ライフサイエンスコーパス: guanine nucleotide

1 change the 6-TGDP adducted on Rac1 with free guanine nucleotide.

2 ctive either with bound GDP or without bound guanine nucleotide.

3 OPS and P-HOPS to be regulated by Ypt7-bound guanine nucleotide.

4 HOPS-dependent fusion, independent of bound guanine nucleotide.

5 tive of the presence or absence of competing guanine nucleotides.

6 o tetramers when ATP is available instead of guanine nucleotides.

7 le is the N1-methylguanosine modification at guanine nucleotide 37 (m(1)G37) located in the anticodon

8 matically accelerated in the presence of its guanine nucleotide-activating protein (GAP), Sec23-Sec24

9 f Ras is relatively insensitive to its bound guanine nucleotide and activation state but depends stro

10 Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers

11 reveals that these integrations are rich in guanine nucleotides and the integrated bacterial DNA may

12 guanosine and adenosine ribonucleosides and guanine nucleotides are readily functionalized with CF(3

13 We show supernumerary guanine nucleotides at the 5' ends of single guide RNAs

14 This work relates the guanine nucleotide-based second messenger regulatory net

15 p)ppGpp in C. crescentus and analyze how the guanine nucleotide-based second messenger system respond

16 out mice and short hairpin RNA to knock down guanine nucleotide binding protein (GNB) isoforms (GNB1,

17 Human guanine nucleotide binding protein like 1 (GNL1) is an e

18 Septins comprise a conserved family of guanine nucleotide binding proteins that polymerize in t

19 We previously showed that guanine nucleotide-binding (G) protein alpha subunit (Ga

20 Family B heterotrimeric guanine nucleotide-binding protein (G protein)-coupled r

21 -sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activatio

22 Immunostaining with guanine nucleotide-binding protein beta 3 (GNB3) and cel

23 subunit of protein kinase A (PRKACA) or the guanine nucleotide-binding protein subunit alpha (GNAS)

24 actions between beta3 integrin and Galpha13 (guanine nucleotide-binding protein subunit alpha 13), re

25 Floxed Des1 mice, on a guanine nucleotide-binding protein subunit alpha transdu

26 Here we show by microarray and RNAi that guanine nucleotide-binding protein subunit alpha13 (Galp

27 h CSNB identified biallelic mutations in the guanine nucleotide-binding protein subunit beta-3 gene (

28 De novo mutations in the guanine nucleotide-binding protein, beta 1 (GNB1) gene,

29 Guanine nucleotide-binding proteins (G proteins) facilit

30 Heterotrimeric guanine nucleotide-binding proteins (G proteins), which

31 OR, and inhibits signaling to heterotrimeric guanine nucleotide-binding proteins (G proteins).

32 of the Galpha Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the in

33 Here, we employed the Gnb4 (guanine nucleotide-binding subunit beta-4) cre driver li

34 Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-protei

35 (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important role

36 MPDH2), the rate-limiting enzyme for de novo guanine nucleotide biosynthesis, is overexpressed in the

37 The guanine nucleotide biosynthetic enzyme inosine monophosp

38 alyzes the rate-limiting step in the de novo guanine nucleotide biosynthetic pathway.

39 dynamics are thought to be regulated by the guanine nucleotide cycle of Rab7.

40 ha, beta, and gamma subunits, are versatile, guanine nucleotide-dependent, molecular on-off switches.

41 The Ras superfamily of small GTPases are guanine-nucleotide-dependent switches essential for nume

42 onal modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galp

43 In Saccharomyces cerevisiae, the guanine nucleotide dissociation inhibitor (GDI) Rdi1 rec

44 show that a Rho family GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), c

45 membrane/cytosol cycle regulated by the Rho guanine nucleotide dissociation inhibitor alpha (RhoGDIa

46 metazoan-specific SESN proteins function as guanine nucleotide dissociation inhibitors (GDIs) for RA

47 nding partner [GPCRs, Gbetagamma, effectors, guanine nucleotide dissociation inhibitors (GDIs), GTPas

48 (GAPs), and in the Rho and Rab subfamilies, guanine nucleotide dissociation inhibitors (GDIs).

49 kDa cytosolic protein that has chaperone and guanine nucleotide exchange (GEF) activity toward hetero

50 diazaspiro[4,4]nonane nucleus to target the guanine nucleotide exchange activity of DOCK5, which is

51 Surprisingly, unlike in eEF1A and EF-Tu, the guanine nucleotide exchange does not cause a major confo

52 how considerably lower intrinsic activity in guanine nucleotide exchange experiments at D2R and conse

53 recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Gol

54 ta1, Ggamma2, and/or Ggamma5, PAK-associated guanine nucleotide exchange factor (betaPIX, ARHGEF7), a

55 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-prote

56 -1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expr

57 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is

58 ng and activating (GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vit

59 activation domain, known to be required for guanine nucleotide exchange factor (GEF) activity of VAV

60 protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor (GEF) and a chaperone

61 monitor GTPase cycling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase ac

62 n, we evaluated the structure and stability, guanine nucleotide exchange factor (GEF) and GTPase-acti

63 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed

64 Here, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the O

65 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with di

66 The guanine nucleotide exchange factor (GEF) epithelial cell

67 in normal.SIGNIFICANCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in th

68 y by regulating the localization of Daple, a guanine nucleotide exchange factor (GEF) for Galphai.

69 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-bin

70 Here, we have identified DOCK6, a guanine nucleotide exchange factor (GEF) for Rac1 and CD

71 ropose that TRAPPII is likely to behave as a guanine nucleotide exchange factor (GEF) for the RAB-A2a

72 The C-terminal guanine nucleotide exchange factor (GEF) module of Trio

73 3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed i

74 Ras activation required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1.

75 Rab11 traffics the guanine nucleotide exchange factor (GEF) Rabin8 to the c

76 eukaryotic Ras-related nuclear protein (Ran) guanine nucleotide exchange factor (GEF) RCC1.

77 The guanine nucleotide exchange factor (GEF) Son of Sevenles

78 The guanine nucleotide exchange factor (GEF) Son of Sevenles

79 ry and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates

80 Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates

81 Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitat

82 ion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifical

83 We identified the dual Rac1/RhoA Rho guanine nucleotide exchange factor (GEF) Trio as a criti

84 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, a

85 ysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

86 Multiplexing revealed guanine nucleotide exchange factor (GEF), GTPase-activat

87 Muk1, a Rab5-specific guanine nucleotide exchange factor (GEF), was identified

88 Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-

89 Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required

90 ll differentiation and function and requires guanine nucleotide exchange factor (GEF)-mediated activa

91 we show that son of sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and

92 r soluble factors: a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a R

93 o and stimulates the catalytic activity of a guanine nucleotide exchange factor (P-REX1) that itself

94 The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as

95 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promote

96 (Rap-1), an effect that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell div

97 e-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also know

98 ariants in GBF1 (Golgi brefeldin A-resistant guanine nucleotide exchange factor 1) in four unrelated

99 nt and actomyosin contraction, including Rho guanine nucleotide exchange factor 2 (GEF-H1, ARHGEF2) a

100 Remarkably, expression of a single gene, Rap guanine nucleotide exchange factor 3 (Rapgef3), was stro

101 Here, an MS-based analysis revealed the Vav guanine nucleotide exchange factor 3 (VAV3), an activato

102 trate 1 by transcriptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor dir

103 GDP-dissociation inhibitor 2 [ARHGDIB], Rho guanine nucleotide exchange factor 6, angiotensin-II typ

104 ab35 (a small monomeric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/

105 tivating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

106 plexes and one of the essential subunits for guanine nucleotide exchange factor activity for Rab1 GTP

107 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro.

108 We determined that the guanine nucleotide exchange factor activity of DOCK8 is

109 EF appears to function independently of Rac1 guanine nucleotide exchange factor activity.

110 protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor and a chaperone.

111 RASGRP1 is an important guanine nucleotide exchange factor and activator of the

112 s feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signal

113 t enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT

114 scle-specific loss of G(12)/G(13) or the Rho guanine nucleotide exchange factor ARHGEF12 have lost my

115 analyzed together, increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity co

116 quires the scaffold protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

117 we show that microexon switching in the Arf6 guanine nucleotide exchange factor cytohesin-1 controls

118 mic domain of the receptor that recruits the guanine nucleotide exchange factor dedicator of cytokine

119 e small GTPase RAB11 as an interactor of the guanine nucleotide exchange factor DEF6, and find disrup

120 Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL

121 Her work has shown that the guanine nucleotide exchange factor Dock8 plays a role in

122 GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

123 e central spindle that concentrates the RhoA guanine nucleotide exchange factor ECT2.

124 tein levels of an Ras1 GTPase activator, the guanine nucleotide exchange factor Efc25, by phosphoryla

125 ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopo

126 he long isoform of intersectin-1 (ITSN-1), a guanine nucleotide exchange factor for Cdc42, as a novel

127 tinct sites in their common target, eIF2B, a guanine nucleotide exchange factor for eIF2.

128 use embryos depends on beta-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42.

129 Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical

130 mponent of the ERK/MAPK pathway, and VAV1, a guanine nucleotide exchange factor for Rho family GTPase

131 vated G(s) can also directly interact with a guanine nucleotide exchange factor for Rho family small

132 ial cell-transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho GTPases that

133 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we repo

134 cation requires the cellular protein GBF1, a guanine nucleotide exchange factor for small Arf GTPases

135 ulated the fMAPK pathway through Cdc24p, the guanine nucleotide exchange factor for the polarity esta

136 ound an interaction between TKS5 and FGD1, a guanine nucleotide exchange factor for the Rho-GTPase CD

137 In this work, we show that the guanine nucleotide exchange factor GBF1, relevant for CO

138 We report that the guanine nucleotide exchange factor GBF1, which activates

139 ts activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

140 ls induced activation and phosphorylation of guanine nucleotide exchange factor H1 (GEF-H1), leading

141 ndent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of

142 subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPa

143 pathway initiated through the cAMP-activated guanine nucleotide exchange factor NCS-Rapgef2 in mice.

144 omain-containing protein that functions as a guanine nucleotide exchange factor of ADP-ribosylation f

145 iting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small GTPase R

146 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary

147 appears to be the first evidence that a Rho-guanine nucleotide exchange factor plays a critical role

148 Here, we show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is ra

149 logical, and lentiviral techniques, that the guanine nucleotide exchange factor RasGRF2 mediates coca

150 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysre

151 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

152 INTERPRETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation

153 ctions as a Galpha-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance R

154 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized

155 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is

156 forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos

157 GIV (aka Girdin) is a guanine nucleotide exchange factor that activates hetero

158 ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA,

159 nge protein, activated by cAMP 1 (EPAC-1), a guanine nucleotide exchange factor that activates the sm

160 fically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimer

161 C3G (RapGEF1) is a ubiquitously expressed guanine nucleotide exchange factor that functions in sig

162 We identified beta-PIX as a predominant guanine nucleotide exchange factor that interacts with C

163 Rgnef (ARHGEF28/p190RhoGEF) is a guanine nucleotide exchange factor that is activated dow

164 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP si

165 P-eIF2alpha inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactiv

166 nteracts through a PDZ ligand motif with the guanine nucleotide exchange factor TIAM-1/GEF in a compl

167 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD

168 hatidylinositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

169 ified the Rac subfamily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key componen

170 lusters in cooperation with the Rac-specific guanine nucleotide exchange factor Tiam2.

171 by the repulsive receptors, mutations in the guanine nucleotide exchange factor Trio strongly enhance

172 We identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensi

173 the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is a

174 ssion, such as the RAB13 GTPase and the NET1 guanine nucleotide exchange factor, and are regulated by

175 ex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation o

176 , beta and gamma) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbet

177 regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, inte

178 of SOS1/EPS8/ABI1 complex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 resul

179 The messenger RNA (mRNA) encoding the guanine nucleotide exchange factor, DOCK4, mutations of

180 1 activation via expression of the bacterial guanine nucleotide exchange factor, EspT.

181 Ric-8b, a guanine nucleotide exchange factor, interacts with Galph

182 to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTE

183 ent membrane recruitment of p115-RHOGEF (RHO guanine nucleotide exchange factor, molecular weight 115

184 ght patterning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

185 of the drug ISRIB, an activator of the eIF2 guanine nucleotide exchange factor, rescues the cell gro

186 n adaptor protein that recruits Ras-specific guanine nucleotide exchange factor, Son of Sevenless 1 (

187 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cogna

188 d Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human

189 how no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domai

190 on impairs Rho protein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide

191 vity via activation of MT-bound Rho-specific guanine nucleotide exchange factor-H1 (GEF-H1) and was a

192 ic QTR-FRET technique enables the linking of guanine nucleotide exchange factor-induced Eu(3+)-GTP as

193 initiation factor 2B (eIF2B), a multisubunit guanine nucleotide exchange factor.

194 terized Scribble binding partner beta-PIX, a guanine nucleotide exchange factor.

195 Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor.

196 n with the SERGEF gene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x

197 three protein families: the ARF GTPases, the guanine nucleotide exchange factors (ARF GEFs) that acti

198 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate

199 ll GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors,

200 Guanine nucleotide exchange factors (GEFs) activate and

201 Guanine nucleotide exchange factors (GEFs) activate and

202 pendent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho

203 ich are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-ac

204 s are established by their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-ac

205 Guanine nucleotide exchange factors (GEFs) are the initi

206 he localization of Tiam1 and Trio, which are guanine nucleotide exchange factors (GEFs) for Rac, ther

207 tor of cytokinesis) proteins are multidomain guanine nucleotide exchange factors (GEFs) for RHO GTPas

208 By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bron

209 The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and T

210 The action of guanine nucleotide exchange factors (GEFs) on the ADP-ri

211 t either the RAS interaction with activating guanine nucleotide exchange factors (GEFs) or receptor t

212 PIX proteins are guanine nucleotide exchange factors (GEFs) that activate

213 of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin,

214 proteins is controlled by their regulators; guanine nucleotide exchange factors (GEFs), GTPase activ

215 The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activ

216 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associa

217 es of binary interactors, both effectors and guanine nucleotide exchange factors (GEFs), showed induc

218 vated with precise spatiotemporal control by guanine nucleotide exchange factors (GEFs).

219 ila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

220 rged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs).

221 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

222 activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs).

223 s of Ras GTPases are triggered by Ras GTPase guanine nucleotide exchange factors (RasGEFs) in general

224 in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase

225 phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to

226 ays form in response to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family

227 e role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

228 in cytoskeleton dynamics, including numerous guanine nucleotide exchange factors and GTPase-activatin

229 RAPPs) are multi-protein complexes acting as guanine nucleotide exchange factors and possibly as teth

230 ctions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and inters

231 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GT

232 plex formed of atypical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 th

233 IQSEC1-3 encode guanine nucleotide exchange factors for the small GTPase

234 1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T

235 Morpholinos targeting two other guanine nucleotide exchange factors not known to be in t

236 These guanine nucleotide exchange factors regulate the spatiot

237 educed after T cell-specific deletion of the guanine nucleotide exchange factors Sos1 and Sos2, which

238 ity-based ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42

239 RasGRPs are guanine nucleotide exchange factors that are specific fo

240 G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammali

241 DOCK3 is a member of the DOCK family of guanine nucleotide exchange factors that regulate cell m

242 are known to be Rab effectors and Rab GEFs (Guanine nucleotide Exchange Factors) that regulate vesic

243 via Rho-family small GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activati

244 uiting two related brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in

245 Arf1 is activated by guanine nucleotide exchange factors, but essential roles

246 nitially, SmgGDS proteins were classified as guanine nucleotide exchange factors, but recent findings

247 nvolve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 deg

248 transcriptional upregulation of Rac-specific guanine nucleotide exchange factors, Rac activation, and

249 Thus, Rho guanine nucleotide exchange factors, the activators of t

250 reduce the levels of active RAS is to target guanine nucleotide exchange factors, which allow RAS to

251 screens targeting Rho-GTPases effectors and guanine nucleotide exchange factors.

252 but rather, through direct activation of the guanine nucleotide exchange protein Epac by cAMP.

253 Guanine nucleotide exchange proteins directly activated

254 -G279S(7.44) was more effective in promoting guanine nucleotide exchange than wild-type A(1)R.

255 Several Rac guanine nucleotide exchange-factors (Rac-GEFs) were also

256 ociation, thereby preventing agonist-induced guanine nucleotide exchange.

257 eric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPC

258 ane trafficking, and their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which co

259 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates

260 dent vesicular trafficking of Rabin8, a Rab8 guanine-nucleotide exchange factor (GEF), to the mother

261 eracting vesicle-associated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates

262 Rho guanine-nucleotide exchange factor (RhoGEF) proteins as

263 hat endosome-associated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPas

264 utophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3.

265 We identify the guanine-nucleotide exchange factor dPix as an effector o

266 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of

267 GBF1 encodes a guanine-nucleotide exchange factor that facilitates the

268 -dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally d

269 Here we investigate whether the RhoGEF (Rho guanine-nucleotide exchange factor) protein Tiam1 plays

270 factor ARF GTPase by the SEC7 domain of ARF guanine-nucleotide exchange factors (ARF-GEFs), resultin

271 tein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged

272 The 2 EPAC isoforms, EPAC1 and EPAC2, are guanine-nucleotide exchange factors for the Ras-like GTP

273 cess and modulate G proteins via a cytosolic guanine-nucleotide exchange modulator (GEM), GIV/girdin;

274 Upon growth factor stimulation, the guanine-nucleotide exchange modulator dissociates Galpha

275 nt G protein activation by a novel family of guanine-nucleotide exchange modulators (GEMs) remains un

276 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates

277 ational change contributed to a high rate of guanine nucleotide-exchange factor (GEF)-dependent and -

278 tive factor (GBF1) and brefeldin A-inhibited guanine nucleotide-exchange factors (BIG1 and BIG2).

279 by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG

280 mulatory effects of heterologously expressed guanine nucleotide-exchange factors or of constitutively

281 umferential single septin filaments, the Rho guanine-nucleotide-exchange factor (RhoGEF) Bud3, and th

282 The extruded cytosine and last guanine nucleotides form water-mediated hydrogen bonds,

283 riants, two point mutants predicted to alter guanine nucleotide handling, one that disrupts cilia loc

284 Guanine nucleotide homeostasis is central to photorecept

285 te-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP

286 e pathway mutants, some in which adenine and guanine nucleotide metabolism is uncoupled.

287 The co-purification of guanine nucleotide on the beta-tubulin in the trimer is

288 logical conditions that require expansion of guanine nucleotide pools.

289 We examined the role of Ras Guanine Nucleotide Releasing Factor 1 (RasGRF1) and 2 (R

290 and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and relat

291 al 2) and RASGRF2 gene (Ras protein-specific guanine nucleotide-releasing factor 2) with all clinical

292 by overexpression of the RasGEF RasGRP1 (Ras guanine nucleotide-releasing protein 1), was recently im

293 conformations in the absence and presence of guanine nucleotides, respectively, whereas the TbGMPR oc

294 Addition of guanine nucleotides resulted in changes in the solvent a

295 a unique 'G-loop' element that accounts for guanine nucleotide specificity.

296 mosomes frequently contain tandem repeats of guanine nucleotides that can form stacked structures sta

297 with the first cytosine and the two opposing guanine nucleotides to confer specificity.

298 Small GTPases alternatively bind GDP/GTP guanine nucleotides to gate signaling pathways that dire

299 demonstrate that the binding of adenine and guanine nucleotides to the canonical nucleotide binding

300 eave dsRNA at preferred sites, among which a guanine nucleotide was enriched at a specific position (