ライフサイエンスコーパス: guanylate kinase

1 ture to function relationship of a mammalian guanylate kinase.

2 esidues largely prevent GMP binding to yeast guanylate kinase.

3 3 domain, and a GUK domain with homology to guanylate kinase.

4 the GK domain in SAP97 encodes an authentic guanylate kinase.

5 ology motif 3, and a domain with homology to guanylate kinase.

6 h substrates and products could bind to free guanylate kinase.

7 ach other and 52-54% identity with the yeast guanylate kinase.

8 nnels and receptors, and membrane-associated guanylate kinases.

9 sequence similarity with low-molecular-mass guanylate kinases.

10 ity to CaM kinase II and membrane-associated guanylate kinases.

11 SAP90 family of membrane-associated putative guanylate kinases.

12 nylate kinase domains in membrane-associated guanylate kinases.

13 (TARPs) and PSD-95-like membrane-associated guanylate kinases.

14 itment domain-containing membrane-associated guanylate kinase 1 (CARMA1) and/or the Toll-like recepto

15 spase-recruitment domain membrane-associated guanylate kinase 1 (CARMA1) signalosome through the coor

16 K+") patient-derived cell lines and identify guanylate kinase 1 (GUK1), a guanosine diphosphate (GDP)

17 otein 1, adenosine deaminase-like protein 1, guanylate kinase 1, and nucleoside diphosphate kinase at

18 otein related to MAGUKs (membrane-associated guanylate kinases); (2) Mint1, a putative vesicular traf

19 ly, we show that MAGI-2 (membrane-associated guanylate kinase), a scaffold protein required for PTEN

20 es designed to lack either protein kinase or guanylate kinase activity are functional, indicating tha

21 indings demonstrate that membrane-associated guanylate kinase adaptor proteins can modulate ion chann

22 Arabidopsis guanylate kinases (AGKs) exhibit a high degree of conser

23 la enterica serovar Typhimurium, gmk encodes guanylate kinase, an essential enzyme involved in the sy

24 membrane complex with a membrane-associated guanylate kinase and AKAP5, which constitutively attenua

25 revealed that specific amino acid changes in guanylate kinase and in the beta and beta' subunits of R

26 ng HIV-reverse transcriptase (RT), adenylate/guanylate kinase, and human DNA polymerase gamma.

27 The low molecular mass cytosolic forms of guanylate kinase are implicated primarily in the regulat

28 Most or all identified membrane-associated guanylate kinases are components of cell junctions, incl

29 analyzed the dynamic behavior of the enzyme guanylate kinase as it evolved into the GK protein inter

30 We show that guanylate kinase-associated kinesin (GAKIN), a kinesin-l

31 ands for the PSD-95 guanylate kinase domain, guanylate kinase-associated protein (GKAP) and MAP1A, ap

32 two-hybrid screening, a novel protein termed guanylate kinase-associated protein (GKAP) has been isol

33 skeleton by its association with the protein guanylate kinase-associated protein (GKAP).

34 Here we report that guanylate kinase-associated protein (GKAP; also known as

35 nside the membrane; the scaffolding proteins guanylate kinase-associated protein and Shank lay 24-26

36 of a novel synaptic protein, termed GKAP for guanylate kinase-associated protein, that binds directly

37 partate receptor complex/membrane-associated guanylate kinase-associated signaling complex (NRC/MASC)

38 ation by stabilizing its membrane-associated guanylate kinase binding partner PALS1.

39 overlaps with its MAGUK (membrane-associated guanylate kinase)-binding domain.

40 to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kin

41 Guanylate kinase catalyzes the phosphorylation of either

42 The membrane-associated guanylate kinases [Chapsyn-110/postsynaptic density-93 (

43 SD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffoldin

44 teraction, we have constructed a conditional guanylate-kinase-deficient Escherichia coli strain that

45 role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding prote

46 itment Domain (CARD) and Membrane-associated GUanylate Kinase domain (MAGUK)-containing scaffold prot

47 A region containing the mLin-2/CASK guanylate kinase domain also interacts with X11alpha but

48 nts revealed 2 binding surfaces on the beta4 guanylate kinase domain contributing to a 156 +/- 18 mic

49 a loss-of-function mutant mouse lacking the guanylate kinase domain of PSD-95 (PSD-95(GK)), we analy

50 A fragment comprising the SH3 domain and the guanylate kinase domain of synapse-associated protein 10

51 , 40% of the beta-SH3 domain, and 73% of the guanylate kinase domain of the putative membrane-associa

52 Here, we explored whether GMP binding to the guanylate kinase domain regulates MAGUK function.

53 /Discs large/ZO-1 (PDZ)-Src homology 3 (SH3)-guanylate kinase domain sequence.

54 0-residue region within the highly conserved guanylate kinase domain that also directs AID binding.

55 ort polybasic segment at the boundary of the guanylate kinase domain that slows down channel inactiva

56 Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-

57 -Subunits contain one Src homology 3 and one guanylate kinase domain, flanked by variable regions wit

58 Protein ligands for the PSD-95 guanylate kinase domain, guanylate kinase-associated pro

59 ethal mutations of MAGUKs often occur in the guanylate kinase domain, indicating a critical role for

60 action between the PSD-95-associated protein guanylate kinase domain-associated protein (GKAP) and dy

61 tamatergic postsynaptic complex, GKAP/SAPAP (guanylate kinase domain-associated protein/synapse-assoc

62 entral PDZ and SH3 domains, and a C-terminal guanylate kinase domain.

63 clustering of PSD-95 but did not rely on its guanylate kinase domain.

64 tween the protein 4.1 binding domain and the guanylate kinase domain.

65 se at the dynamic interaction of PDZ and SH3-guanylate kinase domains in membrane-associated guanylat

66 t although the individual Src homology 3 and guanylate kinase domains in SAP97 can interact with the

67 N-terminal PDZ and C-terminal guanylate kinase domains of PSD-95 are required for both

68 ramolecular interactions between the SH3 and guanylate kinase domains play a role in the stability of

69 including L27, PDZ, Src homology (SH) 3, and guanylate kinase domains that aggregate adhesion molecul

70 lg1, zona occludens-1) domains, the PDZ3 and guanylate kinase domains were required.

71 large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and p

72 -1) domains as well as intact N-terminal and guanylate kinase domains.

73 -zona occludens-1 (PDZ), Src homology 3, and guanylate kinase domains.

74 ined beta isoforms, which consist of SH3 and guanylate kinase domains.

75 1, and Z02 and that contains DHR-, SH3-, and guanylate kinase domains.

76 Here, we describe the first plant guanylate kinase-encoding genes, AGK1 and AGK2, from Ara

77 Given their apparent lack of guanylate kinase enzymatic activity, the fact that the G

78 The guanylate kinase enzyme (GK(enz)), which catalyzes phosp

79 ket that differ between MAGUKs and authentic guanylate kinase explain this lack of binding, as swappi

80 ally called CARD11) is a membrane-associated guanylate kinase family member that is required for T ce

81 a founding member of the membrane-associated guanylate kinase family of proteins containing PostSynap

82 he leading member of the membrane-associated guanylate kinase family of proteins, which are defined b

83 LIN-2 belongs to the membrane-associated guanylate kinase family of proteins.

84 ession of members of the membrane-associated guanylate kinase family of synaptic scaffolding proteins

85 id system, we isolated a membrane-associated guanylate kinase family protein with multiple PDZ domain

86 ed protein 97 (SAP97), a membrane-associated guanylate kinase family protein.

87 ctor that belongs to the membrane-associated guanylate kinase family, a class of proteins that functi

88 (SAP97), a member of the membrane-associated guanylate kinase family, is believed to associate with A

89 Mpp4) is a member of the membrane-associated guanylate kinase family.

90 Discs Large 1, a MAGUK (Membrane Associated Guanylate Kinase) family member that is the highly conse

91 s a member of the MAGUK (membrane-associated guanylate kinase) family of scaffolding proteins, hDlg i

92 s a member of the MAGUK (membrane-associated guanylate kinase) family that functions as neurexin kina

93 show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein.

94 the presence of a functional, plasmid-borne guanylate kinase for growth under selective conditions.

95 es of this domain share 46-52% identity with guanylate kinases from yeast, Escherichia coli, human, m

96 ed Ca(v)beta containing only the AID-binding guanylate kinase (GK) domain could fully confer voltage

97 finity in vivo interaction of PSD-93 via its guanylate kinase (GK) domain with microtubule-associated

98 ved Src homology 3 (SH3) domain, a conserved guanylate kinase (GK) domain, and a connecting variable

99 phosphorylation of PSD-95 at Ser-561 in its guanylate kinase (GK) domain, which is mediated by the p

100 domains: a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain.

101 In contrast, disruptions of PDZ3, SH3, or guanylate kinase (GK) domains do not affect synaptic tar

102 raction between the Src homology 3 (SH3) and guanylate kinase (GK) domains of MAGUKs is thought to pl

103 in interaction motifs including PDZ, SH3 and guanylate kinase (GK) domains, and these binding sites m

104 The crystal structure of guanylate kinase (GK) from yeast (Saccharomyces cerevisi

105 ng does not influence the intramolecular SH3/guanylate kinase (GK) interaction within PSD-95.

106 The hydroxyl group of Tyr-78 of yeast guanylate kinase (GK) is hydrogen-bonded to the phosphat

107 -subunit identified src homology 3 (SH3) and guanylate kinase (GK) motifs in a tandem arrangement rem

108 95 (PSD-95/SAP-90) is a membrane associated guanylate kinase (GK) PDZ protein that scaffolds glutama

109 the hydration of two proteins, lysozyme and guanylate kinase (GK), in the presence of solutes.

110 SAP102 contains PDZ, SH3, and guanylate kinase (GK)-like domains, which mediate specif

111 Wild type and Y78F mutant yeast guanylate kinase (GKy) were studied to investigate the e

112 The R41M and K14M mutant enzymes of yeast guanylate kinase (GKy) were studied to investigate the e

113 e molecular interaction between (p)ppGpp and guanylate kinase (GMK), revealing the importance of this

114 in, the Src homology 3 (SH3) domain, and the guanylate kinase (GuK) domain.

115 SH3) domain and a region homologous to yeast guanylate kinase (GUK).

116 DHR/PDZs, an SH3, and a region homologous to guanylate kinase (GUK).

117 3 (SH3) domain, and a region of homology to guanylate kinase (GUK); the structure of this core motif

118 Human guanylate kinase (hGMPK) is the only known enzyme respon

119 proteins, members of the membrane-associated guanylate kinase homolog (MAGUK) protein family, which a

120 of the distantly related membrane-associated guanylate kinase homolog, PSD-95.

121 domain of CASK/LIN-2, a membrane-associated guanylate kinase homolog.

122 Membrane-associated guanylate kinase homologs (MAGUKs) are multidomain prote

123 Membrane-associated guanylate kinase homologs (MAGUKs) may play a role in ce

124 class of proteins called membrane-associated guanylate kinase homologs (MAGUKs), which are often conc

125 in proteins known as the membrane-associated guanylate kinase homologs (MAGUKs).

126 amily of proteins termed membrane-associated guanylate kinase homologs (MAGUKs).

127 s a member of the MAGUK (membrane-associated guanylate kinase homologs) family of membrane-associated

128 he multivalent nature of membrane-associated guanylate kinase homologue (MAGUK) targeting, thus begin

129 Membrane-associated guanylate kinase homologues (MAGUKs) are generally found

130 skeletal proteins termed membrane-associated guanylate kinase homologues (MAGUKs).

131 ed CASK, a member of the membrane-associated guanylate kinase homologues family of adaptor proteins.

132 proteins termed MAGUKs (membrane-associated guanylate kinase homologues).

133 proteins termed MAGUKs (membrane-associated guanylate kinase homologues).

134 ecular mass and membrane-associated forms of guanylate kinase homologues, notably found in neuronal t

135 The SH3 and guanylate kinase homology (GK) domain of PSD-95 and SAP1

136 Despite the involvement of guanylate kinase in 6-thioguanine, mercaptopurine, and a

137 o assess the role of specific amino acids of guanylate kinase in structure, function, drug activation

138 MP) bound to wild type and Y78F mutant yeast guanylate kinase in the complexes GKy x Mg(II)ATP, GKy x

139 s of GMP bound to R41M and K14M mutant yeast guanylate kinase in the complexes GKy.MgATP, GKy.MgADP,

140 w perspectives for understanding the role of guanylate kinases in plant cell signalling pathways.

141 GPR30 interacted with membrane-associated guanylate kinases, including SAP97 and PSD-95, and prote

142 Published X-ray crystal structures of yeast guanylate kinase indicate that K14 is part of the "P" lo

143 itment domain-containing membrane-associated guanylate kinase, initiates a unique signaling cascade v

144 ssociated protein 102, a membrane-associated guanylate kinase interacting with NR2A but lacking palmi

145 (CLMP), occludin (OCLN), membrane-associated guanylate kinase inverted 1 (MAGI1), and MAGI2 mRNA expr

146 lysates, MAGI-2/S-SCAM (membrane-associated guanylate kinase inverted 2/synaptic scaffolding molecul

147 ule (S-SCAM; also called membrane-associated guanylate kinase inverted-2 and atrophin interacting pro

148 associates with MAGI-2 (membrane-associated guanylate kinase inverted-2), a protein also known as S-

149 tein 1), renamed MAGI-2 (membrane associated guanylate kinase inverted-2)].

150 Guanylate kinase is a critical enzyme in the biosynthesi

151 Guanylate kinase is an essential enzyme for nucleotide m

152 s with many nucleotide-metabolizing enzymes, guanylate kinase is involved in antimicrobial and antine

153 PSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein at ex

154 PSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein in th

155 is enzymatically much less active than yeast guanylate kinase, its kinase domain is shown to compleme

156 Like other membrane-associated guanylate kinases, its multidomain structure enables it

157 are formed by a Src homology 3 domain and a guanylate kinase-like (GK) domain connected through a va

158 n of the Src homology 3 (SH3) domain and the guanylate kinase-like (GK) domain in the COOH-terminal h

159 GukH binds the Src homology 3 (SH3) and guanylate kinase-like (GK) protein interaction domains o

160 hare a highly homologous membrane associated guanylate kinase-like (MAGUK) domain that binds to alpha

161 ment domain (CARD) and a membrane-associated guanylate kinase-like (MAGUK) domain.

162 at a novel protein termed GAKIN binds to the guanylate kinase-like domain of hDlg.

163 Here, we show that the guanylate kinase-like domain of human discs large protei

164 ivating protein (RapGAP), interacts with the guanylate kinase-like domain of PSD-95 and forms a compl

165 ily of proteins examined, GAKIN binds to the guanylate kinase-like domain of PSD-95 but not of p55.

166 in protein consisting of a carboxyl-terminal guanylate kinase-like domain, an SH3 domain, and three s

167 , a synaptic protein that interacts with the guanylate kinase-like domain, and unlike GKAP, the bindi

168 d of three PDZ domains, an SH3 domain, and a guanylate kinase-like domain.

169 including 6 PDZ domains, 2 WW domains, and a guanylate kinase-like domain.

170 N-terminal and C-terminal extensions of the guanylate kinase-like domain.

171 iscs large/zO-1) domain, an SH3 motif, and a guanylate kinase-like domain.

172 lating interactions with their COOH-terminal guanylate kinase-like domains (GKs).

173 Deletion of PSD-95's Src homology 3 and guanylate kinase-like domains, as well as a point mutati

174 n located between the SH3 and the C-terminal guanylate kinase-like domains.

175 Large/Zona Occludens-1, Src homology 3, and guanylate kinase-like domains.

176 kinase-like domain followed by PDZ, SH3 and guanylate kinase-like domains.

177 h consists of PDZ, Src homology 3 (SH3), and guanylate kinase-like domains.

178 s, an SH3 (Src homology 3) motif, and a GUK (guanylate kinase-like) domain.

179 ween the Src homology 3 (SH3) domain and the guanylate-kinase-like (GUK) domain-prevented association

180 Lin-2 (mLin-2)/CASK is a membrane-associated guanylate kinase (MAGUK) and contains multidomain module

181 ement reminiscent of the membrane-associated guanylate kinase (MAGUK) class of scaffolding proteins.

182 adaptor proteins of the membrane-associated guanylate kinase (MAGUK) family and raises the possibili

183 ibrary yielded CARD11, a membrane-associated guanylate kinase (MAGUK) family member containing CARD,

184 compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds func

185 n-110 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing

186 P-90) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins that assembl

187 s, the discs large (DLG)-membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins

188 ptic density-95 (PSD-95) membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins

189 KEY POINTS: The membrane-associated guanylate kinase (MAGUK) family of synaptic scaffolding

190 The membrane-associated guanylate kinase (MAGUK) family of synaptic scaffolding

191 ustering proteins of the membrane-associated guanylate kinase (MAGUK) family via PDZ domains.

192 teins that belong to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins tha

193 The membrane-associated guanylate kinase (MAGUK) homologs PSD-95/SAP90, PSD-93/c

194 ecruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 1

195 termined previously that membrane-associated guanylate kinase (MAGUK) protein discs large homolog 5 (

196 teins are members of the membrane-associated guanylate kinase (MAGUK) protein family and are likely t

197 of the Discs large (DLG)-membrane-associated guanylate kinase (MAGUK) protein family regulate these p

198 which is mediated by the membrane-associated guanylate kinase (MAGUK) protein SAP97.

199 l of PMCA2b isolated the membrane-associated guanylate kinase (MAGUK) protein SAP97/hDlg as a binding

200 Membrane-associated guanylate kinase (MAGUK) proteins act as molecular scaff

201 Membrane-associated guanylate kinase (Maguk) proteins are scaffold proteins

202 Membrane-associated guanylate kinase (MAGUK) proteins are thought to be scaf

203 otein PSD-95 and related membrane-associated guanylate kinase (MAGUK) proteins assemble signal transd

204 CACNB genes encode membrane-associated guanylate kinase (MAGUK) proteins once thought to functi

205 Membrane-associated guanylate kinase (MAGUK) proteins participate in the ass

206 t excitatory synapses by membrane-associated guanylate kinase (MAGUK) proteins regulates synapse deve

207 he zonula occludens (ZO) membrane-associated guanylate kinase (MAGUK) proteins ZO-1, -2, and -3.

208 e p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, was found in a tripar

209 ayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins.

210 he PDZ domain-containing Membrane-associated Guanylate Kinase (MaGUK) PSD93 as a direct ZDHHC14 inter

211 The common central membrane-associated guanylate kinase (MAGUK) region of Ca(v)beta binds to th

212 ptors and enzymes around Membrane Associated Guanylate Kinase (MAGUK) scaffold proteins are a paradig

213 ors by interactions with membrane-associated guanylate kinase (MAGUK) scaffold proteins.

214 density (PSD)-95 family membrane-associated guanylate kinase (MAGUK) scaffold proteins.

215 ic member in a family of membrane-associated guanylate kinase (MAGUK) scaffolding proteins that inter

216 reported to bind to the membrane-associated guanylate kinase (MAGUK) scaffolding proteins, as well a

217 (hDlg), a member of the membrane-associated guanylate kinase (MAGUK) superfamily, interacts with K(+

218 yn-110, a novel membrane-associated putative guanylate kinase (MAGUK) that binds directly to N-methyl

219 ens-1) domain-containing membrane-associated guanylate kinase (MAGUK) that functions as a scaffold to

220 naptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes

221 2B-calcineurin (CaN) to membrane-associated guanylate kinase (MAGUK)-linked AMPA receptors (AMPARs)

222 ion (SJ) gene encoding a membrane associated guanylate kinase (MAGUK).

223 CASK is a member of the membrane-associated guanylate kinases (MAGUK) homologs, a family of proteins

224 Membrane-associated guanylate kinases (MAGUKs) are a family of scaffolding p

225 Membrane-associated guanylate kinases (MAGUKs) are abundant postsynaptic den

226 Membrane-associated guanylate kinases (MAGUKs) are major components of the p

227 nsity (PSD)-95 family of membrane-associated guanylate kinases (MAGUKs) are major scaffolding protein

228 The Membrane Associated Guanylate Kinases (MAGuKs) are scaffold proteins at cell

229 ludens (ZO) subfamily of membrane-associated guanylate kinases (MAGUKs) are scaffolding molecules tho

230 Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-a

231 Membrane-associated guanylate kinases (MAGUKs) contain multiple protein-bind

232 dance of PSD-95 or other membrane-associated guanylate kinases (MAGUKs) drives the bidirectional chan

233 Membrane-associated guanylate kinases (MAGUKs) organize protein complexes at

234 ecipitates Kv1.2 and the membrane-associated guanylate kinases (MAGUKs) PSD-93 and PSD-95.

235 The membrane-associated guanylate kinases (MAGUKs) PSD-95, PSD-93 and SAP102 are

236 s with the three related membrane-associated guanylate kinases (MAGUKs) PSD-95/SAP90, PSD-93/chapsyn-

237 Membrane-associated guanylate kinases (MAGUKs) regulate cellular adhesion an

238 Membrane-associated guanylate kinases (MAGUKs) regulate the formation and fu

239 (discs large) family of membrane-associated guanylate kinases (MAGUKs) that are components of the po

240 require the function of membrane-associated guanylate kinases (MAGUKs) that contain the PDZ protein-

241 ctly bind to a family of membrane-associated guanylate kinases (MAGUKs) that regulate surface and syn

242 nits and are anchored by membrane-associated guanylate kinases (MAGUKs), but it is unknown whether pa

243 Membrane-associated guanylate kinases (MAGUKs), including SAP102, PSD-95, PS

244 brain plasticity of two membrane-associated guanylate kinases (MAGUKs), SAP102 and PSD95, which form

245 Membrane-associated guanylate kinases (MAGUKs), such as Discs-Large (DLG), p

246 Membrane-associated guanylate kinases (MAGUKs), which are essential proteins

247 ns is the large group of membrane-associated guanylate kinases (MAGUKs).

248 inase (SH3-GK) module of membrane-associated guanylate kinases (MAGUKs).

249 large (DLG) subfamily of membrane-associated guanylate kinases (MAGUKs).

250 ributed to formation of the abortive complex guanylate kinase.MgADP.GMP.

251 e domain of the putative membrane-associated guanylate kinases module, and helix alpha3 of the alpha1

252 beta-interaction domain, membrane-associated guanylate kinases module, and the alpha1-subunit binding

253 id mechanism to identify not only functional guanylate kinase mutants but also those that result in d

254 nserved mLin-7 binding domain in addition to guanylate kinase, PDZ (postsynaptic density 95/discs lar

255 itment domain-containing membrane-associated guanylate kinase protein (CARMA)3 is specifically expres

256 t serine protein kinase; membrane-associated guanylate kinase protein (MAGI)-1, MAGI-2, and MAGI-3],

257 itment domain-containing membrane-associated guanylate kinase protein 1 (CARMA1)-B-cell lymphoma/leuk

258 We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper bra

259 , the only member of the membrane-associated guanylate kinase protein family that contains a Ca2+/cal

260 and other members of the membrane-associated guanylate kinase protein family, as well as Scribble.

261 the DLG subfamily of the membrane-associated guanylate kinase protein family.

262 , we have identified the membrane-associated guanylate kinase protein membrane palmitoylated protein

263 library MAGI-1, a MAGUK (membrane-associated guanylate kinase) protein.

264 d to the large family of membrane-associated guanylate kinase proteins.

265 amily of synaptic MAGUK (membrane-associated guanylate kinase) proteins have been shown to interact,

266 single PDZ domain MAGUK (membrane-associated guanylate kinase) proteins that are expressed in all pri

267 tify novel MAGUK-family (membrane-associated guanylate kinase) proteins that are similar to Nagie oko

268 The membrane-associated guanylate kinase PSD-95 scaffolds N-methyl-d-aspartate r

269 teins of the PSD-95-like membrane-associated guanylate kinase (PSD-MAGUK) family are vital for traffi

270 we show that PSD-95-like membrane-associated guanylate kinases (PSD-MAGUKs) mediate this synaptic tar

271 d (DLG) subfamily of the membrane-associated guanylate kinase-related protein family.

272 protein-97 (SAP97) is a membrane-associated guanylate kinase scaffolding protein expressed in cardio

273 occludens-1] domains of membrane-associated guanylate kinase scaffolding proteins PSD-93 or PSD-95.

274 nd recruitment of MAGUK (membrane-associated guanylate kinase) scaffolding proteins or NMDA receptors

275 major glutamate receptor membrane-associated guanylate kinase scaffolds expressed in the young superf

276 le is a common feature of membrane associate guanylate kinase scaffolds such as Dlg, and these result

277 c homology 3 (SH3) domains, and a C-terminal guanylate kinase sequence.

278 ed sequence homology with the Src homology 3-guanylate kinase (SH3-GK) module of membrane-associated

279 t affinity for GMP but may have retained the guanylate kinase structure to accommodate a related regu

280 a oligomerization reside in 3 regions of the guanylate kinase subdomain of MAGUK.

281 d inositol trisphosphate receptor-associated guanylate kinase substrate (IRAG, Mrvi1, and Jaw1L) are

282 lustering by cytoplasmic membrane-associated guanylate kinases such as postsynaptic density 95 (PSD-9

283 AGI) 3, a novel inverted membrane-associated guanylate kinase that localizes to epithelial cell tight

284 esent a new subfamily of membrane-associated guanylate kinases that allow for multiple targeting comp

285 n-binding domain found in membrane associate guanylate kinases that function in mitotic spindle orien

286 n in and of itself does not encode an active guanylate kinase, that it cannot be activated by its bin

287 Yeast guanylate kinase was expressed at high level in Escheric

288 , but an activator of protein kinase C or of guanylate kinase was ineffective.

289 th cDNA clones encoding enzymatically active guanylate kinase were isolated from mouse B-cell lymphom

290 binds to a PDZ domain of membrane-associated guanylate kinase with inverted orientation (MAGI) 3, a n

291 identify members of the membrane-associated guanylate kinase with inverted orientation (MAGI) and PS

292 scaffold protein called membrane-associated guanylate kinase with inverted orientation (Magi)-1.

293 ntaining protein MAGI-1 (membrane-associated guanylate kinase with inverted orientation protein-1) an

294 e homolog of GASP, i.e., membrane-associated guanylate kinase with inverted orientation-1 (MAGI-1), i

295 LPA(2) interacts with membrane-associated guanylate kinase with inverted orientation-3 (MAGI-3) an

296 TF, the association of "membrane-associated guanylate kinase-with inverted configuration" (MAGI)1-3

297 s, we found that loss of membrane associated guanylate kinase, WW and PDZ domain containing 2 and pro

298 ning to identify MAGI-2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) as a n

299 ase-causing mutations in membrane-associated guanylate kinase, WW, and PDZ domain-containing 2 (MAGI2

300 similarity in amino acid sequence with yeast guanylate kinase (yGMPK), is the least characterized MAG