ライフサイエンスコーパス: granulation tissue

1 d replacement of injured cardiomyocytes with granulation tissue.

2 in myofibroblasts and smooth muscle cells of granulation tissue.

3 tion of necrotic tissue and replacement with granulation tissue.

4 nificantly inhibited in vivo angiogenesis in granulation tissue.

5 f inducible nitric oxide synthase protein in granulation tissue.

6 ermal wound margin and over fibronectin-rich granulation tissue.

7 skin wounds and impaired angiogenesis in the granulation tissue.

8 gnificantly reduced vascularity of the wound granulation tissue.

9 growth factor, is highly expressed in dermal granulation tissue.

10 tion of fibroblasts, and angiogenesis in the granulation tissue.

11 emonstrated peripheral flow at US because of granulation tissue.

12 rregularly organized and highly vascularized granulation tissue.

13 th the abnormal collagen organization in the granulation tissue.

14 d associated with the formation of abdominal granulation tissue.

15 ce re-epithelialization and the formation of granulation tissue.

16 placement by a thin layer of highly vascular granulation tissue.

17 h increased risk of aspiration and laryngeal granulation tissue.

18 necrotic areas, connective tissue stroma or granulation tissue.

19 e the site of injury with newly vascularized granulation tissue.

20 service independently traced wound area and granulation tissue.

21 ient has chronic refractory otorrhea and ear granulation tissue.

22 epithelialization and increased formation of granulation tissue.

23 cterized by more inflammatory, necrotic, and granulation tissue.

24 ement of an intrauterine device, and vaginal granulation tissue.

25 g the formation of new arterioles within the granulation tissue.

26 r, increasingly in antigen-negative areas of granulation tissue.

27 d regulates their cytokine production in the granulation tissue.

28 elimination of tumor cells and formation of granulation tissue.

29 ar density of MRL-MSC-generated experimental granulation tissue.

30 lar weight S100A7 in human wound exudate and granulation tissue.

31 activation of alpha-SMA in myofibroblasts in granulation tissue.

32 d replacement of injured cardiomyocytes with granulation tissue.

33 of alpha-SMA expression in myofibroblasts in granulation tissue.

34 ounds curetted on day 5 were 23% filled with granulation tissue 1 day later and 99% filled 3 days lat

35 Fbln5 is upregulated in the granulation tissue 14 days after full-thickness wounding

36 We identified wound granulation tissue 3 days post-CD in both strains, albei

37 afts demonstrated significantly less lumenal granulation tissue 35.3%+/-32 than the allograft implant

38 roup demonstrated significantly less lumenal granulation tissue 48.3%+/-23.7 when compared with the i

39 ocardium, acutely cryoinjured myocardium, or granulation tissue (6 days after injury).

40 kinking managed intraoperatively (0% vs 7%), granulation tissue after 12 weeks (1% vs 11%), and sutur

41 ts show that Cyr61 is inducibly expressed in granulation tissues after wounding and that Cyr61 activa

42 sis, were occluded with mucus (syngeneic) or granulation tissue (allogeneic).

43 zone beneath neutrophil and macrophage-rich granulation tissue, an active lesion core of FAS cells a

44 histologic response (three of four with >95% granulation tissue and <5% necrosis, one of four with 95

45 the number of myofibroblasts present in the granulation tissue and accelerates wound closure and con

46 inases are rapidly induced in the dermis and granulation tissue and at the leading edge of the epider

47 alse-positive findings due to enhancement of granulation tissue and benign breast tissue remain limit

48 , cryopyrin, and caspase-1, localized to the granulation tissue and cardiomyocytes bordering the infa

49 reases in blood flow and permeability in rat granulation tissue and corresponding vascular changes in

50 n preventing the anisotropic organization of granulation tissue and delaying wound healing.

51 wiss mice resulted in a large stimulation of granulation tissue and fibrosis at the site of injection

52 of wound-site macrophages to fibroblasts in granulation tissue and impairment of such response in di

53 ontrol), especially in cells re-epithelizing granulation tissue and in mucosa in proximity to the ulc

54 Additionally, cells in the granulation tissue and keratinocytes at wound edges show

55 luid collections are surrounded by a wall of granulation tissue and may contain necrotic debris.

56 resorption, and extensive inflammation with granulation tissue and polymorphonuclear leukocytes.

57 serve as a "barrier," limiting expansion of granulation tissue and protecting the noninfarcted myoca

58 ration, and vessel formation to form a thick granulation tissue and re-epithelialization of the wound

59 9.5 were expressed by fibroblasts during the granulation tissue and remodeling phases wound healing.

60 ed transgene expression in myofibroblasts in granulation tissue and responsiveness to transforming gr

61 es of cutaneous wounding resulted in reduced granulation tissue and scarring.

62 Diode lasers can remove granulation tissue and submucosal bacteria, and if it ac

63 dified papilla preservation technique, where granulation tissue and visible calculus were removed wit

64 crypt destruction, erosions, ulcerations, or granulation tissue) and clinical endpoints at the end of

65 ialization, presence or absence of swelling, granulation tissue, and bleeding on gentle palpation wer

66 latelet and fibrin deposition, inflammation, granulation tissue, and finally, fibrous encapsulation.

67 mages correlated with liquefaction necrosis, granulation tissue, and tumor.

68 g wound re-epithelialization, formulation of granulation tissue, and vascularization.

69 significantly and time-dependently affected granulation tissue appearance (P = 0.004).

70 ed wound closure, decreased inflammation and granulation tissue area, and normalized mechanical prope

71 Granulation tissue area, vascularity, and IGF1 and EGF r

72 rkable increase in the vascular component in granulation tissue as compared to Ad-LacZ controls.

73 chondrification centers and persisted within granulation tissue at the expanding soft callus front.

74 On postoperative day 7, the thickness of granulation tissue at the graft-wound bed interface was

75 r-BB protein (n = 2) resulted in only modest granulation tissue at the margin, but no significant dif

76 lized in the preliminary matrix organized in granulation tissue before trabecular bone formation in t

77 ross-linked collagenous matrix is formed and granulation tissue cells become apoptotic.

78 film infection in wounds results in impaired granulation tissue collagen leading to compromised wound

79 and platelet releasate were 14% filled with granulation tissue compared with less than 4% granulatio

80 concept that IL-1Ra modulates MCL-localized granulation tissue components and cytokine production to

81 ing by enhancing basement membrane proteins, granulation tissue components, and angiogenic factors.

82 mulating the M2 macrophages and altering the granulation tissue components.

83 he fibrin inside the chambers is replaced by granulation tissue consisting of new blood vessels, macr

84 examination revealed a characteristic cap of granulation tissue covering tortuous nondysplastic crypt

85 Day 4 wounds were 3% filled with granulation tissue, day 5 wounds 48% filled, and day 7 w

86 is a significant reduction in the extent of granulation tissue deposition and the subsequent formati

87 ing agent, enhancing reepithelialization and granulation tissue deposition by 64+/-5 and 83+/-12% ove

88 in response to injury, resulting in delayed granulation tissue deposition in PKCalpha-/- wounds.

89 analysis showed that epithelium ingrowth and granulation tissue deposition were significantly impaire

90 ithelialization, angiogenesis, inflammation, granulation tissue deposition, and enhanced collagen org

91 , malformed vasculature followed by abundant granulation tissue deposition.

92 y aimed to compare global gene expression in granulation tissue derived from different types of perio

93 is study aimed to compare gene expression in granulation tissue derived from different types of perio

94 thrombus deposition and acute inflammation, granulation tissue development, and ultimately smooth mu

95 repair a 3-day lag occurs between injury and granulation tissue development.

96 on, synthesize growth factors, and stimulate granulation tissue development.

97 Granulation tissue did not form in day 3 wounds, which h

98 exhibited impaired development of functional granulation tissue due to severely reduced differentiati

99 in vessels that developed in sponge-induced granulation tissue during 1 month derived from circulati

100 e is highly induced in dermal fibroblasts of granulation tissue during cutaneous wound repair.

101 the organization and vascularization of the granulation tissue during healing, possibly by modulatin

102 tly stimulates neovascularization within the granulation tissue during the first week of treatment, f

103 y and function in specific cell types in the granulation tissue during the healing process is unknown

104 of TGF beta leading to enhanced formation of granulation tissue, even in the absence of obvious infec

105 Routinely discarded periodontal granulation tissue exhibits epithelial characteristics d

106 Routinely discarded periodontal granulation tissue exhibits lining cell characteristics

107 fter receiving the lower viral dose, cardiac granulation tissue expressed MyoD mRNA and protein, but

108 CTX also reduced dermal granulation tissue fibroblast population increases induc

109 istology showed channel remnants composed of granulation tissue, fibrosis, and new vessels (NV).

110 Once granulation tissue filled the wound and invasive angioge

111 The granulation tissue filling the wound during healing also

112 increased keratinocyte migration (7.5-fold), granulation tissue formation (2.8-fold), cell proliferat

113 ology are currently limited by stent-induced granulation tissue formation adjacent to the stent.

114 using AuNP-coated SEMS successfully treated granulation tissue formation after stent placement in th

115 nsgenic mice and was associated with reduced granulation tissue formation and highly diminished wound

116 imulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of

117 This work directly relates to both granulation tissue formation and regression during wound

118 d cardiomyocytes, while mediating aspects of granulation tissue formation and remodeling.

119 d results in accelerated healing and reduced granulation tissue formation and scarring.

120 into the fibrin-laden wound is critical for granulation tissue formation and subsequent healing.

121 into the fibrin-laden wound is critical for granulation tissue formation and subsequent healing.

122 e, or response to infection, but it promoted granulation tissue formation and suppressed leukocyte ne

123 analysis of skin wounds demonstrated delayed granulation tissue formation and vascularization during

124 cellular/ultrastructural studies and in vivo granulation tissue formation assays combined with transc

125 synthesis or action reduces TGF-beta-induced granulation tissue formation by inhibiting both collagen

126 GA-LL37 NP-treated wounds displayed advanced granulation tissue formation by significant higher colla

127 We initiated local granulation tissue formation either by implanting small

128 to the fibrin matrix significantly increased granulation tissue formation in a dose-dependent manner.

129 sient, role during invasive angiogenesis and granulation tissue formation in a healing wound.

130 on of miR-21 inhibited epithelialization and granulation tissue formation in a rat wound model.

131 onists of alphaVbeta3 specifically inhibited granulation tissue formation in a transient manner durin

132 pendent increase in epithelial migration and granulation tissue formation in both murine and porcine

133 ic blocking of alphavbeta3 function inhibits granulation tissue formation in cutaneous wounds.

134 complete re- epithelialization and profound granulation tissue formation in excisional and incisiona

135 Granulation tissue formation in punch wounds of juvenile

136 uNP)-coated stent for treating stent-induced granulation tissue formation in the rat esophagus was in

137 Lovastatin (5 microM, 8 d) reduced granulation tissue formation in the wound chambers by 64

138 the myocardial scar, suggesting expansion of granulation tissue formation into the noninfarcted terri

139 Granulation tissue formation is a critical step in infar

140 Granulation tissue formation is an example of new tissue

141 During early granulation tissue formation of wound repair, new capill

142 Thus, granulation tissue formation resumed promptly and indepe

143 ial cell chemotaxis, vascular sprouting, and granulation tissue formation upon skin injury, these act

144 ared to their wild-type littermates although granulation tissue formation was nonhomogeneous and ther

145 In addition, improved granulation tissue formation was observed along with hig

146 During granulation tissue formation, alphaVbeta3 was expressed

147 an result in a larger ostium size, decreased granulation tissue formation, and a decreased number of

148 g was induced by rapid re-epithelialization, granulation tissue formation, and accompanied by angioge

149 uced, and careful analysis of wound closure, granulation tissue formation, and angiogenesis revealed

150 with compromised wound closure, insufficient granulation tissue formation, and blunted induction of M

151 fibroblast activation is a limiting step of granulation tissue formation, and continued cell stimula

152 t mice show suppressed inflammation, delayed granulation tissue formation, and markedly reduced colla

153 g delayed contraction, decreased and delayed granulation tissue formation, and reduced new blood vess

154 Wound closure, reepithelialization, granulation tissue formation, and remodeling were delaye

155 ed to accelerate wound re-epithelialization, granulation tissue formation, and synergistically improv

156 telets and macrophages, is not important for granulation tissue formation, and that it reduces vascul

157 are known to be associated with significant granulation tissue formation, and this property provides

158 l-thickness, cutaneous wounds, with enhanced granulation tissue formation, angiogenesis, cell prolife

159 The rate of granulation tissue formation, based on the time to 76-10

160 PO and observed dose-dependent inhibition of granulation tissue formation, consistent with an importa

161 ccelerated reepithelialization and increased granulation tissue formation, fibroblast migration, and

162 with reepithelialization and is followed by granulation tissue formation, including neutrophil and m

163 hese studies show that re-epithelialization, granulation tissue formation, including the establishmen

164 Granulation tissue formation-related variables were sign

165 Granulation tissue formation-related variables were sign

166 ssociated with a proangiogenic effect during granulation tissue formation.

167 ridge formation, decreased inflammation, and granulation tissue formation.

168 ctivation might be the rate-limiting step in granulation tissue formation.

169 ayed wound re-epithelialization and impaired granulation tissue formation.

170 nduced in peri-infarct cardiomyocytes during granulation tissue formation.

171 cantly accelerated, resulting in the limited granulation tissue formation.

172 mal and steroid-impaired pigs, CRT increased granulation tissue formation.

173 is study provided histological evidence that granulation tissue forming under clinically exposed and

174 In 14 and 21 d incised wounds and in chronic granulation tissue from nonhealing ulcers there was stro

175 of active wounds of living T1D subjects, and granulation tissues from mice with streptozotocin-induce

176 unctional enzyme expression by repair cells (granulation tissue) growing into the gap.

177 tor (VEGF), Flk1, and VE-cadherin in ECs and granulation tissues (GTs) of full-thickness wounds.

178 Total RNA was isolated from granulation tissue harvested during routine periodontal

179 sions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conj

180 ranulation tissue compared with less than 4% granulation tissue in control wounds.

181 Furthermore, granulation tissue in fibrinogen-deficient mice failed t

182 at in wild-type mice, the early formation of granulation tissue in fibrinogen-deficient mice was edem

183 roximately 1600 mum within wound (neodermis)/granulation tissue in lesions made on the skin of mice.

184 by topical application of VEGF and FGF-2 to granulation tissue in skin chambers, and 2) suramin, a c

185 is caused by expansion of microvascular-rich granulation tissue in some locations and collagen-rich s

186 backs of Sprague-Dawley rats and 1 wk later, granulation tissue in the chamber was exposed twice dail

187 aryngeal injury (i.e., mucosal ulceration or granulation tissue in the larynx) was present in 57 pati

188 Some patients developed granulation tissue in the larynx, urethra, lacrimal duct

189 wounds, which corresponds with the increased granulation tissue in these wounds.

190 p-regulated in newly formed blood vessels of granulation tissue in vivo.

191 The prerequisites for granulation tissue induction are not known but hypotheti

192 ests angiogenesis with transformation of the granulation tissue into a scar.

193 ocal angiogenesis, and limiting expansion of granulation tissue into the noninfarcted area.

194 Granulation tissue is routinely discarded in periodontal

195 accelerated replacement of cardiomyocytes by granulation tissue leading to a thin mature scar at 14 d

196 e re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal arc

197 ion (loss of respiratory epithelium, luminal granulation tissue, lymphocytic tracheitis) with increas

198 processes including re-epithelialization and granulation tissue matrix deposition.

199 Vbeta3 showed little or no expression in the granulation tissue microvasculature.

200 Granulation tissue myofibroblasts and infiltrating macro

201 e recipient airway demonstrated less lumenal granulation tissue obstruction and better preservation o

202 Four patients with granulation tissue occluding the airway were treated wit

203 dy, we show that CCN3 is highly expressed in granulation tissue of cutaneous wounds 5-7 days after in

204 ntron was expressed in myofibroblasts within granulation tissue of cutaneous wounds in a pattern that

205 showed that, similar to TSP1-null mice, the granulation tissue of double-null mice was not excessive

206 helial cells in blood vessels forming in the granulation tissue of knockout mice.

207 margins of human keloid samples, and in the granulation tissue of newly deposited ECM in a mouse mod

208 ransgene expression in myofibroblasts within granulation tissue of skin wounds.

209 round the healing margins and throughout the granulation tissue of superficial ulcerative wounds.

210 cells of adjacent hair follicles, and to the granulation tissue of the wounds.

211 in processes involved in development of the granulation tissue of wounds, but little is known about

212 re relatively frequent (n = 55, 68%), mainly granulation tissue or local erythema.

213 onia without histological evidence of either granulation tissue or pulmonary fibrosis.

214 PDGF B-chain did not decrease the extent of granulation tissue or vascular lesion formation, and tha

215 The rates of granulation tissue, otalgia, and facial palsy were 90.9%

216 -4.13) and with risk of developing laryngeal granulation tissue (p = 0.02).

217 e assessment of wound area and percentage of granulation tissue (PGT) are important for optimizing wo

218 e healing (24days) and exhibited accelerated granulation tissue production, epithelial maturation, an

219 iferation, in vivo engraftment, experimental granulation tissue reconstitution, and tissue vascularit

220 retained specifically within the presumptive granulation tissue region of the wound at a higher densi

221 Following the granulation tissue removal, intrabony defect was filled

222 is, early wound provisional matrix, and late granulation tissue, respectively.

223 ptozotocin-induced diabetic rats to elicit a granulation tissue response and to collect acute wound f

224 ll surgical sponges to elicit a foreign body granulation tissue response, or by ligating the left com

225 hol sponges were implanted to elicit a naive granulation tissue response, removed at defined time poi

226 N-terminal domain is a key regulator of the granulation tissue response, with important implications

227 pyogenic granuloma is an exuberant growth of granulation tissue secondary to irritation.

228 ponge implants in Flk-1(LacZ) knock-in mice, granulation tissue showed many more LacZ-positive cells

229 ells/blood vessel lumen, M2 macrophages, and granulation tissue size without compromising the mechani

230 Hypoxia peaked in the granulation tissue stage at day 4 and correlated with in

231 In the tuberculous granulation tissue surrounding caseous and liquefied pul

232 monocyte infiltration/giant cell formation (granulation tissue, the intimal and subintimal synovial

233 ment of wound closure, increased blood flow, granulation tissue thickness (GTT), and CD31 that correl

234 db/db mice markedly increased angiogenesis, granulation tissue thickness, and wound closure rates, w

235 terized by decreased contraction and reduced granulation tissue thickness.

236 human vs human comparisons of wound area and granulation tissue tracings.

237 preparation, a palatal mini-flap was raised, granulation tissue was eliminated by means of ultrasonic

238 e angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic d

239 tion, generation of thick, well-vascularized granulation tissue was enhanced, in parallel with increa

240 hire pigs and harvested at various times, no granulation tissue was observed before day 4.

241 In contrast, granulation tissue was observed in wounds receiving fibr

242 alpha-smooth muscle actin and are present in granulation tissue, where they are responsible for wound

243 analysis of esophageal biopsies demonstrated granulation tissue with acute and chronic inflammation.

244 nt of inflammatory macrophages, formation of granulation tissue with angiogenesis, and finally tissue

245 The subacute response exhibited granulation tissue with early fibrous encapsulation (pan