ライフサイエンスコーパス: growth differentiation factor

1 a recently described 18- kDa heparin binding growth/differentiation factor.

2 en cultured in presence of Gdf11, a TGF-beta growth/differentiation factor.

3 n (PAH) by selectively trapping activins and growth differentiation factors.

4 ction of various heparin-binding polypeptide growth/differentiation factors.

5 nown factor is cVg1 (homologous to mammalian growth differentiation factor 1, GDF1), a transforming g

6 Growth/differentiation factor-1 (Gdf-1, encoded by Gdf1)

7 gnificant induction of circulating levels of growth differentiation factor 10 (GDF10) in TDAG51(-/-)

8 lin-dependent kinase-4 (cdk4) and -6 (cdk6), growth differentiation factor 10 (Gdf10), hepatocyte gro

9 y elevated expression of the TGF-beta ligand growth differentiation factor-10 (GDF10), which was foun

10 Growth/differentiation factor-10 (GDF-10) is a TGF-beta

11 Growth differentiation factor 11 (GDF11) and GDF8 are me

12 Growth differentiation factor 11 (GDF11) and myostatin (

13 Growth differentiation factor 11 (Gdf11) belongs to the

14 pothesis that the circulating blood level of growth differentiation factor 11 (GDF11) decreases in ol

15 Growth differentiation factor 11 (GDF11) is a member of

16 we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenati

17 Mice deficient in growth differentiation factor 11 (GDF11) signaling displ

18 Prior studies suggested that inhibition of growth differentiation factor 11 (GDF11) through soluble

19 Here we provide evidence that growth differentiation factor 11 (GDF11), a member of th

20 ing OE at the same time as the gene encoding growth differentiation factor 11 (Gdf11), a TGFbeta fami

21 Expression of growth differentiation factor 11 (GDF11), an ActRIIA lig

22 tralizes myostatin, activin A, activin B and growth differentiation factor 11 (GDF11).

23 ets, we revealed that MeCP2 finely regulates growth differentiation factor 11 (Gdf11).

24 g growth factors, such as BMP2/4, myostatin, growth differentiation factor 11, and transforming growt

25 Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist

26 eport a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual

27 egulates the expression of the gene encoding growth-differentiation factor 11 (Gdf11), a transforming

28 al cell line-derived neurotrophic factor and growth-differentiation factor 11 was defective in bl/bl

29 Growth/differentiation factor 11 (Gdf11) is a transformi

30 They also found that the growth factor growth/differentiation factor 11 is a circulating negati

31 diac hypertrophy which suggests that raising growth/differentiation factor 11 levels may be useful to

32 ACE-536 bound growth differentiation factor-11 (GDF11) and potently in

33 epidermal growth factor receptor], GDF-11/8 [growth differentiation factor-11/8], and RGMC [hemojuvel

34 sought to determine the usefulness of plasma growth differentiation factor 15 (GDF-15) for risk strat

35 Growth differentiation factor 15 (GDF-15) is a biomarker

36 Growth differentiation factor 15 (GDF-15) is a cytokine

37 Growth differentiation factor 15 (GDF-15) is a strong pr

38 Growth differentiation factor 15 (GDF-15) is the first c

39 The level of growth differentiation factor 15 (GDF-15), a circulating

40 Levels of growth differentiation factor 15 (GDF-15), a cytokine se

41 Recently, growth differentiation factor 15 (GDF-15), a cytokine th

42 Growth differentiation factor 15 (GDF-15), a marker of i

43 Growth differentiation factor 15 (GDF-15), high-sensitiv

44 m during infection and inflammation, such as growth differentiation factor 15 (GDF-15).

45 and additional potential biomarkers, such as growth differentiation factor 15 (GDF15) and cell free m

46 One of these mitokines, growth differentiation factor 15 (GDF15) and its recepto

47 f 15 proteins strongly associated with POHP, growth differentiation factor 15 (GDF15) and WAP four-di

48 and subsequent targeted validation revealed growth differentiation factor 15 (GDF15) as a central co

49 Overexpression of growth differentiation factor 15 (GDF15) by bone marrow

50 found that MEG3 stimulates expression of the growth differentiation factor 15 (GDF15) by enhancing p5

51 Elevation in circulating growth differentiation factor 15 (GDF15) correlates with

52 We have previously found up-regulation of growth differentiation factor 15 (GDF15) in glioblastoma

53 Growth differentiation factor 15 (GDF15) is a biomarker

54 Growth differentiation factor 15 (GDF15) is a contributo

55 Growth differentiation factor 15 (GDF15) is a divergent

56 Growth differentiation factor 15 (GDF15) is aberrantly s

57 Growth differentiation factor 15 (GDF15) is an anorectic

58 fusion increases kidney, hepatic, and plasma growth differentiation factor 15 (GDF15) levels in chow

59 ases fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) levels via acti

60 Serum erythropoietin and growth differentiation factor 15 (GDF15) levels were mea

61 supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appe

62 Lastly, D + Q augmented growth differentiation factor 15 (GDF15) transcript and

63 Growth differentiation factor 15 (GDF15) was identified

64 Growth differentiation factor 15 (GDF15), a distant memb

65 Growth differentiation factor 15 (GDF15), a member of th

66 nted increases in ISR gene targets including growth differentiation factor 15 (GDF15), a negative reg

67 analysis, which revealed increased levels of growth differentiation factor 15 (GDF15), along with inc

68 F21), bone morphogenetic protein 8b (BMP8b), growth differentiation factor 15 (GDF15), angiopoietin-l

69 predictors across multiple diseases, such as growth differentiation factor 15 (GDF15), as well as uni

70 ermore, CXCL12 induces downregulation of the growth differentiation factor 15 (GDF15), insulin-like g

71 Contracting skeletal muscle releases growth differentiation factor 15 (GDF15), which is requi

72 onal regeneration-related protein (NREP) and growth differentiation factor 15 (GDF15).

73 s, including the cachexia-promoting protein, growth differentiation factor 15 (GDF15).

74 cell proliferation and higher expression of growth differentiation factor 15 (GDF15).

75 (The Usefulness of Growth Differentiation Factor 15 [GDF-15] for Risk Strat

76 ctor, IL-1, IL-6, and CXCR1/2 chemokines and growth differentiation factor 15 also seems to be very c

77 l included 8 items: age (A), biomarkers (B) (growth differentiation factor 15 and N-terminal pro-B-ty

78 Furthermore, combining TCMCB07 with a growth differentiation factor 15 antibody enhanced treat

79 Growth differentiation factor 15 consistently adds progn

80 Baseline elevated serum growth differentiation factor 15 levels decreased with t

81 2 large studies, high plasma levels of MIC1 (growth differentiation factor 15) before diagnosis of CR

82 Studies on serially measured GDF-15 (growth differentiation factor 15) in acute heart failure

83 Smad7 upregulation via Smad3, whereas GDF15 (growth differentiation factor 15) induced Smad7 through

84 In patients with HTN/DM, GDF-15 (growth differentiation factor 15) was independently asso

85 After multinomial regression, GDF-15 (growth differentiation factor 15) was most important in

86 of macrophage inhibitory cytokine-1 (MIC1 or growth differentiation factor 15), a marker of inflammat

87 oponin I), CRP (C-reactive protein), GDF-15 (growth differentiation factor 15), GAL-3 (galectin-3), a

88 actor-like domains 2, nuclear protein 1, and growth differentiation factor 15).

89 retic peptide, 0.77 [95% CI, 0.68-0.87]; and growth differentiation factor 15, 0.68 [95% CI, 0.58-0.7

90 [207-491] pmol/L vs 152 [90-247] pmol/L; and growth differentiation factor 15, 2.26 [1.44-4.35] vs 1.

91 edictors of CV death/MI were the biomarkers, growth differentiation factor 15, and N-terminal pro-B-t

92 ical and genetic predictors, with plexin B2, growth differentiation factor 15, and renin emerging as

93 yocardial inflammation and fibrosis, such as growth differentiation factor 15, are also powerful pred

94 Regression modeling identified growth differentiation factor 15, CD14+CD16+ monocytes,

95 proteins revealed differential expression of growth differentiation factor 15, dickkopf-related prote

96 Growth differentiation factor 15, GDF15, and glucagon-li

97 the antifibrotic and antiinflammatory factor growth differentiation factor 15, which protects the hea

98 k protein D family members and the mitokine, growth differentiation factor 15.

99 oietic activity and elevated serum levels of growth differentiation factor 15.

100 tumor necrosis factor a receptor II], GDF15 [growth differentiation factor 15], cystatin-C, HGBA1C [H

101 -alpha], jun-D [JunD proto-oncogene], GDF15 [growth differentiation factor 15], FGL1 [fibrinogen like

102 ensitive troponin-T (>14 ng/L), and elevated growth-differentiation factor 15 (>1109 ng/L) identified

103 Growth-differentiation factor 15 (GDF-15) is expressed i

104 Here we identified growth-differentiation factor 15 (GDF15) (also known as

105 rming growth factor beta superfamily member, growth-differentiation factor 15 (Gdf15), that is expres

106 of NT-proBNP, high-sensitive troponin-T, and growth-differentiation factor 15 identify patients at hi

107 (NT-proBNP), high-sensitive troponin-T, and growth-differentiation factor 15 with cardiovascular eve

108 t (NT-proBNP, high-sensitive troponin-T, and growth-differentiation factor 15) at the time of study i

109 natriuretic peptide, cardiac troponin-T, and growth-differentiation factor 15) to apply the previousl

110 than young fibroblasts, including increased growth/differentiation factor 15 (GDF-15).

111 Growth/differentiation factor 15 (GDF15), also known as

112 clin-dependent kinase inhibitor 1a (CDKN1A), Growth/differentiation factor 15 (GDF15), and Prostaglan

113 be differentiated by their ability to induce growth/differentiation factor 15 (GDF15), independent of

114 ith aging markers in human plasma, including Growth/differentiation factor 15 (GDF15), stanniocalcin

115 es circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been

116 induction of the proatherosclerotic cytokine growth/differentiation factor 15 (GDF15).

117 ns in hepatokine expression (e.g., increased growth/differentiation factor 15 [GDF15] and fibroblast

118 culation, including placental growth factor, growth/differentiation factor 15, and matrix metalloprot

119 e], BCAN [brevican core protein], and GDF15 [growth/differentiation factor 15]), retained favorable d

120 din and its putative pathological suppressor growth differentiation factor-15 (GDF-15) in patients wi

121 o-brain natriuretic peptide (NT-proBNP), and growth differentiation factor-15 (GDF-15) in relation to

122 Growth differentiation factor-15 (GDF-15) is a member of

123 In unadjusted analyses, growth differentiation factor-15 (GDF-15) levels and NLR

124 B-type natriuretic peptide (NT-proBNP), and growth differentiation factor-15 (GDF-15) over 12 months

125 Mitochondrial-secreted growth differentiation factor-15 (GDF-15) promotes weigh

126 (N-terminal B-type natriuretic peptide), and growth differentiation factor-15 (GDF-15), as well as in

127 ng were the concentrations of the biomarkers growth differentiation factor-15 (GDF-15), high-sensitiv

128 IMD4), fibroblast growth factor 23 (FGF-23), growth differentiation factor-15 (GDF-15), pulmonary sur

129 Growth differentiation factor-15 (GDF15) is a biomarker

130 Growth differentiation factor-15 (GDF15) is a stress res

131 tio [HR], 2.13; 95% CI, 1.52-2.99; P<0.001), growth differentiation factor-15 (HR, 1.67; 95% CI, 1.32

132 = 0.01), macrophage accumulation (P < 0.01), growth differentiation factor-15 (P = 0.0001), and calci

133 tween pretransplant inflammatory biomarkers (growth differentiation factor-15 [GDF-15], interleukin-6

134 siRNA significantly decreased expression of growth differentiation factor-15 and monocyte chemotacti

135 y with total hemoglobin, yet negatively with growth differentiation factor-15 and non-transferrin-bou

136 d hepcidin increased, and erythropoietin and growth differentiation factor-15 decreased.

137 Growth differentiation factor-15 improved discrimination

138 Growth differentiation factor-15 is a strong predictor o

139 tein, D-dimer, fibrinogen, homocysteine, and growth differentiation factor-15 levels (P<0.001 for all

140 enuated the stress responsive factor GDF-15 (growth differentiation factor-15) and increased the inte

141 rowth factor binding protein 7), and GDF-15 (growth differentiation factor-15) were the top individua

142 te biology (fatty acid binding protein-4 and growth differentiation factor-15), angiopoietin-2 (relat

143 associated with both HF subtypes (NT-proBNP, growth differentiation factor-15, and C-reactive protein

144 diovascular stress, we measured soluble ST2, growth differentiation factor-15, and high-sensitivity t

145 osis factor-related protein 1 (C1QTNF1), and growth differentiation factor-15.

146 oADM (pro-adrenomedullin; HR, 1.60), GDF-15 (growth differentiation factor-15; HR, 1.47), WFDC2 (WAP

147 Growth-differentiation factor-15 (GDF-15) is emerging as

148 Growth-differentiation factor-15 (GDF-15) is emerging as

149 , N-terminal pro-B-type natriuretic peptide, growth-differentiation factor-15, and high-sensitivity C

150 ed the increased expression of TGF-beta1 and growth/differentiation factor-15 (GDF-15) in RGDSP cultu

151 Among outcome-predicting biomarkers, growth/differentiation factor-15 was the strongest and a

152 orming growth factor)/activin pathway (GDF2 [growth differentiation factor 2]/BMP9 [bone morphogenic

153 Here we describe a role for Growth Differentiation Factor 3 (GDF3) on mature adipocy

154 tion but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has not been ful

155 Among these factors, GDF3 (growth differentiation factor 3), a member of the TGF-be

156 th factor beta (Tgfbeta) family member Gdf3 (growth-differentiation factor 3), a close relative of Xe

157 holamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxi

158 integrin alpha-4 (Itga4) and to up-modulate growth differentiation factor-3 (Gdf3), oncostatin-M (On

159 Here, we show that growth differentiation factor 5 (GDF5), a member of the

160 70 and 90, chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF5).

161 proteins 70 and 90, chemokine receptor 4 and growth differentiation factor 5 as the main mediators of

162 In vitro, the gene product growth differentiation factor 5 has been shown to promot

163 Control sequences of growth differentiation factor 5 were used to delete PTHr

164 WSG1 alone and in complex with a BMP ligand, Growth Differentiation Factor 5.

165 Growth/differentiation factor 5 (GDF5) is a neurotrophin

166 One member of this family, Growth/differentiation factor 5 (GDF5), is encoded by th

167 a fraction of a precursor cells that express growth/differentiation factor 5 (Gdf5), the transcriptio

168 hogenetic protein (BMP)-like molecule called growth/differentiation factor 5 (GDF5).

169 Growth/differentiation factors 5, 6, and 7 (GDF5/6/7) re

170 little skate embryos shows the expression of growth differentiation factor-5 (Gdf5) and beta-catenin

171 In both cell types, growth differentiation factor-5 (GDF5), BMP6, and BMP7 s

172 achypodism (bp) which is due to mutations in growth/differentiation factor-5 (Gdf-5) (6), the mouse h

173 We determined that the gene encoding growth differentiation factor 6 (GDF6), which is the lig

174 two duplicated loci of the putative MSD gene growth differentiation factor 6b (gdf6b).

175 dying glaucoma patients, we identified GDF7 (growth differentiation factor 7) hypomethylation as a cr

176 Growth differentiation factor 8 (GDF8) has been implicat

177 Exceptions are TGF-betas 1 to 3 and growth differentiation factor 8 (GDF8), also known as my

178 Growth differentiation factor 8 (GDF8)/myostatin, acting

179 Growth differentiation factor 8 (GDF8; also known as myo

180 g GDF11 or its closely related family member growth differentiation factor 8 actually impairs skeleta

181 phenotype suggests that the ablated product, growth differentiation factor 8 or 'myostatin', may be o

182 of canonical wnt signaling, as well as GDF8 (growth differentiation factor 8), PDGF-D, and neuregulin

183 Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of t

184 In contrast, substantial induction of growth differentiation factor-8 (GDF-8), a highly conser

185 ntified a new murine TGF-beta family member, growth/differentiation factor-8 (GDF-8), which is expres

186 , bone morphogenetic protein 15 (BMP-15) and growth differentiation factor 9 (GDF-9), were up-regulat

187 we investigated the therapeutic potential of growth differentiation factor 9 (GDF-9)-overexpressing E

188 Growth differentiation factor 9 (GDF9) and bone morphoge

189 Growth differentiation factor 9 (GDF9) and bone morphoge

190 ed bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are key regulator

191 Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-specif

192 Here, we identify growth differentiation factor 9 (GDF9) as a GnRH-suppres

193 ction of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 (GDF9) from the oocyte.

194 Growth differentiation factor 9 (GDF9) is an oocyte-expr

195 Candidates included growth differentiation factor 9 (GDF9), bone morphogenet

196 o had an increase in the expression ratio of growth differentiation factor 9 (GDF9):bone morphogeneti

197 of a factor needed for Fshb induction (e.g. growth differentiation factor 9).

198 Although signaling of activins, TGF-betas, growth differentiation factor 9, and nodal converge pref

199 -derived paracrine factors, particularly the growth differentiation factor 9-bone morphogenetic prote

200 e null for the oocyte-specific gene product, growth differentiation factor-9 (GDF-9), a member of the

201 Growth differentiation factor-9 (GDF-9), an oocyte-secre

202 Growth differentiation factor-9 (GDF-9), bone morphogene

203 ment, we have uncovered a new family member, growth differentiation factor-9 (GDF-9), which is requir

204 Growth differentiation factor-9 (GDF9) and bone morphoge

205 criptional activation of pro-growth ligands (growth differentiation factor/bone morphogenetic protein

206 TGF-beta, activins, and growth differentiation factors exert inhibitory effects

207 (PTN) is an 18-kDa heparin-binding secretory growth/differentiation factor for different cell types.

208 ors for the bone morphogenetic protein (BMP)/growth differentiation factor (GDF) family.

209 ensitivity cardiac troponin T (hs-cTnT), and growth differentiation factor (GDF)-15 for HF risk strat

210 pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, myeloperoxidase

211 CTD-negative" families, both of which harbor growth differentiation factors (GDF6, GDF3) implicated i

212 tor-beta superfamily, including activins and growth differentiation factors (GDFs), is aberrantly exp

213 ably alter NOG's ability to bind to BMPs and growth-differentiation factors (GDFs) in a subtle way, t

214 gene, human epoxide hydrolase (EPHX), human growth/differentiation factor (GOF-1), human myocyte-spe

215 , a novel fusion protein, binds activins and growth differentiation factors in the attempt to restore

216 is a fusion protein that traps activins and growth differentiation factors involved in pulmonary art

217 and advanced NBs express a high level of the growth/differentiation factor midkine (MK).

218 rowth factor beta/bone morphogenetic protein/growth differentiation factor (TGFbeta/BMP/GDF)-related

219 lexes of transforming growth factor-B family growth/differentiation factors with their prodomains are

220 es of transforming growth factor-beta family growth/differentiation factors with their prodomains are