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1 as delivered to lysosomes and processed into granulins.
2 ulin is cleaved into smaller peptides called granulins.
3  carriers whereby more GRN is processed into granulins.
4                                          The granulin A repeat unit of GEP is required and sufficient
5      Interestingly, expression of individual granulins alone had little effect on behavior.
6 n old mice expressed low levels of CSF1R and granulin and failed to promote tumor outgrowth, suggesti
7         Despite the unusual structure of the granulin and granulin-polyhedrin inclusions, they intera
8 receptors and the intracellular functions of granulins and progranulin is crucial for understanding t
9                    The function of lysosomal granulins and why their absence causes neurodegeneration
10 radigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9o
11                  GP-5 (Glycoprotein V), GRN (granulin), and MCAM (melanoma cell adhesion molecule) we
12  vitro, whereas increasing concentrations of granulin antibody inhibited cell growth in a dose-depend
13                                              Granulins are a family of protein growth factors that ar
14                              Progranulin and granulins are attributed with roles in cancer, inflammat
15 or the human blood fluke Schistosoma mansoni Granulins are growth factors that drive proliferation of
16                                        These granulins are present in complexes with Tat and P-TEFb i
17                   Our findings indicate that granulins are required to maintain BMP levels to support
18                                We identified granulin as a cyclin T1-interacting protein that repress
19 enome, raising the possibility of developing granulin-based inhibitors of viral infection.
20 tive disulfide bonds lack the characteristic granulin beta-hairpin structure.
21 cterize a progranulin [Biomphalaria glabrata granulin (BgGRN)] from the snail B. glabrata, a natural
22                                              Granulin bound to the histidine-rich domain of cyclin T1
23 rogranulin is proteolytically processed into granulins, but the role of granulins in the pathogenesis
24                                              Granulins DE and E bind Tat but do not interact directly
25                                              Granulins DE and E repress transcription from the HIV-1
26 cing a nuclear localization signal (KRKK) in granulin directed more granulin to the nucleus and resul
27 e peptide adopts a mini-granulin fold with a granulin disulfide connectivity.
28 e for subfamilies, and the carboxyl-terminal granulin domain occurs in two PLCP subfamilies, in which
29  with RD21 (responsive to desiccation 21), a granulin domain-containing cysteine protease implicated
30  members probably evolved by deletion of the granulin domains.
31                        Finally, we show that granulin E, a cleavage product of PGRN, is sufficient to
32                                              Granulin epithelin precursor (GEP) has been implicated i
33 teine-rich polypeptides called epithelins or granulins (epithelin/granulin precursor).
34                     ADAMTS-7 associates with granulin-epithelin precursor (GEP), an autocrine growth
35            This led to the identification of granulin-epithelin precursor (GEP), an autocrine growth
36                                              Granulin-epithelin precursor (GEP/progranulin) is an aut
37 in, acrogranin, PC-derived growth factor, or granulin-epithelin precursor) is a secreted glycoprotein
38             Previous studies showed that the granulin/epithelin precursor (GEP) binds the histidine-r
39                                          The granulin/epithelin precursor (GEP) has been identified a
40 e gel electrophoresis, was identified as the granulin/epithelin precursor by an accurate determinatio
41                                          The granulin/epithelin precursor is a little known growth fa
42                                              Granulin expression inhibited Tat transactivation, and t
43 ains interacting most with perlecan harbored granulins F and B.
44 es indicate that TxVIIB indeed adopts a mini-granulin fold but with the ICK disulfide connectivity.
45 g features that govern formation of the mini-granulin fold rather than the ICK fold and will provide
46 old predicted that the peptide adopts a mini-granulin fold with a granulin disulfide connectivity.
47 toxins and nontoxin proteins with this "mini-granulin" fold.
48                                 We show that granulin formed stable complexes in vivo and in vitro wi
49 in human neurodegenerative disease subjects, granulin fragments accumulated specifically in diseased
50  the first demonstration of a toxic role for granulin fragments in a neurodegenerative disease model.
51 nly detects full-length GRN, no intermediate granulin fragments.
52                             An orthologue of granulin from the human parasitic liver fluke Opisthorch
53                              Substitution of granulin from the Trichoplusia ni granulosis virus (TnGV
54  investigational gene therapy delivering the granulin gene (GRN) using an adeno-associated virus sero
55 rounding the human alphaIIb locus showed the Granulin gene approximately 18 kb downstream to alphaIIb
56                    In 2006, mutations in the granulin gene were identified in patients with familial
57 at expansion in C9orf72 and mutations in the granulin (GRN) and microtubule-associated protein tau (M
58 O) cells identified neuropilin-1 (Nrp-1) and granulin (Grn) as osteocytic-secreted proteins upregulat
59                           We then identified granulin (GRN) as the most upregulated gene in instigati
60 f progranulin (PGRN) due to mutations in the granulin (GRN) gene causes frontotemporal lobar degenera
61                         Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) caus
62 frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have reduced levels of
63                                              Granulin (GRN) is a potent mitogen and growth factor imp
64 ntotemporal lobar degeneration (FTLD) due to Granulin (GRN) mutations might present a specific patter
65                                              Granulin (GRN) mutations represent one of the most frequ
66                                              Granulin (GRN, or progranulin) is a protein involved in
67 ng of PGRN to smaller protein modules called granulins (GRNs) contributes to FTLD and ALS progression
68 ion suggest a potentially important role for granulin in the pathogenesis and/or malignant progressio
69 ly processed into granulins, but the role of granulins in the pathogenesis of neurodegenerative disea
70 etrahedral occlusions with more virions than granulin inclusions but many fewer than wild-type polyhe
71                                   These same granulins increased TDP-43 levels via a post-translation
72  but the large cuboidal inclusions formed by granulin indicate that the amino acid sequence is not th
73                                        Thus, granulin is a cellular protein that interacts with cycli
74  Immunity, Park et al. present evidence that granulin is a cofactor for TLR9 activation, delivering C
75 ins in granuloviruses are located within the granulin matrix.
76 g [3H]thymidine incorporation indicated that granulin may be a glial mitogen, as addition of syntheti
77 oduced, much larger, cryocooled granulovirus granulin microcrystals.
78                                          The granulins, mitogenic growth factors containing repeats o
79 ecursor protein to seven and a half distinct granulin motifs (GRNs), has been implicated in a broad r
80                                   The 2.1-kb granulin mRNA was expressed predominantly in glial tumor
81 nerative-related protein accumulation, human granulin mutation cases were investigated by histochemic
82 wed a neuronal and glial tau accumulation in granulin mutation cases.
83                                              Granulin mutations were initially found in tau-negative
84 (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9orf72) subjects with a pathogenic muta
85                               The failure of granulin or the granulin-polyhedrin chimera to properly
86 he secreted growth factor termed liver fluke granulin (Ov-GRN-1) in pre-malignant lesions by undertak
87 odv-e66, odv-e18), and polyhedra (polyhedrin/granulin, p10, pp34, and fp25k).
88 be a glial mitogen, as addition of synthetic granulin peptide to primary rat astrocytes and three dif
89 ength progranulin/PGRN-1 protein and cleaved granulin peptide.
90                                              Granulin peptides accumulate with age and stress, howeve
91  that even in the presence of intact PGRN-1, granulin peptides suppressed the activity of the lysosom
92 h complex physiological functions, producing granulin peptides that promote inflammatory and anti-inf
93                                              Granulin peptides were also dominant over PGRN-1 in comp
94 l surface receptors for progranulin, but not granulin peptides, have been reported.
95  multiple cysteine-rich, biologically active granulin peptides.
96  change in inclusion shape obtained with the granulin-polyhedrin chimera demonstrates that the primar
97                                            A granulin-polyhedrin chimera produced tetrahedral occlusi
98               The failure of granulin or the granulin-polyhedrin chimera to properly occlude AcMNPV v
99 te the unusual structure of the granulin and granulin-polyhedrin inclusions, they interacted with AcM
100 anulin (PGRN), which is cleaved to lysosomal granulin polypeptides.
101 rived growth factor is acrogranin (epithelin/granulin precursor), a factor that possesses growth-regu
102 es called epithelins or granulins (epithelin/granulin precursor).
103 y analysing the expression of eight proteins-Granulin precursor, Mannan-binding-lectin-serine-peptida
104  an 88-kDa glycoprotein corresponding to the granulin precursor.
105 C cell line and corresponds to the epithelin/granulin precursor.
106 logous to the N-terminal region of the human granulin protein.
107 ese studies suggest that presence of cleaved granulins, rather than or in addition to loss of full-le
108 we show that GEP and some of its constituent granulin repeats can inhibit HIV-1 transcription via Tat
109 alent cation requirements, and we identified granulin repeats that bind differentially to Tat and cyc
110 ests that the processing of progranulin into granulins should be considered as part of disease pathob
111 the secretion of proteinases, cytokines, and granulin, this indicates an inflammation-like state of t
112                                   Binding of granulin to P-TEFb inhibited the phosphorylation of a CT
113 dation of human TDP-43 was impaired when the granulin to PGRN-1 ratio was increased, representing a d
114 ulated CSF-1R and secreted the growth factor granulin to support stromal activation and robust tumor
115 tion signal (KRKK) in granulin directed more granulin to the nucleus and resulted in more structurall
116 specifically interrogate the contribution of granulins to the neurodegenerative process.
117                                              Granulin transcript haploinsufficiency has been proposed
118 pondin motifs of ADAMTS-7/ADAMTS-12 and each granulin unit of GEP mediated their interactions.
119 icipants with prodromal to moderate FTD with granulin variations.
120                                 In addition, granulin was a substrate for CDK9 but not for the other
121                            In contrast, when granulins were coexpressed with TDP-43, they exacerbated
122 vely new class of growth regulators known as granulins, which have tertiary structures resembling the
123                          The interactions of granulins with Tat and cyclin T1 differ with respect to

 
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