ライフサイエンスコーパス: habenula

1 roach and avoidance behavior via the lateral habenula.

2 he thalamus, tectum, octavolateral area, and habenula.

3 neurons receive RPE signals from the lateral habenula.

4 ressing normal and abnormal functions of the habenula.

5 s likely mediated by inputs from the lateral habenula.

6 ic nuclei, lateral hypothalamus, and lateral habenula.

7 activation of cFos expression in the lateral habenula.

8 oflexus, the principal output pathway of the habenula.

9 the serotonergic cell population of the left habenula.

10 sspeptins mRNA in hypothalamic nuclei or the habenula.

11 ly organized descending projections from the habenula.

12 FISH to characterize the cells of the mouse habenula.

13 n two forebrain areas: the telencephalon and habenula.

14 in the VTA, lateral hypothalamus or lateral habenula.

15 scued by viral reexpression of Gpr151 in the habenula.

16 tivation of neurons in the ventral (lateral) habenula.

17 eptibility in the posterior subregion of the habenula.

18 gions may convergently influence the lateral habenula.

19 glutamatergic neurons project to the lateral habenula, a brain area important for generating behavior

20 his, we recorded from neurons in the lateral habenula, a nucleus that encodes RPEs, while monkeys cho

21 Based on anatomical and functional data, the habenula-a phylogenetically old brain structure present

22 arrangements raise the possibility that the habenula accounts for multiple channels of information f

23 ficantly different in MDD subjects, for whom habenula activation decreased significantly with increas

24 In healthy volunteers, habenula activation increased as conditioned stimuli (CS

25 ent evidence, however, demonstrates that the habenula acts as a critical neuroanatomical hub that con

26 he elaboration of dHbl character in the left habenula, albeit by an unknown mechanism.

27 In the medial habenula, alpha5-containing, alpha3-containing, and beta

28 us and hypothalamus, septum and hippocampus, habenula, amygdala, nucleus tractus solitarius, and circ

29 The habenula, an ancient small brain area in the epithalamus

30 bserved in the medial portion of the lateral habenula, an area that receives dense DA innervation via

31 ty contrast is highly non-uniform within the habenula and across the subjects.

32 We found that lateral habenula and dopamine neurons accessed two distinct rewa

33 We found that lateral habenula and dopamine neurons anticipated tasks in two d

34 and unrewarded positions were reversed, both habenula and dopamine neurons reversed their responses a

35 and novelty signals arising from excitatory habenula and dopaminergic ventral tegmentum inputs, whic

36 esized, fluoxetine reduced metabolism in the habenula and increased metabolism in the ventral tegment

37 be mediated by decreasing metabolism in the habenula and increasing metabolism in the ventral tegmen

38 the nicotinic receptors expressed in medial habenula and interpeduncular nucleus during withdrawal.

39 of interest has been focused recently on the habenula and its critical role in aversion, negative-rew

40 benula, we focused our studies on the medial habenula and its primary target, the interpeduncular nuc

41 Neurons of the medial habenula and part of the lateral habenula express the tr

42 The right habenula and posterior tuberculum (diencephalic nuclei)

43 receptor in circumventricular regions of the habenula and septum in mice.

44 GFR4 expression localized only in the medial habenula and subcommissural organ of mice.

45 ikely that the main connectivity between the habenula and the basal ganglia, limbic, and sensory syst

46 cts showed decreased metabolism in the right habenula and the extended medial and orbital prefrontal

47 a, medial and lateral aspects of the lateral habenula and the paraventricular thalamus.

48 Kiss1 immunoreactivity and c-fos mRNA in the habenula and the raphe compared with control.

49 lative to neutral events was observed in the habenula and two regions within the ventral midbrain: on

50 d greater cytochrome oxidase activity in the habenula and ventral tegmental area compared to males.

51 ons or bilateral electrolytic lesions of the habenula and were tested for fear-potentiated startle an

52 n reduce the excitatory drive to the lateral habenula and, consequently, decrease the inhibition onto

53 sing cells were consistently detected in the habenula and, in mature males and females, in the rostra

54 cells were observed in the preoptic region, habenula, and hypothalamus, whereas the tac2b mRNA-conta

55 ed in the olfactory bulbs, hypothalamus, and habenula, and in fiber tracts that coursed in the optic

56 for a network comprising the VTA and SN, the habenula, and mesocorticolimbic structures that supports

57 d nucleus of the stria terminalis, amygdala, habenula, and raphe nucleus), all of which express mu op

58 minal field formed by axons from the lateral habenula, and some molecular markers identified as speci

59 study, we show that both the left and right habenula are competent to adopt left-type molecular char

60 t and converging evidence that points to the habenula as a key brain region for motivation and decisi

61 s subset of brain regions and identified the habenula as a node robustly correlated with PFC activity

62 rapineal influences neurogenesis in the left habenula at early developmental stages as well as neurot

63 ted to aversive targets, such as the lateral habenula, but also that, after abstinence, their synapse

64 Activation of the lateral habenula by aversive events inhibits dopamine neurons tr

65 To unravel conserved habenula circuitry and approach an understanding of thei

66 The habenula circuitry of anuran amphibians, decedents of th

67 ing phylogenetic development, the primordial habenula circuitry underwent various evolutionary adapta

68 ination), amygdala (cognitive bias), lateral habenula (cognitive bias) and hippocampus (cognitive bia

69 situ hybridization experiments of the mouse habenula complex in naive mice and those exposed to an a

70 The habenula complex is appreciated as a critical regulator

71 The lateral habenula (LHb) is part of the habenula complex of the dorsal thalamus.

72 The habenula consists of the medial and lateral nuclei, each

73 sful and unsuccessful) activity in the right habenula decreased in CD in the abstinence/saline condit

74 egin to define a gene regulatory pathway for habenula development in mammals.

75 model in which neurons of the dorsal medial habenula (dMHb) are developmentally eliminated, via tiss

76 tivation of substance P-positive dorsomedial habenula (dMHb) neurons results in simultaneous release

77 Our data show that the habenula-dopamine pathway contains multiple timescales o

78 Our data suggest that the habenula-dopamine pathway motivates anticipation through

79 brainstem nuclei linked to depression (e.g., habenula, dorsal raphe and interpeduncular nucleus).

80 tion remains whether there is a link between habenula dysfunction and monoamine-related disorders, su

81 m the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectivel

82 , weak electrical stimulation of the lateral habenula elicited strong inhibitions in dopamine neurons

83 Studies in animals indicate that the lateral habenula encodes the previously learned negative motivat

84 his factor regulates an extensive program of habenula-enriched genes, but not generic neural properti

85 re consistent with the view that the lateral habenula establishes inhibitory relationships between st

86 the medial habenula and part of the lateral habenula express the transcription factor Brn3a/Pou4f1,

87 IPN innervation, we find that only the left habenula expresses the zebrafish homologue of Neuropilin

88 in cortex, hippocampus, thalamus and medial habenula from autoradiograms using computer assisted ima

89 The habenula has been implicated in a range of different fun

90 These results suggest that the lateral habenula has the potential to adaptively control both re

91 models, in vivo imaging studies of the human habenula have been relatively scarce due to its small si

92 amic nucleus and a downstream structure, the habenula, have a sustained response to blue but not to r

93 in (BF), pedunculopontine nucleus (PPN), and habenula (HB) encode trial-by-trial variation in action

94 The habenula (Hb) is a central structure connecting forebrai

95 The anuran medial and lateral habenula homologs receive differential input from the se

96 seful tool for substructure-resolved in vivo habenula imaging, and provide a groundwork for the futur

97 en done on the function and structure of the habenula in animal models, in vivo imaging studies of th

98 However, involvement of the habenula in dynamic trial-by-trial aversive learning has

99 ods specialized for imaging the midbrain and habenula in humans.

100 data confirm the involvement of the lateral habenula in modulating the activity of rostromedial tegm

101 system and its interactions with the lateral habenula in processing aversive information and learning

102 ions of the medial and lateral nuclei of the habenula in the rat.

103 Past studies have suggested a role for the habenula in voluntary exercise motivation and reinforcem

104 ntial role for the rostromedial tegmentum in habenula-induced feedforward inhibition of dopamine neur

105 ions of the rostromedial tegmentum attenuate habenula-induced inhibition of dopamine neurons signific

106 nfralimbic cortex, basolateral amygdala, and habenula inhibited social play, but not social explorato

107 eir specific projections and relationship to habenula inputs are not well understood.

108 were found to require activation of lateral habenula inputs to the rostromedial tegmental nucleus.

109 ecreased significantly under ketamine in the habenula, insula, and ventrolateral and dorsolateral pre

110 al network modeling pointed to altered intra-habenula interactions as a contributory mechanism.

111 as led to the identification of the midbrain habenula-interpeduncular axis as a critical relay circui

112 The medial habenula-interpeduncular nucleus (MHb-IPN) pathway has r

113 on limbic dopamine circuitry and the medial habenula-interpeduncular nucleus complex, which are crit

114 data suggest that alpha3beta4 nAChRs in the habenula-IPn circuit regulate the motivational propertie

115 tic approaches in the mouse to show that the habenula is a distinctive molecular territory of the CNS

116 The habenula is a dorsal diencephalic structure consisting o

117 The habenula is a phylogenetically conserved brain structure

118 The habenula is a small, evolutionarily conserved brain stru

119 The habenula is a tiny brain region the size of a pea in hum

120 The habenula is an epithalamic structure differentiated into

121 Recent work has shown that the lateral habenula is an important part of the reward circuit by p

122 so suggested that dysfunction of the lateral habenula is associated with psychiatric disorders, inclu

123 Here we reveal that the lateral habenula is critical for negative predictors, but not po

124 The name habenula is derived from the Latin word habena, meaning

125 t circuit-specific plasticity in the lateral habenula is dynamically involved in translating CS-US co

126 Our findings indicate that the habenula is linked with LDTg either by direct reciprocal

127 localized susceptibility enhancement in the habenula is more associated with increased paramagnetic

128 The habenula is uniquely positioned both anatomically and fu

129 The Galphat-S innervation of the habenula is very selective, fibers densely innervating t

130 is coexpressed with Brn3a in the developing habenula, is downstream of Brn3a, and mediates expressio

131 w the multiple streams are organized via the habenula, knowledge of the precise input-output connecti

132 Habenula known to contain alpha3beta2 nAChR exhibited lo

133 However, following conditioned fear stress, habenula-lesioned animals showed decreased PPI which nor

134 is study, we describe an interaction between habenula lesions and stress that produces long-lasting e

135 Furthermore, we found that after habenula lesions, DA neurons' ability to signal graded l

136 , we examined the involvement of the lateral habenula (LHb) and of its inputs onto the rostromedial t

137 ceives glutamatergic inputs from the lateral habenula (LHb) and sends substantial GABAergic projectio

138 ffect EP target regions, such as the lateral habenula (LHb) and thalamus.

139 rong inputs to the RMTg arise in the lateral habenula (LHb) and, to a lesser extent, the SN.

140 Neurons in the lateral habenula (LHb) are transiently activated by aversive eve

141 y by decreasing hyperactivity in the lateral habenula (LHb) brain nucleus.

142 The evolutionarily conserved lateral habenula (LHb) enables dynamic responses to continually

143 lectrophysiological recording in the lateral habenula (LHb) followed by immunohistochemistry.

144 The lateral habenula (LHb) has been implicated in regulation of drug

145 KEY POINTS: The lateral habenula (LHb) has been implicated in regulation of drug

146 The lateral habenula (LHb) has been implicated in the pathophysiolog

147 The lateral habenula (LHb) has been linked to aversion and mood regu

148 The lateral habenula (LHb) has recently been identified as a key reg

149 of Brodmann area 25 (BA25), and the lateral habenula (LHb) in the CMS-induced attenuation of dopamin

150 The lateral habenula (LHb) is a brain structure receiving inputs fro

151 The lateral habenula (LHb) is a key brain region involved in the pat

152 We had previously reported that the lateral habenula (LHb) is activated by cocaine and contributes t

153 The lateral habenula (LHb) is an epithalamic brain structure critica

154 The lateral habenula (LHb) is an epithalamic structure differentiate

155 The lateral habenula (LHb) is bilaterally connected with serotoniner

156 The lateral habenula (LHb) is hyperactive in depression, and thus po

157 The epithalamic lateral habenula (LHb) is implicated as part of the mammalian br

158 The lateral habenula (LHb) is involved in reward and aversion and is

159 The lateral habenula (LHb) is involved in reward, aversion, addictio

160 The lateral habenula (LHb) is part of the habenula complex of the do

161 The lateral habenula (LHb) is part of the habenular complex in the d

162 Recent studies suggesting that the lateral habenula (LHb) may contribute to this type of signaling

163 Neurons located in the lateral habenula (LHb) modulate the activity of DA neurons and D

164 Lateral habenula (LHb) neurons are activated by negative motivat

165 Lateral habenula (LHb) neurons convey aversive and negative rewa

166 tral tegmental area (VTA)-projecting lateral habenula (LHb) neurons is associated with increased pass

167 Lateral habenula (LHb) neurons signal negative "reward-predictio

168 We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmen

169 Separate studies have implicated the lateral habenula (LHb) or amygdala-related regions in processing

170 osine hydroxylase (TH) projecting to lateral habenula (LHb) play a role in reward.

171 Lesions of dorsal column or lateral habenula (LHb) prevented the inhibitory effects of perip

172 The lateral habenula (LHb) processes information about aversive expe

173 Lateral habenula (LHb) projections to the ventral midbrain, incl

174 The lateral habenula (LHb) provides an important source of negative

175 Furthermore, we showed that the lateral habenula (LHb) receives direct synaptic input from the P

176 from the basal forebrain (BF) to the lateral habenula (lHb) that bi-directionally controls the valenc

177 companied by increased firing in the lateral habenula (LHb) that contributes to downstream activation

178 ting the potential of inhibiting the lateral habenula (LHb) to achieve antidepressant and antidepress

179 e 2 (GAD2)-expressing neurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) and that act

180 is that the GPi also projects to the lateral habenula (LHb) which is often associated with the limbic

181 Neuronal activity in the lateral habenula (LHb), a brain region implicated in depression

182 For unclear reasons, the lateral habenula (LHb), a key brain region involved in the patho

183 The lateral habenula (LHb), a key regulator of monoaminergic brain r

184 monkeys indicate that neurons in the lateral habenula (LHb), a nucleus that mediates communication be

185 The lateral habenula (lHb), an epithalamic structure that forms reci

186 e motivational states, including the lateral habenula (LHb), medial habenula (MHb), interpeduncular n

187 eurons, and their projections to the lateral habenula (LHb), negatively regulate the consumption of p

188 Nuclei including the lateral habenula (LHb), the lateral hypothalamus (LH), and the m

189 STPM), posteromedial amygdala (MeP), lateral habenula (LHb), ventral tegmental area, and lateral pont

190 s, we found that some neurons in the lateral habenula (LHb), where activation produces aversive condi

191 isease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the

192 midbrain dopaminergic neurons by the lateral habenula (LHb), which has mainly excitatory outputs, is

193 found that rats with lesions of the lateral habenula (LHb), which is implicated in aversion-mediated

194 st in this structure, especially the lateral habenula (LHb).

195 nuclear complexes, medial (MHb) and lateral habenula (LHb).

196 Consequently, the habenula may be critically important in the pathophysiol

197 , we discuss how deregulation of the lateral habenula may be involved in depressive behaviors.

198 such as the amygdala, ventral striatum, and habenula/mediodorsal thalamus.

199 esses underlying the formation of the medial habenula (MHb) and its unique output, the interpeduncula

200 The medial habenula (MHb) densely expresses nicotinic acetylcholine

201 , but not peptidergic neurons, of the medial habenula (MHb) display spontaneous tonic firing of 2-10

202 The epithalamic medial habenula (MHb) expresses clock genes, but little is know

203 Although the medial habenula (MHb) has been proposed as a site of alpha5 fun

204 nAChRs in the medial habenula (MHb) have recently been shown to play a role i

205 The medial habenula (MHb) is a phylogenetically-conserved epithalam

206 elimination of acetylcholine (ACh) in medial habenula (MHb) neurons alters glutamate corelease and pr

207 pha3* nAChRs are densely expressed by medial habenula (mHb) neurons, which project almost exclusively

208 etylcholine receptors (nAChRs) in the medial habenula (MHb) or interpeduncular nucleus (IPN) triggers

209 ne Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regu

210 find five subtypes of neurons in the medial habenula (MHb) that are organized into anatomical subreg

211 Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN) path

212 (SF), enhanced neural activity in the medial habenula (mHb), a brain region increasingly implicated i

213 re-expressing alpha5 subunits in the medial habenula (MHb), and recapitulated in rats through alpha5

214 including the lateral habenula (LHb), medial habenula (MHb), interpeduncular nucleus (IP), and median

215 Viral expression of beta4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN), and VTA o

216 ulopeduncular pathway consists of the medial habenula (MHb), its output tract, the fasciculus retrofl

217 odulated glutamatergic input from the medial habenula (MHb).

218 streams of information to the contralateral habenula, midbrain, and brainstem.

219 We recorded the activity of habenula neurons and dopamine neurons while rhesus monke

220 ct aversion-related neurons, such as lateral habenula neurons and VTA GABAergic neurons, with minor i

221 mediated by gradual recruitment of activated habenula neurons in zebrafish.

222 onstrate topographic separate populations of habenula neurons projecting via a direct excitatory or i

223 In unrewarded trials, the excitation of habenula neurons started earlier than the inhibition of

224 Activation of these ventral-habenula neurons suppressed downstream neurons in the se

225 eus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons p

226 We found that a subpopulation of lateral habenula neurons transmitted signals resembling IPEs, re

227 The population of lateral habenula neurons was also excited by the punishment itse

228 We found that the population of lateral habenula neurons was most strongly excited by a conditio

229 Many habenula neurons were excited by a no-reward-predicting

230 ive neurons regulate the activity of lateral habenula neurons, thereby governing aggressive behavior

231 ly, IL-18 is produced in the brain in medial habenula neurons, which project IL-18-containing axons t

232 ed nodes, including the mu receptor-enriched habenula node.

233 sity, and connectivity of the left and right habenula nuclei.

234 tac3a was expressed asymmetrically in the habenula of embryos, whereas in adults zebrafish tac3a-e

235 upled receptor (GPCR) highly enriched in the habenula of humans and rodents, is expressed at presynap

236 h analogous microinjections into the lateral habenula of nicotine-treated mice or in mice chronically

237 the GPR151 protein in the medial and lateral habenula of rodent brain.

238 knock-down of Chrna3 gene transcripts in the habenula or interpeduncular nucleus (IPn) increases nico

239 tated withdrawal when microinjected into the habenula or the interpeduncular nucleus, but not into th

240 llidum (VP) projecting to either the lateral habenula or ventral tegmental area contributing to depre

241 tes the stimulatory actions of nicotine on a habenula-pancreas axis that links the addictive properti

242 Here we show that the primate lateral habenula, part of the structure called the epithalamus,

243 The indirect GABAergic habenula pathway derives from neurons in the superficial

244 These data suggest that the thalamo-habenula pathway is involved in the ability of blue ligh

245 volume of the ventral tegmental area (VTA), habenula, periaqueductal gray, cerebellum, hypothalamus,

246 These results demonstrate that the habenula plays a critical role in DA RPE signaling but s

247 Our findings show that the habenula plays a key role in an online aversive learning

248 The habenula plays an important role in brain reward circuit

249 t that the inhibitory input from the lateral habenula plays an important role in determining the rewa

250 f the HCN pacemaker antagonist ZD7288 in the habenula precipitates somatic and affective signs of wit

251 minent in granular layers of the cerebellum, habenula, preglomerular nuclei, and several other dience

252 es of adult brain, the dorsal telencephalon, habenula, preoptic area, hypothalamus, and cerebellum.

253 ordings in monkeys regarding how the lateral habenula processes reward-related information.

254 ent of the IPN, whereas axons from the right habenula project only to the ventral IPN.

255 In contrast to other species, the habenula projecting pallidal nucleus is topographically

256 Here we show that neurons in the habenula-projecting globus pallidus (GPh) in mice are es

257 rate evaluation circuit, which regulates the habenula-projecting globus pallidus (GPh) neurons, exist

258 ctional connectivity between the VTA and the habenula, putamen, and medial prefrontal cortex, whereas

259 ade of IPN neurotransmission from the medial habenula reduced IPN neuronal activation and alleviated

260 Lesioning the habenula reduces light-evoked climbing.

261 hat VTA DA neurons projecting to the lateral habenula release GABA, but not DA, we performed an exten

262 sity of LHb neurons, the neuron types of the habenula remain unknown.

263 l significance of the Kiss1 expressed in the habenula remains unknown.

264 However, habenula responses during aversive processing have yet t

265 ited abnormal negative task-related (phasic) habenula responses during primary aversive conditioning.

266 By contrast, negative habenula responses to monetary reward cue values predict

267 nforcement learning, we demonstrate positive habenula responses to the dynamically changing values of

268 We speculate that the negative habenula responses we observed may result in the loss of

269 Moderate levels were detected in habenula, striatum, amygdala, the cingulate, piriform an

270 bility as a quantitative biomarker for human habenula studies.

271 have not assigned these effects to specific habenula subnuclei.

272 ceptor expression was detected in the medial habenula, suggesting that nicotine's effect was mainly o

273 We detect melanopsin in the habenula, suprachiasmatic nucleus, dorsal thalamus, and

274 Efferents from the left habenula terminate along the entire dorsoventral extent

275 the organization of multiple channels in the habenula that convey parallel streams of information to

276 s (RMTg) arising from cortex, brainstem, and habenula that drive triply dissociable RMTg responses to

277 ChAT were observed in the hypothalamus, the habenula, the optic tectum, the isthmus, the cranial mot

278 In the habenula, these calcium-binding proteins revealed right-

279 currents in the ventral pallidum and lateral habenula, though the net effects on postsynaptic firing

280 crease the GPh activity to drive the lateral habenula to increase the inhibition of the neuromodulato

281 e to correlate subnuclear areas in the mouse habenula to subnuclei, which had been rigorously identif

282 ing the alpha3beta4* subtype from the medial habenula to the IPn.

283 ror signals, through a basal ganglia-lateral habenula-tVTA/RMTg-dopamine-basal ganglia circuit.

284 ely in the nucleus accumbens and the lateral habenula, two brain regions important for depressive-lik

285 ject to the nucleus accumbens (NAc), lateral habenula, ventral pallidum (VP), and amygdala.

286 factory bulbs, ventral/dorsal telencephalon, habenula, ventral thalamus, pretectum, rostral midbrain

287 c areas of the telencephalon, relayed by the habenula via the fasciculus retroflexus.

288 r hyperintensities in BD than UD depression, habenula volume reductions in BD but not UD depression,

289 Individual differences in habenula volume were negatively associated with symptoms

290 lution anatomical images were used to assess habenula volume.

291 In accordance with earlier results, the habenula was activated by perceptual prediction errors.

292 a4 subunit is highly expressed in the medial habenula, we focused our studies on the medial habenula

293 e rostromedial tegmental nucleus and lateral habenula were specifically activated during extinction a

294 y changes, especially between cerebellum and habenula, which correlate with decision outcome.

295 going encoding of experience features in the habenula, which guides recruitment of downstream network

296 h, of which kiss1 neurons are located in the habenula, which project to the median raphe.

297 ic and can drive the activity of the lateral habenula, which, in turn, provides an indirect inhibitor

298 jor sources of input, neurons in the lateral habenula, while animals anticipated upcoming behavioral

299 s one of their sources of input, the lateral habenula, while animals predicted upcoming rewards based

300 ion (0.5 x 0.5 x 0.8 mm(3)) MRI of the human habenula with quantitative susceptibility mapping (QSM)