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1 mass, and dysregulation of blood formation (haematopoiesis).
2 that faithfully recapitulate early embryonic haematopoiesis.
3 olecular pathways that drive early embryonic haematopoiesis.
4 required for the establishment of definitive haematopoiesis.
5 ng to context-specific functions for Lkb1 in haematopoiesis.
6 ature osteoblasts, disrupts the integrity of haematopoiesis.
7 can create a space for postnatal bone marrow haematopoiesis.
8 f the wider regulatory networks that control haematopoiesis.
9 cell-derived angiocrine factors that support haematopoiesis.
10 tically influences both normal and malignant haematopoiesis.
11 ified by our present understanding of clonal haematopoiesis.
12 defects and, in particular, fail to undergo haematopoiesis.
13 ess cdx4, a caudal-related gene required for haematopoiesis.
14 ntial regulator of embryonic development and haematopoiesis.
15 iking parallels to the involvement of SCL in haematopoiesis.
16 factors, which play critical roles in normal haematopoiesis.
17 is gene has a dominant role in commitment to haematopoiesis.
18 were able to contribute only transiently to haematopoiesis.
19 nsistent with roles for this factor in adult haematopoiesis.
20 lated coactivators have contrasting roles in haematopoiesis.
21 ing a function for VEGFR-1 signalling during haematopoiesis.
22 ed to study the functional role of ICAM-1 in haematopoiesis.
23 action of AML1 with CBFbeta is essential for haematopoiesis.
24 echanisms governing the clock-like timing of haematopoiesis.
25 DNA-binding complex which may play a role in haematopoiesis.
26 y elements controlling SCL expression during haematopoiesis.
27 em and exhibit a severe block in fetal liver haematopoiesis.
28 T-cell leukaemias, is normally expressed in haematopoiesis.
29 e and fertile, with no detectable defects in haematopoiesis.
30 ems to study the role of GATA-3 in mammalian haematopoiesis.
31 ations (mCAs) is one manifestation of clonal haematopoiesis.
32 ogrammed cell death, plays a central role in haematopoiesis.
33 ng of CREs centred on pioneer factors across haematopoiesis.
34 malignancies arise from the dysregulation of haematopoiesis.
35 BMECs) play a key role in bone formation and haematopoiesis.
36 he biogenesis of ribosomal RNA (rRNA) and in haematopoiesis.
37 re vital for lifelong maintenance of healthy haematopoiesis.
38 the blood cell formation, a process known as haematopoiesis.
39 d foetal liver, but does not impair yolk sac haematopoiesis.
40 ), improved exercise capacity, and activated haematopoiesis.
41 for RUNX1 and other regulators of definitive haematopoiesis.
42 mutations, leading to therapy-related clonal haematopoiesis.
43 yonic endoderm and mesoderm niche with early haematopoiesis.
44 ages, and in chimeric mice that model clonal haematopoiesis.
45 motherapy and may have undergone oligoclonal haematopoiesis.
46 tic haematopoiesis but impacted regenerative haematopoiesis.
47 radication of leukaemic cells with preserved haematopoiesis.
48 tasis and under conditions of stress-induced haematopoiesis.
49 risk factors include inflammation and clonal haematopoiesis.
50 he underlying structure of early adult human haematopoiesis.
51 tations corrupt the complex process of human haematopoiesis.
52 d using gene expression data from a study of haematopoiesis.
53 served role in vertebrate vasculogenesis and haematopoiesis.
54 el the physiological function of miR-193b in haematopoiesis.
55 od cell counts without affecting bone marrow haematopoiesis.
56 opoietic stem cell homeostasis and malignant haematopoiesis.
57 ontrol developmental processes such as early haematopoiesis.
58 that reveal unprecedented features of native haematopoiesis.
59 aemia and shown normally to be essential for haematopoiesis.
60 on on wider TF networks during developmental haematopoiesis.
61 e our understanding of normal and neoplastic haematopoiesis.
62 nstrain leukaemic self-renewal and malignant haematopoiesis.
63 transcriptional cofactor required for early haematopoiesis.
64 and MYB, a region previously associated with haematopoiesis.
65 R-196b is probably also important for normal haematopoiesis.
69 he human tumour microenvironment, how ageing haematopoiesis affects immune cells that contribute to t
70 opoietic system, but their role in emergency haematopoiesis after MI has not yet been established.
71 s are crucial for tissue repair in emergency haematopoiesis after MI, excessive myelopoiesis can exac
72 anscription factors regulate many aspects of haematopoiesis, although their functions in humoral immu
73 1.14 mutations per cell division in healthy haematopoiesis and 1.37 mutations per division in brain
74 own that Lmo2 and Scl/Tal1 are essential for haematopoiesis and angiogenic remodelling of the vascula
75 nergic neural signals increase during stress haematopoiesis and are amplified through cholinergic ost
81 t, we confirmed resistance of epitope-edited haematopoiesis and concomitant eradication of patient-de
82 2(+) macrophages are derived from definitive haematopoiesis and contribute to inflammation and tissue
84 ple allergic diseases by regulating basophil haematopoiesis and eliciting a population of functionall
85 s, HAEMCODE and ESCODE, which are focused on haematopoiesis and embryonic stem cell samples, respecti
88 erize the lifelong natural history of clonal haematopoiesis and give fundamental insights into the in
90 totic bookmarking as critical for definitive haematopoiesis and highlight a dependency on bookmarkers
91 strates the intrinsic requirement of usb1 in haematopoiesis and highlights PN as a disorder of myeloi
92 o examine the physiological roles of H2AX in haematopoiesis and how the loss of H2AX contributes to d
93 eases, but the clonal contributions to human haematopoiesis and how this changes with age remain inco
94 Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence l
95 tegrins are indispensable for embryogenesis, haematopoiesis and immune responses, possibly because al
96 heral blood stem cell grafts to reconstitute haematopoiesis and immunity in patients with bone marrow
98 nt is a tool for dissecting LMO2 function in haematopoiesis and leukaemia and is a lead for developme
101 chanisms by which lifestyle factors modulate haematopoiesis and leukocyte migration and function in t
102 reveal that Asxl2 is a critical regulator of haematopoiesis and mediates transcriptional effects that
103 ntal timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evi
104 the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immuni
106 protein Ikaros is an important regulator of haematopoiesis and recent work promises to shed light on
107 and phenotypes characterized by ineffective haematopoiesis and risk of transformation to acute myelo
109 n to be essential for embryonic development, haematopoiesis and signalling downstream of a variety of
110 icate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3
111 derived from either embryonic or definitive haematopoiesis and that can be distinguished by the expr
113 point assesses recent developments in clonal haematopoiesis and the related implications for affected
114 fic markers highlighted defects of primitive haematopoiesis and traced back the dramatic reduction in
117 or RUNX1 (AML1) is an important regulator of haematopoiesis, and an important fusion partner in leuka
118 lphaB and CBFA2) is essential for definitive haematopoiesis, and chromosomal translocations involving
119 cription factor Runx1, a master regulator of haematopoiesis, and give rise to haematopoietic cells.
120 ence of yolk sac EMP-derived and HSC-derived haematopoiesis, and identify yolk sac EMPs as a common o
122 serves as an essential regulator of HSCs and haematopoiesis, and more generally, points to the critic
123 recapitulates bona fide human developmental haematopoiesis, and outline some future directions in th
124 derstand IQCG-mediated calcium signalling in haematopoiesis, and propose a model in which IQCG stores
125 the IL17 cytokine family and extramedullary haematopoiesis, and suggests a previously unrecognized i
126 l production sites that confer plasticity to haematopoiesis, and uncover unprecedented heterogeneity
129 cells that contain somatic mutations (clonal haematopoiesis) are commonly acquired with age and incre
134 rough mechanisms that are specific to clonal haematopoiesis as well as shared mechanisms that lead to
135 acrine and endocrine factors that can affect haematopoiesis, as well as potentially nourishing the bo
136 f GATA2 at mitotic exit abolishes definitive haematopoiesis at aorta-gonad-mesonephros, placenta and
137 resolved and cell-state-aware atlas of human haematopoiesis at single-cell resolution, showing an una
139 ody loss had little effect upon homoeostatic haematopoiesis but impacted regenerative haematopoiesis.
140 ave a minimal or late contribution to foetal haematopoiesis but instead largely proliferate during th
141 leen has important functions in immunity and haematopoiesis but little is known about the events that
142 known regulators of developmental and adult haematopoiesis, but how they act within wider TF network
143 icroenvironment has a key role in regulating haematopoiesis, but its molecular complexity and respons
144 ipal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF differe
145 th minimal or no defects in neurogenesis and haematopoiesis, but they die at birth from severe reduct
146 ell supportive niche cells deregulate normal haematopoiesis by causing haematopoietic stem cell dysfu
148 sease subtype, the pattern of involvement of haematopoiesis by KIT(D816V), the HalphaT genotype and s
151 iological functions related to inflammation, haematopoiesis, cell cycle control and tumour susceptibi
152 in blood cells - a condition known as clonal haematopoiesis (CH) - are associated with ageing and pat
153 tations drive the most common form of clonal haematopoiesis (CH) and are associated with increased ac
154 tations in the TET2 gene that lead to clonal haematopoiesis (CH) are associated with accelerated athe
156 er distinct proteomic consequences of clonal haematopoiesis (CH), including an association between TE
157 stic syndromes (MDS) are clonal disorders of haematopoiesis characterised by dysplastic changes of ma
158 ctivation was also associated with increased haematopoiesis-characterized by significantly elevated l
160 eas distal 'constitutive' MAT (cMAT) has low haematopoiesis, contains larger adipocytes, develops ear
161 propose that the mutations leading to clonal haematopoiesis contribute to the increased inflammation
162 lymphoid and myeloid lineages during foetal haematopoiesis, contributing to the increased risk of bo
167 complete understanding of how ageing affects haematopoiesis depends on the analysis of blood cell pro
168 d into cDNA) and found that neurogenesis and haematopoiesis dominate at both the gene and cellular le
169 tial (CHIP), traditionally defined as clonal haematopoiesis driven by a pre-leukaemic mutation in at
170 e a zebrafish mutant defective in definitive haematopoiesis due to a deficiency in the nascent polype
173 e we develop strategies to image multipotent haematopoiesis, erythropoiesis and lymphopoiesis in mice
175 while promoting the accelerated recovery of haematopoiesis following myelosuppression, in part throu
177 Functional and molecular evaluations reveal haematopoiesis from these iPS clones to be indistinguish
178 of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutritional su
179 active research, and understanding of clonal haematopoiesis has developed markedly on the basis of fi
181 how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 spe
185 g clonal diversity is a universal feature of haematopoiesis in aged humans, underpinned by pervasive
186 rom bone, accounting for the localization of haematopoiesis in bone marrow, we assessed mice that wer
189 gene contributes to the disturbance of early haematopoiesis in DS, and that one of the contributors i
190 t, reduced exercise capacity, and restricted haematopoiesis in heart failure, which are worse in pati
194 ss of marker-based approaches for dissecting haematopoiesis in mouse and human is reliant on the pres
197 4kb element is active at sites of definitive haematopoiesis in vivo and PU.1 is detectable in haemoge
199 the importance of FOG-1/NuRD interaction for haematopoiesis in vivo, we generated mice with a mutatio
201 ompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise f
202 f blood cells at multiple sites of embryonic haematopoiesis including the yolk sac, para-aortic splan
203 -Myb and CREB, multilineage defects occur in haematopoiesis, including anaemia, B-cell deficiency, th
204 transcriptional repressor with key roles in haematopoiesis, including regulating self-renewal of hae
207 n, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in
215 says and intravital microscopy, we show that haematopoiesis is reprogrammed upon infection, whereby t
221 e of lymphoma infiltration or extramedullary haematopoiesis, it might be caused by a tumour product;
222 eral commonly mutated driver genes in clonal haematopoiesis may be mediated by TCL1A activation.
226 mpared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments
227 topoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) and l
231 e we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chr
232 ic syndrome precursor states, such as clonal haematopoiesis of indeterminate potential (CHIP) and clo
235 f somatic variants in genes mediating clonal haematopoiesis of indeterminate potential (CHIP) in PAH
238 disease(5)-this phenomenon is termed clonal haematopoiesis of indeterminate potential (CHIP)(6).
246 Sections on communicable diseases, clonal haematopoiesis of indeterminate potential, paediatric as
248 tain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediate
250 ular patterns, or as a consequence of clonal haematopoiesis or trained innate immunity, also contribu
251 revealed the existence of age-related clonal haematopoiesis, or the asymptomatic clonal expansion of
252 iated with a slower expansion rate in clonal haematopoiesis overall, but the effect varied by driver
254 anding the biological consequences of clonal haematopoiesis poses a clinical challenge for both patie
255 tor that is not required for HSC function or haematopoiesis, promotes stem/progenitor cell proliferat
256 ely, these data highlight that LDL-C impacts haematopoiesis, promoting both the number and the proinf
260 plications of CHIP and other types of clonal haematopoiesis rapidly expands, it has become increasing
265 absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts di
267 r specific inflammasomes according to clonal haematopoiesis status could substantially reduce cardiov
268 it has become increasingly clear that clonal haematopoiesis subtypes have substantial heterogeneity w
269 tween metabolic and epigenetic regulation of haematopoiesis, suggesting new targets in haematopoietic
270 to be responsible for age-related changes in haematopoiesis that include a decline in lymphopoiesis a
271 , a zebrafish mutant with an early defect in haematopoiesis that is associated with abnormal anteropo
272 ous developmental contexts, and particularly haematopoiesis, that genes regulating differentiation ar
273 Erythropoietin, a kidney cytokine regulating haematopoiesis (the production of blood cells), is also
275 h it occurs, the different temporal waves of haematopoiesis, the emergence of the first HSCs and the
276 on genetic variants that give rise to clonal haematopoiesis, the JAK2(V617F) (JAK2(VF)) mutation, whi
278 ated perivascular constituents that regulate haematopoiesis through the expression of paracrine facto
279 ematopoietic stem cells (HSC), which sustain haematopoiesis throughout adult life and are specified i
282 ic stem cells (HSCs), which are required for haematopoiesis to persist for the lifetime of the animal
283 stem cells and adult lineages, particularly haematopoiesis, to highlight the general features of thi
285 king similarities between the role of SCL in haematopoiesis/vasculogenesis and the function of other
286 In each of the older subjects, 30-60% of haematopoiesis was accounted for by 12-18 independent cl
289 ly does our study demonstrate that long-bone haematopoiesis was probably not an exaptation to the wat
291 Severe infections are a major stress on haematopoiesis, where the consequences for haematopoieti
292 s single adipocytes interspersed with active haematopoiesis, whereas distal 'constitutive' MAT (cMAT)
293 ineage commitment is an important process in haematopoiesis, which forms the immune system to protect
295 tic mutations in stem cells can cause clonal haematopoiesis, which represents a previously unrecogniz
296 we report that ASXL2 is required for normal haematopoiesis with distinct, non-overlapping effects fr
297 th greatly increased vulnerability to clonal haematopoiesis with specific acquired CN-LOH mutations.
299 ctivation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell
300 e that cytosine analogues restore a balanced haematopoiesis without decreasing the size of the mutate