ライフサイエンスコーパス: gradual

1 al coupling, the change in [Ca(2+)] was more gradual.

2 at early genome activation is continuous and gradual.

3 epresentation of near and far space was more gradual.

4 mbrane (ICM) were noted: abrupt (73.33%) and gradual (26.67%).

5 Moreover, in vivo imaging demonstrated the gradual accumulation of both syn-RA16 and trans-RA16 at

6 Our results are consistent with a gradual accumulation of genomic changes after polyploidi

7 single faces consistent with a slower, more gradual accumulation of perceptual information.

8 l administration of (89)Zr-BVDFO resulted in gradual accumulation of radioactivity in the ipsilateral

9 recent speciation rates but rather with the gradual accumulation of species over time.

10 n two patients for up to 15 weeks revealed a gradual accumulation of T590S, concurrent with drops in

11 This process involves gradual acquisition of mutations in oncogenes and tumor

12 This gradual activation mechanism may also explain how SYK ma

13 ely, we identify factors associated with the gradual adaptation of monocytes to tissue residency.

14 to the cranial neural crest emerged via the gradual addition of network components to the neural cre

15 Gradual aeration with tidal ventilation and PEEP produce

16 eas the increase in bradykinin receptors was gradual after day 3 postinjury.

17 We found a gradual age-dependent, navigational experience-independe

18 The gradual alteration of mortality risk after ICU admission

19 nsequence of the oceanic integration of both gradual and abrupt climate forcings.

20 of the discovery of RGS proteins and of the gradual and continuing discovery of their roles in disea

21 k-initiation models in metals to account for gradual and heterogeneous evolution.

22 trait and population dynamics in response to gradual and increasing changes in the environment.

23 long-term environmental stressors induce the gradual and long-lasting activation of highly conserved

24 stral to Modern Beijing sublineages might be gradual and occur in Southern China, where the presence

25 Ceratophorae is a blend of gradual and punctuated mode.

26 injury.Objectives: To examine the effect of gradual and rapid aeration at birth on: 1) the spatiotem

27 ity, CO(2) fertilization as well as both the gradual and rapid ecosystem changes caused by land use.

28 ng of the very same domains reveals that the gradual and reversible transition between the conducting

29 Gradual and stochastic changes in genomic and epigenomic

30 tivation, beginning at the miR-430 locus, is gradual and stochastic.

31 to free bpee molecules concomitant with the gradual appearance of a new photoluminescence band at sh

32 riven by a dynamic stimulus that indicates a gradual approach to a reward.

33 m, Sherpa, Kathmandu; 1400 m) and following gradual ascent to 5050 m.

34 impler pond scum relatives, and evidence the gradual assembly of the land plant genome, revealing a p

35 th survival, and there was a significant and gradual association between survival and categories of t

36 hat the development of Maya civilization was gradual, assuming that small villages began to emerge du

37 neurons, and parvalbumin-expressing INs and gradual asynchronous recruitment of layer 5 PNs and soma

38 esponse are capable of converting subtle and gradual biological variations into robust outputs to imp

39 Gradual bone uptake was, however, also observed.

40 y is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand break (DSB) misrepa

41 Following over 3 decades of gradual but uneven increases in sea ice coverage, the ye

42 s: OR, 1.6; 95% CI, 1.2-2.1; P < 0.001), (4) gradual change (between -4 and 4 letters) or rapid gains

43 r over hundreds of generations may lead to a gradual change in cell fitness and the establishment of

44 that a resilient interactome arises through gradual change of the network topology.

45 evolved by disruptive innovation rather than gradual change.

46 e an ecosystem that would persist under more gradual change.

47 ediate response to interventions rather than gradual changes in behaviour.

48 Our results showed gradual changes in diffusivity that are indicative of de

49 In response to gradual changes in oxygen influx, this model abruptly tr

50 trast to previous work, which has quantified gradual changes in pupil diameter (the so-called "pupil

51 tadial, which likely occurred in response to gradual changes in temperature- and wind-driven freshwat

52 s in daylength, including both transient and gradual changes observed in realistic light intervals ac

53 l role for oligomerized condensin in driving gradual chromatin compaction by step-like and slow "cree

54 ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, di

55 ity at mid to high latitude sites due to the gradual closure of forests.

56 in the absence of dementia, also results in gradual cognitive decline and is thought to arise, in pa

57 etention, indicating an origin due to major, gradual collapse of a volatile-rich layer.

58 n on muskeg, a mix of partial excavation and gradual compaction with the strategic placement of filli

59 come weaker at the 2-cell stage, followed by gradual consolidation.

60 h initial tacrolimus monotherapy followed by gradual conversion at 3 weeks to PRCL-02 alone (n = 3).

61 With the gradual cooling occurrence in winter, more accumulation

62 in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered pa

63 However, the gradual deactivation of redox mediators during repeated

64 ack of decay after a large perturbation, but gradual decay after a small perturbation.

65 g biomass between 1967 and 1982, followed by gradual decline from 1982 to 2017, with a 2.2-fold net g

66 wed activation-based subclasses, each with a gradual decline from a cytotoxic to a more quiescent phe

67 uted tomography angiography (CTA) revealed a gradual decline in contrast above the level of the carot

68 protein active site FeMo-co observed as the gradual decline in the E(0) resting state intensity that

69 itial improvement in muscle fatiguability, a gradual decline in the effect of pyridostigmine was obse

70 Additionally, there was a gradual decline in the proportion of meningitis cases ca

71 Remarkably, ageing is accompanied by a gradual decline in tissue and cellular NAD(+) levels in

72 has a less severe effect on HSCs, causing a gradual decline of adult HSC numbers and a concomitant i

73 lost were greater in younger patients and a gradual decline was observed with increasing the age at

74 athological tissue (PathSTORM), we uncover a gradual decompaction and fragmentation of higher-order c

75 Taken together, our findings reveal gradual decompaction and fragmentation of higher-order c

76 ong expression in villous trophoblasts and a gradual decrease from proximal to distal cell columns as

77 ulin from swellable MN patches, leading to a gradual decrease in blood glucose levels.

78 and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2).

79 While a gradual decrease in carrier concentration with decreasin

80 uring the initial stages of EMT, there was a gradual decrease in E-cadherin force and lumen pressure

81 2 +/- 5 muM above S. gordonii, followed by a gradual decrease in H2O2 concentration (>30 min) to almo

82 IL monotherapy attained clinical cure with a gradual decrease in parasite load; however, 25% relapsed

83 creasing concentrations of NTP pools cause a gradual decrease in termination and the resulting read-t

84 over the course of history, there has been a gradual decrease in the frequency of primitive retrotype

85 uced adherence of basal keratinocytes, and a gradual decrease in the stemness of hair follicle stem c

86 inoma of the mouse prostate (TRAMP) model, a gradual decrease of >300 % in iCEST contrast following t

87 For 2- and 3-ring PAHs, a gradual decrease of C(free) was observed which reached 6

88 ascent phase of feeding lunges followed by a gradual decrease of heart rate during the prolonged glid

89 ng the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range

90 vaccine (ZVL) provides the best example of a gradual decrease of vaccine immunogenicity with every 10

91 approximately seven years of age and then a gradual decrease thereafter.

92 rea of PTPA, with the surface area showing a gradual decrease with an increase in the ionic radius of

93 observed a short-term increase followed by a gradual decrease, significant for domesticated animals.

94 MPORTANCE The hallmark of HIV infection is a gradual depletion of CD4 T cells, with a progressive dec

95 B) and Nitrosopumilus maritimus (AOA) during gradual depletion of TAN (NH3 + NH4+) and O2 .

96 that the central corneal opacities represent gradual deposition of extracellular lipids.

97 We explore this issue for gradual deterioration via beam breakage of 2-dimensional

98 st in targeting eCB signaling to prevent the gradual development of emotional symptoms and underlying

99 With improved understanding of the gradual development of epilepsy, epigenetic determinants

100 a harder object that does not depend on the gradual development of the predictive modulation of grip

101 these intracortical changes contributed to a gradual differentiation of higher-order from lower-order

102 levels of RE, most likely as the result of a gradual disappearance of HSCs in livers of Lipa(-/-) mic

103 They then undergo an unprecedented gradual disorganization of their nucleus followed by eru

104 atinib-resistant HER2-mutant cancer cells by gradual dose escalation.

105 py and should be started at a low dose, with gradual dose escalation.

106 f CYP 17A1, especially W2A and E3L, led to a gradual drifting of the TM-helix out of the hydrophobic

107 or-to-memory transition in CD4(+) T cells is gradual during malaria and is modulated by antiparasitic

108 ne to a sub-therapeutic concentration, and a gradual elevation to provide a steady-state from day 35-

109 lectrons, helium-3 and heavier ions(2), and 'gradual' events(3,4), which are typically associated wit

110 ilities is revealed by snapshots showing the gradual evolution of arene pai coordination on going fro

111 llowing I2 acquisition, paving the way for a gradual evolution toward innovation.

112 LIPS and RTD membranes exhibit fast and gradual evolution upon a 2abIm-VPLT, respectively, refle

113 We now provide evidence that this gradual evolution, the pace of which is contingent on th

114 tion and empiric deconstruction to unravel a gradual evolutionary trajectory leading from a polypepti

115 inated CD20(+)/CD19(+) B cells followed by a gradual expansion of a CD19(-) cell population in the ri

116 However, gradual exposure to increasing wastewater strength over

117 ain ejection model (CEM), which involves the gradual expulsion of stretched-out chains from the dropl

118 ization of telomerase by Nopp140 KD leads to gradual extension of telomeres.

119 nellid extinction event in Laurentia and the gradual extinction of redlichiids in South China are lin

120 ent method (DEM) is employed to simulate the gradual failure process of the Tangjiashan landslide und

121 slides anti-parallel microtubules apart with gradual force buildup while parallel microtubule bundles

122 different stages of aggregation revealed the gradual formation of flat domains resembling the morphol

123 The results support our hypothesis that gradual formation of mild carotid stenosis along the lif

124 This gradual frequency change is due to ion energy loss from

125 red homeostasis, regenerative potential, and gradual functional decline in multiple tissues and organ

126 of a commercial baked milk biscuit with slow gradual further exposure followed by increasing milk con

127 More gradual glucose starvation, amino acid deprivation or ra

128 memory demand was uniquely associated with a gradual, goal novelty-related reorganization of place ce

129 With gradual growth in content over 15 years, BioModels curre

130 o species that are already under stress from gradual habitat loss and climate change.

131 cally high-spin at 250 K, but they undergo a gradual high -> low spin-crossover on cooling, which is

132 ape mirroring the cancer DNA methylome, with gradual hypermethylation of bivalent developmental genes

133 We show that salbutamol leads to a gradual improvement in muscle strength in ColQ-/- mice.

134 Gradual improvements in fluorescent probes and multi-cam

135 at the increase with depth of tau cr is very gradual in the uppermost several metres of the depositio

136 usands of proteins can be estimated from the gradual incorporation of (2)H or (15)N in the diet.

137 ynamic analysis of band formation revealed a gradual increase in fiber density and alignment between

138 pathophysiologic abnormalities, there was a gradual increase in IBS symptom severity (P < .0001) and

139 nto four temporal stages, and resulting in a gradual increase in membrane fluidity in individuals ran

140 AKI-disease model mice with KNP-1 suggests a gradual increase in renal ONOO(-) levels with disease pr

141 Our framework employs a gradual increase in resolution and map-model agreement a

142 The gradual increase in rigidity correlates with an increase

143 was detected at a BMI of 21 kg/m(2), with a gradual increase in risk with higher BMI, particularly f

144 with slower vertical stalagmite growth and a gradual increase in stable oxygen isotope ratios.

145 In summary, delayed activation coupled with gradual increase in TDP-43(A315T) expression in the cent

146 light to fairly light, with a nonsignificant gradual increase in the Borg score as the study progress

147 sthetic task performance was observed with a gradual increase in the coherent beta oscillations.

148 LTx recipients experienced a gradual increase in weight, resulting from the combinati

149 This is associated with a gradual increase in whole-cell membrane capacitance.

150 lly before shorting, which then results in a gradual increase of internal self-discharge over >25 cyc

151 show that motor slowing is associated with a gradual increase of net excitability in the motor networ

152 and electron-withdrawing groups to afford a gradual increase of the electronic polarization of the h

153 nt groups), the dose-efficacy curve showed a gradual increase up to doses between 20 mg and 40 mg flu

154 In all cohorts, plasma p-tau181 showed gradual increases along the Alzheimer's disease continuu

155 patients with moderate and severe AD showed gradual increases in the levels of T(H)1 cell-, T(H)2 ce

156 e, that photomixotrophic growth results in a gradual inhibition of Q(A) (-) reoxidation in wild-type

157 ing, a liberalized blood glucose target, and gradual insulin titration.

158 hment of A/B compartments, followed by their gradual intensification and expansion.

159 The reaction is modeled via gradual interpolation between the two sets of force fiel

160 this reflector, which is characterised by a gradual lateral decrease in vertical temperature contras

161 suggest that while DOC primarily stems from gradual leaching of surface soils, POC reflects abrupt c

162 Rather than a gradual linear decline in productivity, there is some li

163 a proteoform turnover time of 7 to 33 h with gradual loss from human tear lipid that retains bioactiv

164 on of PRC1 in male germ cells results in the gradual loss of a stem cell population and severe differ

165 A key feature of osteoarthritis is the gradual loss of articular cartilage and bone deformation

166 db mice, showing strong correlation with the gradual loss of beta-cells.

167 There is a gradual loss of both skeletal muscle mass and strength w

168 Mitogen removal in G1 results in a gradual loss of CDK4/6 activity with a high likelihood o

169 f epidermal-activated TGF-beta resulted in a gradual loss of E- or P-selectin-binding central and per

170 Aging is characterized by a gradual loss of function occurring at the molecular, cel

171 Serial passaged LNC resulted in gradual loss of nuclear Pax6 (46 kDa) staining and neura

172 is characterized by insulin resistance and a gradual loss of pancreatic beta cell mass and function(1

173 for Notch in driving transitions during the gradual loss of potency that takes place in the early mo

174 Thus, the gradual loss of TRF1 and concomitant persistent cohesion

175 cell membrane at discrete foci, followed by gradual loss of turgor, subsequent accumulation in the c

176 erized by progressive retinal cell death and gradual loss of vision.

177 ation of these tracts consequentially to the gradual loss of visual field coverage (from intact perce

178 It remains unclear whether rapid or gradual lung aeration at birth causes less lung injury.O

179 To more accurately mimic the onset of gradual matrix stiffening, which is not feasible with co

180 ction is a stepwise process and reflects the gradual maturation of different hippocampal circuits and

181 trast, emerge slowly in concordance with the gradual maturation of foveal architecture and visual sen

182 ng and interpreting both rapid (seconds) and gradual (minutes) chemical changes captured in FSCV reco

183 ning dynamics may explain the evolution of a gradual mood improvement seen with these agents and prov

184 evidence for a hybrid scenario involving the gradual, multifactorial adaptation to the inhibitors thr

185 Therefore, LRP initiation is a gradual, multistep process.

186 leavage-independent NFL trimers, followed by gradual N-glycan restoration coupled with heterologous b

187 The study revealed a gradual narrowing of the band gap at increasing temperat

188 nts a lagged Southern Hemisphere response to gradual ocean-atmosphere warming associated with the cen

189 oceeds rapidly on Ag(111), but is relatively gradual on Au(111).

190 ncubated them for 5 months with a simulated, gradual or abrupt temperature increase of +5 degrees C,

191 Is evolution always gradual or can it make leaps?

192 nd, competing stimulus outside, they exhibit gradual or switch-like response profiles as a function o

193 hanges in neural representations support the gradual organization of discrete episodes into structure

194 Grape seed maturation involves the gradual oxidation of tannins, decreasing excessive bitte

195 genation events are entirely consistent with gradual oxygenation of the planetary surface after the e

196 The gradual pace of transition for human naive PSCs is consi

197 Our results suggest that complex and gradual patterns of gain and loss shaped the methanogen-

198 OH)(3) Cl) with unique features that allow a gradual phase reconstruction during OER due to the etchi

199 We also find deep and gradual population separations within Africa, contrastin

200 Gradual population-level changes in tissues can be drive

201 display rainfall evolution that differs from gradual precessional pacing, suggesting that direct rain

202 In metazoans, spindle assembly is a gradual process involving dynamic microtubules and recru

203 Age-related cognitive decline (ACD) is the gradual process of decreasing of cognitive function over

204 brafish auditory system are a continuous and gradual process that involves the temporal integration o

205 Septal elastosis is a gradual process with a transition from oxytalan to matur

206 ter 3-5 days, suggesting that they reflected gradual processes rather than immediate compensatory ref

207 owever, this approach risks undervaluing the gradual progression from nonlanguage to language over ho

208 Cortical activity showed a gradual progression from small to large scale processing

209 Biological aging is the gradual, progressive decline in system integrity that oc

210 ing dynamics of system change (eg, abrupt vs gradual psychosis onset), and determining the factors to

211 Ecological niche modeling suggested that a gradual range expansion of P. hwangshanensis during the

212 model suggests a more complex picture and a gradual rather than catastrophic demographic movement.

213 between antipsychotics, but most of them are gradual rather than discrete.

214 atopoietic progenitor cells (HPCs) undergo a gradual, rather than precipitous, transition from fetal

215 post-stroke period appears characterized by gradual-rather than sudden-loss of visual processing.

216 animals with long-term graft survival showed gradual rebound of donor-specific antibodies and antibod

217 Activity-dependent synaptic depression and gradual recovery delimited synchronous activity.

218 The gradual recovery from such injury observed in many, but

219 Following drought release, we found a gradual recovery of leaf gas exchange to 50% to 60% of c

220 ed ACV treatment for another 4 days showed a gradual recovery of VGSC functional expression.

221 demonstrate that this switch is mediated by gradual recruitment of activated habenula neurons in zeb

222 rtial effector-like metabolic profile; and a gradual redistribution of aging CD8(+) T(M) from blood a

223 e phase boundary near the substrate drives a gradual reduction in droplet-substrate contact.

224 The gradual reduction in mHR with age reflects a slowing of

225 repetitive low-force movements that cause a gradual reduction in movement speed (or 'motor slowing')

226 lated parasitic plants shows a predominantly gradual reduction in plastid genome composition and prov

227 somatic symptom severity (P < .0001), and a gradual reduction in quality of life (P < .0001).

228 ficantly during the expedition, indicating a gradual reduction in vagal tone.

229 of highly diluted Abs, which are produced by gradual reduction of an Ab concentration to an extremely

230 metazoans during the first week of study and gradual reductions in dinoflagellates and ochrophytes.

231 emporal mass spectral profiles, which reveal gradual refolding and concomitant deprotonation of highe

232 A gradual regression of liver fibrosis was reported (Metav

233 The activation and gradual relaxation of calcium-independent CaMKII measure

234 lets provided protection in the stomach with gradual release in intestinal regions affected by IBD.

235 From this perspective, the localization and gradual release of such a potent immunotherapeutic agent

236 y by their barrier to oxygen and antioxidant gradual releasing.

237 Forest dwarfing via the gradual removal of taller trees by cyclones over many ge

238 nd the corticospinal fasciculus, depicting a gradual reorganisation of these tracts consequentially t

239 he area of improved esthetics, marked by the gradual replacement of dental amalgam with dental compos

240 fts demonstrates their turnover kinetics and gradual replacement of donor-derived HSPCs from a circul

241 In YAP(S127A)-induced tumorigenesis, a gradual replacement of LSECs by CECs was associated with

242 d that silencing establishment proceeded via gradual repression of transcription in individual cells

243 Gradual resorption was also observed, as well as events

244 rved, as well as events in which a period of gradual resorption was followed by rapid deciliation.

245 le period of centuries or millennia before a gradual return to full glacial conditions.

246 going activity patterns reliably tracked the gradual return to homeostasis but not changes in behavio

247 (n = 176) or 24 hours (n = 179), followed by gradual rewarming of 0.5 degrees C per hour until reachi

248 sistently reduced [Ca(2+)] likely reflecting gradual RyR inactivation with >=1.0 mM caffeine.

249 llowed by further linear growth and eventual gradual saturation.

250 logue [Fe(II) (HL)(2) ] (1(B) ), which shows gradual SCO above 350 K.

251 However, even gradual sea-level rise can rapidly increase the frequenc

252 against lithiation/delithiation enables the gradual separation of the metallic Cu phase from the Cu-

253 itudes on the direction of planning, and the gradual shift from goal-directed to habitual behavior ov

254 ned for specific disorders, there has been a gradual shift in the ascertainment strategy toward popul

255 First, a gradual shift of molecular compositions was observed fro

256 The gradual shift of relative ion permeability did not corre

257 vation of bipotential properties followed by gradual shifts toward commitment.

258 The lack of C-strand maintenance leads to gradual shortening of the telomeric dsDNA, similar to th

259 ll-laden collagen, which, in response to the gradual slope of the circumferential ramp, self-organize

260 e rise to either rigorously high-spin (6) or gradual spin-crossover behavior (5) also in the solid st

261 ikely to increase the seismic risk whereas a gradual step-up protocol is likely to decrease it.

262 gyrA and parC were acquired not by a typical gradual, stepwise evolution but all at once.

263 ntailed a single massive transfer event or a gradual stream of transfers remains a matter of debate.

264 eld shifts at newly rewarded arms and to the gradual strengthening of firing in passes between newly

265 With more gradual stressor introduction over longer experimental d

266 ein structure can be studied, even revealing gradual structural differences along a peak.

267 by robust noradrenergic axonal activity and gradual sustained cAMP increases.

268 own-regulation of MEIS1 with age underlies a gradual switch to oxidative metabolism.

269 ottky emission and suggest that the acquired gradual switching originates by the bias induced modific

270 y into the stationary phase is preceded by a gradual, synchronized adaptation in gene regulation that

271 ab produced profound lymphopenia followed by gradual T cell and more rapid B cell reconstitution to a

272 cterized by multilineage priming followed by gradual T cell commitment.

273 The abrupt and gradual temperature increase treatments did not change t

274 nities would not significantly change with a gradual temperature treatment, whereas an abrupt tempera

275 ed by standardized uptake value, there was a gradual temporal increase in (99m)TcO(4)(-) uptake in mu

276 a space-for-time substitution indicated that gradual thermal evolution in high-latitude larvae may of

277 al 'side-on' contact, followed by either (1) gradual tilting to a space-saving 'end-on' configuration

278 occurred spontaneously in either a sudden or gradual timeframe, developing a severe (NRS 6-8) chronic

279 tative cell cycle-dependent expression and a gradual transcription profile change as cells progress t

280 critical role in directing the discrete and gradual transcriptional changes that define T cell devel

281 In higher sensory cortices, there is a gradual transformation from sensation to perception and

282 Our results show that gradual transforming from type-II to type-I heterojuncti

283 Analysis of intermediate HL suggests a gradual transition between the two extreme cases.

284 in metazoans, it has been suggested that the gradual transition from a dynamic genetic regime to a st

285 size distributions of these events exhibit a gradual transition from an incipient power-law slip regi

286 states of the ammoniated electrons over the gradual transition from dilute blue electrolytes to conc

287 ion where oscillations appear and provides a gradual transition from the resting state to the oscilla

288 incorporation of the 2-oxazine followed by a gradual transition toward the 2-oxazoline.

289 2 and/or its target gene Q (AP2L5) result in gradual transitions of glumes to lemmas, and vice versa.

290 are formed at low ion fluences, followed by gradual transitions to solid solution fcc-structured (M(

291 We aimed to examine the effects of gradual treatment withdrawal and whether TFR is feasible

292 a possible decrease in upwelling, led to the gradual ventilation of the Nama Group basins.

293 Whether aridification leads to gradual (versus abrupt) and systemic (versus specific) e

294 A 28-year-old woman presented with gradual vision loss in both eyes and nyctalopia for 2 ye

295 the current presentation there was bilateral gradual visual impairment over two months due to bilater

296 The gradual weakening of SAC during mitotic arrest enables A

297 dom laser threshold, which is expected to be gradual with weak scattering.

298 riant threshold, we found the response to be gradual, with considerable variability driven largely by

299 st, in the Baltic region, the transition was gradual, with little or no genetic input from incoming f

300 /day of extended-release methylphenidate) or gradual withdrawal over 3 weeks, to 4 weeks of placebo.