ライフサイエンスコーパス: granulosa cell

1 d in luteal cells (terminally differentiated granulosa cells).

2 usters associated with germ cells and 6 with granulosa cells.

3 s due to defective proliferation of cuboidal granulosa cells.

4 edgehog (Dhh) and Indian hedgehog (Ihh) from granulosa cells.

5 of luteinizing hormone (LH) receptor by the granulosa cells.

6 rsor cells into male Sertoli cells or female granulosa cells.

7 ding somatic cells, which differentiate into granulosa cells.

8 as a coreceptor in the signaling complex in granulosa cells.

9 ranslation, and initiates differentiation of granulosa cells.

10 lular PI3 Kinase/AKT signaling in follicular granulosa cells.

11 ates Foxl2 and reprograms Sertoli cells into granulosa cells.

12 ate into testicular Sertoli cells or ovarian granulosa cells.

13 nase (MAPK) increased markedly in the mutant granulosa cells.

14 2, Smad3, or both Smad2 and Smad3 in ovarian granulosa cells.

15 d the regulation of target genes in cultured granulosa cells.

16 was deleted via Cre-Lox-mediated excision in granulosa cells.

17 recover from acidosis in a manner resembling granulosa cells.

18 ased apoptosis or decreased proliferation of granulosa cells.

19 ing the pretumoral lesions but not to normal granulosa cells.

20 n addition, many follicles contain apoptotic granulosa cells.

21 6 mRNA was minimally stimulated in preantral granulosa cells.

22 n of the aromatase gene (CYP19A1) in ovarian granulosa cells.

23 l cancers indirectly, by influencing ovarian granulosa cells.

24 o inactivate the Brca1 gene in mouse ovarian granulosa cells.

25 in DF-1, LMH, LMH/2A, and primary theca and granulosa cells.

26 anscription of the aromatase gene in ovarian granulosa cells.

27 ly, possibly through an effector secreted by granulosa cells.

28 results, appears to bind both RI and RII in granulosa cells.

29 he genes up-regulated by GDF9 in cultures of granulosa cells.

30 germ cells were revealed, as well as for the granulosa cells.

31 te along a distinct pathway to become wave 1 granulosa cells.

32 rther highlight the remarkable plasticity of granulosa cells.

33 ed by a reduction in TGF-beta1 expression in granulosa cells.

34 to form ovarian FLCs, including oocytes and granulosa cells.

35 SMAD2/3-responsive transcriptional assays in granulosa cells.

36 n, cGMP begins to decrease in the peripheral granulosa cells.

37 In granulosa cells 82% of identified PGR-regulated genes bo

38 While granulosa cell ablation of individual Smad2 or Smad3 cau

39 olished by actinomycin D, and in transfected granulosa cells activin A stimulated ERalpha promoter ac

40 tes, but this site of expression switches to granulosa cells after the newly assembled primordial fol

41 Conditional loss of endothelin receptor A in granulosa cells also decreased ovulation but did not aff

42 Granulosa cells also secrete mullerian inhibiting substa

43 tory follicles were co-cultured with cumulus granulosa cells, Amh expression was increased at least 2

44 In mouse granulosa cell and cumulus cell expansion assays, mouse

45 ivator genes, and impaired the expression of granulosa cell and oocyte-specific genes.

46 nockdown of SMAD1 and SMAD5 in mouse primary granulosa cells and a human GCT-derived cell line (COV43

47 iator of the biological actions of PR in the granulosa cells and activation of its downstream pathway

48 he ovary increased in surface epithelial and granulosa cells and also in the corpora lutea of GREKO(-

49 ccelerates the differentiation of pfGCs into granulosa cells and causes premature activation of all d

50 s knocked out using CRISPR-Cas technology in granulosa cells and cultured in vitro with BMP-4 stimula

51 a dominant-stable mutant of beta-catenin in granulosa cells and develops late-onset GCT.

52 e shown to regulate both function of ovarian granulosa cells and early embryogenesis in cattle and ch

53 Positive controls as granulosa cells and HEK293 cells stably transfected with

54 In vitro treatment of primary rat granulosa cells and MLTC-1 cells with cyclic AMP (cAMP)

55 creased SR-BI mRNA expression in primary rat granulosa cells and MLTC-1 cells, whereas ACTH had no ef

56 In KGN human ovarian granulosa cells and mouse pulmonary artery smooth muscle

57 s in genes that are expressed in the somatic granulosa cells and not the oocytes.

58 ng, is spatiotemporally expressed in ovarian granulosa cells and plays a critical role in the regulat

59 nhances aromatase expression in both ovarian granulosa cells and primary preadipocytes.

60 A1 modulates aromatase expression in ovarian granulosa cells and primary preadipocytes.

61 tory follicles, we disrupted Erk1/2 in mouse granulosa cells and provide in vivo evidence that these

62 and oocytes needed for energy production by granulosa cells and required for oocyte and follicular d

63 rst genome-wide description of PGR action in granulosa cells and systematic comparison of diverse PGR

64 nt/beta-catenin signaling alters the fate of granulosa cells and that the GCT that arise in Catnb(flo

65 re differentially expressed in heat-stressed granulosa cells and the corresponding EVs, respectively.

66 determination of ovarian surface epithelium, granulosa cells and theca cells.

67 croscopy to examine entire cumulus and mural granulosa cells and their projections in mouse antral ov

68 e produced indirectly by first affecting the granulosa cells and then the oocyte.

69 ls in a manner specific to the population of granulosa cells and to the stage of growth and developme

70 within the developing follicles (oocytes and granulosa cells), and their ovarian mRNA levels increase

71 liferation, differentiation and apoptosis in granulosa cells, and consequently, small abnormal follic

72 /5 leads to upregulation of PDGFA in ovarian granulosa cells, and that a novel regulatory interaction

73 /5 leads to upregulation of PDGFA in ovarian granulosa cells, and that a novel regulatory interaction

74 sforming growth factor (TGF)-beta1, in human granulosa cells, and their expression also increased in

75 s prevents the differentiation of pfGCs into granulosa cells, and this arrests the dormant oocytes in

76 sdifferentiate into their female equivalents-granulosa cells-and testicular tissue reorganizes to a m

77 he sources of ovarian surface epithelium and granulosa cells are known, the origin(s) of theca progen

78 preovulatory follicles is controlled by the granulosa cells around the oocyte.

79 We have used ovarian granulosa cells as a model to investigate this pathway,

80 They are synthesised by follicular granulosa cells as alpha plus betaA/betaB subunits (enco

81 ssion of an 80-kDa AKAP (AKAP 80) in ovarian granulosa cells as they mature from a preantral to a pre

82 tage, and the interactions of germ cells and granulosa cells basing on known and novel pathway were p

83 Thus, inappropriate activation of KRAS in granulosa cells blocks the granulosa cell differentiatio

84 n which the oocyte is coupled to surrounding granulosa cells by gap junctions.

85 estigated the regulation of gremlin in mouse granulosa cells by GDF9 as well as other members of the

86 Oocytes control glycolysis in granulosa cells by regulating expression levels of genes

87 he lineage specification of both Sertoli and granulosa cells by repressing Sf1 expression.

88 d antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.

89 The cGMP is synthesized in the granulosa cells by the transmembrane guanylyl cyclase na

90 s of the FOXL2 transcription factor in adult granulosa cells can reprogram granulosa cells into Serto

91 ous, endometrioid, mucinous, clear cell, and granulosa cell carcinomas and in precursor lesions such

92 enetic proteins (Smad1 and Smad5) in ovarian granulosa cells causes metastatic granulosa cell tumors

93 man mural granulosa cells (MGCs) and cumulus granulosa cells (CGCs) was measured by mass spectrometry

94 e that the TAF4b protein is expressed in the granulosa cell compartment of the mammalian ovarian foll

95 s in two different in vitro models of oocyte-granulosa cell complexes.

96 was increased at least 2-fold compared with granulosa cells cultured alone.

97 osa cells resulted in increased apoptosis of granulosa cells, decreased number of corpora lutea, redu

98 nse to luteinizing hormone (LH), cGMP in the granulosa cells decreases, and as a consequence, oocyte

99 and selected disruption of the Cebpb gene in granulosa cells demonstrate that C/EBPbeta (CCAAT/Enhanc

100 otes PF formation by facilitating oocyte and granulosa cell development.

101 Aromatase expression in ovarian granulosa cells dictates levels of circulating estrogen

102 Thus, preantral granulosa cells differ from cumulus cells in CEEF-depend

103 d functional changes that occur as preantral granulosa cells differentiate into cumulus cells.

104 antral stage, multiple genes associated with granulosa cell differentiation and oocyte maturation wer

105 vation of KRAS in granulosa cells blocks the granulosa cell differentiation pathway, leading to the p

106 ress Cre prior to or after the initiation of granulosa cell differentiation, respectively.

107 Cyclic GMP (cGMP) generated in the granulosa cells diffuses through gap junctions into the

108 ever, constitutive expression of KrasG12D in granulosa cells disrupted normal follicle development le

109 Importantly, the loss of TAF4b in ovarian granulosa cells disrupts cellular morphologies and inter

110 That KrasG12D/Pten mutant granulosa cells do not transform but rather undergo cell

111 Therefore, preantral granulosa cells do not undergo expansion for two fundame

112 latory surge of gonadotropins, but preantral granulosa cells do not.

113 functional interactions of these pathways in granulosa cells during follicular development in vivo, w

114 To analyze the functions of RAS protein in granulosa cells during ovarian follicular development in

115 in the differentiation of somatic cells into granulosa cells during primordial follicle formation.

116 stradiol production from primary rat ovarian granulosa cells (EC50 = 10.5 nm).

117 Inactivation of Lats1/2 in murine granulosa cells either in vitro or in vivo resulted in a

118 Following selective ablation of Edn2 in granulosa cells, Esr2-Edn2KO dams had reduced oocytes ov

119 cond, activation of MAPKs alone in preantral granulosa cells, even in the presence of CEEFs, is not s

120 Taking together, EVs generated from granulosa cells exposed to HS has the potential to shutt

121 Results showed that granulosa cells exposed to HS increased the accumulation

122 nditional knock-in mouse models in which the granulosa cells express a constitutively active KrasG12D

123 yte Ube2i caused defects in both oocyte- and granulosa cell-expressed genes, including NOBOX and some

124 ed a conditional mutant mouse model in which granulosa cell expression of Runx2 and Cbfb was deleted

125 otes canonical WNT signaling but also alters granulosa cell fate decisions by maintaining epithelial-

126 Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance.

127 ygen species, and apoptosis were observed in granulosa cells from aged women.

128 omplete dynamic genetic programs of germ and granulosa cells from E16.5 to postnatal day (PD) 3 were

129 hain cleavage system and primary cultures of granulosa cells from Mln64 mutant mice showed defects in

130 By contrast, granulosa cells from similar preantral follicles possess

131 For this, bovine granulosa cells from smaller follicles were cultured in

132 te the effects of BMPR-IB gene modulation on granulosa cell function in goats.

133 d cell viability were studied to explore the granulosa cell function on BMPR-IB gene modulation.

134 ent of subfertility associated with abnormal granulosa cell function.

135 Primordial follicles, consisting of granulosa cell (GC)-enveloped oocytes are maintained in

136 ivity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through pe

137 including WNT5a and WNT11, are expressed in granulosa cells (GCs) and are differentially regulated t

138 Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of

139 Within the ovarian follicle, granulosa cells (GCs) surround and support immature oocy

140 We used ovarian preantral granulosa cells (GCs) to elucidate the mechanism by whic

141 ignal that drives differentiation of ovarian granulosa cells (GCs).

142 ture oocytes are surrounded and supported by granulosa cells (GCs).

143 a suggest that TAF4b integrates a program of granulosa cell gene expression required for normal ovari

144 l role for Lats1/2 in the maintenance of the granulosa cell genetic program and further highlight the

145 ementation of stress-related EVs in cultured granulosa cells has induced adaptive response to subsequ

146 se following formation of multiple layers of granulosa cells have two major fates: either to continue

147 redundant roles with FOXL2 to maintain fetal granulosa cell identity and combined loss of RUNX1 and F

148 al profiles of six main cell types; oocytes, granulosa cells, immune cells, endothelial cells, periva

149 tes regulate glycolysis and the TCA cycle in granulosa cells in a manner specific to the population o

150 e central role of cyclic GMP (cGMP) from the granulosa cells in maintaining meiotic arrest, but it is

151 Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovar

152 the cellular and EV-coupled miRNAs of bovine granulosa cells in response to HS.

153 ds, including Leydig cells in the testes and granulosa cells in the ovaries.

154 of each follicular cell type (i.e., oocyte, granulosa cells, including cumulus and mural cells), dur

155 Expression in freshly isolated granulosa cells increased with preantral follicle develo

156 ignaling specific to early-stage oocytes and granulosa cells, indicative of oxidative damage as a cru

157 actor in adult granulosa cells can reprogram granulosa cells into Sertoli cells.

158 resses Sox9 to block transdifferentiation of granulosa cells into Sertoli-like cells in the adult mou

159 ne Foxl2 and reprogrammed juvenile and adult granulosa cells into Sertoli-like cells, triggering form

160 ercellular communication between oocytes and granulosa cells is essential for normal follicular diffe

161 Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle develo

162 dependent expression of aromatase in ovarian granulosa cells is inversely correlated with the protein

163 The cell cycle recruitment of granulosa cells is regulated at least in part by hormone

164 sient but not sustained activation of RAS in granulosa cells is therefore crucial for directing norma

165 In the ovary, Fxna mRNA is expressed in granulosa cells; its abundance is maximal 48 hours after

166 R-regulated events: expansion of the cumulus granulosa cell layer that encloses the oocyte and meioti

167 polar bodies, are detached from the cumulus granulosa cell layer, and display spindle and nuclear an

168 n polyovulatory and have disrupted theca and granulosa cell layers.

169 Because disrupting Pten in granulosa cells leads to increased proliferation and sur

170 at indeed, inactivation of the Brca1 gene in granulosa cells led to the development of cystic tumors

171 mours) and stromal tumours (such as juvenile granulosa-cell, Leydig-cell, and Sertoli-cell tumours).

172 ly affects the function of luteinized bovine granulosa cells (LGCs), a model for large-luteal cells.

173 The introduction of ZF4 mutants into a human granulosa cell line resulted in up-regulation of endogen

174 ic expression of the Jun proteins in a human granulosa cell line significantly inhibited an ovary-spe

175 In vitro BA production by human mural granulosa cells (MGCs) and cumulus granulosa cells (CGCs

176 er in vitro or in vivo resulted in a loss of granulosa cell morphology, function, and gene expression

177 eta-catenin pathway are expressed in ovarian granulosa cells; nevertheless, its potential involvement

178 dhesion modulates self-assembly of human KGN granulosa cells, normal human fibroblasts (NHFs), and MC

179 so in embryonic gonads and in spermatids and granulosa cells of adult testes and ovaries, respectivel

180 inge and lunatic fringe are expressed in the granulosa cells of developing follicles.

181 found to be expressed stage specifically in granulosa cells of goats.

182 ls of embryonic testes from 12.5 dpc, and in granulosa cells of growing follicles in adult ovaries.

183 Mullerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed

184 evated levels of phospho-AKT were evident in granulosa cells of immature KrasG12D mice, even in the a

185 hly expressed in cumulus cells than in mural granulosa cells of mouse antral follicles.

186 Unlike granulosa cells of normal ovaries, most (15 of 24) GCT s

187 y, we showed that ER stress was activated in granulosa cells of PCOS patients as well as in a well-es

188 ells, and their expression also increased in granulosa cells of PCOS patients.

189 iently produced prior to follicle rupture by granulosa cells of periovulatory follicles and induces o

190 ing glycolytic enzymes and glycolysis in the granulosa cells of preantral follicles.

191 er-driven knockout of Yap1 in differentiated granulosa cells of preovulatory follicles and luteal cel

192 otein present in ovaries and is localized to granulosa cells of preovulatory follicles and to luteal

193 ses 1 and 2) are activated by an LH surge in granulosa cells of preovulatory follicles, we disrupted

194 he cumulus and virtually absent in the mural granulosa cells of preovulatory follicles.

195 the role of mTOR signaling and KIT ligand in granulosa cells of primordial follicles for follicle act

196 ominate in the cortex and differentiate into granulosa cells of quiescent primordial follicles.

197 at ovarian PRDC transcripts are localized in granulosa cells of selective follicles.

198 KrasG12D induced cell cycle arrest in granulosa cells of the KrasG12D;Cyp19-Cre mice but not i

199 ormone (LH) activates receptors in the mural granulosa cells of the ovarian follicle.

200 equires productive interactions with somatic granulosa cells of the ovarian follicle.

201 mone (FSH) receptor is expressed only in the granulosa cells of the ovary and the Sertoli cells of th

202 amma) as a target of regulation by PR in the granulosa cells of the preovulatory follicles during the

203 These findings suggest that ER stress in granulosa cells of women with PCOS contributes to the in

204 l process most represented in germ cells and granulosa cells or common to both cell types at each spe

205 dal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells.

206 ported expression of genes by germ cells and granulosa cells, our analyses identified 5 distinct cell

207 Preantral granulosa cells (PAGCs) differentiate into cumulus cells

208 ls, which we refer to as primordial follicle granulosa cells (pfGCs).

209 GDF9 acts as a paracrine factor and affects granulosa cell physiology.

210 regnant females lacking Becn1 in the ovarian granulosa cell population have a defect in progesterone

211 endogenous pH(i) regulation, and reveal that granulosa cells possess multiple mechanisms for carrying

212 udy identify YAP1 as a critical regulator of granulosa cell proliferation and differentiation.

213 ression within the ovary results in impaired granulosa cell proliferation and theca cell recruitment

214 and TGF-beta signaling pathways to regulate granulosa cell proliferation, differentiation, and survi

215 a significant increase in both germ cell and granulosa cell proliferation.

216 pathway caused by the decrease in INPP4B in granulosa cells promotes an ovarian environment defectiv

217 r the existence and functioning of an oocyte-granulosa cell regulatory loop.

218 Proliferation of granulosa cells-required for this transition-and express

219 Production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9

220 promoter-driven knockout of Yap1 in ovarian granulosa cells resulted in increased apoptosis of granu

221 follicle-stimulating hormone-treated ovarian granulosa cells, resulting in enhanced progesterone synt

222 The cGMP decrease in the granulosa cells results in rapid cGMP diffusion out of t

223 signaling effector beta-catenin (CTNNB1) in granulosa cells results in the formation of premalignant

224 esponding normal DNA as well as a tumor-only granulosa cell sample.

225 We report that in the absence of FSH, granulosa cells secrete a subthreshold concentration of

226 We identified the granulosa cell-secreted SDF-1 as a main chemoattractant

227 reverse transcription-PCR assays on cultured granulosa cells showed that both ERalpha and ERbeta mRNA

228 viability upon modulation of BMPR-IB gene in granulosa cells similar to that are documented in sheep

229 n's health and fertility, global and ovarian granulosa cell-specific androgen-receptor (AR) knockout

230 the supporting cell lineage and becomes pre-granulosa cell-specific as the gonads differentiate.

231 In vivo, granulosa cell-specific loss of Lats1/2 caused the ovari

232 tic and apoptotic cells and cells expressing granulosa cell-specific marker genes.

233 Here, we show that TAF4b controls the granulosa-cell-specific expression of the proto-oncogene

234 sa cells transition through a differentiated granulosa cell state prior to transdifferentiating towar

235 in breast cancer, thyroid, and preovulatory granulosa cells, suggesting that the PKA-dependent depho

236 Proliferating granulosa cells support the progression of follicular gr

237 ctivin beta A-expressing germ cells; (c) pre-granulosa cells surrounding primordial follicles.

238 estrogen and FSH and demonstrate compromised granulosa cell survival.

239 rmined by the action of aromatase in ovarian granulosa cells that converts testosterone to estradiol.

240 aintained by cyclic GMP from the surrounding granulosa cells that diffuses into the oocyte through ga

241 Here we describe two AR-mediated pathways in granulosa cells that regulate ovarian follicular develop

242 cytes and FSH in the transition of preantral granulosa cells to cumulus cells competent to undergo ex

243 MAPKs were activated by EGF in preantral granulosa cells to essentially the same levels as in cum

244 yte pH(i), indicate that gap junctions allow granulosa cells to exogenously regulate oocyte pH(i) aga

245 To assess the competence of preantral granulosa cells to generate responses associated with ex

246 supports the proliferation of differentiated granulosa cells to keep up with the demand of cells to c

247 zing hormone then acts on receptors in outer granulosa cells to rapidly decrease cGMP.

248 dings could explain the distinct response of granulosa cells to T and DHT and provide a molecular mec

249 fects may involve a differential response of granulosa cells to the androgens testosterone (T) and di

250 facilitates the effect of BMP2 on somatic to granulosa cell transition.

251 Preantral granulosa cells treated with EGF, but not those treated

252 novel gene-gene interactions supportive for granulosa cell tumor development were also observed betw

253 X-linked gene (Gct4) that strongly supports granulosa cell tumor development.

254 Chr) 4 (Gct1) and have revealed new loci for granulosa cell tumor susceptibility (Gct7-Gct9) on Chrs

255 8 backcross females examined, we detected 81 granulosa cell tumor-bearing animals and compared their

256 ; nevertheless, its potential involvement in granulosa cell tumorigenesis has not been examined.

257 Gct1 on Chr 4 is a fundamental oncogene for granulosa cell tumorigenesis in mice and has identified

258 d Sp1 in controlling PDGFA expression during granulosa cell tumorigenesis.

259 d Sp1 in controlling PDGFA expression during granulosa cell tumorigenesis.Oncogene advance online pub

260 ption factor is pathognomonic for adult-type granulosa cell tumors (AGCT) and a diagnostic marker for

261 Wnt/beta-catenin signaling occurs in ovarian granulosa cell tumors (GCT) and have created the Catnb(f

262 this end, human (n = 6) and equine (n = 18) granulosa cell tumors (GCT) were analyzed for beta-caten

263 in ovarian granulosa cells causes metastatic granulosa cell tumors (GCTs) in female mice and phenocop

264 on of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life

265 Granulosa cell tumors also developed in G12V mice.

266 gh prevalence of FOXL2 and KRAS mutations in granulosa cell tumors and in mucinous tumors, respective

267 aneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant

268 t inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls.

269 ng apoptosis, leading to the accumulation of granulosa cell tumors that reactivates the epithelial pr

270 ) in mice results in an ovarian phenotype of granulosa cell tumors that renders the animals infertile

271 KRAS in Sertoli cells also caused testicular granulosa cell tumors that showed gene expression patter

272 opment of ovarian serous adenocarcinomas and granulosa cell tumors.

273 n/Kras mutant mice were infertile but lacked granulosa cell tumors.

274 mice become infertile and develop metastatic granulosa cell tumors.

275 follicles, and by ovarian dysgerminomas and granulosa cell tumors.

276 istopathological diagnosis was of a juvenile granulosa cell tumour.

277 Granulosa cell tumours of the ovary are rare, hormonally

278 ta protein in testis, ovary, lymphoid cells, granulosa cell tumours, and a subset of malignant melano

279 e carrying a Brca1 mutation in their ovarian granulosa cells, two thirds of which develop ovarian or

280 proliferation and viability was observed in granulosa cells upon BMPR-IB modulation.

281 We propose that granulosa cells use cytoplasmic projections to search fo

282 Here we characterised PGR activity in mouse granulosa cells using combined ChIP-seq for PGR and H3K2

283 pressed in theca cells, triggers a signal in granulosa cells via apolipoprotein E receptor 2 and the

284 s" latent GDF9, enabling potent signaling in granulosa cells via type I receptors (i.e. activin recep

285 diffuses into the sink provided by the large granulosa cell volume, such that by 20 min the cGMP conc

286 hermore, differentiation of both Sertoli and granulosa cells was blocked when Wt1 was deleted before

287 Metabolic coupling between oocytes and granulosa cells was not affected in follicles from the s

288 From a microarray study on mouse ovarian granulosa cells, we discovered that the estrogen recepto

289 anti-proliferative effects of KRAS(G12D) in granulosa cells, we sought to determine whether KRAS(G12

290 Granulosa cells were also found to possess a V-type H(+)

291 When preantral granulosa cells were co-cultured with oocytes from early

292 Mural granulosa cells were found to possess randomly oriented

293 dominant stable beta-catenin mutant in their granulosa cells were generated.

294 The F3 generation granulosa cells were isolated and found to have a transg

295 (c)GMP into the oocyte from the surrounding granulosa cells, where it is produced by the guanylyl cy

296 was predominantly expressed in proliferative granulosa cells, whereas the inactive form of YAP1 (cyto

297 ocyte growth is supported by theca cells and granulosa cells, which establish dynamic and highly orga

298 ting oocyte development as well as providing granulosa cells with a proliferative signal that require

299 8-fold by transient co-transfection of human granulosa cells with a Wt1 expression construct.

300 FSH acts on granulosa cells within the immature follicle to inhibit