ライフサイエンスコーパス: hair growth

1 ation, melanocyte development and apoptosis, hair growth).

2 , and cellular development (for example root hair growth).

3 rther suggest a crucial role of LIPH gene in hair growth.

4 s an important role in the control of normal hair growth.

5 ify how JAK-STAT signaling actively inhibits hair growth.

6 ing certain phases of normal or pathological hair growth.

7 e active phase), thereby facilitating robust hair growth.

8 neurogenic skin inflammation, which inhibits hair growth.

9 ding of the complex network governing cyclic hair growth.

10 med calcium spiking) and alterations in root hair growth.

11 o Peronospora parasitica infection, and root hair growth.

12 pheomelanogenesis and eumelanogenesis during hair growth.

13 tion of TAT-Cre recombinase failed to affect hair growth.

14 reduced inflammatory response and increased hair growth.

15 plays a critical role in the maintenance of hair growth.

16 n and cytoprotection to appetite control and hair growth.

17 rate the dermal papilla, a key component for hair growth.

18 novers and five cycles of depilation-induced hair growth.

19 transit-amplifying cells (TAC) that maintain hair growth.

20 been used to address the cyclical nature of hair growth.

21 act in the same pathway in the regulation of hair growth.

22 follicle cycle, with concomitant accelerated hair growth.

23 of mice, and have investigated their role in hair growth.

24 ir follicles to enter anagen with consequent hair growth.

25 oisomer, 17-alpha-estradiol, did not inhibit hair growth.

26 telogen and enter anagen, thereby initiating hair growth.

27 ining protein, as a unique repressor of root hair growth.

28 edling photomorphogenesis, and root and root hair growth.

29 itor expansion associated with the phases of hair growth.

30 , is both necessary and sufficient to induce hair growth.

31 ss-induced inhibition of HFSC activation and hair growth.

32 1 were required for the nociceptor-triggered hair growth.

33 nstrations that HAP stem cells can stimulate hair growth.

34 AtSfh1 activity in supporting polarized root hair growth.

35 morpha rhizoid and Arabidopsis thaliana root hair growth.

36 re may have therapeutic potential to promote hair growth.

37 ablishment and maintenance of polarized root hair growth.

38 ify genes regulated by RSL4 that affect root hair growth.

39 he hair follicle environment that may impact hair growth.

40 in inflamed tissues, skin sensitization, and hair growth.

41 ges in root length, root branching, and root hair growth.

42 aling promoted adipocyte differentiation and hair growth.

43 ial therapeutic targets for modulating human hair growth.

44 ities to fine tune Wnt signaling for desired hair growth.

45 B to activate Shh in matrix cells to sustain hair growth.

46 me mobilized to fuel tissue regeneration and hair growth.

47 sm to restore both DP cell number and normal hair growth.

48 he population dynamics resulting in rhythmic hair growth.

49 hh signaling contributes to DP formation and hair growth.

50 otheses about the impact of interventions on hair growth.

51 s the role of the inner root sheath in human hair growth.

52 tle is known of their functions in postnatal hair growth.

53 .0, 13] mm wide, corresponding to 1 month of hair growth.

54 ar structure of root hairs, and reduces root hair growth.

55 PS, used as a control, had no effect on root hair growth.

56 ling pathway with an essential role in human hair growth.

57 n Arabidopsis resulted in inhibition of root hair growth.

58 major effect of altered lipid metabolism on hair growth.

59 (RSL4) is necessary and sufficient for root hair growth(2).

60 ssion of these constructs results in stunted hair growth, a phenotype that has also been observed in

61 tinib and afatinib, "alopecia"in erlotinib, "hair growth abnormal" in afatinib, but not in "nausea" a

62 important implications toward restoration of hair growth after injury, disease, and aging.

63 e viable and fertile but display accelerated hair growth after shaving and also enlarged meibomian gl

64 % of Epi-Insig-DKO mice exhibited defects in hair growth along with other skin abnormalities, includi

65 root hair tip growth based on disrupted root hair growth and [Ca(2+)](cyt) signatures in mlo15-4.

66 e results support the hypothesis that murine hair growth and attendant melanogenesis can be regulated

67 , in human hair follicles, thereby promoting hair growth and causing hypertrichosis.

68 as associated with a marked decrease in root hair growth and curling.

69 nd matrix cells may play roles in regulating hair growth and cycling.

70 ions of the hair follicle that contribute to hair growth and cycling.

71 ucidate a molecular mechanism that regulates hair growth and development, particularly in controlling

72 esults suggest that lipase H participates in hair growth and development.

73 length, suggesting a role for AGC2-1 in root hair growth and development.

74 g molecular mechanisms of Hoxc13 function in hair growth and development.

75 patterns and influence different aspects of hair growth and development.

76 cycle suggests a possible role in regulating hair growth and differentiation.

77 nd fibroblast-supported mechanism to promote hair growth and enabling the efficient restoration of th

78 eatment, the hydrogel scaffolds promoted new hair growth and epidermal morphology and thickness simil

79 ras(G12D)) in the skin had strong effects on hair growth and hair shape, steady state changes in down

80 t improved follicle vascularization promotes hair growth and increases hair follicle and hair size.

81 naling in the niche dramatically accelerates hair growth and induces follicle multiplication in mice.

82 e role of Bcl-2 expression in the control of hair growth and keratinocyte apoptosis, we have used tra

83 showed that exogenous glutamic acid promotes hair growth and keratinocyte proliferation.

84 ure of the epidermis that is responsible for hair growth and lubrication of the epithelium.

85 microtubule cytoskeleton is involved in root hair growth and orientation, we applied microtubule anta

86 i-organs that cycle through phases of active hair growth and pigmentation (anagen), apoptosis-driven

87 argets for therapeutic intervention in human hair growth and pigmentation disorders.

88 study demonstrates that dWAT regulates human hair growth and pigmentation through HGF secretion, and

89 ies of hair matrix progenitors that regulate hair growth and pigmentation, partly by creating an SCF-

90 that define 56 cell types and states during hair growth and rest.

91 The molecular mechanisms controlling human hair growth and scalp hair loss are poorly understood.

92 zed role for WNT signaling in the control of hair growth and structure, as well as presenting the fir

93 t be guided largely by patient distress with hair growth and subjective perceptions as opposed to cli

94 including the dermal papilla that regulates hair growth and the arrector pili muscle, which controls

95 ing reliably interpretable murine studies on hair growth and to highlight key experimental caveats to

96 ose their stem cell potency to contribute to hair growth and undergo premature differentiation instea

97 ated from tissue prior to, during, and after hair growth and used to probe Affymetrix Drosophila gene

98 ta(18)O values (which can indicate season of hair growth) and 25(OH)D(3) concentrations in some indiv

99 or Mpzl3 in the control of skin development, hair growth, and adipose cell functions.

100 milestones-including Tanner stages, axillary hair growth, and age at menarche or voice break and firs

101 mal differentiation, skin barrier formation, hair growth, and eye function.

102 ed numbers of lateral roots and reduced root hair growth, and fails to support normal root colonisati

103 vulgaris, acne scars, skin rejuvenation and hair growth, and for therapeutic applications including

104 decreased body mass, lordokyphosis, reduced hair growth, and generalized fat, muscle and organ atrop

105 n microinjection is sufficient to induce new hair growth, and pharmacological TGF-beta inhibition res

106 ollicular dermal papilla is known to control hair growth, and steroid hormones regulate receptor and

107 immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NF

108 l labyrinth morphology, lung lobe septation, hair growth, and vascularization of kidney glomeruli.

109 results in impaired epidermal proliferation, hair growth, and wound healing.

110 as undetectable in telogen, increased during hair growth, and, after reaching the highest values in a

111 characterize the biological role of VEGF for hair growth, angiogenesis, and follicle cycling.

112 Topical treatments to modulate hair growth are generally limited by low drug bioavailab

113 the mechanisms by which they regulate human hair growth are still poorly understood.

114 r findings have therapeutic implications for hair growth as well as chronic wounds and cancers, where

115 reservoir of epidermal stem cells, promoting hair growth, as well as stimulating tissue repair after

116 In vivo hair growth assays showed that GFP-positive cells could

117 steroid molecule, RHP1, which promotes root hair growth at nanomolar concentrations without obvious

118 c acid has long been known to alter skin and hair growth but an exact mechanism is unclear.

119 root hair tip is not only essential for root hair growth, but also dependent on the cytoplasmic calci

120 within the hair follicle maintain the cyclic hair growth, but whether these stem cells also contribut

121 rpolarization in dermal fibroblasts promotes hair growth by enhancing fibroblasts Wnt signaling respo

122 n IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain H

123 Wild-type cells are co-opted into new hair growths by beta-catenin mutant cells, which non-cel

124 m, corresponding to approximately 10 days of hair growth, by using a high spatial resolution exit con

125 Hair growth can be induced from resting mouse hair folli

126 Hh-agonist-induced hair growth caused no detectable differences in epiderma

127 sing in vivo imaging we found that, early in hair growth, cells have multiple actin bundles and hairs

128 te factors that are expressed or lost during hair growth cessation.

129 netic alopecia (AGA) is a condition of scalp hair growth characterized by progressive miniaturization

130 minoxidil and that tolbutamide may suppress hair growth clinically; novel drugs designed specificall

131 of Krox20 lineage cells results in arrest of hair growth, confirming the critical role of KROX20(+) c

132 Thus, hair growth constitutes a major experimental variable th

133 crine and/or autocrine functions, such as in hair growth control.

134 n of DNA methylation as a novel approach for hair growth control.

135 Most strategies to enhance Wnt signaling for hair growth create a state of constitutive Wnt activatio

136 licular location even upon completion of the hair growth cycle 21 d later.

137 jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into

138 sting hair follicles were recruited into the hair growth cycle and epithelial outgrowths formed from

139 ical; however, the factors that regulate the hair growth cycle are still poorly understood.

140 adverse effect may produce insights into the hair growth cycle as well as potential therapeutic targe

141 Researchers should be aware that hair growth cycle drives prominent molecular, cellular,

142 modelling during the regression phase of the hair growth cycle is coordinated by the contraction of t

143 The hair growth cycle is generally recognized to comprise ph

144 ave made use of the fact that in rodents the hair growth cycle is synchronized, well characterized, a

145 pression in the bulge was independent of the hair growth cycle stage.

146 was delivered during different stages of the hair growth cycle, followed by histologic and gross obse

147 eted by adipocytes are known to regulate the hair growth cycle, it is unclear whether the epidermis c

148 In the telogen phase of the hair growth cycle, PAI-2 was limited to the postmitotic

149 ts in the follicle outer-root sheath and the hair growth cycle, respectively, the hair defect in the

150 ent increased hair survival during the first hair growth cycle, the level of protection having a slig

151 elanocytes in epidermis to UV nonresponsive, hair growth cycle-coupled melanogenesis in hair follicle

152 ilaggrin-negative matrix cells and displayed hair growth cycle-dependent expression.

153 cation and differentiation status during the hair growth cycle.

154 a4 in a highly coordinated manner during the hair growth cycle.

155 rent stages of the depilation-induced murine hair growth cycle.

156 observed in conjunction with changes in the hair growth cycle.

157 expression at different stages of the human hair growth cycle.

158 d postnatal day 18 and did not depend on the hair growth cycle.

159 icles are in the anagen stage of their first hair growth cycle.

160 o function as mediators or regulators of the hair growth cycle.

161 the follicle during the anagen phase of the hair growth cycle.

162 plies a regulatory role for IGF-I during the hair growth cycle.

163 hronizing adipocyte differentiation with the hair growth cycle.

164 al proliferation and differentiation and the hair growth cycle.

165 l and spatial expression patterns during the hair-growth cycle by quantitative real-time PCR and in s

166 icroarray dataset of mRNA expression for the hair-growth cycle in mouse back skin, predicting both pr

167 The hair-growth cycle is an example of a cyclic process that

168 ls may provide a mechanism through which the hair-growth cycle is regulated by cell survival.

169 t many more genes may be associated with the hair-growth cycle than have been identified in the liter

170 The hair-growth cycle, a complex biological system requiring

171 in that are associated specifically with the hair-growth cycle.

172 transcription factor in the midphase of the hair-growth cycle.

173 nt, using a model of predictable synchronous hair growth cycles in the infantile and adolescent mice.

174 are not significantly depleted by successive hair growth cycles.

175 atonin has been experimentally implicated in hair growth cycling, pigmentation physiology, and melano

176 ho show an inherited form of hair loss and a hair growth defect.

177 known as GC13 mice), known to develop severe hair growth defects and alopecia, as a tool for defining

178 aging and pharmacologic modification of root hair growth defects in rhd3 suggest that there is interp

179 The severe hair growth defects observed upon aberrant expression of

180 Hair growth defects of homozygous toku mice were partial

181 riants, but not ACT7, fully rescued the root hair growth defects of single and double mutants.

182 d to elevated lipid synthesis and subsequent hair growth defects.

183 y mice showed almost complete restoration of hair growth, dermal ridges, sweat glands and molars.

184 e of vitamin D receptor in the regulation of hair growth directly, we used the human keratin 14 promo

185 y provide useful therapeutic tools for human hair growth disorders based on premature or retarded cat

186 agonists may be useful for the management of hair growth disorders characterized by premature entry i

187 e underlying principles of hair development, hair growth disorders, and skin cancers.

188 HF cycling abnormalities underlie many human hair growth disorders, the accurate classification of in

189 In addition, hair growth from grafted wrfr skin is impaired.

190 often ensue, such as strictures, infection, hair growth, graft shrinkage, diverticuli, and even mali

191 psychoemotional stress can have an impact on hair growth has been treated with skepticism and assigne

192 veral processes, including limb development, hair growth, hearing and gametogenesis.

193 y RHD2/AtrbohC NADPH oxidase is required for hair growth; here we show that SCN1/AtrhoGDI1 is a compo

194 ors involved in wound healing and regulating hair growth; however, their role in skin regeneration af

195 skin effects, namely drug-induced excessive hair growth (hypertrichosis), is insufficiently understo

196 scoring method assessing androgen-dependent hair growth in 9 body areas.

197 ifluoromethylornithine could also reactivate hair growth in animals with complete hair loss.

198 into the cytoplasm that is required for root hair growth in Arabidopsis thaliana.

199 , but also provide a new tool to modify root hair growth in different plant species.

200 Stimulation of hair growth in hair loss has been a difficult goal to ac

201 ve identified FGF5 as a crucial regulator of hair growth in humans for the first time, to our knowled

202 leted rat cortical neurons and impaired root hair growth in loss-of-function mutants of the ATL1 orth

203 Hair growth in mice is neither asynchronous nor fully sy

204 verexpression is sufficient to induce robust hair growth in mice, whereas germline and conditional de

205 air follicle stem cell (HFSC) quiescence and hair growth in mice.

206 re, we report that thymosin beta4 stimulates hair growth in normal rats and mice.

207 owed marked acceleration of the onset of new hair growth in the region of AdShh administration to ski

208 the PPR in the hair cycle, we have evaluated hair growth in the traditional K14-PTHrP (KrP) and an in

209 ture has been established for some time, but hair growth in vitro is limited and generally terminates

210 ha and IL-1 beta are important inhibitors of hair growth in vitro.

211 ose their HF-inducing properties, but during hair growth in vivo, they reside within the HF bulb and

212 Thus, thymosin beta4 accelerates hair growth, in part, due to its effect on critical even

213 During hair growth, increase in total follicular papilla size w

214 a-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla

215 otection was maintained during two cycles of hair growth indicated that the clonogenic cells had been

216 ation of a specific COX-2 inhibitor restored hair growth, indicating that the alopecia was attributab

217 or on epithelial hair cells, rescue enhanced hair growth induced by dermal nevus melanocytes.

218 As a hair growth inducer, noggin increases Shh mRNA in the HF

219 ase induction in postnatal skin and that the hair growth-inducing effect of noggin is mediated, at le

220 preactivation reduced premature catagen and hair growth inhibition induced by oxidative stress (H2O2

221 Hair growth is associated with pronounced vascular-endot

222 In mammals hair growth is cyclical; however, the factors that regul

223 These data confirm that the cessation in hair growth is not due to a loss of the inductive capaci

224 ing high levels of E2F1, mice have decreased hair growth likely as a result of aberrant apoptosis in

225 ponses to pathogen infection and normal root hair growth, linking defense response regulation with th

226 cyclical and initially synchronous nature of hair growth makes the hair follicle an ideal system with

227 , weight gain, Anti-Mullerian Hormone (AMH), hair growth, menstrual irregularity, fast food consumpti

228 in the skin to increase skin permeability to hair growth-modulating drugs.

229 testing may facilitate testing of candidate hair growth modulatory agents in human HF organ culture

230 During hair growth Mwh is found in growing hairs, where we sugg

231 As stem cells become activated during hair growth, NFATc1 is downregulated, relieving CDK4 rep

232 Tanner stage 5 for pubic hair growth occurred 6-9 months later on average for boy

233 ce by topical treatment and promoted obvious hair growth on mice.

234 l treatments for selected disorders of human hair growth or pigmentation (e.g., chemotherapy-induced

235 r genitalia growth, Tanner stage 5 for pubic hair growth, or testicular volume (TV) >/= 20 mL in eith

236 intervention modalities in distinct skin and hair growth pathologies.

237 l modulation of gene expression, stimulating hair growth pathways while suppressing fibrosis and infl

238 s, including increased body weight, abnormal hair growth pattern, lymphoma, mammary tumors, and endom

239 We also reviewed early accounts of "hair growth patterns" from classical literature.

240 nd by delayed entry and progression into the hair growth phase (anagen).

241 ction in embryonic skin, initiation of a new hair growth phase in postnatal skin requires neutralizat

242 administration of noggin protein induces new hair growth phase in postnatal telogen skin in vivo.

243 of BMP4 signaling by noggin is essential for hair growth phase induction in postnatal skin and that t

244 ws that MadB1-4 contribute to polarized root hair growth, phenocopying myosins, whereas MadA1-4 are r

245 ty is commonly misconstrued as a significant hair growth phenotype in mutant mice or in drug-treated

246 y be the long-sought 'chalone' inhibitors of hair growth postulated by classical experiments.

247 e follicular epithelial cells to prolong the hair growth process.

248 f the agouti signaling protein (ASIP) during hair growth produces the red/yellow pigment pheomelanin.

249 d phenotype toku is characterized by delayed hair growth, progressive hair loss, and excessive accumu

250 Finally, we assessed the hair growth-promoting effects of lipids using in vitro h

251 xidil and acyclovir to improve modulation of hair growth promotion and inhibition, respectively.

252 lysis, are less useful due to differences in hair growth rate between individual hairs.

253 cells, which do not normally participate in hair growth, re-populate the lost stem-cell compartment

254 e as well as the apical localization of root hair growth regulator ROP2 is oscillated in rhd3 Interes

255 DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1

256 ementation in the culture medium upregulated hair growth-related genes and promoted the proliferation

257 factors for multiple hair morphogenesis and hair-growth-related pathways.

258 onic hair follicle development and postnatal hair growth rely on intercellular communication within t

259 ce, effective strategies for promoting human hair growth remain elusive.

260 egulate hair follicle progenitors to control hair growth remains unclear.

261 4) that encodes the master regulator of root hair growth, repressing RSL4 translation and thus root h

262 In plants, root hair growth requires polar nuclear migration into the ou

263 es in both mouse and man suggest that proper hair growth requires their spatio-temporally coordinated

264 ng this pulse is modulated as part of a root hair growth response to low phosphate.

265 ith a neutralizing anti-VEGF antibody led to hair growth retardation and reduced hair follicle size.

266 L4 feedback regulatory loop that limits root hair growth, shedding new light on the mechanism underly

267 mutant, which is defective in sustained root hair growth, showed an altered [Ca2+]c distribution comp

268 erties and home back to the bulge niche when hair growth stops.

269 ely related dermal fibroblasts, can maintain hair growth suggesting cell type-specific molecular sign

270 c skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity.

271 our data identify Sox2 as a key regulator of hair growth that controls progenitor migration by fine-t

272 We find that the DKO mice have a defect in hair growth that is markedly worse than that of SGK3(-/-

273 ur understanding of the regulation of normal hair growth, the basis of hereditary hair loss diseases,

274 s, e.g., minoxidil and diazoxide, can induce hair growth, their mechanisms require clarification.

275 hlight the importance of lipids in promoting hair growth through HIF-1 signaling, suggesting that thi

276 mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular

277 cells and their progeny to fuel and maintain hair growth throughout the life of an organism.

278 ynamic adipogenic program that occurs during hair growth to uncover an unrecognized regulator of ASC

279 These transgenic mice have delayed hair growth, underdeveloped ears, and shorter tails.

280 duced Spp1-expressing dermal fibroblasts and hair growth via a TRPV1 neuron and CGRP-dependent mechan

281 Here, we explore why hair growth wanes with age.

282 Similar defective hair growth was observed in kinase-inactive GK5 mutant m

283 ch stochasticity is that precise patterns of hair growth waves differ from mouse to mouse, even in li

284 Furthermore, hair growth waves in mice are initiated by probabilistic

285 genetic disorder characterized by excessive hair growth, we discover that chromatin deletions or an

286 aBK allele, somatic, testicular, genital and hair growth were grossly affected and influenced by the

287 Moreover, isolated dermal tissue induced hair growth when implanted into inactivated hair follicl

288 retards anagen entry and consequently delays hair growth, whereas loss of Msi2 enhances hair regrowth

289 lly produced signalling factors that sustain hair growth, whereas the molecular basis of AGA in women

290 duced a profound and prolonged inhibition of hair growth while treatment with the biologically inacti

291 promote barrier function, wound healing and hair growth, while limiting cancer development.

292 efects were found in HAT-L4 knockout mice in hair growth, wound healing, water repulsion and body tem