal PorB and serum resistance were simulated when

208 orB and serum resistance were simulated when gonococcal PorB was expressed in a meningococcal backgro

209 rB.1B, we discovered that strains expressing gonococcal PorB.1B in the presence of sialylated lipooli

210 ains expressing either meningococcal fHbp or gonococcal PorB.1B, we discovered that strains expressin

211 ontribute to the antiapoptotic effect of the gonococcal porin, PIB.

212 o OMV antigens, and between the antigens and gonococcal proteins.

213 induces antibodies in humans that recognize gonococcal proteins.

214 ilarity of MeNZB OMV and Bexsero antigens to gonococcal proteins.

215 No gonococcal resistance to aBL developed after 15 successi

216 We obtained data from the Gonococcal Resistance to Antimicrobials Surveillance Pro

217 The capacity of polyamines to increase gonococcal resistance to cationic antimicrobial peptides

218 lamine (PEA) decoration of lipid A increases gonococcal resistance to complement-mediated bacteriolys

219 addition, we found that polyamines increase gonococcal resistance to complement-mediated killing by

220 pump operon and, as a consequence, levels of gonococcal resistance to host antimicrobials (e.g., anti

221 al repressor of the mtrCDE operon, increases gonococcal resistance to these agents.

222 t that polyamines can significantly increase gonococcal resistance to two structurally diverse cation

223 nvestigated to assess the nature of the anti-gonococcal response.

224 d in adherent gonococci, two are part of the gonococcal RpoH regulon.

225 (FISH) probes specific for meningococcal and gonococcal rRNA were used to demonstrate the expression

226 ing detergent-extracted OMV, did not produce gonococcal SBA in humans.

227 heptose (Hep) glycan substitutions influence gonococcal serum resistance.

228 ipooligosaccharide (LOS) with sialic acid by gonococcal sialyltransferase (Lst), utilizing host-deriv

229 fection of B cells produced small amounts of gonococcal-specific IgM, IgM specific for irrelevant Ags

230 s as the primary target of Opa proteins, the gonococcal specificity for this human family of receptor

231 NOMV-KO vaccines also elicited SBA against a gonococcal strain (P < .0001 vs the adjuvant-only contro

232 Each gonococcal strain carried one of three different alleles

233 t of crgA (DeltacrgA) in the serum-sensitive gonococcal strain F62.

234 t the outer membrane transporter FetA allows gonococcal strain FA1090 to utilize the xenosiderophore

235 ression of FbpABC was required for growth of gonococcal strain FA19 in the presence of enterobactin a

236 hosphoethanolamine (PEA) from the lipid A of gonococcal strain FA19 results in increased sensitivity

237 erobactin and salmochelin promoted growth of gonococcal strain FA19.

238 ccharide beta-chain did not impact levels of gonococcal (strain FA19) resistance to normal human seru

239 OS or whole bacteria, compared with LOS from gonococcal strains 1291 and GC56 with reduced levels of

240 of the strains, meningococcal strain 89I and gonococcal strains 1291 and GC56, representing high, int

241 explaining the absence of the GGI from some gonococcal strains and the maintenance of variant GGIs i

242 ) is an epidemiological tool that classifies gonococcal strains based on sequence differences in regi

243 Several gonococcal strains bind the classical complement pathway

244 nhance monitoring of antimicrobial resistant gonococcal strains by identifying gonococcal populations

245 rt that LOS from different meningococcal and gonococcal strains have different potencies to activate

246 s required for C4BP binding to Por1B-bearing gonococcal strains MS11 and 1291 but not to FA19 (Por1A)

247 uman infection, is on the rise worldwide and gonococcal strains resistant to many antibiotics are eme

248 re of RMS and target methylated motifs in 25 gonococcal strains sequenced with Single Molecule Real-T

249 We show that only those gonococcal strains that bind C4BP require properdin for

250 Loss of PEA from lipid A in three additional gonococcal strains that expressed diverse PorB molecules

251 Ab-mediated complement-dependent killing of gonococcal strains that inhibit the classical pathway by

252 We investigated the emergence and spread of gonococcal strains with decreased susceptibility to ceph

253 trol rFHbp vaccine against meningococcal and gonococcal strains.

254 F-kappaB activity than released fragments in gonococcal supernatants and tended to induce less interl

255 imilar modest ligand-blocking effects on the gonococcal surface but different effects in Escherichia

256 els of gonococcal transmission, new tools in gonococcal surveillance may provide useful data to aid t

257 amines in genital mucosal fluids may enhance gonococcal survival during infection by reducing bacteri

258 The MtrC-MtrD-MtrE system is important for gonococcal survival in the murine genital tract, and der

259 antimicrobial peptides, suggesting a role in gonococcal survival in vivo Here, we evaluated the contr

260 In vivo testing of the role of catalase in gonococcal survival is critical since several physiologi

261 acquisition and GGI-encoded gene products in gonococcal survival within cervical epithelial cells.

262 ible nitric oxide synthase activity promoted gonococcal survival within pex cells.

263 ng the importance of D-lactate metabolism in gonococcal survival.

264 poH-regulated genes also modulates levels of gonococcal susceptibility to H(2)O(2).

265 d to repress rpoH expression and to increase gonococcal susceptibility to hydrogen peroxide (H(2)O(2)

266 centrally involved in determining levels of gonococcal susceptibility to penicillin and provides a f

267 epressor of the efflux pump operon, decrease gonococcal susceptibility to penicillin.

268 ssion of two other loci that are involved in gonococcal susceptibility to penicillin: ponA, which enc

269 inactivation of lptA, resulted in increased gonococcal susceptibility to polymyxin B, as reported pr

270 genes (kat, ccp, and mntC) does not increase gonococcal susceptibility to the phagocytic respiratory

271 These results suggest that the gonococcal T4SS may be present in single copy per cell a

272 Unlike other gonococcal T4SS proteins we have investigated, protein l

273 Similar to other F-like T4SSs, the gonococcal T4SS requires a putative membrane protein, Tr

274 nal studies showed that in contrast with the gonococcal T4SS, the meningococcal T4SS does not secrete

275 Using a three-dimensional structure of gonococcal TbpA, we investigated two hypotheses, i.e., t

276 latory data demonstrating that production of gonococcal TdfH and TdfJ are unresponsive to or upregula

277 In this study, we found that production of gonococcal TdfH is both Zn and Zur repressed.

278 Four gonococcal TdTs facilitate utilization of iron or iron c

279 ding studies, was more often associated with gonococcal the most common VR types.

280 h to examine the role of NrrF in controlling gonococcal transcription.

281 The gonococcal transferrin-iron uptake system is composed of

282 impeded development of operational models of gonococcal transmission, new tools in gonococcal surveil

283 e most well-studied type IV filaments is the gonococcal type IV pilus (GC-T4P) from Neisseria gonorrh

284 The gonococcal type IV secretion system secretes DNA during

285 riaxone (CRO) for treatment of uncomplicated gonococcal urethritis and cervicitis in the United State

286 ride bactericidal monoclonal Ab (mAb) 2C7, a gonococcal vaccine candidate Ab, attenuates vaginal colo

287 consideration in evaluating the efficacy of gonococcal vaccine candidates.

288 As no gonococcal vaccine is available, prevention relies on pr

289 ct AMR, novel therapeutic antimicrobials and gonococcal vaccine(s) in particular is crucial.

290 st gonorrhea, this has renewed interest in a gonococcal vaccine, and several candidates are in develo

291 e encoded proteins could form the basis of a gonococcal vaccine, rabbits were orally infected with S.

292 ther impetus for use of the 2C7 epitope in a gonococcal vaccine.

293 rhea will inform the development of Ab-based gonococcal vaccines and immunotherapeutics.

294 y how blocking Abs influence the efficacy of gonococcal vaccines.

295 sed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice.

296 We observed that gonococcal variants that produced type IV pili secreted

297 able, suggesting that they are essential for gonococcal viability.

298 ence of BamD, but not BamE, is essential for gonococcal viability.

299 reviously identified the NG1686 protein as a gonococcal virulence factor that protects against both n

300 H directly binds calprotectin, which enables gonococcal Zn accumulation in a TdfH-dependent manner an