ライフサイエンスコーパス: half-maximal

1 or mechanisms of resistance, we measured the half maximal (50%) inhibitory concentration (IC(50)) of

2 but the exponential growth rate and time of half maximal Abeta concentration are constant.

3 confirmed these 4-AP-sensitive currents with half maximal activation at -13.85 +/- 1.17 mV and half m

4 ast activating and inactivating current with half maximal activation at -27.08 +/- 3.48 mV and -25.51

5 by the Hill equation (Hill coefficient 2.7, half maximal activation at 2.0 muM [Ca(2+)](i)).

6 s, the calcium concentration associated with half-maximal activation (Ca(1/2)) of the Ca-ATPase, 290

7 activated by decreasing PO2, with a PO2 for half-maximal activation (P50) not significantly differen

8 Half-maximal activation and inactivation occurred at -23

9 annel activates and inactivates rapidly with half-maximal activation at -18 mV and half-maximal fast

10 ly cooperative dose-dependent manner, with a half-maximal activation at 0.47 microM and a maximal inc

11 e was essentially identical in EPI and ENDO (half-maximal activation at 9-10 mM [Na(+)](i) or approxi

12 kidney (HEK) 293 cells expressing GLIC show half-maximal activation at pH 6, close to the pK(a) of h

13 The half-maximal activation concentration for glucose 6-phos

14 +) concentration, with Hill coefficients and half-maximal activation concentrations very close to the

15 Cation concentrations for half-maximal activation decrease by >100-fold with each

16 In contrast, the half-maximal activation of bovine rod PDE6 required mark

17 tial AZ heterogeneity whereby the voltage of half-maximal activation of Ca(2+) influx ranged over app

18 Half-maximal activation of the FRET-GCK sensor was estim

19 nied by a decrease in agonist affinity, with half-maximal activation rates achieved at 0.77 mM GABA i

20 Each SUMO shifts the half-maximal activation voltage (V1/2) of IKs approximat

21 ded changes in either HCN conductance or its half-maximal activation voltage resulted in graded chang

22 eeper voltage-dependence and a more negative half-maximal activation voltage than Cav1.2 and Cav3.1.

23 by pCa50 (-log of [Ca(2+)]free required for half-maximal activation), decreased in McTnT1-44 (alpha-

24 g of [Ca(2+)]free concentration required for half-maximal activation), increased significantly at bot

25 ubunit-induced left shift in the voltage for half-maximal activation.

26 osmolality, but not the osmolality, yielding half-maximal activity (Pi(1/2)/RT), decreased with the l

27 biologically defined effect size threshold, half-maximal activity concentration (AC50), and lowest e

28 The concentration for half-maximal activity derived from the Hill equation mod

29 63-mV decrease in voltage required to reach half-maximal activity per log increase in [Na+].

30 By integrating these data we observed that half-maximal Akt activity was achieved at a threshold le

31 ion at half maximal amplitude, full width at half maximal amplitude, amplitude, wave speed, rise, and

32 ral event parameters (e.g., full duration at half maximal amplitude, full width at half maximal ampli

33 tivation a significant predictor of morphine half-maximal antinociceptive dose (ED50) values.

34 The rate of refolding is half-maximal at 30 muM reduced PDI when the reduced clie

35 The effect of Cl-(o) was half-maximal at approximately 60 mm.

36 lowered the effective RNA concentration for half-maximal ATPase activity.

37 Concentrations required for half-maximal ATPase stimulation ( K m (D)) correlated wi

38 whereas the actin concentration required for half-maximal ATPase was reduced dramatically (30-fold).

39 The concentration for half-maximal BDM activation (K(0.5)) was state-dependent

40 gamma domains bind strongly to heparin, with half-maximal binding at a concentration of approximately

41 roteins revealed that FX binds specifically (half-maximal binding, 3 mug/mL) to the extracellular dom

42 ed the gliclazide concentration, producing a half-maximal block of G334D and R201C channels and sugge

43 Half-maximal block of I(Li) is increased by 3.2-, 3.8-,

44 ) in brain slices from wild type mice with a half-maximal blockade at 88 nm.

45 ty as acceptor/donor ratio required to reach half-maximal BRET [bioluminescence resonance energy tran

46 equaled 17% +/- 4% at pCa 6.0 (approximately half-maximal Ca2+ activation).

47 n temperature in relaxing conditions, with a half-maximal change at approximately 19 degrees C.

48 Tmax left [L] = 2.9 +/- 1.5 min, the time of half maximal concentration [T1/2max] R = 8.8 +/- 3.7 min

49 similarly by PUVA following PAR1 (effective half-maximal concentration (EC50), 8.4 +/- 1.1 versus 4.

50 2.1/K(V)2.2 channels, guangxitoxin (GxTX)-1 (half-maximal concentration approximately 1 nmol/l), has

51 on-dependent and partially reversible with a half-maximal concentration constant IC(50) of 2.6 microm

52 sociation tendency, secondary structure, and half-maximal concentration for supramolecular assembly,

53 all inhibited by extracellular Ca(2+) with a half-maximal concentration of approximately 20 mum.

54 Experiments using a half-maximal concentration of DAMGO demonstrate that nor

55 philized platelets (150 x 10(3)/microl), the half-maximal concentration of FVIII required to accelera

56 charge had to move for activation of Cav1.3 half-maximal conductance (Cav1.3: 68%; Cav1.2: 52%; Cav3

57 g dose of exogenously added epitope yielding half-maximal CTL triggering against uninfected target ce

58 Contrastingly, voltages at half-maximal current and timecourses of currents obtaine

59 One-half maximal currents were induced by nitrate concentrat

60 However, although time to half-maximal cytoplasmic reaccumulation after cytokine w

61 Values for half-maximal displacement of the probes indicated that t

62 Half-maximal displacement was achieved at a plasma caffe

63 t acetylcholine was attenuated (mean [SE] of half-maximal dose for dilation, 8.9 [0.2] x 10(-8) vs 4.

64 The difference between the half-maximal dose for the excitation response and the co

65 became slower as [MgADP] was increased, with half-maximal effect at 0.5 mM [MgADP]; the pre- and post

66 s in a concentration-dependent manner with a half-maximal effect at approximately 5 ng/mL.

67 Further, the half-maximal effect concentration of C5a and the predict

68 rom recombinant GluN1/GluN3A receptors, with half-maximal effect in the physiologic pH range.

69 The system appears quite sensitive, with a half-maximal effect on a Pqrr reporter at 140 pM C8-AHL.

70 ng an increased free Ca(2+) concentration at half-maximal effect on channel activation, a reduced ste

71 h a Hill coefficient of approximately two, a half-maximal effect reached by nearly 500 nm Ca(2+) , an

72 The D50 (concentration producing half-maximal effect) for cocaine and U-50,488H was 10.3

73 nitiated with 0.2 pM tissue factor (TF), the half maximal effective concentration (EC(50)) for DHG in

74 The detected values of half maximal effective concentration (EC(50)) of lauric

75 The half maximal effective concentration (EC(50)) was 0.37 m

76 e predominant neuronal isoform, KCNQ2/KCNQ3 [half maximal effective concentration (EC(50)), 60 +/- 20

77 cytotoxic to CXCR4(+) cancer cells in vitro (half maximal effective concentration (EC50 ) approximate

78 dimeric DARPin, DLD-4, inhibited TcdB with a half maximal effective concentration (EC50) of 4 pM in v

79 We found the half maximal effective concentration (EC50) of lutropin

80 ial cell membrane at concentrations near the half maximal effective concentration (EC50) of several m

81 er maximal reactivity (P = .001) and a lower half maximal effective concentration (P = .002) than did

82 centration-dependent antiestrogenic activity half maximal effective concentration [(EC50): 4.5muM)].

83 show PS inhibits time- and dose-dependently (half maximal effective concentration [EC(50)] = 27 +/- 3

84 r cyclic adenosine monophosphate inhibition (half maximal effective concentration [EC50]: 0.21 +/- 0.

85 The half maximal effective concentration for Cryptosporidium

86 mutated HCK gatekeeper greatly increased the half maximal effective concentration for ibrutinib and A

87 PAH-PASMC was concentration dependent with a half maximal effective concentration of 0.20 micromol/L.

88 reduces parasite infection in vitro, with a half maximal effective concentration of 100 nM.

89 cyanobacteria Microcystis aeruginosa with a half maximal effective concentration of 21 and 5 mug/mL,

90 f (18)F-PF-05270430 specific binding, with a half maximal effective concentration of 69.4 ng/mL in pl

91 at the blood concentration was >10 times the half maximal effective concentration of miltefosine (med

92 CD-sens (1/EC(5)(0) x 100, where EC(5)(0) is half maximal effective concentration) value was independ

93 The half maximal effective concentration, EC(50), for the CR

94 Half maximal effective concentrations (EC50) obtained af

95 Overall, half maximal effective concentrations (EC50s) were lower

96 For the V787E recombinant virus, the half maximal effective concentrations for ganciclovir, f

97 der the concentration-versus-time curve over half-maximal effective concentration (AUC:EC50) of 108.6

98 ed an analogue with a roughly 70-fold better half-maximal effective concentration (EC(50)) against Sh

99 ose-concentration response profiles, and the half-maximal effective concentration (EC(50)) values for

100 The half-maximal effective concentration (EC50) for the dend

101 nship to more depolarizing potentials with a half-maximal effective concentration (EC50) of 1.8 muM.

102 sponsive CaP cells and prostaspheres, with a half-maximal effective concentration (EC50) ranging from

103 The half-maximal effective concentration (EC50) value of the

104 antitative dose-response characteristics and half-maximal effective concentration (EC50) values using

105 Also, glucose-excited neurons increased (half-maximal effective concentration [EC(50)] = 0.54 mmo

106 but not its catabolites, caused cell death (half-maximal effective concentration [EC(50)] = 2 nM) by

107 oduced concentration-dependent contractions (half-maximal effective concentration [EC(50)] = 2.5 micr

108 d potent p110delta small molecule inhibitor (half-maximal effective concentration [EC(50)] = 8nM).

109 tical model predicted a significantly higher half-maximal effective concentration for IL-1beta-induce

110 agonist dose-dependently caused pain with a half-maximal effective concentration of 0.31 mum Coinjec

111 We found that GLP-1 enhances GSIS at a half-maximal effective concentration of 0.4 pM.

112 showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar an

113 d chemotherapeutic resistance, with a higher half-maximal effective concentration than that of cells

114 RASs in NS5A that increased the half-maximal effective concentration to ledipasvir by mo

115 nbound BIC CSF concentrations were above the half-maximal effective concentration value in all patien

116 in sputum and BAL, which corresponded to the half-maximal effective concentration values for protease

117 hibited the most potent anti-IAV effect with half-maximal effective concentration values of 0.14 and

118 ntative RNAs were found that exhibit EC(50) (half-maximal effective concentration) values for c-di-GM

119 ogic assays against chemotherapeutic agents (half-maximal effective concentration).

120 pronil) were within an order of magnitude of half-maximal effective concentrations (EC50) of nontarge

121 The half-maximal effective concentrations (EC50) were 2.4x10

122 solated 12 naturally occurring mAbs with low half-maximal effective concentrations for binding, 5 of

123 46619, a stable analog of prostaglandin H(2) Half-maximal effective potential (V(0.5)) determined for

124 Inhibition was dose-dependent with half-maximal effects at approximately 15-20 muM.

125 Half-maximal effects of Ca(2+) were observed at approxim

126 saturable ethanol dose-response curve with a half-maximal enhancement at 16 mM, close to the legal bl

127 y with half-maximal activation at -18 mV and half-maximal fast inactivation at -29 mV.

128 ased, as was the frequency needed to produce half maximal force (P < 0.05).

129 d the velocity of contraction (time to reach half-maximal force) induced by the phosphatase inhibitor

130 ker, twitch half-relaxation times longer and half maximal forces reached at lower frequencies than fo

131 formation but increased the concentration of half-maximal FRET (K(D)) by >4-fold.

132 ormational stability studies showed that the half-maximal GdnHCl (Gdn1/2) concentration for denaturat

133 ubled the ammonia concentration required for half-maximal glutamine synthesis.

134 We found that the half-maximal I(Ks) activation voltage in hESC-CMs and in

135 urement of the inhibition zone diameter, the half maximal (IC50) and the minimal (MIC) inhibitory con

136 ted TNFR1 trimers were sufficient to trigger half-maximal IL8 production, more than 2500 cell-bound o

137 maximal activation at -13.85 +/- 1.17 mV and half maximal inactivation at -55.07 +/- 5.54 mV.

138 .15 mV in somas and dendrites, respectively; half maximal inactivation at -58.91 +/- 2.34 mV and -49.

139 e over widely different membrane potentials (half-maximal inactivation (V0.5) at -100 mV and -50 mV i

140 on and 1 nM dexamethasone was sufficient for half maximal induction of GUS activity.

141 Half maximal induction was achieved with 0.2 microm dexa

142 ) and the steroid concentration required for half-maximal induction (EC50) of GR-mediated gene expres

143 The concentrations of inducers required for half-maximal induction of BiFC complex formation by all

144 vity assays measured TCN concentrations with half-maximal inhibition (IC(50)) of matrix metalloprotei

145 P6981 [2-(3-stibonophenyl)malonic acid], had half-maximal inhibition at ~5 nM for CREB.

146 roscopy, while DELI tended to produce higher half-maximal inhibition constants (IC50s) than FCM, with

147 ied with the GAP and the Galpha subunit, but half-maximal inhibition of the GAP activity of PLC-beta1

148 C transport; the concentration necessary for half-maximal inhibition was 17 +/- 1 muM.

149 ivated aconitase in a dose-dependent manner (half-maximal inhibition was observed with approximately

150 er concentrations of ONOO- were required for half-maximal inhibition.

151 /ITD mutant leukemia cell lines revealed the half maximal inhibitory concentration (IC50) for inhibit

152 that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assa

153 The half maximal inhibitory concentration (IC50) of (111)In-

154 e factor fND, was in good agreement with the half maximal inhibitory concentration (IC50) of 0.018 nM

155 lable NET in a dose-dependent manner, with a half maximal inhibitory concentration (IC50) of 0.087 +/

156 Half maximal inhibitory concentration (IC50) of BA were

157 The DPP-IV half maximal inhibitory concentration (IC50) of H4, a po

158 combinant human and rat P2X7R orthologs, the half maximal inhibitory concentration (IC50) of JNJ-5417

159 equilibrium dissociation constant (K(d)) and half maximal inhibitory concentration (IC50) values.

160 Regarding antioxidant activities, the half maximal inhibitory concentration (IC50) was 215.86

161 inhibited both mitochondrial O2 consumption [half maximal inhibitory concentration (IC50): 3.8muM] an

162 vitro, 3-BrPA affected Hep3B cell viability (half maximal inhibitory concentration = 0.15 mmol/L), an

163 oportin degradation and ferritin expression (half maximal inhibitory concentration = 19.8 +/- 4.6 nmo

164 Compared with FAPI-04 (half maximal inhibitory concentration [IC(50)] = 32 nM),

165 -resistant strains of Plasmodium falciparum (half maximal inhibitory concentration [IC50] = 1-2 uM),

166 dated a thieno[3,2-b]pyrrole compound with a half maximal inhibitory concentration of <10 micromol/L,

167 The half maximal inhibitory concentration of (18)F-GP1 to GP

168 onse curve of this blocking agent revealed a half maximal inhibitory concentration of 40 nM which is

169 tiviral activity against HIV-1(HXB2), with a half maximal inhibitory concentration of 89 nM.

170 Targeted nanospheres achieved the half maximal inhibitory concentration of PTX on SUM159 c

171 he neutralization ability is measured as the half maximal inhibitory concentration of the antibody (I

172 is, giving levels far exceeding the cellular half maximal inhibitory concentration values (>100,000-f

173 Unexpected sensitivity to dasatinib with half maximal inhibitory concentration values below 20 nM

174 nhibited peptidyl-prolyl isomerase activity (half maximal inhibitory concentration values, 0.2-16.2 m

175 ndrial swelling, by preventing mPTP opening (half maximal inhibitory concentration values, 1.4-132 mu

176 with cisplatin; shifting the cisplatin IC50 (half maximal inhibitory concentration) from 30 muM to 5

177 enospecies, whereas 221-7 was borreliacidal (half maximal inhibitory concentration, < 1 nM) against B

178 u-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitory concentration, 1-2 nM).

179 ted osteoclast differentiation and function (half maximal inhibitory concentration, 50 nmol/L), incre

180 Mean half maximal inhibitory concentrations (EC50) for calciu

181 Their DPP-IV half maximal inhibitory concentrations (IC(50)) ranged f

182 nst the tested five human cancer cells, with half maximal inhibitory concentrations (IC(50)s) of 13.2

183 ibitory peptides, LPVP and MPVQA, had DPP-IV half maximal inhibitory concentrations (IC50) of 87.0+/-

184 Here, we present half maximal inhibitory concentrations (IC50) results fo

185 ons of reaction centre photocurrents yielded half maximal inhibitory concentrations of 208nM and 2.1m

186 The half maximal inhibitory concentrations were </= 5 x 10(-

187 ity profiles, including 6 with submicromolar half maximal inhibitory concentrations.

188 cological studies using the cardiac MPS show half maximal inhibitory/effective concentration values (

189 f interest, in the MCL cell lines with lower half-maximal inhibitory concentration (0.1-0.5 muM), pev

190 At its half-maximal inhibitory concentration (15 nM), D5 strong

191 ed robust inhibition on Wnt signaling with a half-maximal inhibitory concentration (IC(5)(0)) of 20 m

192 aromatic side arms showed improved potency (half-maximal inhibitory concentration (IC(50)) <1 muM) a

193 oic acid (7), showed a 60-fold lower shifted-half-maximal inhibitory concentration (IC(50)) for CYP4Z

194 The half-maximal inhibitory concentration (IC(50)) geometric

195 Our inhibitor has a half-maximal inhibitory concentration (IC(50)) of 0.007

196 The conjugate has a half-maximal inhibitory concentration (IC(50)) toward Sk

197 wo synthesized diflunisal derivatives showed half-maximal inhibitory concentration (IC(50)) values 1

198 remely potent inhibitors were obtained, with half-maximal inhibitory concentration (IC(50)) values in

199 ve of their drug resistance properties, with half-maximal inhibitory concentration (IC(50)) values in

200 e series as an antiproliferative agent, with half-maximal inhibitory concentration (IC(50)) values in

201 The most potent bNAbs have median half-maximal inhibitory concentration (IC(50)) values in

202 an order of magnitude increase in imatinib's half-maximal inhibitory concentration (IC(50)).

203 bance capacity (ORAC) assays with a measured half-maximal inhibitory concentration (IC50) for the bes

204 roperties with isoeugenol showing the lowest half-maximal inhibitory concentration (IC50) values of m

205 n kinetics were determined for 28 drugs with half-maximal inhibitory concentration (IC50) values rang

206 onferred the highest increase in oseltamivir half-maximal inhibitory concentration (IC50), and E119D

207 umarin derivatives, were identified, and the half-maximal inhibitory concentration (IC50), inhibition

208 ctivity of bisubstrate-like NNMT inhibitors (half-maximal inhibitory concentration 1.41 muM).

209 /l) and glucose-inhibited neurons decreased (half-maximal inhibitory concentration [IC(50)] = 1.12 mm

210 % +/- 6% stability in serum), PSMA affinity (half-maximal inhibitory concentration [IC(50)] range 19.

211 it P-gp was tissue-independent (maternal BBB half-maximal inhibitory concentration [IC50], 5.67 +/- 1

212 f 0.4 mg MP0112 resulted in levels above the half-maximal inhibitory concentration and neutralization

213 t achieved ultrahigh neutralization potency (half-maximal inhibitory concentration as low as 0.058 ng

214 the bo3 oxidase is inhibited by sulfide with half-maximal inhibitory concentration IC50 = 1.1 +/- 0.1

215 The half-maximal inhibitory concentration IC[Formula: see te

216 reduced K(ATP) channel ATP sensitivity (the half-maximal inhibitory concentration increased from app

217 SARS-CoV-2 in vitro with remarkable potency (half-maximal inhibitory concentration of <2 ng/ml).

218 llization studies manifest that BM30 (with a half-maximal inhibitory concentration of 0.89 +/- 0.10 m

219 ition activities against mTOR and HDAC1 with half-maximal inhibitory concentration of 1.2 and 0.19 nM

220 s: Exendin-4-IRDye 800CW binds GLP-1R with a half-maximal inhibitory concentration of 3.96 nM.

221 the protein for blebbistatin, resulting in a half-maximal inhibitory concentration of 36.3 +/- 4.1 mi

222 X has a high affinity for the GLP-1R, with a half-maximal inhibitory concentration of 6.3 nM.

223 ry lung cells to CS extract 0.2-0.75% with a half-maximal inhibitory concentration of approximately 0

224 The half-maximal inhibitory concentration of ATP-responsive

225 lts: Each of the compounds binds PSMA with a half-maximal inhibitory concentration of no more than 10

226 nd IL-22) in lymphocytes and monocytes, with half-maximal inhibitory concentration values <100 nM.

227 Half-maximal inhibitory concentration values for eotaxin

228 The half-maximal inhibitory concentration values of our newl

229 of these compounds inhibited M(pro), showing half-maximal inhibitory concentration values that ranged

230 Results: The potency (half-maximal inhibitory concentration) of the P2X7 recep

231 ues for c-di-GMP as low as 90 nM and IC(50) (half-maximal inhibitory concentration) values as low as

232 For each inhibitor, IC (half-maximal inhibitory concentration) values determined

233 e inhibition was dose-dependent with IC(50) (half-maximal inhibitory concentration) values of 123 and

234 0.006 mM vs. 0.137 +/- 0.007 mM; LS vs. HS; half-maximal inhibitory concentration, 0.055 nM).

235 or of (99m)TcO4(-) uptake via hNIS in vitro (half-maximal inhibitory concentration, 0.55-0.56 muM (in

236 (3) had the most promising properties (e.g., half-maximal inhibitory concentration, 19.2 +/- 5.8, tum

237 nding; >95% internalization), high affinity (half-maximal inhibitory concentration, 6.4-12.7 nM), and

238 d the murine variants of the CXCR4 receptor (half-maximal inhibitory concentration, 8 nM [human]/2 nM

239 y inhibition of Na(v)1.5 (874 and 231 umol/L half-maximal inhibitory concentration, fast and late sod

240 2 million small molecules and measured their half-maximal inhibitory concentration.

241 ic acid o-tolylamide (TM(inh)-23) with 30 nM half-maximal inhibitory concentration.

242 itopes on the RBD neutralized the virus with half-maximal inhibitory concentrations (IC(50) values) a

243 Half-maximal inhibitory concentrations (IC(50)) and rate

244 covery of AMT inhibitors with sub-micromolar half-maximal inhibitory concentrations (IC(50)) in a LOX

245 med reactions, although with relatively high half-maximal inhibitory concentrations (IC50 > 50 muM).

246 01) and 39-fold higher IFNbeta (P < 0.00001) half-maximal inhibitory concentrations (IC50) than did d

247 Half-maximal inhibitory concentrations (IC50) were obtai

248 than the globular isomer, with low nanomolar half-maximal inhibitory concentrations (IC50).

249 ntivirus and authentic SARS-CoV-2 virus with half-maximal inhibitory concentrations (IC50s) in the 10

250 ent in vitro anti-Plasmodium properties with half-maximal inhibitory concentrations (IC50s) of 2.9 +/

251 hibit H3K9 Jumonji demethylase KIAA1718 with half-maximal inhibitory concentrations in low micromolar

252 against the majority of tested viruses, with half-maximal inhibitory concentrations in the high nanom

253 tudies using FR-alpha-positive KB cells gave half-maximal inhibitory concentrations of 27.1 +/- 3.7 a

254 These compounds have half-maximal inhibitory concentrations of approximately

255 Half-maximal inhibitory concentrations of native HNPs to

256 We also show that the half-maximal inhibitory concentrations of the full-lengt

257 arate a variety of RNA and DNA duplexes with half-maximal inhibitory concentrations ranging from 0.7

258 were similarly sensitive to (BIP)(2)B, with half-maximal inhibitory concentrations ranging from 0.7

259 The half-maximal inhibitory concentrations were independent

260 ipocytes FoxO1 nuclear exclusion has a lower half-maximal insulin dose than GLUT4 translocation, and

261 ernalization of both IgM and FcmuR, reaching half-maximal internalization of cell-bound IgM within 1

262 200, 2, and 0.25 microM Ca(2+) and with the half-maximal K201 inhibitory doses (IC50) estimated at 1

263 ive potentials, but shifted the potential of half-maximal Kv11.3 channel activation to more depolariz

264 raordinary potency (concentration to achieve half-maximal neutralization [Neut50] = 0.03 mug/ml).

265 is of the nucleotide-binding data shows that half-maximal occupancy of a second catalytic site occurs

266 The insulin concentration for the half-maximal pAkt-tAkt response was nearly 3-fold higher

267 gnificantly change in the presence of Ca(2+) Half-maximal phosphorylation was attained at 8 mumMg(2+)

268 d lower Km (substrate concentration at which half-maximal product formation is achieved by an enzyme.

269 on between the MarA concentration needed for half-maximal promoter activity in vivo and marbox bindin

270 The ionic strength yielding half-maximal ProP activity was more anion-dependent than

271 ays after the onset of symptoms had variable half-maximal pseudovirus neutralizing titres; titres wer

272 s at low [Ca(2+)] dropped 2-fold and (b) the half-maximal rate of cGMP synthesis was attained at a hi

273 occurs in a low-pH-dependent manner, with a half-maximal rate of fusion occurring at pH 5.5.

274 sphate ions across the plasma membrane, with half maximal rates attained at physiological levels of p

275 Half-maximal rates for histamine (4 h) and IL-4 (5 h) se

276 Half-maximal receptor occupancy by eliprodil occurred at

277 ry occurred more slowly between IBL stimuli (half-maximal recovery rate of ~46 min).

278 The belatacept concentration associated with half-maximal reduction (EC50) of CD154 expression was ca

279 tions, we observe good agreement between the half-maximal regulatory activity (T(50)) and the affinit

280 When compared with control patients, half maximal relaxation time (RT50) at 60 per minute was

281 aicin (Emax) and the capsaicin dose inducing half-maximal response (ED50).

282 aicin (Emax) and the capsaicin dose inducing half-maximal response (ED50).

283 tion of the stimulus required to provide the half-maximal response (S(50)).

284 e sensor at a concentration corresponding to half-maximal response is 13.6 ng/mL x Hz.

285 tivities from 8-13% DeltaF/F per 100 mV, and half-maximal response times from 4-7 ms.

286 g to determine the capsaicin dose inducing a half-maximal response, which was subsequently administer

287 ntially to four-way junction (4WJ) DNA, with half-maximal saturation of 1.4 +/- 0.4 nM compared to 20

288 f products, the K(M) (the [ATP] required for half-maximal speed) was 28 +/- 1 microM, and the maximum

289 The insulin concentration for the half-maximal stimulation of the pAkt-tAkt ratio was used

290 that: (i) the MarA concentrations needed for half-maximal stimulation varied by at least 19-fold amon

291 e of the [Ca(2+)]i response to approximately half-maximal stimulation with 100 nm ACh ( approximately

292 ey have rapid twitch kinetics (full width at half-maximal stress: 11 +/- 1 ms) and a high twitch/teta

293 l absolute temperature was sigmoidal, with a half-maximal tension at 10-12 degrees C; the relation wi

294 2.25 +/- 0.32 and substrate concentration at half maximal transport (K(t)) = 1.53 +/- 0.88 mmol/L, wh

295 ws enhanced sigmoidal kinetics with COX, and half-maximal turnover is observed at a Cyt c substrate c

296 duronidase-deficient mouse fibroblasts, with half-maximal uptake estimated as 1.6 nM.

297 aB activation of luciferase expression, with half-maximal values of 10-25 nM.

298 The concentrations to induce half-maximal vasodilation were comparable for nitropruss

299 ion and a significant right-shift in channel half maximal voltage for activation.

300 MiRP3 shifts the half-maximal voltage for activation (V(1/2)) approximate