ライフサイエンスコーパス: guardian

1 dical Charitable Trust (managed by Perpetual Guardian).

2 sent was obtained from each participant or a guardian.

3 from each participant or participant's legal guardian.

4 igh acceptability scored by child and parent/guardian.

5 uberculosis had been diagnosed in his female guardian.

6 ethod as reported by the patient, parent, or guardian.

7 tation) as judged by the patient, parent, or guardian.

8 ed sex-related matters with their parents or guardian.

9 patient, parent, or the legally responsible guardian.

10 nt was obtained from the patient's parent or guardian.

11 for nurses, residents, relatives, and legal guardians.

12 fects and satisfaction to patients and their guardians.

13 all participants or the participants' legal guardians.

14 s obtained from all participants' parents or guardians.

15 sent was obtained from all subjects or their guardians.

16 cceptable to school-age children and parents/guardians.

17 ureus isolates colonizing children and their guardians.

18 ty was reported by the children's parents or guardians.

19 al carriage was 35% for children and 28% for guardians.

20 y 28, 2020, and identify any message sent by guardians.

21 rimary home addresses provided by parents or guardians.

22 ed in the dataset or their parents and legal guardians.

23 aliva) cohort with informed consent by their guardians.

24 tory diseases were collected from parents or guardians.

25 d LRTI occurrence was reported by parents or guardians.

26 ulties Questionnaire completed by parents or guardians.

27 sing additional stress in patients and their guardians.

28 We present Uup and RadD as genomic guardians.

29 tudy sponsor, investigators, and parents and guardians.

30 ent was obtained from all patients and legal guardians.

31 1%) were initiated by parents, relatives, or guardians, 126 (10%) by physicians, and 112 (9%) by othe

32 f research participants and/or their parents/guardians about the availability of research results, a

33 Guardian access of adolescent patient portal accounts co

34 ectional study to estimate the prevalence of guardian access to adolescent patient portal accounts wa

35 age of adolescent portal accounts indicating guardian access.

36 unts with outbound messages were accessed by guardians across the 3 institutions.

37 eive vaccine (pupil cases) and their parents/guardians (adult cases) and girls who received dose 1 (p

38 ivalent vaccine (Gardasil) and their parents/guardians (adult controls) were enrolled from 39 schools

39 rve, in both T. gondii and A. thaliana, as a guardian against aberrant transcriptional read-throughs.

40 ived as a liver-derived and plasma-operative guardian against bloodborne pathogens, is increasingly r

41 itical, nontranscriptional role of GPS2 as a guardian against hyperstimulation of the TNF-alpha-induc

42 CDKL3 serves as a guardian against MASLD and also may function as a progno

43 dependent kinase-like 3 (CDKL3) as a primary guardian against MASLD progression.

44 e we discuss the new revelations about these guardians against HSV infection and the consequences of

45 stress response were identified as the major guardians against lethal spontaneous DNA damage, efficie

46 particularly the NLRP3 inflammasome, act as guardians against noninfectious material.

47 ructure (2 parents, one parent, or unrelated guardian), age, and age squared.

48 Shelter residents or guardians aged >=3 months reporting acute respiratory il

49 bservational measure completed by the parent/guardian and a self-report measure completed by the two

50 costs, direct (out-of-pocket) and indirect (guardian and coping) costs from the individual patient p

51 Tumor suppressor p53 is a genome guardian and important negative regulator of the cell cy

52 ed consent was obtained from each patient or guardian and minor assent was obtained from all children

53 dren (from 5-13 years old) and their parents/guardians and examined them at baseline and regular inte

54 ttee and written informed consent (parent or guardian) and assent (pupils) was obtained.

55 or whom testing was requested by a parent or guardian, and individuals who tested HIV-negative within

56 the previous year, time living with current guardian, and intra-household clustering for adequacy of

57 rmed consent was provided by their parent or guardian, and lived less than 30 km from the study clini

58 phocytes, educational level of the parent or guardian, and race or ethnic background.

59 S produces reports for the child, the parent/guardian, and the child's physician with child-specific

60 "insufficient collaboration among teachers, guardians, and doctors," which could be improved by the

61 E-mail provides a means for parents, guardians, and health care professionals to obtain patie

62 ncipal investigators, participants and their guardians, and laboratory personnel.

63 stigators, participants and their parents or guardians, and sponsor representatives advising on trial

64 Participants, their parents or guardians, and the study team were masked to vaccine all

65 English speaking, and a legal and custodial guardian; and infant having had consumed 2 oz or more in

66 ntrast-enhanced MR imaging and (b) parent or guardian assessment.

67 therapy, (b) correlate with proxy parent or guardian assessments, and (c) correlate with magnetic re

68 Participants, parents or guardians, assessors, and the trial statistician were no

69 Race was self-reported by parents or guardians at admission or assessed by the registration t

70 ages were estimated to have been accessed by guardians at least once.

71 th the patient and their family and/or legal guardian before initiation.

72 nant, able to read, they and their parent or guardian both had the necessary documentation necessary

73 ve correlation between subject and parent or guardian change in VAS score between baseline and follow

74 Each parent/guardian completed an ease-of-use survey.

75 Parents or guardians completed a Computer-Assisted Personal Intervi

76 was measured by the TF index, and parents or guardians completed a questionnaire on demographics and

77 Guardians completed a questionnaire to assess acceptabil

78 kg, and able to participate with parental or guardian consent (unless an emancipated minor) were elig

79 in Harare, Zimbabwe, were offered PITC, with guardian consent and child assent.

80 lly sampled (in a 1:4 ratio) and parental or guardian consent sought for their participation.

81 total of 1,641 year-one children with parent/guardian consent took part in baseline assessments prior

82 ICU between June 2021 and April 2022 and had guardian consent were included.

83 ld be offered with patient assent and parent/guardian consent.

84 cs across Gaza, with 3229 (84.7%) parents or guardians consenting for their children to participate.

85 ants (n = 57) in Hispanic Americans from the GUARDIAN Consortium (n = 2,560).

86 ed homework, grade repetition, and parent or guardian contacted by school.

87 Although 10% of guardians declared administration of anti-malarial drugs

88 to describe the scent marking activity of 3 guardian dogs as they defend livestock from coyote depre

89 CI, 1.28-2.57; I2 = 0.00%), higher levels of guardian education (OR, 1.60; 95% CI, 1.06-2.43; I2 = 71

90 atus, highest educational level of parent or guardian, federal poverty level of the household, and pr

91 or depression; lived with a consenting legal guardian for at least 6 months; and spoke English were i

92 ll child patients age 6 and older, and legal guardians for adult patients unable to self-complete the

93 Almost all parents/guardians found the swabs acceptable.

94 We propose that decorin can be considered a "guardian from the matrix" because of its innate ability

95 s study, and the subjects and/or a parent or guardian gave informed consent.

96 ngs point to a novel function for Smad4 as a guardian gene that maintains genomic stability.

97 Tumor suppressor genes (TSGs) are guardian genes that play important roles in controlling

98 y transplant providers serving as both organ guardians (given the organ scarcity) versus advocates fo

99 older, or attending with a male or a younger guardian had significantly lower odds of being offered H

100 gical characteristics (both child and parent/guardian) have not been studied from the perspective of

101 A parent/guardian identified youth ages 12-17 years with arthriti

102 ned either from the patient or the parent or guardian in all patients.

103 hrough pathways such as the 'mitochondria as guardian in cytosol' (MAGIC) whereby cytosolic misfolded

104 roteostasis mechanism MAGIC (mitochondria as guardian in cytosol) and provide evidence that it may ex

105 l discuss the importance of SETX as a genome guardian in suppressing aberrant R-loop formation and an

106 n unexpected tumour-promoting role of genome guardians in enforcing the oncogene-induced differentiat

107 Participants and their parents or guardians, individuals involved in assessment of any out

108 Surveillance data collection included parent/guardian interviews, chart reviews, and collection of mi

109 Parents or guardians, investigators, and all other trial staff were

110 ll as for strategies to enhance parental and guardian involvement in HIV research when safe and appro

111 size, 91,642 children) regarding parents' or guardians' judgments of whether their children's insuran

112 Our molecular results clearly indicate that guardian males do indeed consume their own genetic offsp

113 n, raise the possibility that cannibalism by guardian males is directed primarily or exclusively towa

114 Furthermore, field observations suggest that guardian males routinely eat offspring from their own ne

115 The activation of p53 is a guardian mechanism to protect primary cells from maligna

116 nction of p53 protein, also known as "genome guardian", might be impaired by the overexpression of it

117 These guardian molecules and their corresponding physiologic p

118 d and speak English; and the parent or legal guardian of a child 18 years or younger presenting to 1

119 a genome-wide screen in yeast to identify a guardian of aneuploid cell fitness conserved across spec

120 vity to inhibit PDH, highlighting SIRT4 as a guardian of cellular metabolism.

121 de that the Cdk2/Cdk4/NPM pathway is a major guardian of centrosome dysfunction and genomic integrity

122 These findings reveal Nrf1 as a guardian of cholesterol homeostasis and a core component

123 ontaining Ubiquitin-Conjugating Enzyme) is a guardian of chromosome integrity and activator of ATM si

124 The blood-brain barrier (BBB), a critical guardian of communication between the periphery and the

125 Proofreading is the primary guardian of DNA polymerase fidelity.

126 The parent or guardian of each enrolled child (n = 1124) was asked a s

127 Glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis, although its membrane-protectiv

128 TRIB3 emerges as an important guardian of genome integrity.

129 We propose that PTEN acts as a guardian of genome integrity.

130 ir findings indicate that p53 may exert its "guardian of genome" duties at least in part via safeguar

131 anoids impair the role of wild-type p53 as a guardian of genomic integrity by a process distinct from

132 The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to

133 Our findings establish CSE as an essential guardian of homeostatic brain health and identify it as

134 nfections, highlighting the role of p53 as a guardian of immune integrity.

135 This study suggests that p53 serves as a guardian of immunological functions and that the p53-STA

136 vide new insight into p120-catenin's role as guardian of intercellular junction dynamics.

137 at the transcriptional corepressor TLE3 is a guardian of luminal cell fate in breast cancer and opera

138 egulators of lymphoid lineage identity and a guardian of lymphocyte homeostasis.

139 es in Saccharomyces suggested that Hop2 is a guardian of meiotic chromosome synapsis with the ability

140 with a normal physiological role of bcl2 as "guardian of microtubule integrity."

141 Our findings identify ATM as a guardian of mitochondrial output, as well as genomic int

142 Cancerous inhibitor of PP2A (CIP2A), a guardian of oncoprotein MYC, is identified as a candidat

143 Considered as the guardian of proteostasis, the proteostasis network (PN)

144 ken together, we propose that RapA acts as a guardian of RNAP by which RapA prevents nonspecific DNA

145 our findings support a role for DNMT3A as a guardian of the epigenetic state at enhancer regions, cr

146 s composed of GABAergic neurons is termed as guardian of the gateway and is an important regulator of

147 reticular complex might be described as the guardian of the gateway", a reciprocal relationship we n

148 The p53 tumor suppressor acts as a guardian of the genome by preventing the propagation of

149 cient cells failed to activate p53, a master guardian of the genome rarely mutated in ccRCC and showe

150 n homolog (PTEN) is a tumor suppressor and a guardian of the genome that is frequently mutated or del

151 The tumor suppressor p53 is known as a guardian of the genome that mediates the cellular respon

152 It exerts its function as guardian of the genome through an intricate interplay of

153 upport a model which extends p53's role as a guardian of the genome to include transactivation-indepe

154 he tumor suppressor p53 is considered as the guardian of the genome which is activated following geno

155 rminus of LIF1/XRCC4, a recently recognized "guardian of the genome" against cancer.

156 p53 has been proposed as the "guardian of the genome" and ceramide has been suggested

157 The tumor suppressor protein p53, the "guardian of the genome", is inactivated in nearly all ca

158 Referred to as the "guardian of the genome", p53 is the most frequently muta

159 sponse to genotoxic stress and loss of this 'guardian of the genome' is an important step in carcinog

160 olutionarily conserved role in metazoans as 'guardian of the genome', mediating cell-cycle arrest and

161 As 'the guardian of the genome', the tumor suppressor protein p5

162 DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a

163 e p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse physiological

164 ation of tumor suppressor genes such as the "guardian of the genome," p53, and the cyclin-dependent k

165 amage and has been designated as the histone guardian of the genome.

166 apart easily, and p53 exercises its role as guardian of the genome.

167 Thus, we propose that PTEN is a new guardian of the genome.

168 sly formulated 'dual model' of p53's role as guardian of the genome.

169 val signals, permitting p53 to function as a guardian of the genome.

170 mage, and has therefore earned the title of "guardian of the genome." In this issue of Genes & Develo

171 coded by the TP53 gene, is recognized as the guardian of the human genome because it regulates many d

172 The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway.

173 ice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a p

174 Our work identifies Srrt as a molecular guardian of the pluripotent cell state.

175 ential to elicit its redox function and as a guardian of the reduced state of its own cysteine residu

176 These results suggest that EZH2 serves as a guardian of uterine epithelial integrity, partially via

177 Eligible parents were legal guardians of a 3-to-5-year-old child, lived with their c

178 actors--the 4E-BP protein family--operate as guardians of a translational control checkpoint in lung

179 The parents or guardians of all eligible infants (aged <6 months) under

180 The parents or guardians of all participants provided written informed

181 med consent was obtained from the parents or guardians of all subjects.

182 of a specialized set of immune cells as sole guardians of antimicrobial resistance.

183 Lysosomes, guardians of cell health, can sustain physical damage fr

184 (ADP-ribose) polymerases which are notorious guardians of cellular integrity are demodified by macro

185 Parents/guardians of children aged <16 years admitted to l'Hopit

186 68 [85.00%] were female) identified as legal guardians of children aged 7 to 18 years with a first ca

187 Parents and guardians of children aged 90 days to 11.9 years who wer

188 Eligible adults were the parents or guardians of children and adolescents included in the su

189 their reproductive years (or with parents or guardians of children) and be prepared to discuss fertil

190 ish a major IR regulatory mechanism and link guardians of chromosome stability to nutrient metabolism

191 At study enrollment, parents or guardians of each subject completed a questionnaire, and

192 Guardians of FA children who underwent oral food challen

193 oom has predictably made households vigilant guardians of fruit on the tree, but it has not incited i

194 DNA ligases are essential guardians of genome integrity by virtue of their ability

195 sults suggest that wh is a new member of the guardians of genome stability because it regulates FEN1'

196 DNA ligases are essential guardians of genomic integrity, and ligase dysfunction u

197 olutionarily conserved processes that act as guardians of genomic integrity.

198 ng on FoxP3+ regulatory T cells (Tregs), key guardians of immune tolerance, we combined single-cell c

199 Patients or guardians of minors were approached for consent.

200 e mimics the loss of Bax and Bak, two potent guardians of mitochondrial apoptotic potential.

201 sease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged m

202 Innate lymphoid cells (ILCs) are guardians of mucosal immunity, yet the transcriptional n

203 e brain, suggesting their potential roles as guardians of neuronal longevity.

204 eals a specialized function for BRM cells as guardians of the alveoli.

205 sical immune cell function, microglia act as guardians of the brain by promoting phagocytic clearance

206 repair (DDR) proteins are well recognized as guardians of the genome that are frequently lost during

207 xpose an Achilles' heel of topoisomerases as guardians of the genome, and they have broad implication

208 these transactions and have been termed the guardians of the genome.

209 le RNA biogenesis factors and RNase H act as guardians of the genome.

210 tein family members are often referred to as guardians of the genome.

211 Intestinal Paneth cells are considered to be guardians of the gut microbiota, but the events linking

212 FR) superfamily have been designated as the "guardians of the immune system" due to their roles in im

213 between DC subsets, with cDC2 functioning as guardians of the mucosa.

214 targets HIF2alpha and CITED2, which are key guardians of the quiescence and stemness of CML LSCs.

215 ts support models in which miRNAs can act as guardians of the transcriptome.

216 r via cytokine secretion, and functioning as guardians of tissue homeostasis.

217 , these data indicate that Tet2 and Tet3 are guardians of Treg cell stability and immune homeostasis.

218 promoters, innocent bystanders, or essential guardians of tumors, according to the stage and origin o

219 r tumor suppressors including the important "guardian" of the genome, p53.

220 t Lsh plays an important role as 'epigenetic guardian' of the genome to protect against deregulation

221 007), as was having understanding parents or guardians (OR 1.13, 95% CI 1.01 to 1.26, p = 0.036).

222 Thus, ECs may function as mucosal 'guardians' orchestrating frontline IgG and IgA class swi

223 Discussions were held with the patient's guardian outlining the clinical issues and the risks of

224 Parents/legal guardians (participants) completed surveys at baseline,

225 A total of 1594 parents or guardians participated at health system A, 1537 at healt

226 require training on counselling children and guardians, particularly male guardians, who are less lik

227 Here, we discuss how these guardian pathways function, how their activities interse

228 edle stick during admission with a parent or guardian present, English as the primary language.

229 Thus, Ikaros acts as a guardian preventing autoimmunity by promoting BCR anergy

230 eloid cell leukemia 1 (Mcl-1), a prosurvival guardian protein from the Bcl-2 family.

231 The cell cycle is controlled by guardian proteins that coordinate the process of cell gr

232 e time of first OCT imaging, and a parent or guardian provided written informed consent.

233 Guardians provided information about socioeconomic disad

234 s (or, if younger than 18 years, their legal guardians) provided written informed consent and were gi

235 age, at which point we gave their parents or guardians questionnaires, and measured the children's lu

236 Parent/guardian ratings of children on a measure of temperament

237 a Facebook ads, ResearchMatch, and parent or guardian referrals.

238 , the infants had surgery, or the parents or guardians refused surgery.

239 s associated with HCWs offering and children/guardians refusing HIV testing were investigated using m

240 Race and ethnicity (determined via parent or guardian report at visit check-in), sex, payer, language

241 ng) and TBI on CT imaging in children with a guardian report of acting abnormally with (1) no other f

242 ome cannabis smoking, measured by: parent or guardian report of in-home cannabis smoking; number of d

243 Parent or guardian report of race and ethnicity for a child was us

244 A guardian report that a child is acting abnormally is a r

245 A guardian report that the child was acting abnormally aft

246 cale study (N = 4,497), English-speaking dog guardians reported on their dogs' life histories, curren

247 lying medical conditions; and had parent- or guardian-reported normal sleep (8-11 hours/night).

248 Patient race and ethnicity were guardian-reported vs hospital assigned as Black, Hispani

249 Patient self-reported (or parent/guardian-reported) race, ethnicity, and language for car

250 han 2 years with minor blunt head trauma and guardian reports of the child acting abnormally with no

251 er, these studies define GPS2 as a molecular guardian required for precise control of inflammatory re

252 These results reveal a novel genome guardian role for RAG2 and suggest that similar 'end rel

253 It is hypothesised that the ligands play a guardian role in stabilising the Au particle size, which

254 vities of TP53 mutations but also the genome-guardian role of p53 and its inactivation during tumor d

255 ort cells; in turn, the somatic cells play a guardian role, providing information that prevents self-

256 There has been substantial reliance on the guardian's recall in recent surveys, and, worryingly, in

257 ay survey questions are presented, or in the guardian's recall of vaccination for children without a

258 he only known possible source for his female guardian's tuberculosis, an investigation of the child's

259 Here, we assessed the ability of the Ocean Guardian Scuba7 and Kevlar material to reduce the likeli

260 Overall, the Ocean Guardian Scuba7 and Kevlar reduced the impact of blackti

261 Parent or guardian self-reported clinician recommendation was cate

262 Removal of this guardian side chain permits enzyme closure and increases

263 nter study, and patients or their parents or guardians signed written informed consent.

264 The GUARD during Ischemia Against Necrosis (GUARDIAN) study enrolled 2,918 patients assigned to the

265 eening Against Rare Disease in All Newborns (GUARDIAN) study was a multisite, single-group, prospecti

266 screener assessing identity, behaviors, and guardian support), at 32 urban or suburban care clinics

267 Guardian systems and their over arching importance in th

268 of pathological altruism, altruism bias, and guardian systems may help open many new, potentially use

269 P-mediated microautophagy as a key organelle guardian that preserves lysosome integrity, offering new

270 -based dataset produced by the newspaper The Guardian, The Counted, to identifiable NVSS mortality re

271 ing allocation from participants' parents or guardians, their medical care providers, and all trial s

272 sing Icare ONE by clinic examiner and parent/guardian, then using Goldmann applanation (masked physic

273 and then linked by the British newspaper The Guardian to CTs according to 2010 Census geographies.

274 1.2%-1.5%) were reported by their parent or guardian to have deafness or hearing problems.

275 Without ACE2 acting as a guardian to inactivate the ligands of B1R, the lung envi

276 s an unexpected role of PLK1 as a chromosome guardian to maintain centromere integrity for chromosome

277 . report on a protein complex that acts as a guardian to protect these folding intermediates from bei

278 perceived unsuitability of the accompanying guardian to provide consent for HIV testing on behalf of

279 ess than 16 years were invited via parent or guardian to receive a single, parenteral dose of vaccine

280 sions, and society has authorized parents or guardians to act on behalf of children.

281 conducted with children and their parents or guardians to collect data about cumulative life stress.

282 sult, at least in part, from an inability of guardians to differentiate between kin and nonkin within

283 ere less confident in approaching parents or guardians to discuss youth mental health issues than in

284 women and enrolled 2537 and their parents or guardians to receive a cash transfer programme (n=1225)

285 1 and arginase equip H. pylori with a "renox guardian" to overcome abundant nitrosative and oxidative

286 cytokine receptors but are controlled by a 'guardian' transcription factor, itself endowed with an S

287 Thus, in the GUARDIAN trial, the cardioprotective efficacy of caripor

288 Inhibitors of Apoptosis Protein (IAPs) are guardian ubiquitin ligases that keep classic proapoptoti

289 well-patient population of 500 children and guardians was determined.

290 Both the research team and parents or guardians were aware of treatment allocation.

291 Parents or guardians were blinded to allocation assignment until in

292 rs, participants, and their parents or legal guardians were blinded to group assignments.

293 Male guardians were less likely to consent to their child bei

294 Guardians were masked to group assignment.

295 Young women (and their parents or guardians) were randomly assigned (1:1), by use of numbe

296 CaN appears as a guardian which prevents an excessive progenitor prolifer

297 ng or ocular specimen collection, and have a guardian who could provide consent for participation.

298 Of the 940 guardians who tested with the child, 186 (19.8%) were HI

299 ng children and guardians, particularly male guardians, who are less likely to engage with health car

300 written consent was obtained from parents or guardians, with assent from the child where appropriate,