ライフサイエンスコーパス: granule

1 fferent compositions coexist inside the same granule.

2 s decreases regeneration and increases G3BP1 granules.

3 ed a 13-fold drop in the number of secretory granules.

4 are enriched in insoluble and electron-dense granules.

5 bon-dense shell and were stored in multicore granules.

6 nts in the pale acinar cells by myriad mucus granules.

7 in phase separation and a key component of P granules.

8 STARCH1 (PTST1) that targets GBSS to starch granules.

9 asmic inclusions that resemble polyphosphate granules.

10 ction of RNA-protein condensates like stress granules.

11 grity, cell death, and presence of cell-free granules.

12 ocytosis of the insulin-containing secretory granules.

13 their similarities with the eukaryotic mRNP granules.

14 t on PrLD assembly and recruitment to stress granules.

15 the host cells associated with human stress granules.

16 d have severely impaired exocytosis of lytic granules.

17 er models of preferential release of younger granules.

18 he formation of eIF2alpha-independent stress granules.

19 -transfected insect cells behave like stress granules.

20 distinct aggregates in the vicinity of, germ granules.

21 that allows controlled release of secretory granules.

22 microscopy showed poor convergence of lytic granules.

23 ween the PM and the remaining nearby insulin granules.

24 ral and spatial distribution of specific RNP granules.

25 o CD1a(+)Langerin(+)cells containing Birbeck granules.

26 the formation of neuroendocrine and neuronal granules.

27 and cytoplasmic messenger ribonucleoprotein granules.

28 are (2/2, 50%) ducts and rare acinar zymogen granules (3/4, 75%).

29 tion, such as upon enrichment in RNA-protein granules, a process that appears conserved in diverse ce

30 rare recessive platelet disorder with alpha-granule abnormalities and mutations in NBEAL2.

31 ly uncharacterized RBPs that modulate stress granule abundance, highlighting the applicability of our

32 e glycosylated, are targeted to each type of granule according to their time of expression, a process

33 SEM images revealed damaged starch granules after size reduction.

34 to assess insulin secretion as a function of granule age in pancreatic islet beta cells.

35 Insulin granule age is underappreciated as a determinant for why

36 model of insulin secretion and identify how granule aging is affected by variation in the beta-cell

37 metabolism restrained the assembly of stress granules, an indicator of chemoresistance.

38 th major basic protein (MBP) Ab to visualize granules and assessed by flow cytometry.

39 l similarities between P granules and stress granules and identify intrinsically-disordered proteins

40 ls predominantly associates with azurophilic granules and LC3(+) autophagosomes.

41 insight into the relationship between stress granules and LLPS, for example, in the context of protei

42 unctions in the biogenesis of platelet dense granules and melanosomes, which like WPBs are lysosome-r

43 -1.1 condensates do not correspond to stress granules and might represent novel metabolic subcompartm

44 s to distinct subcellular foci adjacent to P granules and Mutator foci, two phase-separated condensat

45 by prominent nuclear and cytoplasmic TDP-43 granules and nuclear pore defects.

46 is X and sialyl-Lewis X in the intracellular granules and on the cell surface, respectively.

47 n fused in sarcoma (FUS) forms physiological granules and pathological fibrils, which facilitate RNA

48 1B is a protein component of Drosophila germ granules and plays an important role in germline develop

49 emonstrate that in vivo mRNA localization to granules and self-assembly within granules are governed

50 r observations reveal similarities between P granules and stress granules and identify intrinsically-

51 The discovery of atrial secretory granules and the natriuretic peptides stored in them ide

52 clear what regulates localization of insulin granules and their interactions with the PM within singl

53 ess causes additional mRNAs to localize to P granules and translational activation correlates with P

54 ssociated with mRNA-binding proteins, stress granule, and P-body proteins, which suggests regulated p

55 Ds that were efficiently recruited to stress granules, and found that aromatic amino acids, which hav

56 tides into two distinct compartments, stress granules, and Q-bodies, is triggered by the exhaustion o

57 cessing bodies (P-bodies, or PBs) and stress granules, and the ER membrane.

58 rater in Elysium Planitia on a smooth sandy, granule- and pebble-rich surface with few rocks.

59 Ribonucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phas

60 Starch granules are composed of two distinct glucose polymers -

61 components and their dynamics in and out of granules are currently being intensively studied.

62 Cell-free eosinophil granules are found in tissues in eosinophilic diseases,

63 ization to granules and self-assembly within granules are governed by different mRNA features: locali

64 se levels, but the mechanisms by which these granules are identified and prioritized for secretion re

65 These granules are involved in trafficking MMP-9 from the stro

66 Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which major

67 RNA granules are protein/RNA condensates.

68 These granules are reflective of previously described proteaso

69 esis in the bone marrow, distinct neutrophil granules are successively formed.

70 lled "targeting by timing." Therefore, these granules are time capsules reflecting different times of

71 f cathelicidin in neutrophils and macrophage granules as also observed in most antimicrobial peptides

72 ts showed void spaces on the treated melanin granules as compared to the untreated sample, indicating

73 correlates with disassembly of axonal G3BP1 granules as well as increased phospho-G3BP1 and axon gro

74 eins as drivers of RNA condensation during P granule assembly.

75 Mutations in a number of stress granule-associated proteins have been linked to various

76 s causing structural abnormalities in starch granules at maturity.

77 f Syp and the number of msp300:Syp:eIF4E RNP granules at the synapse, suggesting that these particles

78 ity induce the formation of antiviral stress granules (avSGs) by regulating activation of double-stra

79 d as amyloid fibrils within acidic secretory granules before release into the blood stream.

80 tional amyloid state within acidic secretory granules before they are released into the blood.

81 ch was associated with defects in both lytic granule biogenesis and synaptic actin remodeling.

82 functions such as synthesis of mediators and granule biogenesis.

83 s, including new insights into the action of GRANULE BOUND STARCH SYNTHASE (GBSS), the major glucosyl

84 ons of Arabidopsis (Arabidopsis thaliana) in GRANULE-BOUND STARCH SYNTHASE (GBSS), encoding the enzym

85 in an ectopic manner, whereas genes encoding granule-bound starch synthase, debranching enzymes, pull

86 e of previously described proteasome storage granules but display unique properties.

87 tes with endogeneously fluorescent cytotoxic granules but wild-type-like killing capacity.

88 43 and its CTD are also known to form stress granules by coacervating with RNA in the cytoplasm durin

89 try and marked depletion of intracytoplasmic granules by light microscopy.

90 Second, the binding and transport of insulin granules by MT motors prevents their stable anchoring to

91 It did not occur in mice lacking alpha-granules, C type lectin receptor-2 (CLEC-2), or protease

92 phase separation, including nucleoli, stress granules, Cajal bodies, and numerous additional bodies,

93 /Gal-10 interacts with both human eosinophil granule cationic ribonucleases (RNases), namely, eosinop

94 vesicular transport of the potent eosinophil granule cationic RNases during both differentiation and

95 ABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functiona

96 hese results indicate that Tiam1 promotes DG granule cell dendrite and synapse stabilization late in

97 Notably, DG granule cell dendrites and synapses develop normally in

98 that Tiam1 promotes the stabilization of DG granule cell dendritic arbors, spines, and synapses, whe

99 ablish Tiam1 as an essential regulator of DG granule cell development, and identify it as a possible

100 cerebellum and brainstem revealed a reduced granule cell layer and a reduction in size of pontine nu

101 ) was used to transcriptomically profile the granule cell layer of the dentate gyrus (DG-GCL) in huma

102 constructing an integrate-and-fire model of granule cell layer population activity, we find that the

103 we investigate the role of ACh in regulating granule cell layer synaptic integration in male rats and

104 first stage of this processing occurs in the granule cell layer.

105 rough the sublamination of the molecular and granule cell layers, which is not observed in the domest

106 ural stem cells that generate olfactory bulb granule cell neurons were electroporated with SLC7A5 or

107 s studied; however, standardization to total granule cell numbers indicated that the two groups of wi

108 otein 2 (Jdp2) is expressed predominantly in granule cell progenitors (GCPs) in the cerebellum, as wa

109 trate that ACh can modulate population-level granule cell responses by altering the ratios of excitat

110 suggest that Tiam1 is a key regulator of DG granule cell stabilization and function within hippocamp

111 GABA(A) receptor subunit at the mossy fiber-granule cell synapse are perturbed, as well as the inner

112 lved in long term potentiation at cerebellar granule cell-to-Purkinje cell synapses.

113 l eyeblink conditioning, and both global and granule-cell-specific CB1KOs display normal cerebellum-d

114 Finally, cerebellar granule-cell-specific CB1KOs exhibit normal eyeblink con

115 normal functional development of adult-born granule cells (abGCs) in the olfactory bulb.

116 We recorded populations of dentate gyrus granule cells (DG GCs) and lateral entorhinal cortex (LE

117 gion of the hippocampus give rise to dentate granule cells (DGCs) and astrocytes throughout life, a p

118 t mice in which the vast majority of dentate granule cells (DGCs) fail to develop - including nearly

119 to study chemosensory tuning in AOB external granule cells (EGCs), interneurons hypothesized to broad

120 ia toxin-based ablation of >50% of mature DG granule cells (GCs) or by prolonged brain-specific VEGF

121 By contrast, interneurons, such as GABAergic granule cells (GCs), integrate across multiple channels

122 when cultured with mouse cerebellar glia and granule cells and fired large calcium currents, measured

123 eceptor GluD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer

124 result of decreased competition with mature granule cells for synaptic inputs.

125 DG granule cells, which compete with mature granule cells for synaptic integration.

126 2-photon time-lapse imaging of SP-transgenic granule cells in mouse organotypic tissue cultures we fo

127 endrocytes, striatal neurons, and cerebellar granule cells in the context of altered microtubule dyna

128 , increases D1 receptor expression in mature granule cells in the dentate gyrus.

129 hich form abundant synaptic projections onto granule cells in the olfactory bulb (OB), express the sy

130 Moreover, deletion in granule cells of the OB of Bai3, a postsynaptic GPCR tha

131 a second class of local excitatory inputs to granule cells that are more powerful than distal inputs

132 bution of adult-born (abGC) and mature (mGC) granule cells to epileptiform network events remains unk

133 efficacy of perforant path transmission onto granule cells upon LFS.

134 deletion of Tiam1 in male mice results in DG granule cells with simplified dendritic arbors, reduced

135 altered short-term plasticity at synapses on granule cells, as well as anxiety-like behavior and a pa

136 al, but not the production, of adult-born DG granule cells, possibly because of greater circuit integ

137 comparatively higher populations of residing granule cells, proliferating NSCs and BrdU+ neurons in t

138 Granule cells, the most common interneuron in the olfact

139 s it restricts the survival of adult-born DG granule cells, which compete with mature granule cells f

140 of excitation and inhibition onto individual granule cells.

141 mes and perforin through fusion of cytotoxic granules (CG) at the target cell interface, the immune s

142 have distinctive organisation and content of granules compared with peripheral blood NK cells.

143 Mutations of the RNA granule component TDRD7 (OMIM: 611258) cause pediatric c

144 or direct challenge with histamine, a major granule component.

145 s dependent on downstream RNAi factors and P granule components but is independent of the viral senso

146 Transport granule components hnRNPF and ch-TOG interact weakly wit

147 alescence with cytoplasmic ribonucleoprotein granule components, including FMRP.

148 vives a long-standing question of why starch granules contain amylose, rather than amylopectin alone.

149 Here, we show that a novel RNP granule containing the mRNAs for axonemal dynein motor p

150 DBBM granules containing conjugated drugs C3 and C6 induced g

151 cond type of RNP granule, here named founder granules, contains oskar mRNA, which encodes the germ pl

152 ivation, suggesting a link between increased granule content and dNK1 responsiveness.

153 Changes in the proteome, granule content and NET formation also occurred in human

154 rculation and caused the progressive loss of granule content and reduction of the NET-forming capacit

155 at times of day or in mouse mutants in which granule content was low.

156 induced platelet spreading, release of their granule content, and the generation of three types of mi

157 r septins in regulating the release of lytic granule contents during NK cell-mediated killing.

158 hat platelets release their alpha- and dense-granule contents in both non-severe and severe forms of

159 Interestingly, granule convergence and cytolytic function were restored

160 ylococcus aureus, consistent with a specific granule deficiency.

161 d how MPT-SURF analysis of nuclear chromatin granules defines nuclear mechanical phenotypic features,

162 observed in mice that lacked platelet-dense granules, dense granule secretion machinery, glycoprotei

163 tween stromal and endothelial cells via VEGF granules, developing the vascular network critical for e

164 results show how compartmentalization in RNP granules differentially controls fates of mRNAs localize

165 sein kinase 2alpha (CK2alpha) triggers G3BP1 granule disassembly in injured axons.

166 eneration can be accelerated by axonal G3BP1 granule disassembly, releasing axonal mRNAs for local tr

167 ibit strongly disrupted insulin and glucagon granule docking and exocytosis.

168 ation initiation and termination, and stress granule dynamics.

169 ontrolled-release pellets, particles, beads, granules, etc.

170 d translational activation correlates with P granule exit for two mRNAs coding for germ cell fate reg

171 rotein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broa

172 Cytotoxicity, lytic granule exocytosis, and the phosphorylation of Pyk2 are

173 ntial activity in cell division and cortical granule exocytosis, in developmentally programmed cell d

174 tes defined the position where PB and stress granule fission occurs.

175 Some RNP granules form, in part, through the formation of intermo

176 sal mechanism by which membraneless cellular granules form.

177 RNA condensation in vitro and limits stress granule formation in cells.

178 nucleocytoplasmic mislocalization and stress granule formation, both markers of neuronal injury.

179 ntribute to competent mRNA export and stress granule formation, both self-association domains are ind

180 ) microglia are sufficient to promote TDP-43 granule formation, nuclear pore defects and cell death i

181 ned in the Golgi apparatus, and no secretory granules formed for this variant, impairing its stimulat

182 A granule fraction (G(in)) produced by egg yolk centrifuga

183 or 5 and 10 min, and centrifuged to generate granule fractions (G(P1) to G(P4)) and plasmas (P(P1) to

184 le size to 14.8 mum and disintegrated starch granules from the attached endosperm.

185 ructured MT network preferentially withdraws granules from the PM.

186 syntaxin binding protein 2 to promote lytic granule fusion.

187 In summary, this comprehensive neutrophil granule glycome map, the first of its kind, highlights n

188 The secretory granule has an acidic pH but, on exocytosis, the beta-en

189 -2 diabetes, accompanying changes to insulin granules have not been established.

190 stigate whether these drugs prebound to DBBM granules have the potential to achieve rapid and enhance

191 A second type of RNP granule, here named founder granules, contains oskar mRN

192 ay engages with the membraneless organelle P granule in Caenorhabditis elegans.

193 show that Y. pestis also inhibits release of granules in a T3SS-dependent manner.

194 rolled-release pellets, particles, beads, or granules in any physiologically-relevant environment in

195 ng protein Pur-alpha, as a component of germ granules in C. elegans We show that PLP-1 is essential f

196 etailed, three dimensional morphology of the granules in conjunction with previously published geoche

197 imilarly to cyanophycin (C(10)H(19)N(5)O(5)) granules in cyanobacteria.

198 ranslation, based on the formation of stress granules in human cells, revealed cell cycle-associated

199 with beta-actin mRNA in actively transported granules in living neurons.

200 h time after injury and the presence of CD68 granules in microglia surfaces opposed to motoneurons.

201 odies in Orfelia fultoni and in smaller dark granules in Neoditomiya sp, consists of a high molecular

202 elicase activity, induce ectopic RNA-protein granules in neural progenitors and neurons, and impair t

203 ions of secondary pigment cells, nor pigment granules in the extensions of the cone cell projections

204 We identified distinct FMRP-containing granules in the growing axons of Atoh1(+) neurons and po

205 identifies a novel role of antiviral stress granules induced by RNase L as an antiviral signaling hu

206 SS5 and other proteins implicated in starch granule initiation allows us to propose how SS5 may act

207 diverse proteins have been implicated in the granule initiation process in Arabidopsis (Arabidopsis t

208 sed structural protein influential in starch granule initiation.

209 al translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly und

210 s by transferring myeloperoxidase-containing granules into tumor cells.

211 of granzyme B, a key component of cytotoxic granules involved in T cell-mediated target cell-killing

212 reciated as a determinant for why an insulin granule is selected for secretion and may explain why ne

213 The release of these granules is dependent on intracellular calcium (Ca(2+))

214 Localization to P granules is not required for translational repression bu

215 idated, the major membrane protein in atrial granules is peptidylglycine alpha-amidating monooxygenas

216 A characteristic feature of these granules is their acidic pH inside the granule lumen, wh

217 at display filaggrin-containing keratohyalin granules (KGs) whose function is unclear.

218 et profiling gene expression of the external granule layer in the cerebellum of control and condition

219 FUS in the cytoplasm and formation of stress granule-like inclusions.

220 (4) impacts beta-cell activity by regulating granule localization and/or priming and calcium signalin

221 tions between low translational status and P granule localization within the progenitor germ lineage.

222 these granules is their acidic pH inside the granule lumen, which is required to process precursors o

223 in allows quantitative analyses of cytotoxic granule maturation, transport and fusion in vitro with s

224 PLP-1 orthologs localized on RNA granules may similarly contribute to germline gene silen

225 sms leading to CSSs, including impairment of granule-mediated cytotoxicity, specific viral infections

226 ll wall integrity, protein matrix and starch granules more severely than 600 MPa; however, tightly-pa

227 Granule morphology, X-ray pattern, molecular order, and

228 that SMB55 cells, and the primary cerebellar granule neuron precursors (GNPs) from which they derive,

229 ocytes) were trans-differentiated from tumor granule neuron precursors (GNPs), which normally never d

230 dulloblastomas that originate from unipotent granule neuron progenitors in the brain.

231 e extracellular matrix to control cerebellar granule neurons (CGN) GZ occupancy.

232 t of the chromatin remodeling enzyme Chd4 in granule neurons of the mouse cerebellum increases access

233 se using HEK-293 cells and murine cerebellar granule neurons, along with bioluminescence, calcium FLI

234 ously studied the phenotype of dentate gyrus granule neurons, we turned our attention to studying the

235 aling that preferential secretion of younger granules occurs in glucose-stimulated insulin secretion.

236 Zn(2+) accumulation in the insulin secretory granules of pancreatic beta cells.

237 c origin for iron precipitation around chert granules on the shallow shelf of one of the oldest supra

238 sic residues within the trans-Golgi network, granules, or at the cell surface/endosomes.

239 nt cross-linking of proinsulin and secretory granule peptides.

240 cted but surprisingly had no effect on lytic granule polarization and directional secretion.

241 g as key for mediating cytotoxic killing and granule polarization in freshly isolated CD8(+) T cells

242 A(4) promoted NK cell LIMK expression, lytic granule polarization to the immune synapse and cytotoxic

243 rting the age-dependent release of different granule pools and confirm earlier models of preferential

244 At least two types of RNP granules populate the germ plasm, a cytoplasmic domain a

245 higher enzyme activities of MPO in distinct granule populations.

246 Dense granule protein 12 (GRA12) is implicated in a range of p

247 Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte gr

248 veals an interaction with the constitutive P granule protein DEPS-1.

249 e show that one of these genes encodes dense granule protein GRA45, which has a chaperone-like domain

250 eriment was also found for RtoK mutants of P-granule protein LAF-1, underscoring that, to a degree, i

251 essed by measurement of secreted azurophilic granule protein resistin and profiling of the secretome,

252 ied avSGs showed interaction of a key stress granule protein, G3BP1, with only PKR and Rig-I and not

253 tightly-packed complexes of globular starch granules-protein-cell wall fiber formed at HHP <= 450 MP

254 , several epitopes originated from beta-cell granule proteins (e.g., SCG3, SCG5, and urocortin-3).

255 a large range of molecules, including unique granule proteins that can potentially kill tumour cells.

256 but not other cell death-inducing cytotoxic granule proteins, strongly inhibits Lm in human placenta

257 lasmin-mediated degradation of diverse alpha-granule proteins; and platelet-dependent, accelerated fi

258 rmed detailed functional analyses of insulin granules purified from cells subjected to model treatmen

259 r localization, phase separation, and stress granule recruitment of CIRBP in cells.

260 This co-occurred with active MBP-positive granule release and the expression of integrin CD11b.

261 C. albicans actions on platelet activation, granule release, and aggregation.

262 ans does not appear to affect alpha or dense granule release, C. albicans exerts a significant attenu

263 voked platelet integrin activation and alpha-granule release.

264 increase of 'intermediate cells' containing granules resembling those of exocrine zymogen and endocr

265 alline and morphological structure of starch granules, respectively.

266 r assembly, biochemical reactions and stress granule responses to cellular adversity.

267 e that lacked platelet-dense granules, dense granule secretion machinery, glycoprotein (GP) VI, or th

268 known, but it has been suggested that stress granule (SG) formation is important in this process.

269 tation to perturbation, most notably, stress granule (SG) proteins, which responded differently to di

270 ase 3 X-linked) is a key component of stress granules (SG) and is postulated to affect protein transl

271 Stress granules (SGs) are condensates of mRNPs that form in res

272 Stress granules (SGs) are cytoplasmic assemblies of proteins an

273 Stress granules (SGs) are evolutionarily conserved condensates

274 Processing bodies (PBs) and stress granules (SGs) are prominent examples of subcellular, me

275 Stress granules (SGs) are ribonucleoprotein (RNP) assemblies th

276 e molecules stored in long-lasting secretory granules (SGs) are secreted in response to external stim

277 the pancreatic beta-cells, insulin secretory granules (SGs) exist in functionally distinct pools, dis

278 ropeptides and peptide hormones by secretory granules (SGs) is central to physiology.

279 Insulin secretory granules (SGs) mediate the regulated secretion of insuli

280 map, the first of its kind, highlights novel granule-specific glycosylation features and is a crucial

281 ding symptoms, the absence of platelet alpha-granules, splenomegaly, and bone marrow (BM) fibrosis.

282 d and phase separated, reminiscent of stress granule substructure or nanoscale liquid droplets.

283 rface between membraneless ribonucleoprotein granules, such as processing bodies (P-bodies, or PBs) a

284 calization of dendritic ZBP1 and PAT1 within granules that also contain kinesin-I.

285 ted with Syp in vivo and forms ribosome-rich granules that contain the translation factor eIF4E.

286 THASE5 (SS5), regulates the number of starch granules that form in Arabidopsis chloroplasts.

287 RBPs) that influence the formation of stress granules, the punctate protein-RNA assemblies that form

288 he pH increases from acidic in the secretory granule to neutral level in the blood, thus it is sugges

289 transfer of phosvitins from pressure-treated granule to plasma.

290 g-standing question: Are mRNAs directed to P granules to be translationally repressed, or do they acc

291 Insulin is stored in secretory granules to facilitate rapid release in response to risi

292 ) in beta cells are the proximity of insulin granules to the plasma membrane and their anchoring or d

293 dominant targets, a feature shared by stress granules to which G3BP1 family proteins localize under s

294 Granule trafficking was driven by active AMPK enriched o

295 in accumulation at the immune synapse, lytic granule trafficking, and cytotoxicity.

296 oteasomes, unlike other CP tags, localize to granules upon nitrogen starvation.

297 atures governing PrLD localization to stress granules upon stress.

298 rticle tracking (MPT) technique on chromatin granules, we designed a SURF (Speeded Up Robust Features

299 4(-/-) mice, lipofuscin and melanolipofuscin granules were found to contribute to NIR-AF, indicated b

300 Herein, neutrophil subcellular granules were fractionated by Percoll density gradient c