ライフサイエンスコーパス: hamper

1 the lack of methods for their production has hampered access to their utility.

2 e heterogeneity of alphabeta thymocytes have hampered analyses of their intrathymic differentiation.

3 site and observed that this change severely hampered antibody stability and its ability to interact

4 perones reduces the ER-resident MR1 pool and hampers antigen presentation and MAIT cell activation.

5 ty and a marker for their identification has hampered attempts to overcome T cell inhibition and unle

6 se tissue damage, inflammatory spillover and hampered axon regeneration.

7 e derivatives as therapeutic agents has been hampered because of poor drug-like properties as well as

8 However, progress has been hampered because shared genetic influences related to fo

9 de in noncoding regions of the genome, which hampers biological inference and translation of genetic

10 ctive ligands have been reported(2,8,10-12), hampering both the understanding of circadian biology an

11 ts widespread application, however, is still hampered by a lack of access to biomass-enriched with AN

12 eus manipulates protective immunity has been hampered by a lack of antigen-specific models to interro

13 Therapy developments have been hampered by a lack of biomarkers that can reliably predi

14 very of specific Artemis inhibitors has been hampered by a lack of crystal structures.

15 s) in large nationwide cohorts are currently hampered by a lack of knowledge about spatial and spatio

16 uit as a tool for synthetic biology has been hampered by a lack of mechanistic understanding of its f

17 thorough assessment of their impact has been hampered by a lack of methodology to measure the amount

18 rogressive multiple sclerosis (PMS) has been hampered by a lack of reliable biomarkers to monitor neu

19 nderstanding the epidemiology of FP has been hampered by a lack of robust serological assays to monit

20 preventing recurrent pregnancy loss has been hampered by a lack of standardized definitions, the unce

21 potent, specific inhibitors of GGT1 has been hampered by a lack of structural information regarding s

22 lity, research on olfactory communication is hampered by a lack of tractable methods.

23 Chagas drug discovery has been hampered by a lack of validated assays to establish trea

24 tochondrial changes in multiple sclerosis is hampered by a paucity of non-invasive techniques to inve

25 velopment of new therapies for HGSC has been hampered by a paucity of preclinical models in which new

26 , the development of new treatments has been hampered by an imperfect understanding of the biological

27 s in understanding these mechanisms has been hampered by an incomplete knowledge of the neural underp

28 However, neurohumoral blocker withdrawal was hampered by cardiac comorbidities.

29 r, conventional manufacturing approaches are hampered by challenges with scalability and interdonor v

30 igning direct developmental roles to them is hampered by complex mutant phenotypes that often emerge

31 hy-mass spectrometry (LC/MS) HTE methods are hampered by compound co-eluting, possible ion suppressio

32 argeting the ZIKV envelope protein have been hampered by concerns for cross-reactive responses that i

33 However, their clinical use has been hampered by confounders such as patient co-morbidities,

34 However, SUD-related research is hampered by continued arguments over which animal models

35 Diagnosis of NSAIDs hypersensitivity is hampered by different factors, including the lack of val

36 pattern regulation, but their study has been hampered by difficulties in monitoring and manipulating

37 ple drugs from one MOF are rare, potentially hampered by difficulties in postsynthetic loading of mor

38 Such forecasts are hampered by ecological uncertainties associated with non

39 ection, yet in many clinical scenarios it is hampered by false positives.

40 weak efficacy in a mouse model of VL but was hampered by glucuronidation.

41 ecause previous PET studies in HCC have been hampered by high background liver signal, we investigate

42 Comparability of the 103 studies is hampered by high heterogeneity of the studies' designs a

43 LR, readily available, is hampered by high recurrence rates.

44 y in lung adenocarcinoma has previously been hampered by inappropriately tailored in vitro assays of

45 Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptiv

46 lation of oral protein formulations has been hampered by inefficient penetration of drugs through the

47 s, although their wider application has been hampered by instability problems.

48 n global health and low-resource settings is hampered by insufficient data diversity, nontransparent

49 de reverse transcriptase inhibitors is often hampered by insufficient phosphorylation.

50 gration into optoelectronic devices has been hampered by issues of colloidal and photophysical instab

51 The available treatments are hampered by issues such as toxicity, variable efficacy,

52 ding of DOM reactivity in natural systems is hampered by its complex molecular composition.

53 f MS-based proteomics to the clinic has been hampered by its complexity and the substantial time and

54 e application of CAR in food preservation is hampered by its high volatility, low solubility in water

55 delivery of H(2) S to biological systems is hampered by its toxicity at high concentrations.

56 dentify potential DMD therapeutics have been hampered by lack of a small animal model that recapitula

57 larity as to the role of RLPs in CVD risk is hampered by lack of a widely accepted definition and a p

58 us disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respirator

59 th mechanistic understanding of NCs has been hampered by lack of an in vitro assay that can track NC

60 on models, its empirical validation has been hampered by large scale and slow rate of the interaction

61 heoretical predictions(4-6) based on BBN are hampered by large uncertainties on the cross-section of

62 gies that uniquely identify single cells are hampered by limitations in barcode measurement.

63 he molecular basis of myocardial fibrosis is hampered by limited access to tissues from human patient

64 ory roles, yet their detailed study is often hampered by limited clinical sample availability.

65 In contrast, the United States, hampered by limited testing capacity, has prioritized te

66 Myelin imaging is often hampered by long scanning times, complex postprocessing,

67 conduct of clinical endpoint studies may be hampered by low incidence of disease, especially for con

68 However, hiPSC-derived TEVGs are hampered by low mechanical strength and significant radi

69 ing low-molecular-weight inhibitors has been hampered by low specificity and high toxicity issues.

70 ression studies in human mast cells has been hampered by low yields of human mast cell cultures and t

71 all procedures, current understanding may be hampered by methodological limitations that obscure dyna

72 f therapeutics for brain tumors is seriously hampered by multiple barriers to drug delivery, includin

73 SPIM), the achievable optical performance is hampered by optical degradations encountered in both the

74 ctrum aminoglycoside antibiotic whose use is hampered by ototoxic side-effects.

75 ng potential therapies in clinical trials is hampered by our inability to distinguish between patient

76 ng of serotonergic circuitry, which has been hampered by our inability to monitor serotonin release a

77 on, unlike aboveground shoot competition, is hampered by our inability to observe roots.

78 of improved therapeutic strategies has been hampered by our incomplete understanding of this recepto

79 monolayers, where excitonic condensation is hampered by Peierls instability, or other bilayers, wher

80 py still relies on antibody-based antivenom, hampered by poor access, frequent adverse reactions, and

81 evidence that the spread of a gene drive is hampered by reproductive behaviour in a natural populati

82 empted to quantify stillbirth risk have been hampered by small event rates, a limited range of predic

83 ng of Chinese land biosphere fluxes has been hampered by sparse data coverage(2-4), which has resulte

84 e of biological and pathological changes, is hampered by structural complexity distinctive from image

85 lerance is possible in a field that has been hampered by suboptimal outcomes.

86 versity responses to climate change has been hampered by substantial variation in the rates and even

87 ent, and the targeting of Na(V)1.9, although hampered by technical constraints, might also be moving

88 This goal has been hampered by technical difficulties and the challenge of

89 Current research in the field is not only hampered by the absence of a gold standard for PAC analy

90 pts to quantify river connectivity have been hampered by the absence of a harmonized barrier database

91 Hampered by the absence of evidence and theoretical mode

92 This stabilization was hampered by the BCR-pathway inhibitor Ibrutinib, support

93 Its practical application is, however, hampered by the capacity and voltage fade after long cyc

94 potential application of antibodies is often hampered by the challenge in generating nonimmunogenic a

95 echniques have been proposed, they have been hampered by the challenge of accounting for dramatic con

96 s a long-standing goal in drug discovery but hampered by the difficulties associated with the targeti

97 eciphering the structure of ERRbeta has been hampered by the difficulties in obtaining a pure and sta

98 mpts to investigate Wnt-FZD interactions are hampered by the difficulties in working with Wnt protein

99 impaired linear and ponderal growth has been hampered by the difficulty in directly sampling the smal

100 C-H heteroarylation methodology is currently hampered by the difficulty of removing the directing gro

101 However, their clinical application is hampered by the difficulty to deliver them into cancer c

102 However, the utility of this approach is hampered by the existence of multiple models, each with

103 ng, but the introduction of such measures is hampered by the fact that a sizeable part of the populat

104 tation of historical recombination events is hampered by the fact that driver genes are often express

105 , small molecule-based targeting of SHP2 was hampered by the failure of orthosteric active-site inhib

106 of the findings from these investigations is hampered by the heterogeneity of the methods used to mea

107 ange of diseases, but vaccine development is hampered by the high number of serotypes.

108 nprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA

109 pertoire of T cell specificities for HCMV is hampered by the immense protein coding capacity of this

110 However, studying this dynamic is hampered by the inability to selectively activate indivi

111 levels to different metabolic conditions, is hampered by the lack of a fast NAD(+)-dependent desuccin

112 rization of the in vivo function of MltG was hampered by the lack of a growth or morphological phenot

113 of the etiology of these phenotypes has been hampered by the lack of animal models due to embryonic l

114 Development of novel treatments have been hampered by the lack of available animal models recapitu

115 he function of many imprinted genes has been hampered by the lack of corresponding mutant phenotypes,

116 The advancement of UTUC research is hampered by the lack of disease-specific models.

117 es, but technological implementation will be hampered by the lack of high-throughput techniques for e

118 ational vaccine design efforts are currently hampered by the lack of knowledge regarding viral epitop

119 interventions that slow or reverse aging is hampered by the lack of non-invasive metrics that can pr

120 ate treatment response in clinical trials is hampered by the lack of objective molecular biomarkers c

121 n analytical results in gluten-free foods is hampered by the lack of reference materials (RM).

122 cal organ transplantation has, however, been hampered by the lack of sensitivity of conventional inst

123 cterization of immune responses is currently hampered by the lack of systems enabling quantitative an

124 rotein molecules in nanopores(1-5) have been hampered by the lack of techniques with sufficient sensi

125 of CAR-T cell therapies for solid tumors is hampered by the lack of truly tumor-specific antigens an

126 Management of both GCA and PMR is hampered by the lack of universally accepted definitions

127 tions downstream of transcription factors is hampered by the large number of genes whose expression c

128 Diagnostic tests for fish allergy are hampered by the large number of under-investigated fish

129 nd efforts to develop drugs and vaccines are hampered by the limited knowledge of the molecular detai

130 , the characterization of the variability is hampered by the limited size of the sampled repertoires.

131 or efforts to derive these indices have been hampered by the need for sophisticated and not easily re

132 g selectivity between WNTs and FZDs has been hampered by the paucity of purified WNT proteins and by

133 ful vaccine against human cytomegalovirus is hampered by the peculiar biology of this infection.

134 ranthropus and Homo in South Africa has been hampered by the perceived complex geological context of

135 ts to eradicate Plasmodium vivax malaria are hampered by the presence of hypnozoites, persisting stag

136 the development of novel therapies have been hampered by the scarcity of suitable cell culture models

137 y-friendly electrolysis process is currently hampered by the slow kinetics of the oxygen evolution re

138 this expansion toward aquatic soft robots is hampered by the slow response of most light-driven polym

139 ition, but genetic studies to date have been hampered by the small size of the assembled cohorts.

140 Ca) in oxygen reduction reaction is severely hampered by the tight-bonding of active centers with hyd

141 study of their bioactivities has always been hampered by their difficult obtention.

142 Detection of malaria hotspots is hampered by their heterogenous spatial distribution, and

143 rization of most organometallic compounds is hampered by their high reactivity, in particular, toward

144 immune responses against primary tumours is hampered by their immunosuppressive microenvironment and

145 ral administration of these drugs is largely hampered by their low and highly variable bioavailabilit

146 performance of such systems is still largely hampered by their poor electrical conductivities.

147 nanobodies as capture antibodies is greatly hampered by their poor performance after passive adsorpt

148 ve to macromolecules but have generally been hampered by their rapid clearance from tumors, thus dimi

149 onal gene analysis of Agrobacterium has been hampered by time-consuming mutation strategies.

150 targeting molecules such as Hsp70 have been hampered by toxicity issues.

151 haran Africa, but previous studies have been hampered by unknown biases due to excessive loss to foll

152 However, the performance of these methods is hampered by using limited information, i.e. only the tit

153 ages of hypersensitivity pneumonitis (HP) is hampered by variable presentation, heterogeneous or unde

154 is information, but measurement precision is hampered by various sources of errors caused by instrume

155 y regimens, but their oral administration is hampered by very low and highly variable oral bioavailab

156 les in the liquid phase, a difficult process hampered by weak intermolecular forces, is achieved thro

157 omponents into the PDMS that would, in turn, hamper cells and/or tissues cultured in the devices.

158 osition and dynamics of transplantation have hampered clinical translation.

159 initions and validated reference values have hampered clinical use.

160 c guilds for more than 20% of species, which hampers comparability across studies.

161 ata from treatment-naive patients are scarce hampering comprehensive analyses of the complex interact

162 erstanding of infectious disease impacts and hampers conservation efforts.

163 affect ecological and conservation outcomes hampers decision-making.

164 systematic experimental investigation, which hampered detailed insight into the molecular biology and

165 erse genetic tools for choanoflagellates has hampered direct tests of gene function and impeded the e

166 res and mechanisms of action remain unclear, hampering drug development.

167 Its widespread use has been hampered due to concerns about nodular regenerative hype

168 ever, structural studies of HBV RT have been hampered due to its unexpectedly poor solubility.

169 its functional domains, which was previously hampered due to the lethality of the gene.

170 ticle-based biomedical applications has been hampered due to undesired off-target effects.

171 luctuations in prostate-specific antigen can hamper early diagnosis of castration-resistant prostate

172 However, the presence of the cavity can hamper efficient laser cooling of ions because of geomet

173 of safe drinking water, which could in turn hamper efforts in China and other LMICs toward universal

174 the study of M. haemolytica pathogenesis has hampered efforts to better understand the molecular inte

175 pecially leading up to their extinction, has hampered efforts to develop a robust picture of their ev

176 e specifically in individual transcripts has hampered efforts to elucidate causal relationships betwe

177 ability to infect humans, which has severely hampered efforts to predict the next zoonotic viral outb

178 ty of Oligocene whale skeletons [12, 13] has hampered efforts to understand the evolution of fluke-po

179 iral therapy, mainly in CD4(+) T cells, thus hampering efforts for a cure.

180 ructural mechanism remains unclear, however, hampering efforts to design drugs with desired signaling

181 This hampers efforts to develop a more coherent picture of gl

182 nd times for laboratory diagnostic tests and hamper epidemic control or patient treatment efforts.

183 ol groups complicates cross-link regulation, hampering fabrication and the long-term stability/perfor

184 , and versatile monitoring have consistently hampered further advances in analyzing cell or tissue be

185 ycogen accumulation, decreased glycemia, and hampered glucagon-induced gluconeogenesis, thus preventi

186 Galc knockdown hampered growth, motility, and invasive capacity of B16-

187 ects on B-cell differentiation, specifically hampering gut lymphocyte homing and IgA(+) plasma cell d

188 istance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and eliminatio

189 Ovarian cancer has few known risk factors, hampering identification of high-risk women.

190 stingly, phospholipid synthesis was severely hampered in cells in which PlsX was detached from the me

191 ation may have immunologic consequences that hamper innate and adaptive antiviral immune responses fo

192 er types of membrane building blocks and has hampered integration of phospholipid synthesis into arti

193 mong the different GIRK channel subtypes has hampered investigations into their precise physiological

194 d availability of serum-derived RIG severely hamper its wide use in resource-limited countries.

195 ty and biochemical heterogeneity of 10E8 has hampered its development for clinical use.

196 omposition of H(2) O(2) at room temperature, hampering its application for quantitative analysis.

197 r stability of fish hydrolyzed collagen (HC) hampers its applications, especially as food ingredients

198 cal feature of atrial fibrillation that also hampers its treatment; the underlying molecular mechanis

199 could yield a metabolism-based blueprint for hampering Legionnaires' disease.

200 s in soil C storage are not well understood, hampering long-term predictions of climate C-feedbacks.

201 rs and increased neutrophils, accompanied by hampered lymphocyte proliferation but increased monocyte

202 symptomatic carriers of Plasmodium parasites hamper malaria control and eradication.

203 However, ion-suppressing effects of TEA hamper mass spectrometry (MS) instrumentation sensitivit

204 , its deficiency causes a metabolic blockade hampering mitochondrial energetics and respiration.

205 enue in CMT1B and also suggest that PERK may hamper myelination via mechanisms outside its role in th

206 However, VA-ECMO might hamper myocardial recovery.

207 cell (PSC) lines is a prevailing issue that hampers not only experimental reproducibility but also l

208 Limited evidence-based studies hamper our knowledge on the long-term effects of the pro

209 A fixed clustering 'resolution' hampers our ability to identify and visualize echelons o

210 This lack of full-length genomes hampers our ability to understand the molecular drivers

211 Ablation of Zeb2 hampered outgrowth of primary melanomas in vivo, whereas

212 knowledge of M. kansasii infection has been hampered owing to the lack of an effective animal model

213 that PKA phosphorylation of the DEP1 domain hampers P-Rex1 binding to negatively charged membranes i

214 However, the success of these probes is hampered partly due to the inflammatory host tissue resp

215 nto personalized treatment regimens has been hampered partly due to uncertainties in deviating from g

216 tantly, the IGFBP7-induced type II rosetting hampers phagocytosis of IRBC by host phagocytes.

217 bility and underlying neuropathogenicity has hampered poliovirus-based vector applications.

218 is methods are often tedious and unscalable, hampering practical applications.

219 e and reliable DNA reference database, which hampers precise species identification and DNA based bio

220 ls that recapitulate the genetics of ACC has hampered progress in the field.

221 ities or loosely collected species have also hampered progress in the way we assess and conserve biod

222 ably detect RanBP9 in vivo has significantly hampered progress in understanding the biological functi

223 y and novel anti-androgen agents has further hampered progress.

224 f a common framework for studying all SVs is hampering progress towards a more systematic assessment

225 These, in particular, hamper quantitative assessment of spatially resolved vel

226 ron-beam lithography, whose limitations have hampered rapid innovations and broad applications of con

227 absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purp

228 t pharmacological blockade of TAK1 signaling hampered ribosome biogenesis (RBG) by reducing expressio

229 arge-scale genome structure variations could hamper sexual reproduction, causing reproductive isolati

230 rent effects in laser design, which has been hampered so far by the lack of a coherent ME formalism.

231 t just an epiphenomenon of parasite exposure hampering specificity of allergy diagnostics; mechanisti

232 man embryonic kidney 293 (HEK293) cells) has hampered studies of its biophysical and pharmacological

233 ogenic ligands can overcome these therapies, hampering success of this approach.

234 ysiology in specific mucosal niches has been hampered technically by an overabundance of host RNA.

235 k tissue may obscure association signals and hamper the biological interpretation of findings, these

236 a and supplements are unresolved issues that hamper the clinical applicability of these approaches.

237 m/z 1000, while MALDI matrix ions generally hamper the detection of smaller singly charged fragments

238 s, induced protective cytokines, and did not hamper the drug-metabolizing enzymes in hosts.

239 Biological barriers hamper the efficient delivery of drugs and genes to targ

240 ss, variability in spectrometer features may hamper the production of comparable spectra due to inher

241 iability between experiments and lower yield hampered the cross comparison between individual lines a

242 This has hampered the design of effective treatments that could p

243 disparate interpretations of resilience have hampered the development of a common currency to quantif

244 group where network-structured phylogeny has hampered the development of diagnostic methods for speci

245 ion mechanisms of their syntheses, which has hampered the development of new reagents of the same fam

246 ability to form hydrogen bonds, has severely hampered the development of the field.

247 sis of neurodegenerative disorders (NDs) has hampered the development of therapeutics whose effect wo

248 come available and the lack of such data has hampered the disentangling of biotic and abiotic effects

249 e scarcity of taxon-specific information has hampered the efficacy of these endeavors.

250 cular collisions(2-5), however, have greatly hampered the engineering of low-entropy molecular system

251 This rather narrow focus has hampered the establishment of a comprehensive view of CH

252 ed, and other pre-analytical variables, have hampered the identification of disease-associated miRNom

253 ferent radiosensitivities, which in turn has hampered the identification of genetic elements responsi

254 ics further revealed that proteolysis mostly hampered the oxidized peptides rather than the deamidate

255 echnical and methodological limitations have hampered the site-specific investigation of the conforma

256 tively on EP2 and EP4 receptors on NK cells, hampered the TME switch, and enabled immune evasion.

257 will change due to relative sea-level rise, hampering the ability to forecast delta response to glob

258 ark, H2AK15pUbT12, that regulates the DDR by hampering the activity of 53BP1 at damaged chromosomes.

259 of certain GPL classes over others, thereby hampering the analysis of suppressed species and greatly

260 standing of their evolutionary behaviour and hampering the characterisation of the determinants of th

261 narrow therapeutic windows for these agents, hampering the development of new drugs.

262 The major unmet need and crucial challenge hampering the exciting potential of RNAi therapeutics in

263 are only poorly understood to date, greatly hampering the predictability and design of improved enzy

264 ide the freshly produced stocks, potentially hampering the reactivity of the individual M13 filaments

265 e wide structural diversity of carbohydrates hampers the characterization of specific glycan determin

266 immune responses, this shortcoming severely hampers the development of effective immunotherapies.

267 ificant overhead to computer simulations and hampers the development of intuitive local pictures and

268 complexity of the parasite-host interactions hampers the identification and characterization of T cel

269 he challenges posed by climate change, which hampers the implementation of mitigation policies.

270 raction between PYR1/PYL4 and ABI1/ABI2, and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PY

271 Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glut

272 B from the gC-null virus, suggesting that gC hampers the recognition of gB epitopes in the viral part

273 a current lack of mechanistic understanding hampers the reliable lifetime prediction and performance

274 e inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxi

275 introduce (11)C into organic molecules often hampers the use of this radioisotope.

276 ion, however, have inherent limitations that hamper their capabilities and versatility.

277 uptake due to their structure significantly hamper their in vivo performances.

278 , suffer from strong inhomogeneity which may hamper their practical application.

279 es, T7SS defects induce oxidative stress and hamper their response to LA challenge.

280 ructure and limited area scaling at low cost hamper their use in several emerging applications.

281 man disease, many obstacles remain that have hampered their clinical use; thus, continued research ef

282 ncy and poor pharmacokinetic properties have hampered their development to treat sickle cell disease

283 elation of CT mechanism with their structure hampered their further development.

284 tissue specificity, among other reasons, has hampered their translation to clinical settings.

285 O donors; however, synthetic challenges have hampered their use.

286 ruction under external stimuli, considerably hampering their commercialization.

287 rrently used probes are not well-understood, hampering their effective applications.

288 ding of their photophysics is still limited, hampering their quantitative application.

289 required significant manual curation, which hampers their scalability for the ever-increasing deluge

290 each other and how disease-causing mutations hamper this interaction.

291 ly alternating polarity electric signals has hampered this technological advance.

292 tions in presentation and aetiology, thereby hampering timely and adequate management.

293 nect between human and animal studies, which hampers translation of microbiome findings to the clinic

294 This has hampered translational research and our ability to ident

295 inase-dead form, LKB1K78I, was sufficient to hamper tumor aggressiveness and metastatic dissemination

296 The pyridinium cation hampers uptake of OPs into the central nervous system (C

297 guration, these changes were insufficient to hamper utility in cancer margin assessment with spatiall

298 There was moderate variation between centres hampering valid regional comparisons.

299 terogeneities in retinal disease models have hampered validation of this hypothesis.

300 on and nanosecond relaxation measurement has hampered various applications of studying correlated ele