ライフサイエンスコーパス: hair

1 s of the natural pigment called melanin from hair.

2 e ratios or quantities of amino acids in the hair.

3 very short primary roots and elongated root hairs.

4 ent atrichoblast cells that do not form root hairs.

5 ed with 0.94-fold lower ART concentration in hair (95% confidence interval, 0.89 to 0.99).

6 ecurity with levels of ART concentrations in hair among women living with human immunodeficiency viru

7 ansins have cell-specific functions, in root hair and pollen tube development, for example.

8 n, with few examining the decontamination of hair and scalp.

9 ially effective at removing MeS and BeS from hair and underlying scalp.

10 distinct motile puncta in L. japonicus root hairs and in Nicotiana benthamiana leaves.

11 wth that occurs during the formation of root hairs and pollen tubes or de novo formation of cell plat

12 a mix of soil particle entanglement in root hairs and the action of adhesive root exudates.

13 icularia and Spirodela, which both lack root hairs and the root hair expansin clade EXPA-X.

14 in bundles are required for shaping bristle, hair, and scale morphology.

15 ontain cellular extensions such as bristles, hairs, and scales.

16 ajor actin-bundling proteins in bristles and hairs are known, this information on scales is unknown.

17 olution details that even individual cuticle hairs are observed.

18 sing hydroxamic acids immobilized on resins (HAIRs) as stable and versatile building blocks for the p

19 ver, we show that skin organoids form planar hair-bearing skin when grafted onto nude mice.

20 lead (Pb), copper (Cu), and chromium (Cr) in hair, blood, urine, nails, and saliva from 635 Italian a

21 idative stress/damage within the human scalp hair bulb.

22 genically-active melanocytes from the anagen hair bulbs of affected human scalp remains unclear, oxid

23 n, including the kinocilium and the V-shaped hair bundle essential for mechanotransduction.

24 mediates this effect by changing location of hair bundle establishment or positions of HCs since daug

25 eld maps, and sensitivity curves that show a hair bundle is desensitized by efferent stimulation.

26 al HC pattern by changing the location where hair bundle is established in HCs.

27 ne and the codon level for five of these six hair bundle link proteins.

28 titutions were found in unique groups of six hair bundle link proteins.

29 ey stereociliary proteins involved in normal hair bundle morphogenesis, such as CDC42, RAC1, EPS8 and

30 ks connecting neighboring stereocilia during hair bundle morphogenesis.

31 acid substitutions consistent with abnormal hair bundle morphology and reduced hearing sensitivity.

32 undles with displacement clamping to control hair bundle motion and measure forces.

33 The hair bundle of cochlear hair cells is the site of audito

34 owed that transcription factor Emx2 reverses hair bundle orientation and its expression in the mouse

35 divides to form two daughter HCs of opposite hair bundle orientations.

36 I-BAR protein family, is a newly identified hair bundle protein that is localized to the tips of the

37 y, we tested the effects of efference on the hair bundle response to mechanical stimulation.

38 recovery of mechanoelectrical transduction, hair bundle stiffness, and spontaneous bundle oscillatio

39 biological control parameter for tuning the hair bundle's mechanical sensitivity.

40 e mechanical responsiveness of an individual hair bundle.

41 nt system's capabilities at the level of the hair bundle.

42 e regulators and late Six1 deletion disrupts hair-bundle polarity.

43 Six1 targets a wide range of hair-bundle regulators and late Six1 deletion disrupts h

44 ant larvae retain normal gross morphology of hair bundles and proper trafficking of known MET compone

45 econds after Ca(2+) chelation, especially if hair bundles are deflected toward their short edges.

46 Using hair bundles from the rat's cochlea and the bullfrog's s

47 Although the dynamics of individual hair bundles has been extensively investigated, the infl

48 r from criticality suggested that individual hair bundles may be regarded as nonisochronous oscillato

49 ation to the ankle-link region in developing hair bundles moreover depends on the presence of PCDH15-

50 ly on the capacity of mechanically sensitive hair bundles to transduce vibrations into electrical sig

51 ely disrupt the tip links of individual frog hair bundles with displacement clamping to control hair

52 echnique of mechanically coupling two active hair bundles, enabling us to probe the dynamics of the c

53 hat provides mechanical coupling between the hair bundles.

54 ng conditions requires infection of the root hairs by soil symbiotic bacteria, collectively referred

55 cular players serving efferent control of LL hair cell (HC) activity have not been identified.

56 Each hair cell (HC) precursor of zebrafish neuromasts divides

57 (ARHL) is associated with the loss of inner hair cell (IHC) ribbon synapses, lower hearing sensitivi

58 Outer hair cell (OHC) nonlinear capacitance (NLC) represents v

59 After hair cell ablation, YAP accumulated in supporting cell n

60 eft ([K(+) ](c) ) contributes to setting the hair cell and afferent membrane potentials; the potassiu

61 anscription factors that serve dual roles in hair cell and neuronal development (e.g. Neurod1, Atoh1

62 ) modules mediate planar polarization of the hair cell apical cytoskeleton, including the kinocilium

63 tores harmonin protein expression in sensory hair cell bundles, prevents hair cell loss, improves hea

64 sensitivity and frequency selectivity of the hair cell by modulating its membrane potential.

65 As a result, this potassium-sensitive hair cell conductance pairs with the potassium-sensitive

66 Hair cell counts (both inner and outer) as well as frequ

67 Hair cell death and consequent hearing loss are common r

68 rs protection against aminoglycoside-induced hair cell death via paracrine signaling that requires ex

69 gainst aminoglycoside- and cisplatin-induced hair cell death.

70 Hair cell depolarization leads to calcium influx and act

71 opose a dual mechanism for GFI1 in promoting hair cell development, consisting of repression of neuro

72 ant FGF ligands may contribute to vestibular hair cell differentiation and supports a developmental m

73 rgic signaling in supporting cells regulates hair cell excitability by controlling the volume of the

74 ive root hair cells to instead adopt the non-hair cell fate.

75 ting from acoustic pressure and active outer hair cell force to the inner hair cells that synapse on

76 its effect on the mechanical response of the hair cell has not been established.

77 ecific and early marker of Type-I vestibular hair cell identity.

78 e-related cochlear synaptic degeneration and hair cell loss in mice with enhanced alpha9alpha10 choli

79 ture cochlea, prior to the onset of hearing, hair cell loss stimulates neighboring supporting cells t

80 ssion in sensory hair cell bundles, prevents hair cell loss, improves hearing sensitivity, and amelio

81 ototoxic drugs, infections, and aging cause hair cell losses.

82 form the tip-links, whose tension gates the hair cell mechanoelectrical transduction channels.

83 sed to function as a motor that tensions the hair cell mechanotransduction (MET) complex, but conclus

84 MC1 has been shown to constitute the pore of hair cell mechanotransduction channels, but little is kn

85 Synaptic puncta move all over the hair cell membrane during recovery, translocating far fr

86 hts MYO7A's essential role in tensioning the hair cell MET complex.

87 sults suggest that fluid motion due to outer hair cell motility can help maintain longitudinal homeos

88 dressed for a comprehensive understanding of hair cell MT at molecular and atomic levels.

89 nt advances, we propose a unifying theory of hair cell MT that may reconcile most of the functional d

90 lates neighboring supporting cells to act as hair cell progenitors and produce new hair cells.

91 d mouse cochleas, we demonstrated that inner hair cell stereocilia developed in specific stages, wher

92 pses between auditory nerve fibers and their hair cell targets without destroying the hair cells them

93 cre);RiboTag mice to evaluate changes to the hair cell translatome in the absence of GFI1.

94 auditory-nerve terminals extend towards the hair cell's apical end to re-establish contact with them

95 emonstrated at large appositions such as the hair cell-calyx afferent synapses present in central reg

96 and postnatal supporting cells into induced hair cell-like cells (iHCs).

97 iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic

98 Hair cell-specific expression of the known HSP70 recepto

99 Transgenic, hair cell-specific expression of Tmc2b-mEGFP rescues the

100 al-associated genes as well as activation of hair cell-specific genes required for normal functional

101 Here, I review the various hair cell-tuning mechanisms used among vertebrates.

102 onses, vestibular-induced eye movements, and hair-cell activity as assessed with FM dye labeling and

103 licylate or KCl solutions that reduced outer-hair-cell function and SFOAE amplification.

104 Despite complete loss of hair-cell function, tmc triple-mutant larvae retain norm

105 toxin (DT) receptor was expressed behind the hair-cell specific Pou4f3 promoter.

106 rical transduction (MET) channels at tips of hair-cell stereocilia.

107 ay also use prestin at high frequencies, but hair cells <1 kHz show electrical resonance.

108 LL hair cells (HCs) share structural, functional, and molec

109 elays the differentiation of mechano-sensory hair cells (HCs).

110 nsducing stereocilia in both inner and outer hair cells (IHCs and OHCs).

111 two types of mechanotransducer cells, inner hair cells (IHCs) and outer hair cells (OHCs).

112 Mammalian cochlear inner hair cells (IHCs) are specialized sensory receptors able

113 Inner hair cells (IHCs) are the primary receptors for hearing.

114 Inner hair cells (IHCs) are the primary sensory receptors of t

115 mice, outer hair cells (OHCs), but not inner hair cells (IHCs), began to lose their third row of ster

116 al ganglion neurons (SGNs) on cochlear inner hair cells (IHCs), resulting in loss of synapses, a proc

117 day 7 (P7), before the primary sensory inner hair cells (IHCs), which become competent at about the o

118 Cochlear outer hair cells (OHCs) are among the fastest known biological

119 In Baiap2l2 deficient mice, outer hair cells (OHCs), but not inner hair cells (IHCs), bega

120 s, including those associated with the outer hair cells (OHCs).

121 cer cells, inner hair cells (IHCs) and outer hair cells (OHCs).

122 ectromechanical properties of cochlear outer hair cells (OHCs).

123 , differentially regulates the maturation of hair cells along the cochlea.

124 d reduced number of synapses between sensory hair cells and auditory neurons.

125 tional RBF mutants that produced ectopic non-hair cells and determined that this cell fate switch is

126 ry region, which gives rise to sound-sensing hair cells and neighboring supporting cells (SCs).

127 of spontaneous correlated activity in inner hair cells and spiral ganglion neurons, which begins at

128 -pass transmembrane proteins are enriched in hair cells and underlie nonsyndromic human deafness.

129 In mammals, cochlear hair cells are only produced during development and thei

130 or destructive, which implies that the outer hair cells can either amplify or reduce vibrations in th

131 elopmental model in which Type-I and Type-II hair cells develop in parallel rather than from an inter

132 icles were sufficient to improve survival of hair cells exposed to the aminoglycoside antibiotic neom

133 ure striolar region of the utricle, labeling hair cells following EdU birthdating, and demonstrates t

134 Inner hair cells from TMIE mutant mice show altered postsynapt

135 This mechanical sense begins in hair cells grouped into neuromasts dotted along the anim

136 While hair cells in the cochlea are established targets of cis

137 The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable t

138 t the development of low- and high-frequency hair cells is differentially regulated during developmen

139 t the development of low- and high-frequency hair cells is differentially regulated during pre-hearin

140 The hair bundle of cochlear hair cells is the site of auditory mechanoelectrical tra

141 The finite number of hair cells means that the cochlea itself can be thought

142 HA immunopuncta also occurred in inner hair cells of pre-hearing (P7) but not in adult mice.

143 Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effec

144 d to tonotopic variations in the constituent hair cells or cytoarchitecture of the organ of Corti.

145 e copy signal acted with high selectivity on hair cells polarized to be activated by posterior deflec

146 EUROD1 regulon and are normally expressed in hair cells prior to GFI1 onset.

147 We show that burst firing of mouse inner hair cells prior to hearing onset requires P2RY1 autorec

148 Auditory hair cells receive olivocochlear efferent innervation, w

149 Solution effects on inner hair cells reduced auditory nerve compound action potent

150 potentials; the potassium efflux from type I hair cells results from the interdependent gating of thr

151 eriments reveal that, in developing cristae, hair cells stratify into an upper, Tmc2a-dependent layer

152 nd active outer hair cell force to the inner hair cells that synapse on afferent nerves.

153 eir hair cell targets without destroying the hair cells themselves.

154 Afferent synapses were lost from inner hair cells throughout the aged cochlea, together with so

155 IO23 (APUM23), which caused prospective root hair cells to instead adopt the non-hair cell fate.

156 t engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death.

157 te into progenitor-like cells and to produce hair cells via mitotic and nonmitotic mechanisms.

158 The maturation of high-frequency (basal) hair cells was also affected in Ca(V) 1.3(-/-) mice, but

159 Cochlear hair cells were conditionally and selectively ablated in

160 Immunolabeled hair cells were used to visualize the spiraling BM in th

161 Mechano-sensory hair cells within the inner ear cochlea are essential fo

162 orm mechanotransduction channels in cochlear hair cells without TMIE.

163 a type of sensory receptor cells (the outer hair cells) in response to the acoustic vibrations.

164 nsitize the channel to PIP(2) depletion from hair cells, and alter the channel's unitary conductance

165 phibians, and birds which readily regenerate hair cells, are responsible in part for the mammalian ea

166 In growing root hair cells, ARK1 comets predominantly localize on the gr

167 n triggers K(+) efflux and depolarization of hair cells, as well as osmotic shrinkage of supporting c

168 er scale-between internal structures such as hair cells, basilar membrane (BM), and modiolus with ext

169 and post-synaptic markers on cochlear inner hair cells, in guinea pigs surviving from 1 day to 6 mon

170 membrane currents in low-frequency (apical) hair cells, such as I(K,n) (carried by KCNQ4 channels),

171 t the tips of the tall stereocilia in mature hair cells, together with PCDH15 isoforms CD1 and CD2; L

172 ng in mammals uses somatic motility of outer hair cells, underpinned by the membrane protein prestin,

173 correlate with synaptic position on sensory hair cells, we combined patch clamping with fiber labeli

174 In contrast, zebrafish lateral line hair cells, which detect water motion, require Tmc2a and

175 ed cochlea, together with some loss of outer hair cells.

176 ng force for sound transduction by inner ear hair cells.

177 fter supporting cells regenerate replacement hair cells.

178 sducing stereocilia in mature mouse cochlear hair cells.

179 e transducing stereocilia in mature cochlear hair cells.

180 flux, and subsequent depolarization of inner hair cells.

181 , and exosomal HSP70 interacted with TLR4 on hair cells.

182 act as hair cell progenitors and produce new hair cells.

183 co-moves with RHD3 during tip growth of root hair cells.

184 of transducing stereocilia in mouse cochlear hair cells.

185 upts cochlear blood flow and damages sensory hair cells.

186 the mechanotransduction channel of cochlear hair cells.

187 cutting much softer materials such as human hair, cheese, or potatoes.

188 F development, and mature follicles produced hair co-occurring with epithelial tumors.

189 processes produces the diversity of skin and hair color among human populations, and defects in these

190 tability; these sets ranged in size from 28 (hair color) to 3,400 (height) to 2 million (number of ch

191 s meta-analysis with GWAS of nevus count and hair color, and transcriptome association approaches, un

192 cted link between puberty timing and natural hair colour, possibly reflecting common effects of pitui

193 We found that higher hair cortisol levels were specifically related to lower

194 related to cumulative glucocorticoid levels (hair cortisol), parenting stress, and performance on mem

195 stress did not significantly correlate with hair cortisol, and there was no evidence to suggest that

196 ws: hair Mn, 0.08 mug/g; hair Cu, 9.6 mug/g; hair Cr, 0.05 mug/g; and blood Pb, 1.3 mug/dL.

197 At low levels of hair Cu (10th percentile, 5.4 mug/g), higher concentrati

198 ations were as follows: hair Mn, 0.08 mug/g; hair Cu, 9.6 mug/g; hair Cr, 0.05 mug/g; and blood Pb, 1

199 In secondary analyses, saliva Mn, hair Cu, and saliva Cr were selected as the biomarkers m

200 e data suggest that LGR4 promotes the normal hair cycle by activating HF stem cells and by influencin

201 n Lgr4(-/-) mice can effectively reverse the hair cycle delay.

202 Through recurrent bouts synchronous with the hair cycle, quiescent melanocyte stem cells (McSCs) beco

203 ROOT HAIR DEFECTIVE3 (RHD3) is an atlastin GTPase involved in

204 In women, aging leads to reduced hair density and thinner fibers and can result in female

205 hesis of ethylene to fine-tune root and root hair development, which are important for seedling estab

206 n important role in regulating root and root hair development.

207 er regulation of root meristem size and root hair development.

208 ates LGR4 as a potential target for treating hair disorder in the future.

209 ous structure, the removal of free lipids in hair does not lead to an increase of water permeability.

210 e (PPD) is a strong contact allergen used in hair dye that is known to cause allergic contact dermati

211 urthermore, in Arabidopsis, KAR-induced root hair elongation depends on ACS7 Thus, we reveal a connec

212 ela, which both lack root hairs and the root hair expansin clade EXPA-X.

213 ts spent 9% of their time touching their own hair, face, neck, and shoulders (HFNS).

214 Hair follicle (HF) development is orchestrated by coordi

215 d (ATM) protein within melanocytes in anagen hair follicle bulbs.

216 ion, MC and keratinocyte precursors from the hair follicle bulge of untreated vitiligo skin and vitil

217 iligo, the melanocyte (MC) precursors in the hair follicle bulge proliferate, migrate, and differenti

218 We showed that hair follicle cells from HS patients had an increased nu

219 D to regulate epidermal differentiation and hair follicle cycling and, in so doing, to promote barri

220 HH gene correlates with chemotherapy-induced hair follicle damage or the degree of CIA, respectively.

221 mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promo

222 em cells and prevented their commitment to a hair follicle lineage.

223 te resembles transit-amplifying cells of the hair follicle matrix, with AP-1 and TGFB cooperativity d

224 e key role of ATM in the protection of human hair follicle melanocytes from oxidative stress/damage w

225 rves form a dual-component niche to modulate hair follicle stem cell (HFSC) activity.

226 In this work, we characterized hair follicle stem cells (HFSCs) isolated from HS patien

227 nerves form "synapse-like" connections with hair follicle stem cells to promote hair regeneration in

228 creased BCL2 gene and protein expressions in hair follicle tissues.

229 We then discuss the epidermis and hair follicle, to provide a non-skeletal example of a ti

230 n skin microenvironment, these cells express hair-follicle lineage markers and contribute to hair fol

231 s in adult mice can heal by regenerating new hair follicles and adipocytes in their center.

232 Cutaneous changes seem to start around hair follicles and involve activation of cells of the in

233 Finally, in organ-cultured human scalp hair follicles as well as in patients undergoing chemoth

234 mpathetic nerves, arrector pili muscles, and hair follicles form a tri-lineage unit to cause piloerec

235 ilization of stem cells to regenerate anagen hair follicles in AA and intraepidermal melanocytes in v

236 replication forks was altered in ORSCs from hair follicles of HS patients, leading to activation of

237 tent skin competence explaining why aberrant hair follicles or sebaceous glands are sometimes observe

238 the aging dermal environment on female scalp hair follicles remains unclear.

239 ied epidermis, fat-rich dermis and pigmented hair follicles that are equipped with sebaceous glands.

240 Hair follicles were shorter, not reaching the adipose la

241 hance skin repair, including regeneration of hair follicles with arrector pili muscles in healed woun

242 uctures in skin such as nerves, vasculature, hair follicles, and sebaceous glands.

243 bundles that target Merkel cells in organoid hair follicles, mimicking the neural circuitry associate

244 r-follicle lineage markers and contribute to hair follicles, sebaceous glands and/or epidermis renewa

245 using spatiotemporal gene ablation in murine hair follicles, we uncover a critical role for the trans

246 ng the skin and eventually homing within the hair follicles.

247 with pigmentary status in canities-affected hair follicles.

248 Root hairs form from trichoblast cells that express RBOHC and

249 trichoblasts and elevated frequency of root hair formation compared with the wild type.

250 dants control the level of H(2)O(2) and root hair formation.

251 oss of BMP signaling in the lineage leads to hair graying due to a block in melanocyte maturation.

252 Stress has long been associated with hair graying, yet there is little evidence to substantia

253 Instead, hair greying results from activation of the sympathetic

254 report that, in mice, acute stress leads to hair greying through the fast depletion of melanocyte st

255 Canities (or hair greying) is an age-linked loss of the natural pigme

256 that define 56 cell types and states during hair growth and rest.

257 d postnatal day 18 and did not depend on the hair growth cycle.

258 promote barrier function, wound healing and hair growth, while limiting cancer development.

259 The increases in ROS and root hairs in tt4 are reversed by genetic or chemical complem

260 o truncatula requires repolarization of root hairs, including the rearrangement of cytoskeletal filam

261 role for one ROS, H(2)O(2), in driving root hair initiation and demonstrated that localized synthesi

262 Auxin-induced root hair initiation and ROS accumulation were reduced in an

263 Motile cilia are highly complex hair-like organelles of epithelial cells lining the surf

264 particular, twitching-mode motility employs hair-like pili to transverse moist surfaces with a jitte

265 Chemotherapy-induced hair loss (alopecia) (CIA) remains a major unsolved prob

266 nner fibers and can result in female-pattern hair loss.

267 as recombinant Shh protein partially rescued hair loss.

268 , the downregulation of Shh signaling in the hair matrix is a critical early event.

269 ves both MeSCs and melanocytes of the anagen hair matrix of proinflammatory signals required for full

270 The decontamination of hair may therefore be challenging for first responders,

271 Median metal concentrations were as follows: hair Mn, 0.08 mug/g; hair Cu, 9.6 mug/g; hair Cr, 0.05 m

272 (n = 444), and (c) cortisol concentration in hair (n = 1210).

273 cid-specific isotope ratio analysis of scalp hair of American individuals to predict soft biometric t

274 The scalp hair of each donor was washed, dried, homogenized and ac

275 simulate contamination of uncovered skin and hair of health care workers wearing personal protective

276 late (BeS) applied to and recovered from the hair of volunteers.

277 he role of Wnt ligands in the orientation of hairs of Drosophila wings, an established system for the

278 of-function lines phenocopy the stunted root hair phenotype of other Atget lines, its heterologous ex

279 '))-bi(2H-1,4-benzothiazine) scaffold of red hair pigments is disclosed herein.

280 mpaired movement of basal progenitors during hair placode morphogenesis and diminished migration of m

281 hortness of breath, fear of progression, and hair problems) of the five multi-item scales showed resp

282 g, shortness of breath, fear of progression, hair problems, and surgery-related symptoms) plus 15 sin

283 ptomics with genetics, we show that emerging hair progenitors produce both WNTs and WNT inhibitors.

284 Without NFI TFs, SCs lose their hair-regenerating capability, and produce skin bearing s

285 ons with hair follicle stem cells to promote hair regeneration in response to cold.

286 ower with 4% chlorhexidine soap, appropriate hair removal, adequate preoperative systemic antibiotic

287 Carbon and nitrogen isotope ratios in hair sampled from 65 communities across the central and

288 72 weeks, and concentrations of tenofovir in hair samples from individuals reporting HIV risk and adh

289 sease, characterized by severe skin disease, hair shaft defects, atopic diathesis, and increased susc

290 red for severity of skin condition, specific hair shaft defects, atopy, and recurrent infections.

291 gh performance for analysis of these dyes in hair shampoo and an orange juice as real samples with ac

292 associated with lower ART concentrations in hair, suggesting that food insecurity may be associated

293 Most angiosperms produce trichomes-epidermal hairs that have protective or more specialized roles.

294 ves, which depletes the stem cells that give hair their color.

295 , from police samples, biological fluids and hair to sewage water has risen.

296 Tail hair, toenail, faeces, plasma and urine were collected q

297 Hair treatments, such as chemical straitening and dying,

298 subcellular distribution of lipids in human hair was investigated to better understand their role in

299 In 78 mother-infant dyads, maternal hair was sampled postnatally, and infants underwent magn

300 Our findings showed that greater hair zinc levels were associated with lower brain activi