ライフサイエンスコーパス: gossypol

1 ary metabolites (especially coumarinates and gossypol).

2 -MS analysis to be essentially free of toxic gossypol.

3 nd arachidonic acid) mimicked treatment with gossypol.

4 o pan-Bcl-2 family inhibitors, obatoclax and gossypol.

5 t hydrocarbon of cotton phytoalexins such as gossypol.

6 y reduced the apoptosis induced by TRAIL and gossypol.

7 ses of apogossypol 2- to 4-times higher than gossypol.

8 eins, with binding potency comparable to (-)-gossypol.

9 group of Ala-1 by stoichiometric amounts of gossypol.

10 may exist for tirilazad and the antioxidant gossypol.

11 lipophilic antioxidants such as tirilazad or gossypol.

12 on cancer cells (COLO 225) were treated with gossypol.

13 ms of actions of certain polyphenols such as Gossypol (a compound from cotton seed extracts) and Purp

14 We investigated whether gossypol, a BH3 mimetic that is currently in the clinic,

15 Gossypol, a cottonseed extract derivative, acts as a BH3

16 first committed step of the biosynthesis of gossypol, a phytoalexin that defends the plant from bact

17 The combination of the STAT3 decoy and gossypol, a small molecule targeting Bcl-X(L), also yiel

18 ance through promoting suberin biosynthesis, gossypol accumulation and expression of JA signaling def

19 Gossypol acetate (GAA), a gynecological medicine that ha

20 on-approved natural compounds and identified gossypol acetic acid (GAA) as a potent inhibitor of oxid

21 Gossypol also down-regulated cell survival proteins (Bcl

22 This study demonstrated that gossypol and ethanol extracts differentially regulated c

23 l viability and VEGF expression regulated by gossypol and ethanol extracts using lipopolysaccharides

24 Gossypol and its derivatives are the main components of

25 re increased substantially by treatment with gossypol and its expression was critical for the gossypo

26 city and efficacy in mice of natural product gossypol and its semisynthetic derivative apo-gossypol,

27 In contrast, gossypol and lipopolysaccharides were toxic to macrophag

28 ignificantly (capsaicin) or insignificantly (gossypol and nicotine) induced L-ACY-1 expression in H.

29 the systemic absence of glands that contain gossypol and other protective terpenoids.

30 Most relevant, the levels of gossypol and related terpenoids in the foliage and flora

31 l molecules (e.g. oblimersen, obatoclax, and gossypol), antifols (e.g. pralatrexate), proteasome inhi

32 Gossypol appears to prevent or delay the observed cell i

33 This may increase cottonseed value by using gossypol as a health intervention agent.

34 gent), cyclopamine (hedgehog inhibitor), and gossypol (Bcl-2 inhibitor).

35 We have successfully used RNAi to disrupt gossypol biosynthesis in cottonseed tissue by interferin

36 Additionally, the expression of gossypol biosynthetic genes and defense-related genes PD

37 ants lacking these dirigent proteins produce gossypol but are devoid of hemigossypolone and heliocide

38 ace promotes only the noncovalent binding of gossypol, but not the covalent modification.

39 d culture of P. falciparum trophozoites with gossypol caused induction in expression of Pf MDH, while

40 ossypol and its semisynthetic derivative apo-gossypol, compounds that bind and inhibit antiapoptotic

41 Gossypol decreased the mRNA levels of DGAT, GLUT, TTP, I

42 Gossypol dramatically reduced macrophage viability but c

43 Overall, our results show that gossypol enhances TRAIL-induced apoptosis through the do

44 We demonstrated previously that gossypol failed to directly inhibit BCL2 in cells or ind

45 In vivo, using the maximum tolerated dose of gossypol for sequential daily dosing, apogossypol displa

46 Therefore, elimination of gossypol from cottonseed has been a long-standing goal o

47 e combination of erlotinib, STAT3 decoy, and gossypol further enhanced cell growth inhibition and apo

48 Gossypol (Gsp), a natural toxin concentrated in cottonse

49 Plant polyphenol gossypol has anticancer activities.

50 icial diet assays using purified terpenoids (gossypol/heliocide H1/4) were conducted.

51 Gossypol, however, did not exhibit this property.

52 We report here that AT-101, a derivative of gossypol in clinical trials, overcomes stroma-mediated r

53 , apogossypol displayed superior activity to gossypol in terms of reducing splenomegaly and reducing

54 ence the kinetics of modification of PLA2 by gossypol in the aqueous phase, and the enzyme at the int

55 Gossypol, in conjunction with spectroscopic and kinetic

56 Gossypol increased VEGFa and VEGFb mRNA levels up to 27

57 anolamines, phosphatidic acids, sterols, and gossypol, indicating the broad range of metabolites and

58 Gossypol induced cell death in a concentration- and time

59 ROS); however, antioxidants did not abrogate gossypol-induced cell death.

60 , and thus, gene silencing of CHOP abolished gossypol-induced DR5 expression and associated potentiat

61 Calcium chelation also abrogated the gossypol-induced increase in calcium, ER stress, and NOX

62 Gossypol-induced receptor induction was not cell type-sp

63 APK or JNK) activation was also required for gossypol-induced TRAIL receptor induction; gene silencin

64 iescent lymphocytes, we investigated whether gossypol induces apoptosis in these cells and what mecha

65 Gossypol induction of the death receptor required the in

66 The results showed that gossypol inhibited cell survival with decreased expressi

67 Gossypol is a putative BH3 mimetic proposed to inhibit B

68 A rapid initial noncovalent binding of gossypol is followed by a slow covalent modification of

69 Gossypol is shown to covalently modify secreted phosphol

70 possible to significantly reduce cottonseed-gossypol levels in a stable and heritable manner.

71 NOXA and Mcl-1 are critical determinants for gossypol-mediated cell death in ABT-737-resistant cells.

72 poptosis, suggesting that AIF contributes to gossypol-mediated cytotoxicity in CLL lymphocytes.

73 in these cells and what mechanism underlies gossypol-mediated cytotoxicity.

74 Residual activity of the gossypol-modified PLA2 from several different sources is

75 The aim was to uncover the effects of gossypol on cell viability and gene expression in cancer

76 in the cells; many of them are regulated by gossypol or ZFP36/TTP in cancer cells.

77 but insignificantly inhibited (capsaicin and gossypol) or induced (nicotine) it in H. assulta.

78 ation of sesquiterpene synthase genes in the gossypol pathway exemplifies the chemical diversity of l

79 -8, -9, and -3 activity assays revealed that gossypol potentiated TRAIL-induced apoptosis in human co

80 Gossypol promotes binding of PLA2 to the interface, and

81 Here, we demonstrate that gossypol rapidly increased activity of phospholipase A2

82 landed cottonseed tend to be associated with gossypol, reducing extraction efficiency.

83 eral pathways including DGAT, GLUT, TTP, IL, gossypol-regulated and TTP-mediated pathways.

84 ypol and its expression was critical for the gossypol response.

85 nt manner; 24-hour incubation with 30 microM gossypol resulted in 50% cell death (median; range, 10%-

86 drug delivery of paclitaxel, cyclopamine and gossypol, resulting in tumor growth inhibition and prolo

87 In particular, gossypol suppressed the expression of genes coding for C

88 ing the transition of hemigossypol away from gossypol synthesis toward a hydroxylation pathway that l

89 und that reactive oxygen species produced by gossypol treatment was critical for TRAIL receptor induc

90 Although gossypol was effective only in resistant cells, obatocla

91 Oxamic acid did not inhibit Pf MDH, while gossypol, which interacts at the nucleotide binding site

92 t apogossypol is superior to parent compound gossypol with respect to toxicology and efficacy, sugges

93 represented the major adverse activities of gossypol, with apogossypol far less toxic.

94 to cytotoxicity induced by apogossypol than gossypol, with LD50 values of 3 to 5 microM and 7.5 to 1

95 derutilized because of the presence of toxic gossypol within seed glands.