ライフサイエンスコーパス: half

1 earing a 3-methoxy-1,3-dioxopropyl group (BC half).

2 thirds, and reduced risk of death by nearly half.

3 rten the half-life of c-Myc by approximately half.

4 after one electron was transferred in the WT half.

5 the mutual information between each pair of halves.

6 Almost half (45%) of children with PARDS received at least one

7 rs (age range: 11-64 years), with just under half (46%) having up to primary education or less.

8 In our global meta-analysis, almost half (46.2%) of 652 P-addition field experiments reveal

9 r cells (OPCs), and these contributed almost half (47%) of all changes in gene expression.

10 More than half (53%) experienced severe dry eye (ie, dry eye daily

11 before putting on a face mask, and more than half (55.3%, 62.1%) of those who touched (n=8108, 79.8%)

12 find that ITs and PNAs stored more than one-half (58%; 41,991 MtC) of the region's carbon in 2016 bu

13 More than half a century ago, W.

14 tterns of snakes within an African landscape half a century ago.

15 While more than half a century has passed since the introduction of lith

16 For half a century now, the barrel cortex of common laborato

17 erization despite efforts spanning more than half a century.

18 ality of landlocked migratory salmonids over half a century.

19 (TB) remain poorly understood, despite over half a million incident cases worldwide in 2017.

20 Nearly half a million insects were caught, representing at leas

21 fected millions of people of which more than half a million succumbed to the viral disease, COVID-19.

22 A half-active complex combining one WT and one D274A monom

23 status of the participants, being reduced to half after a period of weight stabilization.

24 ive features by incorporating two, two-and-a-half and three- dimensional architectures, thereby enabl

25 ral studies in recent years showed that tRNA halves and distinct Y RNA fragments are abundant in the

26 bstituted dihydrodipyrrin-carboxaldehyde (AD half) and a dipyrromethane bearing a 3-methoxy-1,3-dioxo

27 other product-related impurities, including half antibodies.

28 G6PD mutations are known: approximately one-half are polymorphic and therefore common in various pop

29 and CTP make Bs-FtsZ, an enzyme that is only half as efficient as a truncated version that lacks the

30 14.8+/-5.3, respectively), and approximately half as many eyes in the FAi-treated group when compared

31 imilar to pure GA) and increases linearly to half at 3 years.

32 m (standard error of mean) than the temporal half at 4.1 +/- 2.1 mum (P < .001).

33 ng TRD surgery had low vision pre-op, almost half attained VA that was > 20/80 five years post-op.

34 Nevertheless, nearly one-half billion tons of carbon were lost from both ITs and

35 eptum which divide the cell in two identical halves can be used in daughter cells, irrespective of it

36 otential of 0.55 V vs. RHE and a record high half-cell solar-to-hydrogen conversion efficiency of 4.3

37 ble hydrogen electrode) and a cathodic-side (half-cell) ethylene power conversion efficiency of 55 +/

38 The rGO@3D-Cu symmetric cells and half-cells achieve state-of-the-art plating and strippin

39 Over the past half century, migratory birds in North America have show

40 HCMV-associated disease, yet after nearly a half-century of research and development in this field w

41 eric transition states stemming from the two half-chair conformations of their lithium chelate.

42 creased incidence of SHM that was reduced by half compared with parental WT Ramos B cells, demonstrat

43 ution of intact land is reduced by more than half compared with previous assessments of the global ca

44 In each half cycle of the transport process, there is a state in

45 nts received crossover treatment with either half-dose PDT or HSML.

46 subunits and possesses a C-terminal flexible half emanating from the inner rim of the upper hexon cha

47 engineering revealed that two enhancers with half EREs could not compensate for the lack of a full ER

48 merically pure forms of regioisomeric methyl half esters.

49 Less than half felt confident in knowing when to use an adrenaline

50 is unique in the actinide series because its half-filled 5f (7) shell has lower energy than other 5f

51 were performed included axial and coronal T2 half-Fourier acquisition single-shot turbo spin-echo (HA

52 elf-propelled particle system, consisting of half-gold-coated titania (TiO(2)) particles, in which we

53 Mutating both half GR binding sites did not significantly reduce GR- a

54 een visiting PCPs less often, and nearly one half had no PCP visits in a given year by 2016.

55 atients with deep molecular responses, up to half have been able to discontinue therapy.

56 d region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all

57 developmental boundary between the two tail halves in the chicken, then followed major developmental

58 Median serum HBsAg half-life (t(1/2)) was estimated as 1.3 [0.9-1.8] days c

59 yridine-4,6(5H,7H)-dione), has a long plasma half-life (~ 24 hours) in mice, suggesting possible bind

60 on stainless steel, plastic, and nitrile for half-life 2.3-17.9 h.

61 pared to those administered 40 mg (clearance half-life 5.5 hours [95% confidence interval {CI}, 5.2-6

62 his effort is the modulation of autoantibody half-life and blocking access of autoantibodies to fragm

63 ular islatravir-triphosphate exhibits a long half-life and prolonged virological effects.

64 this compound suffered from a short in vivo half-life and suboptimal potency in whole blood.

65 ch is likely to extend the compound's plasma half-life and thus assist in drug delivery into tumors.

66 ce of production and degradation and measure half-life by quantifying the rate of decay after experim

67 was more appropriate for capturing effective half-life distributions.

68 The parasite clearance half-life following artemether-lumefantrine treatment wa

69 ted by the invasive administration and short half-life in blood circulation.

70 moderate selectivity to EP2, a short plasma half-life in rodents (1.7 h) and low aqueous solubility

71 However, it is labeled with the short half-life isotope (11)C.

72 uch product is (60)Fe, a radionuclide with a half-life of 2.6 My that is predominantly produced in ma

73 l RBD-specific serum IgG titers waned with a half-life of 49 days, nAb titers and avidity increased o

74 d EGFR2 (HER2) signaling, SHP2 increases the half-life of activated Ras by blocking recruitment of Ra

75 ant was 0.29 +/- 0.09 min-1, equivalent to a half-life of approximately 2.4 minutes.

76 ssay revealed that EMD tended to shorten the half-life of c-Myc by approximately half.

77 Though the blood elimination half-life of contrast agents is about 90 minutes, recent

78 (1)O(2) in surface waters, the environmental half-life of DA due to singlet oxygen-induced transforma

79 The half-life of ELKS is on the timescale of days and not we

80 These findings show that prolonging the half-life of Nkx3.1 reduces proliferation, enhances DNA

81 therapy-resistant phenotype, stabilizes the half-life of p53 and uses p53 to initiate a slow-cycling

82 Although the half-life of PEG~TLZ and released TLZ in the mouse was o

83 The half-life of recombinant factor VIII ranges from 15 to 1

84 s are comparable to those of APOBEC3G with a half-life of roughly 6 h postinfection, demonstrating th

85 The short half-life of SS1P is due to its very rapid filtration by

86 rogated or depleted at a rate defined by the half-life of the protein.

87 AFM13 in the combination setting revealed a half-life of up to 20.6 hours.

88 that HN3-ABD-T20 had a 45-fold higher serum half-life than HN3-T20 (326 minutes vs. 7.3 minutes); co

89 ab is a monoclonal antibody with an extended half-life that is being developed to protect infants for

90 iments indicated that cytoplasmic Cx43 had a half-life that was 50% shorter than membrane-associated

91 This reveals rapid turnover (half-life ~7-10 h), which we confirmed by in vivo pulse-

92 short-lived (146)Sm-(142)Nd system (~100-My half-life).

93 s it is known to impact efficacy, stability, half-life, and immunogenicity.

94 efinitely among HIV-uninfected participants (half-life, infinity; 95% confidence interval, 309 years

95 pHLIP ICG exhibits a multi-hour circulation half-life, offering protracted delineation of vasculatur

96 did not alter FcgammaRIIIa or FcRn binding, half-life, or their ability to deplete target cells in F

97 Klotho transcription and diminished protein half-life, whereas cleavage by ADAM proteases was not mo

98 ed metabolic clearance and increased in vivo half-life.

99 elin-expressing tumors and has a short serum half-life.

100 at HPK1 down-regulates AXL and decreases its half-life.

101 ules with increased specificity and extended half-life.

102 d rapidly absorbed with a 14.5-hour terminal half-life.

103 ssary for RBM24-based elevation of Sox2 mRNA half-life.

104 ned rapidly among HIV-infected participants (half-life; 39 years; 24-108 years; P = .001).

105 ice, regardless of its much shorter reported half-life; however, adverse effects toward the placenta

106 eak external quantum efficiency of 17.3% and half-lifetime of approximately 100 h.

107 Our new study shows that four-and-a-half LIM domain protein (FHL1) is one of the host factor

108 s knowledge gap, we investigated dissipation half-lives (DT50s) of 31 substances (mainly pharmaceutic

109 s suggests that OPEs with longer atmospheric half-lives and relatively high octanol-air partitioning

110 Compartment-specific degradation half-lives are essential pieces of information in the re

111 identified nuclides include those that have half-lives down to [Formula: see text].

112 by regressing the experimentally determined half-lives in activated sludge against average soil half

113 d bi- and multivariate models for predicting half-lives in soil by regressing the experimentally dete

114 heir use for compounds with relatively short half-lives is not clear and may require either a longer

115 om solution was extremely rapid; the average half-lives of (129)I(-) and (129)IO(3)(-) in soil soluti

116 days, respectively, and then dissipated with half-lives of 1.33 and 4.33 days, respectively.

117 n can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant t

118 Compared to protein-boosted regimens, half-lives of gp120-specific antibodies were longer but

119 flies, and nematodes, thereby specifying the half-lives of most short-lived miRNAs.

120 nome-wide RNA decay pathway that reduces the half-lives of mRNAs based on overall 3' UTR structure fo

121 approximately two orders of magnitude, with half-lives of per-site recovery of steady-state methylat

122 rm and the second another intermediate, with half-lives of seconds.

123 ves in activated sludge against average soil half-lives of the same chemicals extracted from regulato

124 NA sequence changes and typically have short half-lives of two to three generations.

125 Branched PFOS isomers had shorter half-lives than linear PFOS isomers.

126 and mRNAs expressed at low levels with short half-lives were enriched in the polysomes of upf1 mutant

127 Delayed images, up to 10 half-lives with (18)F-FDG, revealed biologic insight and

128 thiosulfate, respectively) results in rapid (half-lives ~20-60 min), photochemically induced nucleoph

129 to compounds with relatively long biological half-lives, but their use for compounds with relatively

130 LTD(4), and LTE(4), have different biologic half-lives, cellular targets, and receptor specificities

131 n effects on their light absorption, thermal half-lives, photostationary states, fatigue, and quantum

132 h phases and amplitudes in cryo-EM, and that half-maps with independent errors are available in cryo-

133 sting health care workers to use elastomeric half-mask respirators (EHMRs), widely used in constructi

134 -resistant strains of Plasmodium falciparum (half maximal inhibitory concentration [IC50] = 1-2 uM),

135 tiviral activity against HIV-1(HXB2), with a half maximal inhibitory concentration of 89 nM.

136 oic acid (7), showed a 60-fold lower shifted-half-maximal inhibitory concentration (IC(50)) for CYP4Z

137 SARS-CoV-2 in vitro with remarkable potency (half-maximal inhibitory concentration of <2 ng/ml).

138 s: Exendin-4-IRDye 800CW binds GLP-1R with a half-maximal inhibitory concentration of 3.96 nM.

139 X has a high affinity for the GLP-1R, with a half-maximal inhibitory concentration of 6.3 nM.

140 of these compounds inhibited M(pro), showing half-maximal inhibitory concentration values that ranged

141 d the murine variants of the CXCR4 receptor (half-maximal inhibitory concentration, 8 nM [human]/2 nM

142 ey have rapid twitch kinetics (full width at half-maximal stress: 11 +/- 1 ms) and a high twitch/teta

143 The intensity and full width half maximum (FWHM) of the focusing peak are associated

144 cer cells in particular with a submicromolar half maximum inhibition value mainly by inducing apoptos

145 ncy of 32.5%, CIE(y) ~ 0.12, a full width at half maximum of 29 nm, and a T80 (time to 80% of the ini

146 with H(2)O exhibited increased full width at half maximum of the elution band of up to 30% in compari

147 concentrations of agonist were required for half-maximum inhibition of dopamine-induced cAMP accumul

148 ve identified flood-rich periods in the past half millennium in various regions of Europe(2).

149 r 200 million malaria cases globally lead to half-million deaths annually.

150 vation up-regulate the expression of 5'-tRNA half molecules in human monocyte-derived macrophages (HM

151 ar membrane at a frequency approximately one-half octave below CF, in accordance with the experimenta

152 In some African countries, more than one-half of 45- to 49-y-old mothers have experienced the dea

153 d data reveal germline recombination in over half of 64 commonly used Cre driver lines, in most cases

154 .25 m of SLR (very likely by year 2050) with half of all beachfront shoreline at risk by 0.74 m of SL

155 More than half of all DCIS lesions were high grade (52.6%; 393 of

156 ative dataset that contains data from nearly half of all discharges from nonfederal hospitals in the

157 er one-third of proteins, with approximately half of all enzymes requiring metal to function.

158 erences between four mouse strains) in about half of all investigated strain comparisons.

159 Approximately half of all miRNA reside within intronic regions and are

160 More than half of all tropical forests are degraded by human impac

161 Only half of Americans register as organ donors.

162 ld season has been shown to account for over half of annual methane (CH(4) ) emissions and can offset

163 n an integrated healthcare system, more than half of antibiotic use occurred in the emergency departm

164 Consequently, half of apicomplexan proteins are unique and uncharacter

165 More than half of bisexual (55%) and gay or lesbian (51%) individu

166 se, they are highly toxic, and approximately half of cancer patients have tumors that are either intr

167 Although about half of cells with extra centrioles in a population were

168 HPV16 causes half of cervical cancers worldwide; for unknown reasons,

169 More than half of critical care organizations reported having burn

170 Only half of disturbance-prone forests, which lacked tolerant

171 We found that over half of essential AAs had delta(13) C values that did no

172 cellular carcinoma worldwide, with more than half of HCC patients being chronic HBV carriers, even if

173 Over half of hospitalized patients (8/14) were discharged hom

174 Over half of human promoters are associated with CpG islands

175 Less than half of human zygotes survive to birth, primarily due to

176 Further, China's power sector could cut half of its 2015 carbon emissions at a cost about 6% low

177 7-MOB1A complex revealed that the N-terminal half of LegK7 is structurally similar to eukaryotic prot

178 ng teleost fishes, which comprise nearly one-half of living vertebrate species.

179 and stress buffering occurs in approximately half of male stressed mice that closely interact with na

180 Transposable elements (TEs) make up half of mammalian genomes and shape genome regulation by

181 le of Connecticut nursing homes in the first half of May 2020.

182 Less than one-half of Medicare patients achieved a TO following hepato

183 testing increased among PLWH; however, only half of MSM were tested for CT or GC during 2016-2017 an

184 protein kinase (MAPK) signaling are found in half of myeloma patients and contribute to proteasome in

185 dyad, stress transmission happens in nearly half of naive partners and stress buffering occurs in ap

186 e p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually.

187 via breastfeeding is responsible for nearly half of new infections of children with HIV.

188 onment, for which our model can only explain half of our observation.

189 In the nucleus, more than half of P-TEFb are sequestered in the inactive-state 7SK

190 Almost half of participants (45.2%) reported a pre-surgery hist

191 Over half of participants carried MC1R variants known to incr

192 Half of patients had a history of FESS (functional endos

193 About half of patients received monotherapy as 2 L chemotherap

194 Approximately half of patients reported nasal polyps.

195 early data show partial responses in nearly half of patients with lung cancer.

196 ve blood cultures were observed in less than half of patients, with Staphylococcus aureus and enteroc

197 More than half of procedures in the US are performed in outpatient

198 More than half of residents with positive test results were asympt

199 ractions could accurately classify the first half of SA scans.

200 Almost one-half of SCEs (49%) were preventable; the majority of pre

201 The other half of socially defeated rats show long-latencies to de

202 Fewer than half of surgical patients with preoperative MOLST have d

203 the transcription start site (TSS)-proximal half of the +1 nucleosome is largely independent of Rad2

204 the 38 and 269 unique motifs from more than half of the 292 and 1912 motif-allele pairs analyzed usi

205 when using the gravity method for infusion, half of the activity is infused after 3.5 min, and 95% i

206 estimated the treatment delay times at which half of the AGMs were no longer expected to survive as 1

207 In half of the blocks, a buccal bone dehiscence of random e

208 (DFT) calculations showed that approximately half of the calculated association enthalpies can be att

209 optic atrophy, associated with foveopathy in half of the cases.

210 More than half of the cell lines (60%) were considered to be sensi

211 analysis of this well-characterized cohort, half of the children with severe asthma no longer had se

212 nown "u" wave occurring after the c wave, in half of the cohort.

213 Half of the cows received a supplementation of vitamin E

214 We found that, on average, half of the cytoplasmic HIV-1 RNAs are being actively tr

215 photosynthetic activity accounts for roughly half of the daily CO(2) fixation that occurs on Earth.

216 In nearly half of the diffracting waveforms, we detected seismic w

217 ng for confidence ratings only in the second half of the experiment.

218 Approximately one-half of the G6PD mutations are instead sporadic: rare pa

219 that dystrophin restoration in approximately half of the heart still allows for marked vulnerability

220 Cer), are significantly upregulated in about half of the human colorectal carcinomas (CRC) and in oth

221 that iCO(2) is likely responsible for about half of the increase.

222 Strikingly, almost half of the interactions were not previously detected by

223 Transposable elements make up half of the mammalian genome.

224 locations ranging from two to seven sites in half of the mutant cI genes studied.

225 About half of the participants had symptom networks that were

226 The other half of the participants performed the task without any

227 showed silent contractures in approximately half of the patients and no myotonia.

228 Half of the patients had improvement of index symptoms a

229 ing treatment duration, we found that almost half of the patients with drug-resistant TB were cough a

230 ternative seed sequences and share less than half of the predicted targets with the canonical form.

231 ession, portals were incorporated into about half of the proheads that were made.

232 Here we show that about half of the recorded VTA DA neurons perform multiplexing

233 not report participants' race/ethnicity, and half of the remaining study samples were at least 90% wh

234 easured in cells collected from the proximal half of the small intestine of Hnf4alphagamma(DKO) and c

235 filtration rate categories in approximately half of the studied cases.

236 Half of the studies (n = 27) were conducted in North Ame

237 mations suggested that turns corresponded to half of the total population of structural elements, whe

238 -hybrid maize breeding programs in the first half of the twentieth century(1), maize yields have incr

239 ained by supply-side variables, and at least half of the variation in treatment outcomes occurs withi

240 as better achieved using the 24-2C grid, but half of the visual field test locations did not coincide

241 s performing HP surgeries utilized less than half of their beds on average.

242 st one druggable alteration, while more than half of them are from our candidate gene group, which wo

243 ce to 40 million low-income Americans-nearly half of them children.

244 pairs for the proteasome subunits, more than half of them intersubunit.

245 EUHC interventions would cost approximately half of these amounts (3.7% [2.6-5.3] of 2015 GNI in LIC

246 Over half of these compounds (430) antagonized at least one o

247 ing at 4274 (83%) of 5140 subsequent visits; half of these participants later restarted PrEP.

248 However, up to half of these tumors recur within 20 years.

249 Only half of those with ALF during pregnancy appeared to have

250 Considering that the N-terminal half of TIMP-1 is sufficient for TIMP-1's MMP-inhibitory

251 to a world without carbon markets, or almost half of what EU governments promised to reduce under the

252 resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites.

253 irectly with the hydrophobic and hydrophilic halves of the CA II active site.

254 umber of different labeling schemes, the two halves of the molecule can be distinguished, so that the

255 result of this transition, the intracellular halves of the S6 helices bend and rotate by about 100 de

256 Ordered BCP line arrays with half-pitch of 6.4 nm are demonstrated on stripes >80 nm

257 HCA) and ventricular fibrillation, more than half present with refractory ventricular fibrillation un

258 tion, the two-terminal conductance is always half-quantized.

259 nt, mainly catechin and its isomers, whereas half-rate fertilizer (330 Kg/ha), presented the highest

260 ernally or paternally related-e.g., paternal half-siblings-using the locations of autosomal IBD segme

261 high-risk full sibships and 2,596 high-risk half sibships containing at least one home-reared and on

262 The ATP-triggered half-site release rate of KIF1A was similar to the stepp

263 one p53 dimer in the tetramer binds to each half-site.

264 3 response elements consist of two decameric half-sites, and data suggest one p53 dimer in the tetram

265 ized into two parts with an incipient meron (half-skyrmion) character(11,12).

266 A half-space dislocation model is used to simulate the the

267 eful in a point of care setting, though this half-strip LFA may serve as a useful starting point for

268 l variants and causative genes for more than half such disorders remain to be discovered(1).

269 nd (negative) phase of the bipolar pulse was half that of the first (positive) phase but progressivel

270 The cART was initiated in approximately half the animals five weeks post-infection, and morphine

271 ality rates, then this could reduce by about half the increase in AGB relative to the increase in wNP

272 unction concordance than the 24-2 locations, half the locations in the 24-2C grid fell close to or ou

273 Half the logs were placed at a site scheduled for a pres

274 ding stiffness, which accounts for more than half the measured difference between DNA and RNA.

275 ation of body wall muscle, but approximately half the normal levels of the giant UNC-89 isoforms, dis

276 r CNN- and gaussian-filtered bone scans with half the number of counts was compared with standard bon

277 Nearly half the participants (49%) had had no angina during the

278 More than half the patients remained asymptomatic during the stres

279 ore advanced development and 7.5 points (one half the SD) representing a clinically important differe

280 PD-L2 abundance exceeded PD-L1 in over half the specimens and the drug target proteins all disp

281 The combination of Intralipid with half the standard clinical dose of Abraxane reduces the

282 2ph scattering rates are as large as nearly half the value of the one-phonon rates, and that includi

283 onger-term climate fluctuations and close to half the world's lake area is in high northern latitudes

284 Human Cytomegalovirus (HCMV) infects over half the world's population, is a leading cause of conge

285 Whole-body retention half-time averaged 198 +/- 75 h.

286 ed 2.4% +/- 2.0% and cleared with a biologic half-time of 243 +/- 144 h (27 patients) or longer (9 pa

287 aged 22% +/- 12% and cleared with a biologic half-time of 271 +/- 185 h (36 patients) or longer (6 pa

288 mong human herpesviruses-uses its N-terminal half to bridge hexon MCP subunits and possesses a C-term

289 hanges by pai, as predicted by the theory of half-vortices in a PDW state(6,7).

290 These spin textures are localized within a half-wavelength of light, and exist on the timescale of

291 patients needed mechanical ventilation, over half were discharged home by the end of follow-up.

292 f structural elements, whereas the remaining half were equally distributed between beta-strand and un

293 ARHL cases vs. 7.5% of controls (P = 0.001); half were previously unknown (AF < 0.000002).

294 All patients were Caucasian and half were sporadic.

295 ation of phosphorylation is reduced by about half when either of the two H2A genes is mutated to the

296 s featuring a phosphorus center in the lower half, which engenders a unique element of axial chiralit

297 mean value of -2.9 prism diopters (PD) and a half-width of the 95% limit of agreement of +/-11.4 PD.

298 LSO AP half-widths were also fast, but absolutely required Kv3.

299 ired Kv3.3 subunits for fast repolarization (half-widths: 0.25 +/- 0.08 ms, n = 19 wild-type, 0.60 +/

300 s than selective testing, of which more than half would be oropharyngeal only.