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1 e the biological and clinical impact of each hallmark.
2 hich oxidative stress is often an associated hallmark.
3 absence of Alzheimer's disease pathological hallmarks: amyloid plaques (A), phosphorylated tau (T),
4 les and MRI-defined hypoxia levels in cancer hallmark analysis, we identified a distribution of level
5 3) protein is a master regulator of most key hallmarks and enablers of cancer, including cell prolife
7 factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and metabolic rewiring are well-e
9 he TET1 survival effect through eight cancer hallmarks: apoptosis, cell cycle, cell death, cell motil
10 l neurogenesis impairment, macrocephaly, and hallmark ASD behaviors, which resembled patient phenotyp
11 in the cerebral cortex, histopathologically hallmarked by amyloid beta (Abeta) extracellular plaques
12 diomyocyte remodeling and dedifferentiation, hallmarked by myolysis, glycogen accumulation, and alter
13 ated murine B-cell proliferation in vitro, a hallmark cell subtype found in the pathology of index ca
14 ated AMELX, KI enamel lacks enamel rods, the hallmark component of mammalian enamel, and, unlike WT e
16 the so called anomalous Josephson effect-the hallmark effect of superconducting spintronics-which can
18 PV-evoked currents in mature neurons exhibit hallmark fast rise and decay phases, newborn neurons dis
21 Immunosuppression of unknown aetiology is a hallmark feature of glioblastoma and is characterized by
24 oenvironment varies between tumor types, but hallmark features include immune cells, stromal cells, b
25 oots expressing the cognate PrpS resulted in hallmark features of the P rhoeas SI response, including
26 y that a change in receptor specificity is a hallmark for adaptation to humans and evolution toward a
28 ic locations of the cingulum bundle may be a hallmark for the early prediction of Alzheimer's disease
29 ound that dynamic chromatin loops are better hallmarks for cellular differentiation than compartment
31 key modulator of type I IFN production, the hallmark function of pDCs, commending Hv1 as an attracti
33 motherapy for various solid tumors, triggers hallmark immunostimualtory DAMP release (e.g., calreticu
35 D) at so-called phosphoswitches, which are a hallmark in response to growth factors, cytokines or str
36 y, defects in insulin secretion constitute a hallmark in the progression of patients from a state of
37 he overaccumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), in
39 ed system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but
43 ratory energy metabolism at night, uniting a hallmark mechanism of TOR regulation across eukaryotes.
46 e show that the transition to action has the hallmark of a critical transition that is accompanied by
47 g high-frequency respiration (sniffing) is a hallmark of active odorant sampling by mammals; however,
52 glandin E(2) (PGE(2))-degrading enzyme, as a hallmark of aged tissues, including skeletal muscle.
57 channels lack a P-loop selectivity filter, a hallmark of all known K(+) channels, raising the questio
60 of insoluble amyloid fibrils, a histological hallmark of Alzheimer disease (AD) and two dozen related
61 beta deposition into plaques is a pathologic hallmark of Alzheimer disease appearing years before the
62 ues and fibrils in the brain parenchyma is a hallmark of Alzheimer's disease (AD), but a mechanistic
63 and misfolded tau protein are a pathological hallmark of Alzheimer's disease and other tauopathy cond
64 gation from monomers into amyloid fibrils, a hallmark of Alzheimer's disease, is crucial for the deve
68 ion of polyarthritis and polyarthralgia is a hallmark of arthritogenic alphavirus infections, with an
73 sults suggest that recurrent connectivity, a hallmark of biological visual systems, may be essential
74 Similar to KPC mice, tissue atrophy was a hallmark of both neoplasia and pancreatitis models in th
77 elomerase reactivation is a nearly universal hallmark of cancer cells which enables replicative immor
79 Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells resistant to che
81 ed to normal tissues and this is an emerging hallmark of cancer, which brings a potential opportunity
85 ose, we show that suppression of Malat1 is a hallmark of CD4(+) T cell activation, but its complete d
94 fear behavior in the absence of danger is a hallmark of disabling anxiety disorders that affect mill
96 on structures has been hindered by latency-a hallmark of EBV infection-and atomic structures are thus
97 ol of fear response, and its impairment is a hallmark of emotional disorders like post-traumatic stre
100 the pioneer transcription factor FOXA1 are a hallmark of estrogen receptor-positive (ER(+)) breast ca
103 ate that nonequilibrium two-state folding, a hallmark of FimA with the Nte inserted in the pilus rod-
104 responses with a raised glucose threshold, a hallmark of functional maturity, and function within day
106 on of sensori-cognitive information may be a hallmark of genetic effects on the brain that contribute
107 tive retinal ganglion cell degeneration is a hallmark of glaucoma, the leading cause of irreversible
114 arge singlet exciton diffusion lengths are a hallmark of high performance in organic-based devices su
115 eostasis during HIV infection.IMPORTANCE The hallmark of HIV infection is a gradual depletion of CD4
117 alteration (SCNA) rather than mutation is a hallmark of hormone-secreting adenomas and that SCNAs co
120 the pathogenesis of periportal steatosis, a hallmark of human pediatric non-alcoholic fatty liver di
125 ether the NR controls neuronal assemblies, a hallmark of information exchange between the HPC and mPF
130 s inside the superconducting gap, which is a hallmark of linearly dispersing modes in one dimension.
131 an anti-tumorigenic state is considered as a hallmark of M1 and can be a direct indication of respons
132 cell functional inhibition (exhaustion) is a hallmark of malaria and correlates with impaired parasit
141 nt of sodium channels at nodes of Ranvier, a hallmark of myelinated axons, underlies effective saltat
142 key chemokine for neutrophil infiltration (a hallmark of NASH), is highly elevated in NASH patients b
144 brain and represents an important pathologic hallmark of neurodegenerative diseases including Alzheim
146 Protein misfolding and aggregation is the hallmark of numerous human disorders, including Alzheime
147 d epithelial tissue damage is a pathological hallmark of numerous inflammatory conditions including i
149 the effects of intermittent hypoxia (IH), a hallmark of OSA, on senescence in human white preadipocy
151 ncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet the metabolic
153 for normal tissue regeneration, it is also a hallmark of pathological processes, including malignancy
154 Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic met
155 L) by the upstream protein kinase RIPK3 is a hallmark of pathway activation, the precise checkpoints
158 The H2A.Z histone variant, a genome-wide hallmark of permissive chromatin, is enriched near trans
165 nterstitial fibrosis (MIF) is a histological hallmark of several cardiac diseases that alter myocardi
166 ECM) deposition and stiffening is a physical hallmark of several solid cancers and is associated with
171 ted sodium (Na(V)) channels are a functional hallmark of the axonal initial segment in vertebrates.
174 ormation in schizophrenia might constitute a hallmark of the illness, which indeed should be further
177 Glucose-stimulated insulin secretion is the hallmark of the pancreatic beta-cell, a critical player
178 Extracellular matrix (ECM) remodeling is a hallmark of the pathology of gastrointestinal disorders.
180 trum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome corona
192 ed microarchitecture of collagen type I is a hallmark of wound healing and cancer that is commonly at
194 ic (i.e., complete wetting surfaces with the hallmark of zero contact angle for water droplets).
195 profiles and global DNA hypomethylation are hallmarks of 2i exposure, but it is unclear whether epig
197 ' CD8(+) T cells (CD8-MP cells) that exhibit hallmarks of activation and innate-like functional prope
199 oAbeta), we analyzed cellular and behavioral hallmarks of AD, GR signaling pathways, processing of am
201 amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring
206 rmal binocular vision and reduced acuity are hallmarks of amblyopia, a disorder that affects 2%-5% of
207 these neuroimmune interactions are becoming hallmarks of and potential therapeutic targets for multi
210 rtholog FLP-34 displays conserved structural hallmarks of bilaterian-wide NPY/NPF neuropeptides.
212 luated based on its ability to replicate two hallmarks of bistability during auditory streaming: the
213 The Warburg effect is one of the metabolic hallmarks of cancer cells, characterized by enhanced gly
220 d immune and metabolic signalling can affect hallmarks of cancer, including chronic inflammation, epi
221 complementary capabilities, defined as the "hallmarks of cancer," include the ability of tumor cells
225 AKT and of how these events couple two major hallmarks of cancer: growth factor independence through
228 itive correlation of monounsaturated PC with hallmarks of cell proliferation and hepatic carcinogenes
230 e the ultrastructural features and molecular hallmarks of chemical synaptic-like contacts: narrow int
231 sphorylation and aggregation, are considered hallmarks of cognitive deficits in Alzheimer's disease.
232 and DNA methylation profiles are considered hallmarks of colorectal cancer development, the precise
233 expansion and increased neuronal number are hallmarks of cortical evolution, particularly in humans.
234 ition of excitatory neurons, which are known hallmarks of cortical plasticity during juvenile critica
235 We used a variety of techniques to examine hallmarks of cystinosis-including cystine accumulation,
239 e notably, critically ill patients displayed hallmarks of extrafollicular B cell activation and share
242 DUX4 expression, dystrophic muscle presented hallmarks of FSHD histopathology, including muscle degen
250 que remodeling and contraction, and impaired hallmarks of inflammation resolution, including dampenin
254 y gland morphogenesis, sEV treatment induced hallmarks of malignant transformation, with deregulated
255 Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke
256 helicase/chaperone activity, and exhibit the hallmarks of maturation observed for SG proteins that ph
259 , border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, patho
263 nges in the timing or nature of the cellular hallmarks of normal ageing might be key to understanding
266 hus, pathogenic alpha-synuclein exhibits key hallmarks of prion strains, which provides evidence that
268 ased waveform amplitude are neuron-intrinsic hallmarks of seizure invasion that impede traditional sp
270 he proposed framework may indeed exploit the hallmarks of spatially explicit ecological approaches an
273 ected enrichment of gene sets related to the hallmarks of the disease, which highlights the biologica
275 Importantly, RGN promoted multiple known hallmarks of tumor dormancy including activation of p38
279 distribution of levels associated with each hallmark; oxidative phosphorylation and G(2)-M checkpoin
281 enes (DEGs), followed by gene ontology (GO), Hallmark pathway enrichment and protein-protein interact
282 Elucidation of these previously unknown RMC hallmarks paves the way to new clinical trials for this
283 deficient cells lead us to conclude that the hallmark phenotype of Torsin manipulation represents abe
285 ractions can be exploited to control ferroic hallmark properties such as the size and morphology of d
288 e aberrant accumulation of this pathological hallmark shared across adult-onset neurodegenerative dis
290 nophialum)-infected tall fescue (E+) and are hallmark signs of fescue toxicosis (FT), a disease exace
292 he molecular level to directly prevent their hallmark symptoms of deficiency like anemia or birth def
293 tentional differences that often precede the hallmark symptoms of social communication impairments.