ライフサイエンスコーパス: guanine

1 carbons), and the nature of the nucleobase (guanine).

2 location in the genome of O(6)-carboxymethyl-guanine.

3 could bind simultaneously with major-groove guanines.

4 was to assess the value of (18)F-arabinosyl guanine ((18)F-AraG) as a noninvasive tool that profiles

5 h 9-(4-[(18)F]-fluoro-3-[hydroxymethyl]butyl)guanine ([(18)F]FHBG) of B7H3-sr39tk CAR T cells in an o

6 the TBA-thrombin binding indicated enhanced Guanine 4 (G4) structural stability of TBA upon interact

7 NER), binds avidly to abasic sites and 8-oxo-guanine (8-oxoG), suggesting a noncanonical role in base

8 extended gRNAs with one or two non-matching guanines added to the 5' end were used, Sniper1-Cas9 sho

9 and occurs independently of both O(6)-methyl guanine adduct cytotoxicity and MUTYH-dependent glycosyl

10 sites, as well as minor-groove and exocyclic guanine adducts.

11 ow that in addition to converting adenine to guanine, adenine base editors also convert cytosine to g

12 changes to the ligand binding pocket of the guanine/adenine class to achieve a change in ligand pref

13 Within the guanine/adenine class, seven groups of RNAs were identif

14 he disease burden score and cytosine-adenine-guanine age product score.

15 e reported inhibitors are negatively charged guanine analogues with negligible cell permeability.

16 sphate backbone and the major-groove edge of guanine and (ii) simultaneous cation-pai contacts betwee

17 Here, we show that guanine and adenine nucleotides exert positive and negat

18 L(-1), and 48.8 nmol L(-1) were recorded by guanine and adenine respectively.

19 biosensor and monitoring oxidation signal of guanine and adenine.

20 chromosome contain different proportions of guanine and cytosine nucleotides.

21 ps provided by thymine and requires adjacent guanines and a correctly orientated A/T-rich flanking se

22 pecifically, we have measured the effects of guanines and base mismatches on the electron transfer ra

23 integration at specific DNA stretches where guanines and/or cytosines are 30 base pairs apart and th

24 arying binding affinity, particularly preQ1, guanine, and 2,6-diaminopurine.

25 Guanine- and cytosine-rich nucleic acid sequences have t

26 Herein, we identified crystalline guanine as the enigmatic large-capacity and rapid-turnov

27 ng at positions -2 to -5 of the PFS and by a guanine at position -1, which is not recognized by base

28 hat N reserves were rapidly accumulated from guanine available in the environment as well as biosynth

29 study of local DNA conformations, using the guanine base analog 6-methyl isoxanthopterin (6-MI) as a

30 nesium ion and a tilt in the position of the guanine base because of the additional carbon introduced

31 The guanine base of the dinucleotides interacts with a vacan

32 mainly by constraining the triphosphate and guanine base positions while leaving the ribose flexible

33 switches in the G-loop (which recognizes the guanine base) and lid-loop (poised over the nucleotide p

34 f, responsible for hydrogen bonding with the guanine base, abolished the GTPase activity but not ATPa

35 groups situated on the O (6) position of the guanine base.

36 Alkylation of guanine bases in DNA is detrimental to cells due to its

37 ere, we demonstrate that endogenous oxidized guanine bases in G4 sequences and the subsequent activat

38 nt regarding the putatively critical role of guanine bases in the most widely proposed transport mech

39 The adenine, cytosine, and guanine bases of DNA are susceptible to alkylation by th

40 rs, these observations may suggest a role of guanine-binding proteins (G-proteins) in retinal vascula

41 ed that the storing capacity for crystalline guanine by the marine dinoflagellate Amphidinium cartera

42 Guanine (C(5)H(5)N(5)O) may act similarly to cyanophycin

43 se (SCA3/MJD), the expanded cytosine adenine guanine (CAG) repeat in ATXN3 is the causal mutation, an

44 DNA and RNA sequences rich in guanine can fold into noncanonical structures called G-q

45 structure is shown to be capable of binding guanine-containing dinucleotides in micromolar affinity.

46 les governing the SD fitness landscapes: (1) Guanine contents, rather than canonical SD motifs, best

47 cilitated by unmethylated cytosine-phosphate-guanine (CpG) DNA as well as DNA containing cytosine at

48 9 recognizes unmethylated cytosine-phosphate-guanine (CpG) motifs present in viral, bacterial, and fu

49 s, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methyl

50 t to identify significant Cytosine-phosphate-Guanine (CpG) sites and differentially methylated region

51 ylation (DNAm) at 720,077 cytosine-phosphate-guanine (CpG) sites and prenatal maternal smoking among

52 riod at asthma-associated cytosine-phosphate-guanine (CpG) sites and such an association was sex-spec

53 ion of DNA methylation in cytosine-phosphate-guanine (CpG) sites and surrounding regions was obtained

54 tion patterns at specific cytosine-phosphate-guanine (CpG) sites predictably change with age and can

55 al analysis at individual cytosine-phosphate-guanine (CpG) sites, thus ignoring correlations in the m

56 ed DNA methylation at 605 cytosine-phosphate-guanine (CpG) sites, which were associated with future T

57 DNA methylation at 5,458 cytosine-phosphate-guanine (CpG) sites.

58 thylation of histones and cytosine-phosphate-guanines (CpGs) in gene promoters and other regulatory r

59 basis of the eye anatomy, we deduce that the guanine crystals form a reflective layer producing the s

60 We show that the outer layer indeed contains guanine crystals.

61 We observe that guanine + cytosine (G + C) content and CpG density surro

62 ate-specific codon bias is determined by the guanine-cytosine (GC) content of differentially expresse

63 onship between open reading frame length and guanine-cytosine (GC) content presents universally subst

64 exhibited very high evolutionary rates, low Guanine-Cytosine (GC) content, small genome sizes, and l

65 of mutation rates correlates with increased guanine-cytosine (GC) content, suggesting a key role for

66 ess repeats, or too high or too low windowed guanine-cytosine (GC) content.

67 ariations of Z-linked inversions, repeat and guanine-cytosine (GC) contents, as well as W-linked gene

68 formed by molecular self-assembly of a fused guanine-cytosine base (G C base).

69 r altered target sites with varied levels of guanine-cytosine base content.

70 A guanine-deficit G-quadruplex structure formation by a se

71 tes, such as dGMP, GMP, and cGMP, as well as guanine-derivative drugs.

72 These guanine-derived oxidative DNA lesions interfere with bot

73 By surveying more than 400 000 cytosine guanine dinucleotide (CpG) sites measured from periphera

74 to impaired H3K27me3 spreading from cytosine guanine dinucleotide islands, which is reminiscent to th

75 further identified 155, 46, and 168 cytosine-guanine dinucleotide regions associated (FDR-P < 0.05) w

76 identified significantly associated cytosine-guanine dinucleotide regions for 82 transcripts (false d

77 cytosines within the CpG (cytosine-phosphate-guanine) dinucleotide context across the genome using Ma

78 ethylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ mon

79 to quantify associations at 720,077 cytosine-guanine dinucleotides (CpGs), with adjustment for matern

80 cation of targeted panels of single cytosine guanine dinucleotides from multiple independent loci.

81 A methylation at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts inc

82 of EF-Tu from the guanosine triphosphate to guanine diphosphate conformation during aa-tRNA accommod

83 differentially methylated cytosine-phosphate-guanine (dmCpG) sites (false discovery rate (FDR) <= 0.0

84 ctively inserted opposite O(6)-carboxymethyl-guanine DNA by an engineered polymerase and is required

85 xchange factor 1 (P-REX1), a chemotactic Rac guanine exchange factor (RacGEF).

86 erminal domain that shares homology with the Guanine Exchange Factor (residues Met164 to Glu231), a P

87 maS radionucleotide exchange assay measuring guanine exchange factor activity that can be applied aft

88 p-eIF2) in turn sequesters the eIF2-specific guanine exchange factor eIF2B to block eIF2 recycling, t

89 Guanine exchange factor H1 (GEF-H1), a RhoA activator, i

90 mans, loss-of-function mutations in DOCK8, a guanine exchange factor involved in hematopoietic cell m

91 hile at a tyrosine residue (Tyr-82) inhibits guanine exchange factor Rgl2-mediated nucleotide exchang

92 nsions in C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic c

93 triphosphatases (GTPases) by their specific guanine exchange factors (GEFs) and their GTPase-activat

94 tions within key cellular targets, including guanine for nucleic acids, unsaturated lipids, and targe

95 n species (ROS), which promotes oxidation of guanine forming 7,8-dihydro-8-oxoguanine (8-oxoG).

96 ochemical oxidation of DNA nucleobases i.e., guanine (G) and adenine (A) in physiological pH (7.4) bu

97 Single-stranded DNA or RNA sequences rich in guanine (G) can adopt non-canonical structures known as

98 by combining two emergent properties of the guanine (G) heterocycle in DNA, namely, oxidation sensit

99 Oxidation of the guanine (G) heterocycle to 8-oxo-7,8-dihydroguanine (OG)

100 cules to inosine (I), which is recognized as guanine (G) in translation.

101 ur-stranded structures that can be formed in guanine (G) rich nucleic acid sequences.

102 ve determination of nucleobases, for example guanine (G), adenine (A), and thymine (T) in a beef and

103 nine (A) and thymine (T) or cytosine (C) and guanine (G), but G-rich DNA can form four-stranded G-qua

104 Oxidation of guanine generates several types of DNA lesions, such as

105 Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hy

106 Moreover, 8-oxo-guanine impedes EXO1 but enhances resection by BLM-DNA2,

107 removes alkyl groups at the O(6)-position of guanine in DNA.

108 ssile phosphate and anchors the general base guanine in position for nucleophile activation.

109 onship with the amount of O(6)-carboxymethyl-guanine in the target sequence.

110 fully delocalized across up to five adjacent guanines in a G-tract on the EPR time scale.

111 specific reaction between N(3)-kethoxal and guanines in ssDNA.

112 Tgif1 (thymine-guanine-interacting factor 1) and Tgif2 repress gene exp

113 structures form through self-recognition of guanines into stacked tetrads, and considerable biophysi

114 Guanine is particularly susceptible to oxidation, and 8-

115 ytoplankton nitrogen pool size and dynamics, guanine is proposed to be an important storage form part

116 We propose that crystalline guanine is the elusive N depot that mitigates the negati

117 nt with detection of characteristic oxidized guanine lesions (8-oxodG) in the treated cells, we obser

118 Pol nu and Pol theta in bypassing alkylated guanine lesions in human cells.

119 This is the first structure of a guanine-metabolite-fill-in vG4 based on a human gene pro

120 Guanine metabolites and drugs were tested and showed a c

121 Significantly, guanine metabolites are involved in many physiological a

122 n and stabilized by physiologically relevant guanine metabolites, such as dGMP, GMP, and cGMP, as wel

123 gnostic factors (extent of resection, methyl-guanine-methyl-transferase (MGMT) promoter methylation,

124 ro by efficiently competing with the adenine/guanine mononucleotides for the allosteric sites.

125 ly reported an important role of adenine and guanine mononucleotides that bind to the regulatory Bate

126 formation by a sequence containing (4n - 1) guanines, n denoting the number of G-tetrad layers, was

127 RNA cap structure is first methylated at the guanine-N-7 (G-N-7) position by nonstructural protein 14

128 ional nsp14 protein which possesses ExoN and guanine-N-7 methyltransferase (G-N-7 MTase) activities,

129 The RNA guanine-N7 methyltransferase (RNMT) in complex with RNMT

130 ies arginine readout of cognate backbone and guanine nucleobase interactions in a variety of protein-

131 known replication errors because of oxidized guanine nucleosides (8-OHdGTPs).

132 le is the N1-methylguanosine modification at guanine nucleotide 37 (m(1)G37) located in the anticodon

133 f Ras is relatively insensitive to its bound guanine nucleotide and activation state but depends stro

134 Human guanine nucleotide binding protein like 1 (GNL1) is an e

135 (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important role

136 (GAPs), and in the Rho and Rab subfamilies, guanine nucleotide dissociation inhibitors (GDIs).

137 diazaspiro[4,4]nonane nucleus to target the guanine nucleotide exchange activity of DOCK5, which is

138 activation domain, known to be required for guanine nucleotide exchange factor (GEF) activity of VAV

139 protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor (GEF) and a chaperone

140 n, we evaluated the structure and stability, guanine nucleotide exchange factor (GEF) and GTPase-acti

141 Here, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the O

142 y by regulating the localization of Daple, a guanine nucleotide exchange factor (GEF) for Galphai.

143 Here, we have identified DOCK6, a guanine nucleotide exchange factor (GEF) for Rac1 and CD

144 ropose that TRAPPII is likely to behave as a guanine nucleotide exchange factor (GEF) for the RAB-A2a

145 The C-terminal guanine nucleotide exchange factor (GEF) module of Trio

146 eukaryotic Ras-related nuclear protein (Ran) guanine nucleotide exchange factor (GEF) RCC1.

147 The guanine nucleotide exchange factor (GEF) Son of Sevenles

148 Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates

149 We identified the dual Rac1/RhoA Rho guanine nucleotide exchange factor (GEF) Trio as a criti

150 Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-

151 Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required

152 o and stimulates the catalytic activity of a guanine nucleotide exchange factor (P-REX1) that itself

153 The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as

154 ariants in GBF1 (Golgi brefeldin A-resistant guanine nucleotide exchange factor 1) in four unrelated

155 nt and actomyosin contraction, including Rho guanine nucleotide exchange factor 2 (GEF-H1, ARHGEF2) a

156 Remarkably, expression of a single gene, Rap guanine nucleotide exchange factor 3 (Rapgef3), was stro

157 Here, an MS-based analysis revealed the Vav guanine nucleotide exchange factor 3 (VAV3), an activato

158 GDP-dissociation inhibitor 2 [ARHGDIB], Rho guanine nucleotide exchange factor 6, angiotensin-II typ

159 ab35 (a small monomeric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/

160 plexes and one of the essential subunits for guanine nucleotide exchange factor activity for Rab1 GTP

161 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro.

162 EF appears to function independently of Rac1 guanine nucleotide exchange factor activity.

163 protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor and a chaperone.

164 scle-specific loss of G(12)/G(13) or the Rho guanine nucleotide exchange factor ARHGEF12 have lost my

165 we show that microexon switching in the Arf6 guanine nucleotide exchange factor cytohesin-1 controls

166 mic domain of the receptor that recruits the guanine nucleotide exchange factor dedicator of cytokine

167 e small GTPase RAB11 as an interactor of the guanine nucleotide exchange factor DEF6, and find disrup

168 Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL

169 Her work has shown that the guanine nucleotide exchange factor Dock8 plays a role in

170 e central spindle that concentrates the RhoA guanine nucleotide exchange factor ECT2.

171 tein levels of an Ras1 GTPase activator, the guanine nucleotide exchange factor Efc25, by phosphoryla

172 ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopo

173 tinct sites in their common target, eIF2B, a guanine nucleotide exchange factor for eIF2.

174 use embryos depends on beta-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42.

175 mponent of the ERK/MAPK pathway, and VAV1, a guanine nucleotide exchange factor for Rho family GTPase

176 vated G(s) can also directly interact with a guanine nucleotide exchange factor for Rho family small

177 ial cell-transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho GTPases that

178 cation requires the cellular protein GBF1, a guanine nucleotide exchange factor for small Arf GTPases

179 ound an interaction between TKS5 and FGD1, a guanine nucleotide exchange factor for the Rho-GTPase CD

180 In this work, we show that the guanine nucleotide exchange factor GBF1, relevant for CO

181 ls induced activation and phosphorylation of guanine nucleotide exchange factor H1 (GEF-H1), leading

182 pathway initiated through the cAMP-activated guanine nucleotide exchange factor NCS-Rapgef2 in mice.

183 iting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small GTPase R

184 appears to be the first evidence that a Rho-guanine nucleotide exchange factor plays a critical role

185 logical, and lentiviral techniques, that the guanine nucleotide exchange factor RasGRF2 mediates coca

186 nge protein, activated by cAMP 1 (EPAC-1), a guanine nucleotide exchange factor that activates the sm

187 We identified beta-PIX as a predominant guanine nucleotide exchange factor that interacts with C

188 Rgnef (ARHGEF28/p190RhoGEF) is a guanine nucleotide exchange factor that is activated dow

189 P-eIF2alpha inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactiv

190 nteracts through a PDZ ligand motif with the guanine nucleotide exchange factor TIAM-1/GEF in a compl

191 lusters in cooperation with the Rac-specific guanine nucleotide exchange factor Tiam2.

192 ssion, such as the RAB13 GTPase and the NET1 guanine nucleotide exchange factor, and are regulated by

193 The messenger RNA (mRNA) encoding the guanine nucleotide exchange factor, DOCK4, mutations of

194 of the drug ISRIB, an activator of the eIF2 guanine nucleotide exchange factor, rescues the cell gro

195 n adaptor protein that recruits Ras-specific guanine nucleotide exchange factor, Son of Sevenless 1 (

196 ic QTR-FRET technique enables the linking of guanine nucleotide exchange factor-induced Eu(3+)-GTP as

197 Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor.

198 initiation factor 2B (eIF2B), a multisubunit guanine nucleotide exchange factor.

199 ll GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors,

200 Guanine nucleotide exchange factors (GEFs) activate and

201 Guanine nucleotide exchange factors (GEFs) are the initi

202 tor of cytokinesis) proteins are multidomain guanine nucleotide exchange factors (GEFs) for RHO GTPas

203 The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and T

204 The action of guanine nucleotide exchange factors (GEFs) on the ADP-ri

205 t either the RAS interaction with activating guanine nucleotide exchange factors (GEFs) or receptor t

206 PIX proteins are guanine nucleotide exchange factors (GEFs) that activate

207 proteins is controlled by their regulators; guanine nucleotide exchange factors (GEFs), GTPase activ

208 s of Ras GTPases are triggered by Ras GTPase guanine nucleotide exchange factors (RasGEFs) in general

209 in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase

210 in cytoskeleton dynamics, including numerous guanine nucleotide exchange factors and GTPase-activatin

211 RAPPs) are multi-protein complexes acting as guanine nucleotide exchange factors and possibly as teth

212 educed after T cell-specific deletion of the guanine nucleotide exchange factors Sos1 and Sos2, which

213 ity-based ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42

214 G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammali

215 DOCK3 is a member of the DOCK family of guanine nucleotide exchange factors that regulate cell m

216 are known to be Rab effectors and Rab GEFs (Guanine nucleotide Exchange Factors) that regulate vesic

217 nitially, SmgGDS proteins were classified as guanine nucleotide exchange factors, but recent findings

218 transcriptional upregulation of Rac-specific guanine nucleotide exchange factors, Rac activation, and

219 reduce the levels of active RAS is to target guanine nucleotide exchange factors, which allow RAS to

220 screens targeting Rho-GTPases effectors and guanine nucleotide exchange factors.

221 but rather, through direct activation of the guanine nucleotide exchange protein Epac by cAMP.

222 Guanine nucleotide exchange proteins directly activated

223 -G279S(7.44) was more effective in promoting guanine nucleotide exchange than wild-type A(1)R.

224 Several Rac guanine nucleotide exchange-factors (Rac-GEFs) were also

225 Guanine nucleotide homeostasis is central to photorecept

226 logical conditions that require expansion of guanine nucleotide pools.

227 We examined the role of Ras Guanine Nucleotide Releasing Factor 1 (RasGRF1) and 2 (R

228 eave dsRNA at preferred sites, among which a guanine nucleotide was enriched at a specific position (

229 This work relates the guanine nucleotide-based second messenger regulatory net

230 p)ppGpp in C. crescentus and analyze how the guanine nucleotide-based second messenger system respond

231 Family B heterotrimeric guanine nucleotide-binding protein (G protein)-coupled r

232 -sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activatio

233 actions between beta3 integrin and Galpha13 (guanine nucleotide-binding protein subunit alpha 13), re

234 Floxed Des1 mice, on a guanine nucleotide-binding protein subunit alpha transdu

235 Guanine nucleotide-binding proteins (G proteins) facilit

236 OR, and inhibits signaling to heterotrimeric guanine nucleotide-binding proteins (G proteins).

237 Here, we employed the Gnb4 (guanine nucleotide-binding subunit beta-4) cre driver li

238 ational change contributed to a high rate of guanine nucleotide-exchange factor (GEF)-dependent and -

239 tive factor (GBF1) and brefeldin A-inhibited guanine nucleotide-exchange factors (BIG1 and BIG2).

240 ctive either with bound GDP or without bound guanine nucleotide.

241 OPS and P-HOPS to be regulated by Ypt7-bound guanine nucleotide.

242 HOPS-dependent fusion, independent of bound guanine nucleotide.

243 dent vesicular trafficking of Rabin8, a Rab8 guanine-nucleotide exchange factor (GEF), to the mother

244 We identify the guanine-nucleotide exchange factor dPix as an effector o

245 GBF1 encodes a guanine-nucleotide exchange factor that facilitates the

246 -dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally d

247 factor ARF GTPase by the SEC7 domain of ARF guanine-nucleotide exchange factors (ARF-GEFs), resultin

248 Upon growth factor stimulation, the guanine-nucleotide exchange modulator dissociates Galpha

249 nt G protein activation by a novel family of guanine-nucleotide exchange modulators (GEMs) remains un

250 The Ras superfamily of small GTPases are guanine-nucleotide-dependent switches essential for nume

251 umferential single septin filaments, the Rho guanine-nucleotide-exchange factor (RhoGEF) Bud3, and th

252 guanosine and adenosine ribonucleosides and guanine nucleotides are readily functionalized with CF(3

253 mosomes frequently contain tandem repeats of guanine nucleotides that can form stacked structures sta

254 with the first cytosine and the two opposing guanine nucleotides to confer specificity.

255 Small GTPases alternatively bind GDP/GTP guanine nucleotides to gate signaling pathways that dire

256 te-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP

257 conformations in the absence and presence of guanine nucleotides, respectively, whereas the TbGMPR oc

258 o tetramers when ATP is available instead of guanine nucleotides.

259 First, guanine of a G:C DNA base pair can be oxidized.

260 nd that negative selection acting on central guanines of UTR pG4s is comparable to that of missense v

261 denine base editors also convert cytosine to guanine or thymine in a narrow editing window (positions

262 revents deleterious mutations resulting from guanine oxidation by recognition and removal of adenine

263 ally rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with divers

264 hosphate dehydrogenase (GAPDH), hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1), DNA-directe

265 ents with LND and its variants (hypoxanthine-guanine phosphoribosyltransferase [HGprt]-related neurol

266 sing a knock-in approach at the hypoxanthine-guanine phosphoribosyltransferase locus, we generated a

267 lases, guanosine deaminase, and hypoxanthine guanine phosphoribosyltransferase, we demonstrate that p

268 we showed that VEZF1 binds directly with DNA guanine quadruplex (G quadruplex, G4) structures in vitr

269 Guanine-quadruplex (G-quadruplex) assemblies provide a u

270 Guanine-quadruplexes (G4s) are non-canonical four-strand

271 Guanine radicals are important reactive intermediates in

272 to existing structures with unusual arginine-guanine recognition, we found that the arginine fork geo

273 er age 18 years, 36 or more cytosine-adenine-guanine repeats in the huntingtin gene, motor symptoms (

274 A conserved guanine residue is positioned to act as the general base

275 Guanine ribonucleotides are analogously oxidized to r8-o

276 rs with phosphorothioate-linked cytosine and guanine rich oligodeoxynucleotides (CpG ODN) and their e

277 Guanine-rich DNA sequences can fold into four-stranded G

278 Guanine-rich DNA sequences have the propensity to adopt

279 Mitochondria are characterized by guanine-rich DNA sequences that spontaneously form unusu

280 The guanine-rich nuclease hypersensitivity element III(1) pr

281 g rG4-seq, we profile the landscape of those guanine-rich regions with the in vitro folding potential

282 also demonstrates a high preference to bind guanine-rich sequences accomplished by a strong fluoresc

283 Guanine-rich sequences are able to form complex RNA stru

284 HyperW injections were used to target the guanine-sensing riboswitch aptamer domain (GSR(apt)) of

285 nts and 414,818 autosomal cytosine-phosphate-guanine sites were used for epigenome-wide methylation a

286 99007 risk alleles create cytosine-phosphate-guanine sites, which are highly methylated and result in

287 ylation levels at 52 CpG (cytosine-phosphate-guanine) sites were associated with incident CHD or myoc

288 stem structure of Hoogsteen hydrogen-bonded guanine tetrads and diverse loop structures.

289 transport mechanism (hopping from guanine to guanine through the pai-stack) appears to be lacking fro

290 ave indicated that the population of WC-like guanine-thymine (G-T) mispairs depends on the environmen

291 y proposed transport mechanism (hopping from guanine to guanine through the pai-stack) appears to be

292 is) guanylyltransferase (Thg1) adds a single guanine to the -1 position of tRNA(His) as part of its m

293 reduced unwinding and adding a non-matching guanine to the 5' end of gRNA influenced unwinding in a

294 adenine (A) during replication resulting in guanine to thymine transversion mutations.

295 A single guanine-to-thymine substitution mutant required much hig

296 en Chlamydia trachomatis, uses YhhQ and tRNA guanine transglycosylase (TGT) homologs that have change

297 ent-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-trans

298 age of exogenic N in the form of crystalline guanine was found broadly distributed across taxonomical

299 The oxidation signals of adenine and guanine were in linear range when the device was subject

300 ller alkyl groups from the O (6) position of guanine, whereas repair of the branched-chain lesions re