ライフサイエンスコーパス: granuloma

1 Predictors of PTT, ECA, and granuloma.

2 ignals are physically segregated within each granuloma.

3 ages undergoing apoptosis in the tuberculous granuloma.

4 atory pathways during the development of the granuloma.

5 hage phagosome and later within the necrotic granuloma.

6 phage recruitment to the forming tuberculous granuloma.

7 pact that this has on the progression of the granuloma.

8 tion of protective lymphoid follicles within granulomas.

9 haracterized by the presence of noncaseating granulomas.

10 ast aggregates, forming fungal-induced glial granulomas.

11 ive host hemostasis through the formation of granulomas.

12 He differed significantly between tumors and granulomas.

13 wed abundance of HIF-1alpha in the center of granulomas.

14 and T cells drive [(64)Cu]-LLP2A avidity in granulomas.

15 a mouse model of human-like necrotic TB lung granulomas.

16 rculosis is the formation of macrophage-rich granulomas.

17 mycobacteria trigger formation of organized granulomas.

18 he HIV infection progressively changes these granulomas.

19 n source are unable to sustain infections in granulomas.

20 pulate Mycobacterium tuberculosis-associated granulomas.

21 e generated detailed molecular maps of human granulomas.

22 population dynamics and heterogeneity within granulomas.

23 bers and reduced CD4(+) T-cell counts within granulomas.

24 nt for long-term M. tuberculosis survival in granulomas.

25 lular response, and cytokine presence within granulomas.

26 nd monocytes, resulting in reduced number of granulomas.

27 rization, function, and bacterial control in granulomas.

28 developed, with foreign-body giant cells and granulomas.

29 vestigated vessel normalization in rabbit TB granulomas.

30 duce the morphological hallmarks of human TB granulomas.

31 nificantly higher concentration of p-CREB in granulomas.

32 ulting in chronic infection and formation of granulomas.

33 increased organ burden in mouse cryptococcal granulomas.

34 echanisms driving dissemination from TB lung granulomas.

35 re to alpha-MSH compared with saline treated granulomas.

36 lung bacterial burdens and poorly organized granulomas.

37 bout the processes that initiate fibrosis in granulomas.

38 y immune parameters associated with human TB granulomas.

39 ), a disease characterized by development of granulomas.

40 Consistent with the altered granulomas, 1,25(OH)2D3-treated mice also exhibited sign

41 everal novel roles for IL-10 in tuberculosis granulomas: 1) decreased levels of IL-10 lead to increas

42 ne findings were presence of >/=1 peripheral granulomas (57.1%), vasculitis (57.1%), vitreoretinal tr

43 Poorly formed granulomas (96%), neutrophils (75%), and necrosis (79%)

44 Pyogenic granulomas, acquired vascular lesions, form on the ocula

45 ssion was significantly reduced in developed granulomas after exposure to alpha-MSH compared with sal

46 g to bacteria and infected cells leaving the granuloma and disseminating, either resulting in additio

47 llular Mtb, and are efficiently delivered to granulomas and extracellular mycobacterial cords in vivo

48 periportal infiltrations, bile duct damage, granulomas and fibrosis.

49 es are among the most abundant cell types in granulomas and have been shown to serve as both critical

50 haracterized by the presence of noncaseating granulomas and is usually treated successfully with immu

51 tes, but there were immunological changes in granulomas and lymph nodes from anti-IL-10-treated anima

52 on and increased cytokine production in lung granulomas and lymph nodes from IL-10-neutralized animal

53 bacteria within IFN-gamma-dependent iNOS(+) granulomas and prevent dissemination.

54 f E-cadherin in macrophages disorganized the granulomas and protected the fish, introducing new ideas

55 Here, we demonstrate CD1b expression in TB granulomas and reveal a central role for meromycolate ch

56 Over the course of infection, granulomas and thoracic lymph nodes experienced dynamic

57 In contrast, tadpoles rarely exhibited granulomas and tolerated persistent M. marinum accumulat

58 espectively), followed by chronic scleritis, granuloma, and chalazion (14.25, 14.25, and 14.25%, resp

59 yst formation, infection, chemosis, pyogenic granuloma, and corneal abrasion.

60 e and included tearing, discomfort, pyogenic granuloma, and dacryocystitis.

61 o multiple non-human primate (NHP) cellular, granuloma, and whole-lung datasets.

62 s, found within Mtb-infected macrophages and granulomas, and can, by encapsulation of a second antibi

63 alled integrin alpha4beta1) binding cells in granulomas, and compared [(64)Cu]-LLP2A with [(18)F]-FDG

64 or host survival, containment of bacteria in granulomas, and control of bacterial burdens in vivo.

65 cruitment and enhanced T-cell recruitment in granulomas, and decreased the bacterial load.

66 reflecting the compartments of macrophages, granulomas, and open cavities as well as parameterizing

67 d granulomas that shared features with human granulomas, and prolonged Mtb containment with unilatera

68 ctional characteristics, accumulated in lung granulomas, and protected against Mtb infection.

69 erin- and Mycobacterium tuberculosis-induced granulomas, and that infection results in lymph vessel s

70 Granuloma annulare (GA) is a common cutaneous inflammato

71 infected with S. mansoni had disrupted liver granuloma architecture and increased mortality, which in

72 ulosis infected mice led to a change in lung granuloma architecture, characterized by a marked decrea

73 While some features such as granuloma are typical signs of OT, atypical features can

74 Granulomas are a hallmark of tuberculosis.

75 Granulomas are also postulated to facilitate egg extrusi

76 Granulomas are complex lung lesions that are the hallmar

77 Granulomas are immune cell aggregates formed in response

78 ediated antileishmanial mechanism, and (iii) granulomas are not necessarily hallmarks of protective a

79 ize that (i) recruited mononuclear cells and granulomas are not required to control infection or resp

80 Lung granulomas are organized structures of host immune cells

81 Granulomas are the pathological hallmark of tuberculosis

82 Granulomas are the pathological hallmark of tuberculosis

83 munologically restrain bacteria growth, some granulomas are unable to control Mtb growth, leading to

84 nce in mycobacteria-which models tuberculous granulomas-are partly determined by a mechanism of tRNA

85 monstrated hepato-splenomegaly with multiple granulomas as well as ascites and a left-sided pleural e

86 oles in (i) mononuclear cell recruitment and granuloma assembly and maturation, (ii) initial control

87 as IFN-gamma and TNF-alpha are required for granuloma assembly during M. avium infections in mice.

88 CCL2, CCL5) or downregulate (CXCL9) initial granuloma assembly, (iii) may enhance (CCL2, CCL5) or hi

89 nfection or respond to Sb chemotherapy, (ii) granuloma assembly, control of infection, and Sb's effic

90 i, CD8(+) T cell mechanisms are required for granuloma assembly, macrophage activation, intracellular

91 mediated MPhi activation is not required for granuloma assembly.

92 nd 47% (21/44) of stranded turtles had renal granulomas associated with S. Typhimurium.

93 al inhibition of the Vegf pathway suppresses granuloma-associated angiogenesis, reduces infection bur

94 edict that MMT may be a mechanism underlying granuloma-associated fibrosis and warrants further inves

95 In tuberculosis, some macrophages in granulomas assume an epitheloid appearance.

96 cell lung cancer adenocarcinomas from benign granulomas at noncontrast CT.

97 -small cell lung cancer adenocarcinomas from granulomas at noncontrast CT.

98 -FDG, may be a useful tool for understanding granuloma biology in TB.

99 s in TB, we used a computational model of TB granuloma biology to identify factors that drive fibrosi

100 rophages undergo secondary necrosis, causing granuloma breakdown and increased mycobacterial growth.

101 -type mice, most bacteria are within iNOS(+) granulomas, but in T-bet(-/-) mice, most bacteria are ou

102 y metabolically active inflammatory cells in granulomas, but lacks specificity for particular cell ty

103 increased host survival, suggesting that the granuloma can also serve a bacteria-protective role.

104 ma protein expression was found in developed granulomas comparing to microparticle unchallenged PBMCs

105 tuberculosis (Mtb) HN878 induces human-like granulomas composed of bacilli-loaded macrophages surrou

106 onic infection and persist in tissues within granulomas composed of macrophages.

107 Granulomas consist of activated immune cells that cluste

108 hallmark of pathogenesis is the formation of granulomas containing multinucleated giant cells (MNGCs)

109 fic polarization and plasticity, or why some granulomas control bacteria and others permit bacterial

110 erstanding M. tuberculosis metabolism within granulomas could contribute to reducing the lengthy trea

111 ed a large in silico repository of in silico granulomas coupled to lymph node and blood dynamics and

112 duction, and other phenotypic changes within granulomas, demonstrating the HIV infection progressivel

113 fferent immune landscapes of M. tuberculosis granulomas depending on the time after infection, the hi

114 UA crystal granulomas develop late in chronic UA crystal nephropath

115 We found that noncaseating granulomas develop rapidly and eventually eradicate infe

116 be, Pagan et al. (2015) reveal that necrotic granulomas develop when macrophage supply is insufficien

117 s of mycobacterial infection, thus impairing granuloma development.

118 erentiation or recruitment occurs throughout granuloma development.

119 n spleen, liver, and lungs and smaller liver granulomas during 60 d of infection compared with wild-t

120 xtrusion (most commonly), tube displacement, granuloma, ectropion, slit punctum, fistula, and infecti

121 n malignant and benign SPNs in patients from granuloma-endemic regions.

122 Our results suggest that peripheral granuloma fibrosis, which is commonly observed, can aris

123 onship between macrophages, fibroblasts, and granuloma fibrosis.

124 isseminating, either resulting in additional granuloma formation (local or non-local) or spread to ai

125 ent-based computational model that simulates granuloma formation and function, FQ plasma and tissue p

126 aptive immune determinants mediating leprosy granuloma formation and function.

127 ction of the liver, spleen, and lymph nodes; granuloma formation and hepatosplenomegaly; and early in

128 In IFN-gamma(-/-) mice, there is deficient granuloma formation and inducible NO synthase (iNOS) ind

129 inhibitor, results in reduced inflammation, granuloma formation and lung pathology.

130 te decades of study, the molecular basis for granuloma formation and restriction of chronic pathogens

131 ma reverses this, coincident with subsequent granuloma formation and substantially extends survival w

132 nuated IL-33-induced type 2 immunity and egg granuloma formation during S. japonicum infection.

133 er of unknown cause that is characterized by granuloma formation in affected organs, most often in th

134 The abolition of granuloma formation in embryos infected with the dehydra

135 vivo cytokine production, gross pathology or granuloma formation in lungs from M.tb DK9897 infected a

136 T cells in the liver and spleen and enhanced granuloma formation in the liver.

137 cumulation, local T cell immune response and granuloma formation in the lungs indicate that the infla

138 , we present a multiscale in silico model of granuloma formation in tuberculosis.

139 hy and proliferation, resulting in excessive granuloma formation in vivo.

140 Granuloma formation is a hallmark of several infectious

141 m marinum model, we found that mycobacterial granuloma formation is accompanied by macrophage inducti

142 lomas in the mouse model and have shown that granuloma formation is dependent upon the enzyme sphingo

143 e transparent larval zebrafish, we show that granuloma formation is intimately associated with angiog

144 gest that the eggshell inhibits foreign body granuloma formation long enough for the miracidium to ma

145 ult anti-M. marinum responses induced active granuloma formation with abundant T cell infiltration an

146 quent decreased NO expression and/or by poor granuloma formation with consequent decreased hypoxic st

147 f E-cadherin function resulted in disordered granuloma formation, enhanced immune cell access, decrea

148 erial burden is dependent on macrophages and granuloma formation, providing the first in vivo experim

149 mensional cell culture model of tuberculosis granuloma formation, using bioelectrospray technology.

150 than WT controls and showed impaired hepatic granuloma formation.

151 nuclease is crucial for Th2 polarization and granuloma formation.

152 8; 95% CI, 1.37-6.94; P = 0.007) resulted in granuloma formation.

153 and extracellular matrix in a 3D model of TB granuloma formation.

154 reign body particles in the bulla stimulates granuloma formation.

155 ge activation, and the Th2 response promotes granuloma formation.

156 n postinfection, including extensive iNOS(+) granuloma formation.

157 ory) macrophage morphology following primary granuloma formation.

158 events, including leukocyte recruitment and granuloma formation.

159 imaging, mycobacterial growth, pathology and granuloma formation.

160 7 and decreased IL-6 and IL-10 levels within granulomas from B cell-depleted animals.

161 At 8 wk postinfection, lung granulomas from IL-10-neutralized animals had reduced cy

162 We validated the model with granulomas from nonhuman primates to delineate myeloid c

163 anulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiase

164 In macaques, granulomas had higher [(64)Cu]-LLP2A uptake than uninfec

165 d a role for PknG in the formation of stable granuloma, hallmark structures of latent tuberculosis.

166 ppressive cytokine IL-10 at the level of the granuloma has proven difficult because of lesional heter

167 Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable e

168 We found that the centers of granulomas have a pro-inflammatory environment that is c

169 : 1) I-RL (n = 14), 2) peri-implant pyogenic granuloma (I-PG) (n = 5), 3) peri-implant peripheral gia

170 = 5), 3) peri-implant peripheral giant cell granuloma (I-PGCG) (n = 9), 4) T-RL (n = 44), 5) tooth-a

171 accine has been associated with chronic skin granuloma in 3 children with primary immunodeficiency.

172 T), eyelid contour abnormalities (ECAs), and granuloma in the 2 most common TT surgery procedures: po

173 tion in the Evicel group, 1 case of pyogenic granuloma in the Tisseel group, and no complications in

174 uences of vascularization of the tuberculous granuloma in the zebrafish-Mycobacterium marinum infecti

175 n, that tracks Mtb infection within multiple granulomas in an entire lung.

176 The effects of B cell depletion varied among granulomas in an individual animal, as well as among ani

177 mirroring in part the development of hypoxic granulomas in human disease progression.

178 ty of mice and during the formation of liver granulomas in mice infected with Schistosoma mansoni.

179 C1 induced apoptosis and completely resolved granulomas in myeloid TSC2-deficient mice.

180 l immunologic characteristics of tuberculous granulomas in nonhuman primates.

181 To understand the role of granulomas in TB, we analyzed the proteomes of granuloma

182 adenopathies in the internal mammary chain; granulomas in the capsule of the implant, which in some

183 ns Deltagcs1) which can be contained in lung granulomas in the mouse model and have shown that granul

184 nscript networks at <10 mum in C57BL/6 mouse granulomas increase complexity with time after infection

185 of CD3(+) T cells decreased as the stage of granuloma increased from stage I to stage IV (P < 0.001)

186 ction of cows with M. bovis, as the stage of granuloma increases from stage I to stage IV, the immuno

187 oma maturation (CCL2, CCL5), (v) may exert a granuloma-independent action that enables self-cure (CCL

188 Histological analysis of these granulomas indicated infiltration of a diverse cadre of

189 t response to Histoplasma capsulatum because granulomas induced by this pathogenic fungus develop hyp

190 Targeting granuloma-induced vascular permeability via vascular end

191 ) LC treatment resulted in fewer bladder egg granuloma-infiltrating macrophages, eosinophils, and T a

192 wever, macrophage-intrinsic pathways driving granuloma initiation and maintenance remain elusive.

193 le control of pulmonary bacterial burden and granuloma integrity, whereas TLR2 signaling on nonhemato

194 Groesser et al. demonstrate that pyogenic granuloma is a RAS pathway-driven tumor.

195 he model incorporated human immune response, granuloma lesions, multi-drug antimicrobial chemotherapy

196 ics and developed an in silico tool to scale granuloma level results to a full host scale to identify

197 the efficacy of MXF, LVX and GFX at a single granuloma level, we integrate computational modeling wit

198 Coalescing and mostly perivascular granuloma-like accumulations of storage-laden CD68(+) mi

199 controls, M. canettii-infected mice yielded granuloma-like lesions for 4/4 lungs at days 14 and 28 p

200 A PUFA-enriched Western diet triggers focal granuloma-like neutrophilic enteritis in mice that lack

201 te a host-pathogen interaction that controls granuloma macrophage polarization and long-term pathogen

202 Thus, manipulating granuloma macrophage polarization represents a strategy

203 or necrosis factor (TNF) signaling limits M2 granuloma macrophage polarization, thereby restricting S

204 Granuloma macrophage subsets are diverse and carry varyi

205 al.) to shift the balance between M1 and M2 granuloma macrophages and resist TNF-mediated clearance

206 Thus, during mycobacterial infection, granuloma macrophages are broadly reprogrammed by epithe

207 Granuloma macrophages exhibit heterogeneous polarization

208 Granuloma macrophages in humans with tuberculosis were s

209 STm preferentially persists in granuloma macrophages reprogrammed to an M2 state, in pa

210 TNF neutralization shifts granuloma macrophages toward an M2 state and increases b

211 sh model, Cronan et al. (2016) now show that granuloma macrophages undergo reprograming events involv

212 lammatory and anti-inflammatory signaling in granuloma macrophages.

213 10) early parasite control, (iv) may promote granuloma maturation (CCL2, CCL5), (v) may exert a granu

214 As granulomas mature, they induce angiogenesis and vascular

215 A crystallizes in the kidney; (2) UA crystal granulomas may form due to pre-existing CKD; and (3) pro

216 An in vitro sarcoidosis-like granuloma model was developed by challenging peripheral

217 a workshop, entitled "3-D Human in vitro TB Granuloma Model" to advance the field.

218 nti-inflammatory properties in this in vitro granuloma model, which is an effect mediated by inductio

219 nt exhibits impaired survival in an in vitro granuloma model.

220 dormancy including a three-dimensional human granuloma model.

221 Several groups are developing cell culture granuloma models.

222 e to pulmonary Mtb, leading to poorly formed granulomas, more severe lung pathology, and increased my

223 producing B cells infiltrated to tuberculous granuloma of patients with ATB.

224 ression is not induced in the lungs and lung granulomas of animals exhibiting latent tuberculosis inf

225 cent of local CD8(+) T cell response in lung granulomas of human tuberculosis patients.

226 haped ring of nuclei that are present within granulomas of infectious etiology.

227 ge response as seen during initiation of the granulomas of primary pathology.

228 t imaging, and poorly formed non-necrotizing granulomas on pathology.

229 enocarcinomas) from benign fungal infection (granulomas) on 120 non-contrast CT studies.

230 early fibrosis, and minority for nonspecific granuloma or mild inflammation.

231 Patients with granuloma or moderate-severe ileitis on biopsy were sign

232 hicken the alveolar septa with poorly formed granulomas or giant cells.

233 domysium or replacing muscle fibers, with no granulomas or vasculitis.

234 The classic immune response is the TB granuloma organized in three dimensions within extracell

235 Schistosome eggs provoke the formation of granulomas, organized immune aggregates, around them.

236 ng establishment of the tuberculosis-induced granuloma pathogenesis.

237 le of IL-33 and its receptor ST2L in hepatic granuloma pathology induced by Schistosoma japonicum inf

238 emonstrate that IL-33 contributes to hepatic granuloma pathology through induction of M2 macrophages

239 Beads also induce granulomas rapidly, through a foreign body response.

240 In human tuberculosis granulomas, regions of extracellular matrix destruction

241 to pre-existing CKD; and (3) proinflammatory granuloma-related M1-like macrophages may drive UA cryst

242 itiated carcinogenesis instruct a long-lived granuloma-resident macrophage differentiation program th

243 Polyploid granuloma-resident macrophages formed via modified cell

244 g samples were positive for live bacilli and granulomas, respectively.

245 ldren, suggests that ocular surface pyogenic granulomas respond to topical timolol treatment, which h

246 ues in acute infection, analyzing individual granulomas revealed that B cell depletion resulted in al

247 pression (Foxp3, Il10), whereas those in the granuloma rims associate with activated T cells and macr

248 proach, suggest that IL-10 at the individual granuloma scale is a critical regulator of lesion outcom

249 e site of infection (e.g., lung) at a single granuloma scale with blood level readouts that can be tr

250 metabolite- and gene-scale perturbations to granuloma-scale outcomes and predicting mechanisms of st

251 To explore how these adaptations influence granuloma-scale outcomes in vivo, we present a multiscal

252 While granulomas serve to physically contain and immunological

253 an 200 cells per muL) detection of choroidal granulomas should be accepted as evidence of disseminate

254 Encapsulated C3HeB/FeJ granulomas show necrotic centers with transcripts associ

255 macrophages and with M2 polarization at the granuloma site.

256 Similarly, at advanced granuloma stages, culture-negative cows demonstrated sig

257 MXF and LVX have higher granuloma sterilization rates compared to GFX; and MXF p

258 rved increased mycobacterial burden, loss of granuloma structure, and increased progression of TB dis

259 ) mice, MIIG mice still develop well-defined granulomas, suggesting that IFN-gamma-mediated MPhi acti

260 UA crystal granulomas surrounded by proinflammatory M1-like macroph

261 l co-cultures, while the volume of pulmonary granulomas surrounding omega1-mutated eggs following tai

262 T-RL (n = 44), 5) tooth-associated pyogenic granuloma (T-PG) (n = 21), and 6) tooth-associated perip

263 nd 6) tooth-associated peripheral giant cell granuloma (T-PGCG) (n = 23).

264 s receiving stenting developed postoperative granuloma than those who did not (87% versus 63%, p = 0.

265 macrophages, resulting in the formation of a granuloma that ruptures into the airways to reinitiate t

266 ith laboratory-adapted Mtb H37Rv resulted in granulomas that are characterized by unorganized cluster

267 We show that STm persists within splenic granulomas that are densely populated by CD11b(+)CD11c(+

268 mastine is also effective within the complex granulomas that are the hallmark of mycobacterial infect

269 eral CD4(+) T-cell depletion correlated with granulomas that contained fewer CD4(+) and CD8(+) T cell

270 tigens secreted through the eggshell trigger granulomas that facilitate egg extrusion into the enviro

271 Pathology to the human host results from granulomas that form around eggs trapped in the liver an

272 eneous bacterial burdens, well-circumscribed granulomas that shared features with human granulomas, a

273 Granulomas, the hallmark of Mtb infection, are complex s

274 Inside granulomas, the pathogen Mycobacterium tuberculosis may

275 fection induces arginase-1-expressing type 2 granulomas, thereby increasing inflammation and TB disea

276 lecule delivery, and decreases hypoxia in TB granulomas, thereby providing a potential avenue to impr

277 t FTY720 reactivates cryptococcosis from the granuloma through a S1P receptor 3-mediated mechanism an

278 , and bacterial populations within each lung granuloma throughout the course of infection and is cali

279 ient immune reaction, and directionally from granuloma to the central veins, suggested that substance

280 0 to the immunological balance necessary for granulomas to control bacterial burden and disease patho

281 ildren with acquired ocular surface pyogenic granulomas treated at Boston Children's Hospital from 20

282 Finally, macaques develop the spectrum of granuloma types seen in humans, providing a unique oppor

283 Human and nonhuman primate granulomas undergoing fibrosis can have spindle-shaped m

284 Because no granulomas were observed and only single lesional eosino

285 Unchallenged PBMCsand developed granulomas were treated daily with 10 muM alpha-MSH or s

286 ause of poor penetration of antibiotics into granulomas where the bacilli reside.

287 is infection in humans triggers formation of granulomas, which are tightly organized immune cell aggr

288 in accumulates within the periphery of these granulomas, while cleaved amyloid beta (Abeta) peptides

289 aB were significantly increased in developed granulomas, while expression of p-CREB was not changed.

290 nderstanding antibiotic dynamics within lung granulomas will be vital to improving and shortening the

291 confirmed the presence of a 3.8 mm parietal granuloma with a few calcifications in the left eye.

292 active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists.

293 tissues, and immunohistochemical analysis of granulomas with known [(64)Cu]-LLP2A uptake identified s

294 Second, stable necrotic granulomas with low CFU counts and limited inflammation

295 n model, which is characterized by organized granulomas with necrotic cores that bear striking resemb

296 We treat in silico granulomas with recommended daily doses of each FQ and c

297 ich lack lymphocytes, also form noncaseating granulomas with similar kinetics, but these control infe

298 eggs rapidly recruit macrophages, which form granulomas within days.

299 Specific spatial organization of granulomas within the lungs is crucial for protective an

300 erentiation of different cell populations in granulomas would be a useful research tool and could imp