ライフサイエンスコーパス: hairpin

1 d higher levels when clustered with a helper hairpin.

2 also on WT TM3/4 and other mutations in the hairpin.

3 tually incompatible pseudoknots and a double hairpin.

4 eculated to fold independently into an alpha-hairpin.

5 elix interaction motif created in the mutant hairpin.

6 and the RNA polymerase that transcribes the hairpins.

7 of a base-pair mismatch in the duplex of the hairpins.

8 e microRNAs (miRNAs) that populated unfolded hairpins.

9 riants with a high affinity for pre-microRNA hairpins.

10 mediated by formation of single-stranded DNA hairpins.

11 ion, accruing structures in units of helical hairpins.

12 ough the unfolding and folding of single DNA hairpins.

13 found to contain beta-structure elements and hairpins.

14 witches constitute sensors for detecting RNA hairpins.

15 expansion mechanisms at the level of slipped hairpins.

16 ist in the processing of otherwise defective hairpins.

17 ping dynamics and conformations of (CAG)n TR hairpins.

18 ing the DNA's original structure or the beta-hairpins.

19 connected along the tail by the splayed beta-hairpins.

20 6 orders of magnitude better than standalone hairpins.

21 We noted that the upstream attenuator hairpin activity is also functionally retained in both v

22 ted by modification of the Upper Stem, first Hairpin and 3' end.

23 l electrophoresis results, the abundances of hairpin and duplex DNA are unaffected by the addition of

24 simultaneously and sequentially bind to both hairpin and duplex DNA.

25 l features observed in the Varkud satellite, hairpin and hammerhead ribozyme classes.

26 res Microprocessor recognition of the helper hairpin and linkage of the two hairpins, yet predominant

27 dly converts from an alpha-helix into a beta-hairpin and moves to interact with the acceptor stem of

28 tropic stability within the tip of the alpha-hairpin and on neighboring N-terminal domain residues.

29 ily insert U1A binding sites into ubiquitous hairpin and/or loop structures should make this approach

30 d T cell tumors, because failure to open DNA hairpins and accumulation of chromosomal breaks may redu

31 deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects.

32 -23) and Abeta(30-36) that fold to form beta-hairpins and assemble to form trimers.

33 amically stable secondary structures such as hairpins and quadruplexes.

34 ation machinery leads to the cleavage of the hairpins and to the activation of the nicking/replicatio

35 hough structures of the autoinhibited (alpha-hairpin) and active (beta-barrel) states and plausible r

36 Pri-miRNAs often contain multiple miRNA hairpins, and this clustered arrangement can assist in t

37 The top part of this imperfect hairpin aptamer was modified in such a way that it can e

38 s composed of regularly arranged standing-up hairpin aptamers.

39 mbling a library of nucleic-acid strands and hairpins as functional modules for evolving networks.

40 s carrying two pairs of metastable catalytic hairpin assembled (CHA) probes, AS1411 aptamer, and pend

41 s, triplex structure formation and catalytic hairpin assembly are discussed.

42 livered the trigger strand of CHA (catalytic hairpin assembly) reaction through a cyclic amplificatio

43 Here, we present a cleavable hairpin beacon (CHB)-enhanced fluorescence detection for

44 tif (DSM), the OB-fold, and a conserved beta-hairpin (beta-HP) in mouse DHX36 in the remodeling of RN

45 tional changes and confers high-affinity RNA hairpin binding, which may be advantageous for functiona

46 le base mismatch at the position next to the hairpin both in vitro and in vivo.

47 sed and conformational fluorescein arsenical hairpin-BRET sensors coupled with high-resolution fluore

48 lization effect not only on the E217G mutant hairpin, but also on WT TM3/4 and other mutations in the

49 nd HIV-1-1 ribosomal frameshift-inducing RNA hairpin, but not ssRNAs or DNAs, at 200 mM NaCl, pH 7.5.

50 Reducing strand slipping in TR hairpins by sequence interruptions at the loop suggests

51 While the cleavage of the hairpins by the constituents associated with the parent

52 d the RNA strand, facilitating pol beta loop/hairpin bypass synthesis and the resolution of TNR R-loo

53 viruses (AAVs) 2 or 8 directed against short hairpin ChREBP to normalize hepatic ChREBP activity to l

54 of these aptamers revealed that A1 adopts a hairpin conformation.

55 Here, using a helical-hairpin construct derived from CFTR's transmembrane (TM)

56 on titration of Nterm and Nterm-ACB with RNA hairpins containing double-stranded regions.

57 We propose that these short hairpins correspond to metastable structures that are tr

58 ntragenic suppressor mutant of the priA beta-hairpin deletion mutant in which 22 codons around the de

59 homopolymers containing as few as 10 tandem hairpins displayed ensemble unfolding/refolding transiti

60 op (so-called kissing) interactions with RNA hairpins displaying partly complementary apical loops.

61 yBac transpososomes: a synaptic complex with hairpin DNA intermediates and a strand transfer complex

62 racterized a flap endonuclease 1 (FEN1) plus hairpin DNA probe (hpDNA) system, designated the HpSGN s

63 The mechanism by which netropsin binds to hairpin DNA remains controversial with two competing mec

64 Here, I demonstrate that hairpinned DNA ends are ineffective for activating the k

65 However, hairpinned DNA ends robustly stimulate certain DNA-PK au

66 y phosphorylated when DNA-PK is activated by hairpinned DNA ends.

67 he second strand cleavage and formation of a hairpin-DNA product requires a global scissor-like movem

68 lly disordered short linear motif and a beta-hairpin docking domain.

69 A mutant lacking the methionine-rich hairpin domain characteristic of this laccase conserves

70 f-function mutations in the flexible helical hairpin domain HP2 and applied linear free energy relati

71 such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-alph

72 this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topolog

73 Strand slipped hairpins during DNA replication, repair and/or recombina

74 lease Artemis is responsible for opening DNA hairpins during V(D)J recombination and for processing a

75 Removal of residues at the tip of the beta-hairpin eliminated PriA DNA unwinding, interaction with

76 ore alpha/beta hydrolase-fold domain and the hairpin, exhibited hormone-independent interactions with

77 s in lipid bilayers, we found that the E217G hairpin exhibits an altered adaptive packing behavior st

78 approach using a small fluorescein arsenical hairpin (FlAsH) targeted to a short tetracysteine sequen

79 llular membranes, depends on the native long-hairpin fold of its RNA to confer functionality.

80 s G4 structures formed relatively quickly, G-hairpins folded extremely slowly, indicating that short

81 treat loop-sequence and ionic effects on RNA hairpin folding.

82 ctures of three types reveal similar 'kinked hairpin' folds, in which the second and third repeats pa

83 ort CPEB3 sequence by zipping it into a beta-hairpin form.

84 t with a mechanism of nucleotide addition by hairpin formation and back-priming.

85 inetics and thermodynamics of DNA duplex and hairpin formation in crowded environments.

86 strand breaks (DSBs) revealed that long-stem hairpin-forming sequences could form foldback inversions

87 mal or distal to the DSB, whereas short-stem hairpin-forming sequences formed foldback inversions whe

88 free-energy landscapes for the different RNA hairpin-forming sequences with variable salt conditions.

89 gnaling aptasensors for the detection of RNA hairpins from the previously described malachite green (

90 Photoexcitation of NDI in these DNA hairpins generates high-yield, long-lived, entangled spi

91 gered reconfigured CDNs are subjected to two hairpins H(C) and H(D), the templates I'/I and J'/J, and

92 e triggered reconfigured CDNs to predesigned hairpins H(E) and H(F), the templates M'/M and N'/N, the

93 Subjecting the parent auxiliary CDN to two hairpins, H(A) and H(B), and two templates T(A) and T(B)

94 By contrast, we show that the beta-hairpin has an inhibitory role in the tail-tube precurso

95 A has a positively charged cleft and a helix-hairpin-helix DNA-binding motif found in other DNA repai

96 d positively charged residues near predicted hairpin hinges that become less constrained in the LD en

97 ures of NEases, modified DNA probes (such as hairpin (HP) probes, molecular beacons, and G- quadruple

98 ed by binding of the protein HEXIM to the 5' hairpin (HP1) of 7SK RNA.

99 We show that Pf3 is inserted as a helical hairpin, i.e., the prospective transmembrane segment mov

100 paired duplex and antiparallel unimolecular hairpin in a pH-dependent manner.

101 eraction between the sensor and the C-linker hairpin in the adjacent pore subunit is the primary dete

102 observe that ribosomes occasionally open the hairpin in two successive sub-codon steps, revealing a p

103 to probe the folding status of reconstituted hairpins in lipid bilayers, we found that the E217G hair

104 s exhibit catalytic properties to cleave the hairpins in the library.

105 A Wnt hairpin inserts into a conserved hydrophobic cavity in t

106 ere we use CRISPR/Cas9 and conditional short hairpin interfering RNA to perform loss-of-function stud

107 ls the obligatory attainment of a non-native hairpin intermediate (H1) that eventually rearranges int

108 The results show that the excised TTAA hairpin intermediate and the TTAA target adopt essential

109 direct visualization of the hypothesized pre-hairpin intermediate of HIV-1 Env and improve our unders

110 d to target cells by Envs in an extended pre-hairpin intermediate state.

111 g the process where gp41 switches from a pre-hairpin intermediate to its post-fusion 6-helical bundle

112 s in a reverse complementary fashion forming hairpins interspersed with bulge loops at distinct posit

113 tion cannot occur in (CAG)n = odd, where the hairpin is "frustrated'' and slips back and forth betwee

114 e X-ray scattering (SAXS), ADAMTS13 adopts a hairpin-like conformation with distal T7-CUB domains clo

115 ore spans the R2 and R3 repeats and adopts a hairpin-like fold that has similarities to but also clea

116 As a result, the ASO forms a hairpin-like structure.

117 4R inverse agonist, contains an exposed beta-hairpin loop composed of six residues (Arg-Phe-Phe-Asn-A

118 g of arginines within a specific beta2-beta3 hairpin loop that arose during selection.

119 tein are braced by the N-terminus and a beta-hairpin loop, and interconnected along the tail by the s

120 HBsAg peptide epitope revealed a stabilized hairpin loop.

121 gle-stranded regions of a bulged helix and a hairpin loop.

122 substrate-binding site-associated re-entrant hairpin loops.

123 and template during replication and in short hairpin loops.

124 trand is blocked and diverted sideways by OB hairpin-loops of Mcm3, Mcm4, Mcm6, and Mcm7.

125 other class of small RNA using (1) a pre-miR hairpin maturation assay, (2) expression levels in a Dic

126 highly conserved residues on a separate Wnt hairpin might contribute to its transfer to receiving ce

127 -concept, this technique was then applied to hairpin monomers functionalized with a mutant green fluo

128 proteins form soluble, stable alpha-helical hairpin monomers, and MmsFcc successfully controls the f

129 y occur without one or the other of the beta-hairpin motifs in the BHD2 or BHD3 domains.

130 GR-DBD binds to a diverse range of RNA hairpin motifs, both synthetic and biologically derived,

131 re than 30,000 tough decoy miRNA inhibitors (hairpin nucleic acids designed to specifically inhibit i

132 inding by the ProQ NTD required a terminator hairpin of at least 2 bp preceding an 3' oligoU tail of

133 The domain 3a helical hairpin of Vps45 is unfurled, exposing the presumptive R

134 The CHB probe is a single fluorophore-tagged hairpin oligonucleotide with five continuous ribonucleot

135 KD) mice because of the requirement for both hairpin opening and end-ligation during V(D)J recombinat

136 We find that hairpin opening occurs during EF-G-catalyzed translocati

137 -PKcs(-/-) ) abrogates end processing (e.g., hairpin opening), but not end-ligation, whereas expressi

138 lease that associates with DNA-PK to mediate hairpin opening.

139 Small hairpin or small interfering (si)RNAs against the common

140 This phenomenon tolerates changes in hairpin order, linker lengths, and the identities of the

141 igger a cascaded hybridization between these hairpin pairs and thus activate multiple Broccoli fluore

142 m Abeta(1-14) to the parent macrocyclic beta-hairpin peptide 1, which comprises Abeta(16-22) and Abet

143 studied, in our laboratory, macrocyclic beta-hairpin peptides derived from Abeta(16-22) and Abeta(30-

144 tures of hexamers formed by macrocyclic beta-hairpin peptides derived from the central and C-terminal

145 eptide macrocycles, stabilized helices, beta-hairpin peptides, and cross-linked helix dimers in 11 di

146 owed that 2 bound selectively to the miR-515 hairpin precursor in cells.

147 2 selectively targets the microRNA(miR)-515 hairpin precursor to inhibit production of miR-515 that

148 ppressor variant and an Ala-substituted beta-hairpin PriA variant displayed wildtype levels of DNA un

149 of proposed method is as follows: Metastable hairpin probe H(1) was modified on electrode surface, bi

150 othermal amplification by a combination of a hairpin probe hybridization and strand-displacement ampl

151 b as a result of the opening of an electrode hairpin probe on a polydopmine-gold (PDA-Au) composite-m

152 izes an electrode-immobilized stem-loop (DNA-hairpin) probe and two DNA adaptor strands complementary

153 By incorporating different hairpin probes in an alternating DNA copolymer, multiple

154 Proximity-based enhancement of suboptimal hairpin processing provides a rationale for genomic rete

155 ns, yet predominantly manifests after helper-hairpin processing.

156 loop, pore loop 1, and the presensor 1-beta hairpin (PS1-betaH).

157 The response of small hairpin RAGE-infected cells to human recombinant HMGB1 w

158 he processing of microRNAs (miRNAs) from the hairpin regions of primary transcripts (pri-miRNAs).

159 ation reveals that the tip of the C-terminal hairpin (residues 125-145) is stably folded in the autoi

160 Nterm binding to the RNA hairpins resulted in CD spectral shifts consistent with

161 In the case of the hairpin ribozyme, pressure slowed down the self-cleavage

162 tion conditions amenable to catalysis by the hairpin ribozyme.

163 eters and DeltaVs comparable to those of the hairpin ribozymes.

164 e performed targeted injection of NOX2 short hairpin RNA (followed by electroporation to facilitate g

165 genetic screens in the CNS using both short hairpin RNA (shRNA) and CRISPR libraries.

166 However, short hairpin RNA (shRNA) and CRISPR-mediated targeting of ISG

167 In Neuro-2a cells, ZIP12 deficiency by short hairpin RNA (shRNA) depletion or CRISPR/Cas9 genome edit

168 1 (LAMP-1)-positive vesicles based on short hairpin RNA (shRNA) gene silencing and the colocalizatio

169 n regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regeneration but to a lesse

170 antiandrogen resistance in an in vivo small hairpin RNA (shRNA) screen of 730 genes deleted in prost

171 694 lentiviral vector, which encodes a short hairpin RNA (shRNA) targeting BCL11A mRNA embedded in a

172 n stromal fibroblasts using lentiviral short hairpin RNA (shRNA) transduction.

173 of KLF4 were significantly reversed by short hairpin RNA (shRNA)-mediated selective depletion of DPYS

174 pulp stem cells stably transduced with small hairpin RNA (shRNA)-STAT3 into immunodeficient mice reve

175 ild-type mice receiving AAV8-scrambled short hairpin RNA (shSCR).

176 n adeno-associated viral vector (AAV2) short hairpin RNA against GSK3beta.

177 luding gene knockdown (KD) mediated by small hairpin RNA and clustered regularly interspaced short pa

178 ' untranslated region (L-3'-UTR) using short hairpin RNA and investigated changes in cell morphology,

179 We also found that ACK1 depletion with short hairpin RNA decreased EGFR degradation when activated by

180 Furthermore, animals treated with NOX2 short hairpin RNA did not develop sustained AF for up to 12 we

181 peripheral blood CLL cells with STAT3 short hairpin RNA downregulated Wnt5a mRNA and protein levels,

182 e electroporated with SLC7A5 or Slc7a5 short hairpin RNA encoding plasmids.

183 esaturase gene was silenced with a transient hairpin RNA expression, resulting in an albino phenotype

184 Small interfering RNA and small hairpin RNA interference and adenovirus transfection wer

185 on of a lentivirus vector to express a short-hairpin RNA into the mHb or IPn to knock-down Chrna3 tra

186 cterizations such as drug-sensitivity, short hairpin RNA knockdown and CRISPR-Cas9 knockout data reve

187 s specific pharmacologic inhibition or short hairpin RNA knockdown of Akt1 in alveolar macrophages bl

188 Short hairpin RNA knockdown of CLC/Gal-10 in human cord blood-

189 Concurrent, but not individual, short hairpin RNA knockdown of FLOT1/2 and AP2A1/2 reduced IGF

190 Using chemical inhibition, short hairpin RNA knockdown, and gain of function approaches,

191 urring during HIV-1 infection, we used short hairpin RNA knockdown, CRISPR deletion, or Abs specific

192 ivity assays, confocal microscopy, and short hairpin RNA knockout of CLC/Gal-10 expression in human C

193 of a human interferon-stimulated gene short-hairpin RNA library, we identified a viral restriction f

194 rtTa mice (controls) and Rosa-rtTa;TRE-short hairpin RNA mice, which have reversible knockdown of ani

195 chemia with NRF2 knockdown by means of short hairpin RNA or an NRF2 inhibitor was tested.

196 Cdk5 inhibition (genetic knockdown by short hairpin RNA or CRISPR/Cas9 and pharmacologic inhibition)

197 letion of G9a by small interfering RNA/short hairpin RNA or inhibition of G9a by specific pharmacolog

198 rhotekin from airway SM tissues using short hairpin RNA or small interfering RNA prevented NM myosin

199 Results from an short-hairpin RNA screen indicated that MAP3K19 is essential f

200 We demonstrated that the AAV small hairpin RNA targeting Ac45 (AAV-sh-Ac45) impaired cellul

201 Importantly, short hairpin RNA targeting USF2 in pathogenic Th17 cells led

202 idated, and used a novel Cre-inducible short-hairpin RNA virus for MSN-subtype-specific knockdown of

203 Transducing 3D CPCs with Notch1-shRNA (short hairpin RNA) did not reduce retention, but significantly

204 terspaced short palindromic repeats or small hairpin RNA), were incubated with PRL or penfluridol and

205 shRNA (short hairpin RNA)-mediated knockdown of talin1 expression in

206 ncer, or BET protein BRD4 depletion by short hairpin RNA, repressed RUNX1, inhibited cell growth, and

207 th bioluminescence, calcium FLIPR, and short hairpin RNA-based gene-silencing assays.

208 Along these lines, short hairpin RNA-mediated depletion of NRP1, but not the use

209 n an in vivo irradiation model, as did short hairpin RNA-mediated depletion of PKCdelta in vitro In b

210 colonoids derived from DRA-KO mice and short hairpin RNA-mediated DRA knockdown in Caco-2 cells.

211 Using an array of methods, including short hairpin RNA-mediated gene silencing, RNA and ChIP sequen

212 Alternatively, short hairpin RNA-mediated knockdown of TRPV3, like the TRPV3

213 Using short hairpin RNA-silenced human MC line LAD2 and stably trans

214 ibitors dichloroacetate and AZD7545 or short hairpin RNA-specific depletion of PDK1, enhanced the eff

215 tained AF increased by >5-fold in NOX2 short hairpin RNA-treated dogs.

216 lational validity of the Bdnf L-3'-UTR short hairpin RNA-treated mice was confirmed by significant cr

217 Hairpin-RNA knock-down constructs reducing PRP expressio

218 Using short hairpin RNAs (shRNAs) against VASH1, VASH2, and SVBP, we

219 R dependency was confirmed by distinct short hairpin RNAs (shRNAs) and high sensitivity of the cell l

220 Recent studies have shown that short hairpin RNAs (shRNAs) can induce gene-specific knockdown

221 Conversely, Aurora B knock down by short-hairpin RNAs (shRNAs) suppresses AKT/GSK3beta/Snail1 sig

222 n p53 expression was knocked down with short hairpin RNAs (shRNAs).

223 L PKCdelta and SOM in incubation using short-hairpin RNAs against PKCdelta or SOM that we developed a

224 ocked down in SKCO-15 monolayers using small hairpin RNAs and cells were analyzed by immunoblot and i

225 ion of small noncoding RNAs, including short hairpin RNAs for RNAi experiments and guide RNAs for CRI

226 Here, we curated a library of short hairpin RNAs for targeted silencing of all known epigene

227 ere overexpressed or knocked down with short hairpin RNAs in AsPC-1 and MIA PaCa-2 pancreatic cancer

228 ce anisotropy revealed that Nterm binding to hairpin RNAs is weak but that the binding affinity incre

229 mice that express hepatocyte-specific small hairpin RNAs or that were given subcutaneous injections

230 we administered lentivirus-expressing short hairpin RNAs targeting either ERalpha or ERbeta into the

231 deno-associated virus (AAV) expressing short hairpin RNAs targeting GHSR (or a control AAV) for RNAi-

232 with adeno-associated virus-expressing small hairpin RNAs targeting Sptlc2.

233 The existence of single hairpin RNAs that modify both the spliceosome and riboso

234 LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a uniqu

235 using CRISPR-Cas9 or knocked down with small hairpin RNAs, or PRKD1 activity was inhibited with the s

236 d down in macrophages and/or IECs with small hairpin RNAs.

237 knocked down in Hepa1-6 cells by using short hairpin RNAs.

238 protein levels were knocked down with small hairpin RNAs.

239 ered to knockdown PAF1 using inducible small hairpin RNAs.

240 pancreatic cancer cell lines by using small hairpin RNAs; cells were injected intravenously into imm

241 s the synthetic utility of a one-rung (i.e., hairpin) seed species, which, at intermediate times, bif

242 rming pulse-EPR measurements on the shortest hairpin, selective addressing of each spin qubit compris

243 hibit Shc in old mice, lentiviral (LV)-short hairpin Shc versus control-LV were used during FFD.

244 apsulated alginate bead model, induced short hairpin (shRNA) knockdown or overexpression of MCT1 quan

245 a cross-beta unit with a single hydrophilic hairpin stabilized through interdigitated glutamine pack

246 an even(odd) number of hanging bases in the hairpin stem.

247 of DNA duplex formation and the formation of hairpin stems, finding that the reaction rate kon is inc

248 agments and conjugated to the end of two RNA hairpin strands.

249 ts, while another features an unusual duplex hairpin structure adjoined to two stacked parallel and a

250 dy, we designed a sequence with an optimized hairpin structure and show that its biophysical and bioc

251 The ability to accurately predict RNA hairpin structure and stability for different loop seque

252 type hTERT promoter sequence does not form a hairpin structure in solution, but rather folds into a c

253 a modified A1 aptamer that does not adopt a hairpin structure induced formation of amyloid fibrils o

254 The hairpin structure is inconsistent with all of our experi

255 They fold up into a hairpin structure that is cleaved at its base by an enzy

256 creased nuclease sensitivity as unimolecular hairpin structures are converted to parallel-stranded ho

257 Using predesigned hairpin structures as triggers, the network generates fu

258 u or Asp that are preorganized to adopt beta-hairpin structures can serve as ligands and assemble wit

259 what features distinguish primary miRNA from hairpin structures in other transcripts is still lacking

260 By integrating additional hairpin substrates into the system, CDN-dictated emergen

261 bs, was defined based on a shared alphaalpha-hairpin supersecondary structural foundation.

262 of the detection was achieved by the use of hairpin surface-tethered probes and the hybridization ch

263 ramework presented here is developed for RNA hairpin systems, the general method may be applied to in

264 A biosensing event occurred when a hairpin target probe recognized miR-196b as a result of

265 ssible mode of its association with poxvirus hairpin telomeres.

266 n mammalian cells by introducing defined RNA hairpins, termed 'regulation elements (RgE)', in the 5'-

267 ining DNA double-stranded breaks (DSBs) with hairpinned termini.

268 gion is predicted to form an unexpected beta-hairpin that may represent an early amyloidogenic interm

269 structure analysis revealed that JM4 forms a hairpin that penetrates the kinase active site, reinforc

270 Q loop of RF2 is rearranged into a long beta-hairpin that plugs the peptide tunnel, biasing a nascent

271 etailed 3D structures for a set of three RNA hairpins that contain a variable, 15-nucleotide loop seq

272 ypes of hairpins were identified: small-loop hairpins that were suppressed by MRE11, SAE2, SLX1, and

273 MRE11, SAE2, SLX1, and YKU80 and large-loop hairpins that were suppressed by YEN1, TEL1, SWR1, and M

274 ly important regions, including the NTD beta-hairpin, the cyclophilin A-binding loop, residues in the

275 ntities of the helper hairpin, the recipient hairpin, the linker-sequence, and the RNA polymerase tha

276 er lengths, and the identities of the helper hairpin, the recipient hairpin, the linker-sequence, and

277 d to a family of designed, zinc-binding beta hairpins, the alterations in the Hst-5 UVRR spectrum are

278 as short telomeric oligonucleotides form a G-hairpin, their longer counterparts form parallel and/or

279 s are conformationally restricted within the hairpin, these structural constraints are relieved in th

280 e also observed that addition of a 20 nt RNA hairpin to the 5' end of a gRNA still supported RNP form

281 n one mechanism, netropsin binding induces a hairpin-to-duplex DNA transition.

282 The hairpin turns formed by pT37/pT46 are remarkably stable

283 olling the oligomerization of metastable DNA hairpins using the hybridization chain reaction (HCR) is

284 Putative pause hairpins were identified for 225 of the 342 strongest Nu

285 Two types of hairpins were identified: small-loop hairpins that were

286 Especially stable hairpins were predicted to form near five shared breakpo

287 usG-dependent pause sites, and some of these hairpins were shown to function in vitro.

288 ch up to 473 identical sensing elements (DNA hairpins) were introduced by rolling circle amplificatio

289 establish that this motif folds into a beta-hairpin, which binds a site in the SNX5/SNX6 phox homolo

290 erminal domain of RfaH refolds from an alpha-hairpin, which is bound to RNA polymerase binding site w

291 ations reveal compensatory roles of the beta-hairpins, which may render robustness in dealing with an

292 ving a J-domain (an ~70-residue-long helical hairpin with a flexible loop and a conserved His-Pro-Asp

293 emperature of both an 8-mer DNA duplex and a hairpin with a stem of 6-nt depending on the excluded vo

294 We find that miR-451, which derives from a hairpin with a suboptimal terminal loop and a suboptimal

295 ifferent fold consisting of two stacked beta-hairpins with opposing beta-strands connected by two par

296 By designing metastable DNA hairpins with shape-defining intramolecular hydrogen bon

297 are prepared within chromophore-modified DNA hairpins with varying spin qubit distances, and are prob

298 quence, we predicted the formation of stable hairpins within close proximity to all future breakpoint

299 of the helper hairpin and linkage of the two hairpins, yet predominantly manifests after helper-hairp

300 Cleavage of the hairpins yields fragments, which reproduces T(1) to repl