ライフサイエンスコーパス: haematopoietic

1 poietic cells, to infer the lineage-specific haematopoietic activity present in human breast tumours.

2 Mechanisms of haematopoietic and cardiac patterning remain poorly unde

3 e hemangiogenic cell lineage development.How haematopoietic and endothelial cell lineages are specifi

4 sion of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues includes new criteri

5 Interferon is found to affect both haematopoietic and mesenchymal BM cells and we specifica

6 the transplantation of primary cells such as haematopoietic and mesenchymal stem cells and, more rece

7 Inflammasomes are broadly expressed in haematopoietic and non-haematopoietic cells and can trig

8 lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate

9 assess the role of NLRP6 expression on host haematopoietic and non-haematopoietic cells.

10 hibits a liver bud-like phenotype, including haematopoietic and stromal cells as well as a neuronal n

11 Altogether, these findings demonstrate that haematopoietic ANGPTL4 deficiency increases atherogenesi

12 We observed that certain human haematopoietic cancer cell lines and canine MDCK II cell

13 herapeutic index, effective in xenografts of haematopoietic cancers resistant to standard of care and

14 the ageing haematopoietic system(3,4) and in haematopoietic cancers(5).

15 SF3B1 protein, a common mutational target in haematopoietic cancers(9), contains a HEAT domain (SF3B1

16 In primary haematopoietic cell cultures, silencing of TRIB3 facilit

17 In the haematopoietic cell line UT7/mpl, silencing of TRIB3 inc

18 ion of survival pathways favouring malignant haematopoietic cell maintenance, defence against excessi

19 Allelic variants of the pan-haematopoietic cell marker CD45, identified as CD45.1 an

20 .1 and CD45.2 donor cells, and characterised haematopoietic cell reconstitution in dual-expressing CD

21 Following periods of haematopoietic cell stress, such as after chemotherapy,

22 s predisposition events, facilitating mutant haematopoietic cell survival and expansion as well as co

23 ely monitored-patients with cancer receiving haematopoietic cell transplantation as they recover from

24 assemia (Hb Sbeta), and underwent allogeneic haematopoietic cell transplantation between Jan 15, 2008

25 HD), the principal toxicity after allogeneic haematopoietic cell transplantation.

26 herapeutic graft-versus-tumour effects after haematopoietic cell transplantation.

27 Each haematopoietic cell type had a distinct metabolic signat

28 he transcriptome-based classifications of 28 haematopoietic cell types.

29 tivation molecule (SLAM) family of homotypic haematopoietic cell-specific receptors, we determined th

30 PARP14 deficiency in haematopoietic cells accelerates the development and inf

31 broadly expressed in haematopoietic and non-haematopoietic cells and can trigger numerous downstream

32 ing, compromised global protein synthesis in haematopoietic cells and caused bone marrow failure in m

33 However, CXCR4 is also expressed in haematopoietic cells and other normal tissues, raising s

34 ntification of the relevant role of ADRB1 in haematopoietic cells during acute injury and the protect

35 Transcriptional programmes active in haematopoietic cells enable a variety of functions inclu

36 We find that haematopoietic cells expressing mutant U2AF1(S34F), incl

37 been established as a marker system to track haematopoietic cells following congenic mouse bone marro

38 SPCs could also be used to cross-correct non-haematopoietic cells in neurodegenerative metabolic dise

39 ot induce cell death in human melanocytes or haematopoietic cells in NSG mice.

40 tocols for the generation of endothelial and haematopoietic cells in vivo and in vitro.

41 The differentiation of haematopoietic cells is regulated by a plethora of so-ca

42 ortant MAM blood group antigen is present on haematopoietic cells of all humans except rare MAM-negat

43 of genomic mutations and clonal selection in haematopoietic cells on the basis of 33,250 autosomal mo

44 Vascular and haematopoietic cells organize into specialized tissues d

45 ents suggest that REGgamma's function in non-haematopoietic cells primarily contributes to the phenot

46 reside in the bone marrow, where stromal and haematopoietic cells regulate their function.

47 uted with wild-type, Nek7(-/-) or Nlrp3(-/-) haematopoietic cells showed that NEK7 was required for N

48 ommunicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation

49 s with alleles that promote the expansion of haematopoietic cells to replace their homologous (alleli

50 to cytokines, hormones and growth factors in haematopoietic cells(1,2).

51 In contrast to other haematopoietic cells, ILC2s selectively express the NMU

52 eness to IFNgamma by myeloid cells and other haematopoietic cells, including T cells or fibroblasts,

53 pletion of neutrophils, ablation of Adrb1 in haematopoietic cells, or blockade of PSGL-1, the recepto

54 Within haematopoietic cells, the accumulation of a small number

55 t uses the transcriptomes of over 200 murine haematopoietic cells, to infer the lineage-specific haem

56 P6 expression on host haematopoietic and non-haematopoietic cells.

57 ation by bystander-like signalling to foetal haematopoietic cells.

58 lely by genetic or epigenetic lesions within haematopoietic cells.

59 which was not previously associated with non-haematopoietic cells.

60 system is supported by Ifnar1-deficient non-haematopoietic cells.

61 (ES) cells to both primitive and definitive haematopoietic cells.

62 -H1-knockout mouse strain and depleted H1 in haematopoietic cells.

63 h the haemogenic endothelium generates early haematopoietic cells.

64 Haematopoietic clones with acquired mutations become com

65 c locations of mutations in their respective haematopoietic clones; these differences predicted the r

66 reduces reperfusion injury by targeting the haematopoietic compartment.

67 the brain requires Ifnar1 deficiency in the haematopoietic compartment.

68 table longitudinally and present in multiple haematopoietic compartments, suggesting a long-lived hae

69 sclerosis, sleep-fragmented mice with either haematopoietic CSF1 deficiency or hypocretin supplementa

70 er Shwachman-Diamond syndrome reproduced key haematopoietic defects and led to the discovery of a neu

71 Understanding how early haematopoietic development occurs is of fundamental impo

72 is Review, we discuss what is known of human haematopoietic development: the anatomical sites at whic

73 t are important for the establishment of the haematopoietic developmental program.

74 our study reveals a positive role for GO in haematopoietic differentiation and suggests that further

75 t stem cells and holds promise for modelling haematopoietic disease in humanized mice and for therape

76 he development of acute leukaemias and other haematopoietic diseases, it has become increasingly reco

77 eoplasms are a heterogeneous group of clonal haematopoietic disorders that are marked by diverse muta

78 Producing these cells would accelerate haematopoietic drug toxicity testing and treatment of pa

79 As an in vitro model of haematopoietic dysfunction, the BM chip may serve as a h

80 for their capacity to promote multi-lineage haematopoietic engraftment in mouse hosts.

81 At BCL2L11, we identify a haematopoietic enhancer hub that is inactivated by the E

82 heir localization and clarify sources of pro-haematopoietic factors.

83 ession that result in heart malformation and haematopoietic failure.

84 of this master regulator of endothelial and haematopoietic fate enhances our understanding of early

85 ependent Wnt target, sufficient to establish haematopoietic fate in early mesoderm when BMP and Wnt c

86 ide in a quiescent state and progress to the haematopoietic fate within a defined time window, within

87 GRS-transduced endothelial cells commit to a haematopoietic fate, yielding rEC-HSCs that no longer re

88 ramme in HE to allow progression towards the haematopoietic fate.

89 w niche and resolved cellular sources of pro-haematopoietic growth factors, chemokines and membrane-b

90 Whereas hypocretin-null and haematopoietic hypocretin-receptor-null mice develop mon

91 itical role during both myeloid and lymphoid haematopoietic lineage commitment.

92 Using cellular model systems of haematopoietic lineage differentiation here we demonstra

93 for the development and survival of multiple haematopoietic lineages.

94 platelet counts, and contribute to multiple haematopoietic lineages.

95 ly in midline gliomas but also identified in haematopoietic malignancies and carcinomas.

96 s are particularly prevalent in sarcomas and haematopoietic malignancies and frequently involve genes

97 Myelodysplastic syndromes (MDS) are haematopoietic malignancies that are characterised by a

98 of the spliceosome are frequently mutated in haematopoietic malignancies.

99 e anlage, remodels into bone and organizes a haematopoietic microenvironment.

100 Haematopoietic multipotential progenitor cells, as well

101 NK cells mediate resistance against haematopoietic neoplasms but are generally considered to

102 The bone marrow, in particular the haematopoietic niche (in rodents, also the spleen), is a

103 anoparticle-mediated RNA interference in the haematopoietic niche could be used to investigate haemat

104 mediated inhibition of cell release from the haematopoietic niche via Mcp1 silencing reduced leukocyt

105 odelling of the skeleton and the bone marrow haematopoietic niche.

106 rst HSCs and the signalling landscape of the haematopoietic niche.

107 composition and function of the specialized haematopoietic niches of the bone marrow during health a

108 in humans and mice(11-18), consistent with a haematopoietic origin of osteoclasts(13,16,19) and studi

109 e myeloid leukaemia (AML) is a malignancy of haematopoietic origin that has limited therapeutic optio

110 Importantly, cells of mesenchymal or haematopoietic origin use distinct modes of migration an

111 ng and that plaque macrophages may not be of haematopoietic origin.

112 et production and an organ with considerable haematopoietic potential.

113 topoietic niche could be used to investigate haematopoietic processes for therapeutic applications in

114 ne beta-YAC bone marrow cells (BMC); c)human haematopoietic progenitor CD34(+) cells, with transfecti

115 transgenic mice alters splicing and reverts haematopoietic progenitor cell expansion induced by muta

116 Continuous thymic homing of haematopoietic progenitor cells (HPCs) via the blood is

117 ls from umbilical cord blood derived CD34(+) haematopoietic progenitor cells and iPSCs; this enhanced

118 riven by the hormone thrombopoietin by which haematopoietic progenitor cells give rise to megakaryocy

119 that in primary cultures derived from human haematopoietic progenitor cells, thrombopoietin-induced

120 lls conditionally blocked at the multipotent haematopoietic progenitor stage to develop a MLL-r model

121 loyed a cellular model of murine multipotent haematopoietic progenitors (Hoxb8-FL) to knock out 39 tr

122 Haematopoietic progenitors and CD14+ monocytes are usual

123 ature and immature megakaryocytes along with haematopoietic progenitors in the extravascular spaces o

124 esolution mapping of malignant versus normal haematopoietic progenitors revealed an increasing fitnes

125 cells (DCs) develop in the bone marrow from haematopoietic progenitors that have numerous shared cha

126 only in the transition but also in allowing haematopoietic progenitors to establish their full diffe

127 c endothelium, which only produced primitive haematopoietic progenitors.

128 ematopoietic stem cells (HSCs) to restricted haematopoietic progenitors.

129 nary analysis further demonstrates that this haematopoietic programme is highly conserved between zeb

130 ation of NF-kappaB-inhibited BM ECs enhanced haematopoietic recovery and protected mice from pancytop

131 appaB promotes improved HSC function and pan-haematopoietic recovery.

132 rated that they are capable of multi-lineage haematopoietic repopulation of myeloablated adult mice s

133 The developmental stage of the block in haematopoietic specification is not known.

134 mogenic endothelial cells, a key step during haematopoietic specification.

135 lomere length in leukocytes and other clonal haematopoietic states-collectively suggesting that MPN r

136 Small molecules that enhance haematopoietic stem and progenitor cell (HSPC) expansion

137 Haematopoietic stem and progenitor cell (HSPC) gene ther

138 that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenan

139 enin-dependent Wnt signalling that regulates haematopoietic stem and progenitor cell emergence.

140 oietic compartments, suggesting a long-lived haematopoietic stem and progenitor cell of origin.

141 model of MDS results in a rapid loss of MDS haematopoietic stem and progenitor cells (HSPCs) and rev

142 It is well established that haematopoietic stem and progenitor cells (HSPCs) are gen

143 ed lncRNA expression profiles from the CD34+ haematopoietic stem and progenitor cells (HSPCs) from pa

144 Haematopoietic stem and progenitor cells (HSPCs) have be

145 y haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs).

146 e extended to more complex diseases in which haematopoietic stem and progenitor cells can be altered

147 s have shown that the genetic engineering of haematopoietic stem and progenitor cells can be an alter

148 actor-mediated cell fate conversion produces haematopoietic stem and progenitor cells from pluripoten

149 leukaemia (AML), arise from the expansion of haematopoietic stem and progenitor cells that acquire so

150 cient to convert haemogenic endothelium into haematopoietic stem and progenitor cells that engraft my

151 n enrichment model to purify a population of haematopoietic stem and progenitor cells with more than

152 m in mice, including the spleen, thymus, and haematopoietic stem and progenitor cells, as well as in

153 tic transcription factors in the majority of haematopoietic stem and progenitor cells.

154 c as well as the maintenance and function of haematopoietic stem and progenitor cells.

155 With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resul

156 in complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging.

157 In the blood, haematopoietic stem cell (HSC) ageing is linked to sever

158 ssociation with numerous processes including haematopoietic stem cell (HSC) fate, inflammation and tu

159 Haematopoietic stem cell (HSC) gene therapy has demonstr

160 oclast precursors arose independently of the haematopoietic stem cell (HSC) lineage and the data from

161 Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone m

162 e, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution a

163 protein quality checkpoint that controls the haematopoietic stem cell (HSC)-niche interaction and det

164 aemia with arrested erythropoiesis, a marked haematopoietic stem cell defect, and rapid lethality.

165 of the fusion tyrosine kinase BCR-ABL1 in a haematopoietic stem cell drives its transformation to be

166 serve that germline genetic variation shapes haematopoietic stem cell function, leading to CHIP throu

167 Yet the expression of BRAF(V600E) in the haematopoietic stem cell lineage causes leukaemic and tu

168 hat lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been a

169 ) cells, CD8(+) T cell memory precursors and haematopoietic stem cell progenitors, but that was disti

170 While Asxl2 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promot

171 Case reports suggest potential benefit after haematopoietic stem cell transplant (HSCT) for patients

172 Autologous haematopoietic stem cell transplantation (AHSCT) has bee

173 Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was

174 za vaccination (IIV) schedules in autologous haematopoietic stem cell transplantation (autoHCT) patie

175 omising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approach

176 5, and CDKN2A/B deletion status, and whether haematopoietic stem cell transplantation (HSCT) had been

177 ne editing strategies, matched sibling donor haematopoietic stem cell transplantation (HSCT) in child

178 al and imaging outcomes following allogeneic haematopoietic stem cell transplantation (HSCT) in two p

179 portant infections to occur after allogeneic haematopoietic stem cell transplantation (HSCT), and an

180 lastic syndrome received upfront therapy (14 haematopoietic stem cell transplantation and 4 chemother

181 ese findings may have relevance for clinical haematopoietic stem cell transplantation and mobilizatio

182 nitoring for non-diagnostic purposes such as haematopoietic stem cell transplantation donor screening

183 g, early progression halted after allogeneic haematopoietic stem cell transplantation from a related

184 Allogeneic haematopoietic stem cell transplantation has been demons

185 long-term neurological benefit of allogeneic haematopoietic stem cell transplantation in adult cerebr

186 of a disorder may be possible, for example, haematopoietic stem cell transplantation in FA and NBS,

187 pathy with axonal spheroids and suggest that haematopoietic stem cell transplantation might have a th

188 adrenoleukodystrophy treated with allogeneic haematopoietic stem cell transplantation on a compassion

189 usly been observed only following allogeneic haematopoietic stem cell transplantation(2,3), may be fe

190 igh-dose chemotherapy followed by autologous haematopoietic stem cell transplantation, and prospectiv

191 luding immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal an

192 Haematopoietic stem cell transplantation, the oral formu

193 nditioning regimens are increasingly used in haematopoietic stem cell transplantation.

194 r eliminating latently infected cells before haematopoietic stem cell transplantation.

195 normalize within 1 year after treatment with haematopoietic stem cell transplantation.

196 tes that manifested concurrent expression of haematopoietic stem cell/progenitor and myeloid progenit

197 astable intermediates that had collapsed the haematopoietic stem cell/progenitor gene expression prog

198 Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensit

199 Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety

200 have an increased bone marrow (BM) long-term haematopoietic stem cells (HSCs) and granulocyte-macroph

201 aemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and multipotent progeni

202 Haematopoietic stem cells (HSCs) are maintained by bone

203 Genetic defects that accumulate in haematopoietic stem cells (HSCs) are thought to be respo

204 oiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well as myeloid and

205 How transplanted haematopoietic stem cells (HSCs) behave soon after they

206 Haematopoietic stem cells (HSCs) emerge during embryogen

207 During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially i

208 Haematopoietic stem cells (HSCs) first arise during deve

209 Aged haematopoietic stem cells (HSCs) generate more myeloid c

210 The biology of haematopoietic stem cells (HSCs) has predominantly been

211 n haematopoiesis, where the consequences for haematopoietic stem cells (HSCs) have only recently star

212 thway yielded high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of hum

213 Adult haematopoietic stem cells (HSCs) mainly reside in the bo

214 Haematopoietic stem cells (HSCs) maintain balanced self-

215 Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult bl

216 Haematopoietic stem cells (HSCs) reside in distinct nich

217 Haematopoietic stem cells (HSCs) reside in specialized m

218 Inactivation of Bcor in haematopoietic stem cells (HSCs) results in expansion of

219 The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system h

220 Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineag

221 tly from tissues and use it to compare mouse haematopoietic stem cells (HSCs) to restricted haematopo

222 es on the life-long regenerative capacity of haematopoietic stem cells (HSCs)(1,2).

223 anisms that govern the self-renewal of human haematopoietic stem cells (HSCs), and why this fails in

224 Haematopoietic stem cells (HSCs), which sustain producti

225 e acquisition of somatic driver mutations in haematopoietic stem cells (HSCs).

226 MPN through profound detrimental effects on haematopoietic stem cells (HSCs).

227 programming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient e

228 supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (H

229 toxicity to normal CXCR4(+) tissues, sparing haematopoietic stem cells and progenitors.

230 fic alterations of the niches, which support haematopoietic stem cells and their progeny, can act as

231 Haematopoietic stem cells are generated from the haemoge

232 ine a CRISPR-based methodology for targeting haematopoietic stem cells by homologous recombination at

233 Here we show that loss of autophagy in haematopoietic stem cells causes accumulation of mitocho

234 cells into autologous authentic engraftable haematopoietic stem cells could aid treatment of haemato

235 However, approximately one-third of aged haematopoietic stem cells exhibit high autophagy levels

236 Ex vivo gene correction in patient-derived haematopoietic stem cells followed by autologous transpl

237 nd longevity, and is critical for protecting haematopoietic stem cells from metabolic stress.

238 ss permeable arterial blood vessels maintain haematopoietic stem cells in a low reactive oxygen speci

239 Strikingly, most haematopoietic stem cells in aged mice share these alter

240 ve selection of certain somatic mutations in haematopoietic stem cells in ageing humans.

241 fusion of monocytic precursors derived from haematopoietic stem cells in the presence of CSF1 and RA

242 With age, haematopoietic stem cells lose their ability to regenera

243 In the absence of vascular Dll4, haematopoietic stem cells prematurely induced a myeloid

244 leeting transition of endothelial cells into haematopoietic stem cells remain undefined.

245 f-renewal capacity similar to those of adult haematopoietic stem cells, and can be used for clonal en

246 while tracking its development (pre-leukemic haematopoietic stem cells, leukemic stem cells [LSCs], a

247 Here, to yield functional human haematopoietic stem cells, we perform morphogen-directed

248 hro-myeloid progenitors (EMPs) distinct from haematopoietic stem cells.

249 eneration potential similar to healthy young haematopoietic stem cells.

250 to preserve the regenerative capacity of old haematopoietic stem cells.

251 homologous recombination at the HBB gene in haematopoietic stem cells.

252 CML or AML progenitor cells and from normal haematopoietic stem cells.

253 ncer, resulting in increased self-renewal of haematopoietic stem cells.

254 nted the maintenance of transplantable human haematopoietic stem or progenitor cells (HSPCs) in cultu

255 ANX-A1-deficiency exaggerates inflammation, haematopoietic stem progenitor cell (HSPC) activity and

256 monstrate that autophagy actively suppresses haematopoietic stem-cell metabolism by clearing active,

257 Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of blood v

258 termination cytokines that normally restore haematopoietic stem-cell quiescence.

259 hrough epigenetic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regen

260 eraction between age at cancer diagnosis and haematopoietic stem-cell transplant.

261 ed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared

262 he 'Berlin patient'-underwent two allogeneic haematopoietic stem-cell transplantation (HSCT) procedur

263 study, treatment before and after autologous haematopoietic stem-cell transplantation (HSCT) with dar

264 o received a myeloablative 10/10 HLA-matched haematopoietic stem-cell transplantation (HSCT).

265 ated acute myeloid leukaemia (two [3%]), and haematopoietic stem-cell transplantation complications (

266 gents, proteasome inhibitors, and autologous haematopoietic stem-cell transplantation has improved ou

267 on predictors in both models were history of haematopoietic stem-cell transplantation, cumulative alk

268 helium followed by screening of 26 candidate haematopoietic stem-cell-specifying transcription factor

269 Priming haematopoietic stem/progenitor cells (HSPCs) in vitro wi

270 and a new Msi2 reporter model, we show that haematopoietic stem/progenitor cells display preferentia

271 eat deal about the phenotype and function of haematopoietic stem/progenitor cells, a major challenge

272 hus, Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells, suggesting a novel

273 ne transfer in osteoclasts in the absence of haematopoietic-stem-cell chimerism, and can rescue an ad

274 Yet, timely transfusion of haematopoietic-stem-cell-derived monocytic cells in newb

275 on to antigen-specific immune cells, diverse haematopoietic, stromal, parenchymal and neuronal cell t

276 zebrafish niches, as well as with mammalian haematopoietic-supportive cells to further the understan

277 with other temporally and spatially distinct haematopoietic-supportive zebrafish niches, as well as w

278 hat changes in the environment contribute to haematopoietic system ageing.

279 ere, we review recent relevant work from the haematopoietic system and discuss how to interpret and i

280 Pcid2 deletion in the haematopoietic system causes skewed lymphoid lineage spe

281 of several tissues related to the immune and haematopoietic system in mice, including the spleen, thy

282 (6)A methyltransferase Mettl3 from the adult haematopoietic system led to an accumulation of HSCs in

283 ene JAK2 is frequently mutated in the ageing haematopoietic system(3,4) and in haematopoietic cancers

284 lex differentiation landscapes including the haematopoietic system, but the molecular mechanisms defi

285 presents the embryonic rudiment of the adult haematopoietic system, remains uncertain.

286 ing embryogenesis and give rise to the adult haematopoietic system.

287 n other rapidly renewing tissues such as the haematopoietic system.

288 on (smFISH) on mouse stem cells derived from haematopoietic tissue to measure the transcription dynam

289 ic architecture between MPN risk and several haematopoietic traits from distinct lineages; that there

290 tal1, the earliest expressed endothelial and haematopoietic transcription factor genes identified to

291 t mice, we study the function of Tal1, a key haematopoietic transcription factor, and demonstrate, co

292 The endothelial to haematopoietic transition (EHT) is a key developmental p

293 The endothelial to haematopoietic transition (EHT) is the process whereby h

294 lacenta and aorta, through an endothelial-to-haematopoietic transition (EHT).

295 dothelial cells which undergo endothelial-to-haematopoietic transition (EHT).

296 herapy protocols, with or without autologous haematopoietic transplantation and a plethora of new age

297 eceptors, we determined that phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blocka

298 s are much more efficient at phagocytosis of haematopoietic tumour cells, compared with non-haematopo

299 ematopoietic tumour cells, compared with non-haematopoietic tumour cells, in response to SIRPalpha-CD

300 nism by which macrophages engulf and destroy haematopoietic tumour cells.