ライフサイエンスコーパス: head group

1 ne tetrapodal anchor and a phenyl or pyridyl head group.

2 this enables late-stage modification of the head group.

3 el, presumably due to its larger hydrophilic head group.

4 in mammalian tissues, releasing the choline head group.

5 d arginine and chloride ion via its carboxyl head group.

6 t manner, producing DAG and a phosphorylated head group.

7 ace for recognition of the PtdIns(3,4,5)P(3) head group.

8 acyl chain and would not allow entry of the head group.

9 c acid moiety as a well-tunable PPAR agonist head group.

10 sion attributed to the doubly charged PGP-Me head group.

11 position of methyl groups on their chromanol head group.

12 at mediates direct contact with the ceramide head group.

13 ted using thermophoresis, according to their head group.

14 he acyl groups with the remaining 16% in the head group.

15 loop regions and phosphate oxygens of the CL head group.

16 ive fullerene dispersions and positive lipid head groups.

17 notions of DMSO-induced dehydration of lipid head groups.

18 netic barrier imposed by phosphoethanolamine head groups.

19 to defined lipids, with and without negative head groups.

20 ace non-antigenic resident lipids with large head groups.

21 trostatic interactions with the phospholipid head groups.

22 charges and the functionalities of POM polar head groups.

23 s binding to negatively charged phospholipid head groups.

24 ith phosphatidylinositol phosphate (PtdInsP) head groups.

25 s, and (iii) in membranes with smaller lipid head groups.

26 ion between charge and size of the different head groups.

27 rough multidentate hydrogen bonding of lipid head groups.

28 tions with negatively charged membrane lipid head groups.

29 /hydrophobic boundary regions near the lipid head groups.

30 ally binding to membranes containing anionic head groups.

31 ted to the hydrophobic character of the tris head groups.

32 s arginine analogues with modified guanidine head groups.

33 om the micelle with Arg20 near the phosphate head groups.

34 mbrane phospholipids and interact with their head groups.

35 surfactants with different chain lengths and head groups.

36 ound in membrane proteins close to the lipid head groups.

37 nd (H-bond) network around the charged lipid head groups.

38 1-P groups derived from phosphatidylglycerol head groups.

39 eir preference for a location near the lipid head groups.

40 e between both proteins and the phospholipid head groups.

41 of the protein likely to interact with lipid head groups.

42 , Arg(62) and Lys(64), with the phospholipid head groups.

43 well as whether it associates with the lipid head groups.

44 near the glycerol backbone and phospholipid head groups.

45 choline, ethanolamine, inositol, and serine head groups.

46 , a dihydroimidazole linker and cyclic amine head groups.

47 ne surface interacting with the phospholipid head groups.

48 on the structure of the exposed polar lipid head groups.

49 and remodeling of both lipid acyl chains and head groups.

50 tonation, determined by the pKa of the lipid head groups.

51 tion and possible intermingling of the lipid head groups.

52 can recognize phosphatidylinositol phosphate head groups.

53 on of BetP especially with the anionic lipid head groups.

54 nzymatic remodeling of acyl chains and polar head groups.

55 amides/gangliosides by the addition of polar head groups.

56 roup of carotenoids with polar and non-polar head groups.

57 the vicinity of the inner and outer leaflet head-groups.

58 nable amines and overall pKa of the cationic head group, (2) the degree of unsaturation of the hydrop

59 he metal atoms or directly contact the polar head group abrogate binding, while mutations within the

60 atty acyl chains, PAs, TrGDGs, TeGDGs, TAGs, head-group-acylated galactolipids, acPG, and some sterol

61 lactosyldiacylglycerols (TrGDGs and TeGDGs), head-group-acylated galactolipids, and head-group-acylat

62 DGs), head-group-acylated galactolipids, and head-group-acylated phosphatidylglycerol (acPG), sulfoqu

63 mes show that the identity of the surfactant head groups affects the local environment experienced by

64 amino acid derivatives bearing a hydroxamate head group allowed the identification of compound 3a tha

65 ecursor or neutral loss scans of their polar head groups allowed the detection of molecular species w

66 gradient NMR of the phosphatidylcholine (PC) head group analogs, dimethyl phosphate and tetramethylam

67 d lipid" conformation, in which the inositol head group and 2'-fatty acid chain bind to a hydrophobic

68 both a small central cavity for the lactone head group and a long hydrophobic channel for its tail.

69 by coincident interactions of Drp1 with the head group and acyl chains of phospholipids.

70 Ligands composed of a catechol head group and an antagonist-like oxypropylene spacer po

71 Both lipids contain a cationic head group and an unsaturated hydrophobic dioleylglycero

72 ture of molecular species defined by a polar head group and characteristic acyl groups esterified to

73 rbon chain structure while SA has a carboxyl head group and GMS has two free hydroxyl groups.

74 a higher ordered membrane state, both in the head group and in the inner core region of the lipid bil

75 ng ethanolamine, or glycerol as phospholipid head group and in the number of cyclopropane bond contai

76 is to decrease the solvated volume of the PC head group and that, from 10 mol% to 20 mol%, DMSO acts

77 s may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding

78 al model for the interaction between the DLO head group and the flippase.

79 es has high specificity for the phospholipid head group and the nature of the fatty acyl chains.

80 hree dye-labeled lipids with different sized head groups and a charge on each lipid of -1.

81 ighly restricted out-of-plane motions of the head groups and also suggests that the angular distribut

82 ell as hydrogen bonding between phospholipid head groups and amine groups of chitosan.

83 the number of water molecules hydrating the head groups and as a function of cholesterol content for

84 ho ester linkers, which removed the cationic head groups and caused the aggregation of the lipoplexes

85 iments were performed to determine the lipid head groups and fatty acid composition.

86 rins with polar pyridinium electron-acceptor head groups and hydrophobic dialkyl-aniline electron don

87 plasma membrane anionic lipids with defined head groups and lipid side chains.

88 ontain phosphocholine or phosphatidylcholine head groups and phospholipid vesicles that mimic T-cell

89 t domain formation, but the effects of lipid head groups and soluble factors in lateral lipid organiz

90 ve responses to phospholipids with a choline head-group and minimal substitution at the sn-2 hydroxyl

91 cking thiol (C=11) with a -CH(3) terminating head group, and 1-dodecanethiol (1-DDT) were investigate

92 asing the number of amines in the protonable head group, and removing the histidine residue from the

93 the latter with phosphomoieties of the lipid head groups appear to stabilize the kinetic state beta'.

94 We developed a series of ionic head groups-appended self-assembled monolayers with C2,

95 cyl tail and the negatively charged carboxyl head group are required for PUFAs to open Kv7.1.

96 generation dendrons with larger hydrophilic head groups are bound identically by these polyanions, i

97 in membrane thinning as the lipid phosphate head groups are drawn toward the center of the bilayer.

98 lear receptor hormones, the phosphoinositide head groups are fully solvent-exposed and complete the L

99 interactions are prevented when the lipids' head groups are masked by the recruitment of cytosolic e

100 mmalian cells, these phosphorylated inositol head groups are predominantly borne by a C38:4 diacylgly

101 Mammalian lipids with zwitterionic head groups are preferred over other lipids for the inte

102 ions, where large amounts of water and lipid head groups are pulled into the bilayer to interact with

103 s in H-bonding between the phosphate and the head groups are responsible for the changes of chemical

104 osolic translocon residues, and phospholipid head groups are shown to favor conformations of the nasc

105 ipids with (2)H-labeled acyl chains or polar head groups are studied using (2)H NMR to yield knowledg

106 nit contains a hydrophilic and a hydrophobic head group, are capable of forming environment-dependent

107 he protein and non-phosphate moieties of the head group as a significant contributor to binding affin

108 r, have significant differences in the sugar head group as well as the ceramide portion.

109 role for vesicular zwitterionic phospholipid head-groups as an additional factor contributing to PEGy

110 o the structural disorder of water and lipid head-groups as the main source of inhomogeneous broadeni

111 vesicles by using the POM clusters as polar head groups, as studied by laser light scattering and TE

112 c perturbation of bilayer integrity by lipid head group-associated Abeta.

113 id surface on SF-1 with the phosphoinositide head group at its nexus and poised to interact with othe

114 GLH-58, or two, in GLH-60 positively charged head groups at each end of the hydrophobic core.

115 ic chain with one or more positively charged head groups at each end.

116 o the hydrophobic center and positioning the head groups at the periphery of the polymer.

117 random coiled and bound to the phospholipid head groups at the water-membrane interface, promoting t

118 fluid hydration layers surrounding the polar head groups attached to the substrate.

119 Glycan head-groups attached to glycosphingolipids (GSLs) found

120 e pai-pai orbitals overlap of the conjugated head groups between neighbouring molecules.

121 und to a Plasmodium GGPPS finding that their head groups bind to the [Mg(2+)](3) cluster in the activ

122 as to expand our knowledge of the ubiquinone head group biosynthesis and its potential metabolic depe

123 nteractions between water and the amphiphile head groups, both at the interface and in the bulk.

124 carboxylate) or cationic (trimethylammonium) head groups, both below and above the critical micelle c

125 G as compared to phospholipids with the same head group but longer hydrocarbon chains.

126 B trisaccharides, with three different lipid head groups but all with "ring-closed" monosaccharide re

127 ed, not only by increasing the amines of the head group, but also by increasing the degree of unsatur

128 ymers and surfactants with trimethylammonium head groups, characterized by strong hydrophobicity (v)

129 The metabolism of the polar head group characterizing each phospholipid class is poo

130 s anionic lipids by virtue of their negative head-group charge either in vivo or in situ.

131 Here, we investigated the effect of lipid head group charges on the signal transduction properties

132 ng sites are partially protected between the head group choline and the sn-2 carbonyl oxygen.

133 rface between the two arms, with the quinone head group close to the terminal iron-sulfur cluster, N2

134 r face partitions closer to the phospholipid head group compared with 3F(14).

135 ophobic part of the bilayer, by fixing lipid head group composition and varying hydrophobic propertie

136 hopanoid content and modified hopanoid polar head group composition mediate growth and survival in et

137 rast, the amount of hopanoids, but not their head group composition, contributes to fitness at low pH

138 k shows a connection between surface forces, head group conformation and dynamics, and surface water

139 We conclude that this is caused by the lipid head group conformation, where the two favored hydrogen-

140 ducts are aryl polyenes, lipids with an aryl head group conjugated to a polyene tail.

141 ned by minor structural modifications to the head group containing the tertiary amine, a tail group t

142 onclude that the acyl chains rather than the head groups define the positions of dimyristoyl-phosphat

143 We find that at higher head group density, the monolayers have more disorder in

144 n of agonists based on structurally distinct head groups derived from canonical or atypical dopaminer

145 ntiviral compounds may require a hydrophilic head group designed to interact with residues at the ent

146 as chain lengths at a specific sn position, head groups, double bond positions and stereochemistry t

147 rionic (phosphocholine, phosphoethanolamine) head groups, doubly mutated V172D/S252F TbSLS1 and D172V

148 to 20 mol%, DMSO acts to gradually collapse head groups down onto the surface and suppress their the

149 lysis suggests that negatively charged lipid head groups electrostatically capture the protein's diso

150 re found to be able to catalyze phospholipid head-group exchange with alkynols to generate alkyne-lab

151 and alkenyl-acyl phospholipids with the same head group exhibited comparable coefficients but differe

152 can capture one antigen with its hydrophilic head group exposed for T-cell recognition, but CD1b stru

153 , indicating a critical role of phospholipid head groups exposed at the DV surface.

154 ls of PIP(2) lie within the membrane and the head group extends downwards to interact with residues i

155 y hub controlling the supply of the aromatic head group for tocochromanol biosynthesis.

156 of using hydrophilic POM macroions as polar head groups for a surfactant system.

157 ops that may interact with the anionic lipid head groups found in membranes.

158 s, primarily through hydrolysis of the polar head group from inositol-containing membrane phospholipi

159 Varying the SAM head group functionality allowed us to quantitatively id

160 diastereomerism between their monosaccharide head groups, glucose and galactose in mammalian cells, g

161 Liposomes with modified lipid head groups have a unique feature of capturing and displ

162 charge near negatively charged phospholipid head groups; however, snorkelling's functional effects a

163 3, 6, 8, 9 and 11), with the -OH terminating head group, i.e., 3-mercapto-1-propanol (3-MPL), 6-merca

164 that phosphoethanolamine and phosphoglycerol head groups impose a kinetic barrier to OMP folding.

165 the metal ion remains directly bound to the head group in a contact ion pair motif as the asymmetric

166 ng transport of the hydrophilic phospholipid head group in a groove outlined by the transmembrane seg

167 odest electrostatic shielding of the sulfate head group in contact with PLA2.

168 g lipid analogues with a range of amino acid head groups in both l- and d-configurations, to produce

169 segregation of alkyl side chains and charged head groups in NILs.

170 assignment of a direct role for GIPC glycan head groups in the impaired processes in iput1 mutants i

171 ration of water molecules past the sulfonate head groups in the lamellar structures.

172 wholly explained by interactions between the head groups in the reverse micelle and the test protein.

173 e oil phase while sticking their hydrophilic head groups in water.

174 e and the surfactant Igepal CO 520 (nonionic head group) in 50/50 wt % cyclohexane/hexane are prepare

175 micelles of the surfactant Aerosol-OT (ionic head group) in isooctane and the surfactant Igepal CO 52

176 ctrostatic interaction between the +3 and -1 head groups increases the cohesion energy of the amphiph

177 phingoid base backbone, rather than from the head group, increasing the specificity and sensitivity o

178 PUFA analogs with a positively charged head group inhibit IKs channels.

179 The head group-interacting residues Arg3.28, Glu3.29, and Ly

180 combined with the previously validated three head group-interacting residues, now complete the mappin

181 The head group is almost completely excluded from contact wi

182 rfactant structure, of which the hydrophilic head group is composed of a folded, stable self-inclusio

183 ids appear at very similar energies when the head group is deprotonated by high subphase pH or expose

184 membrane surface nor the presence of a polar head group is essential for CD36 recognition of free oxi

185 t lateral shift (>1 A) of the galacturonosyl head group is noted at the CD1 surface compared with the

186 while their side chains interact with polar head groups, is proposed for the HIV-1 MSD.

187 an aliphatic, lipid-like ligand with a small head group lacking typical haptenic features, such as ar

188 residues in a manner similar to phospholipid head groups, likely contributing to the success of alkyl

189 ses and phosphatases, and the characteristic head groups make these molecules ideal for regulating bi

190 Well defined detergent head groups (maltose) are found associated with aromatic

191 ons between mu1 and negatively charged lipid head groups may promote ISVP* formation; however, experi

192 nalized with prototypical nonpolar and polar head group: methyl, amino, and nitrile.

193 and interaction with membrane lipid phospho-head groups (MLPHGs).

194 cles has been studied with a large number of head group modifications to the lipids.

195 eromycolate chain dynamics regulate mycolate head group movement, thereby modulating GEM-TCR activity

196 The effect was dependent upon head-group multivalency, because lowered pH suppressed t

197 is hypothesized that His interacts with a Q head group, mutations at four His moderately inhibited N

198 influence of the length and the terminating head group of blocking thiols on the sensitivity and spe

199 The head group of cardiolipin plays major role in activation

200 tion of the phytol chain to the tetrapyrolle head group of chlorophyll, and, as a result of cell-spec

201 ght hydrogen bonds with the glycerophosphate head group of its LPA antigen.

202 The two variants located within the head group of LMNB1 result in a decrease in the nuclear

203 Herein, C60-monoadduct (the head group of micelle) actually served as a nanomediator

204 antibody E06, which binds the phosphocholine head group of oxidized phospholipids but not native phos

205 OPA reacts with the ethanolamine head group of PE in human cells to form pyrrole-containi

206 or stem, the aminoacyl moiety, and the polar head group of PG as the main determinants for substrate

207 to be steric repulsion, because of the large head group of PGP-Me, or possibly out-of-plane bilayer u

208 Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated a

209 sing the allosteric site in complex with the head group of phosphatidyl inositol 3,4,5-trisphosphate

210 phosphate kinase (PIP5K1) phosphorylates the head group of phosphatidylinositol 4-phosphate (PtdIns4P

211 s by adding various amino acids on the polar head group of phospholipids.

212 unoglobulin (Ig) 3 and 34] interact with the head group of PI(4,5)P2 with moderate affinity (apparent

213 ta-sheet C and D, form salt bridges with the head group of PI(4,5)P2.

214 ture of the kindlin-2 PH domain bound to the head group of PIP3, inositol 1,3,4,5-tetraphosphate (IP4

215 ion of the protein with a negatively charged head group of surfactant/LPS promotes a protein-protein

216 irmed the phosphorylation by the phosphonate head group of the active site serine, it also unexpected

217 en Ser(5.46) and Asn(6.55), and the aromatic head group of the ligands.

218 Aminoacylation of the polar head group of the phospholipid phosphatidylglycerol (PG)

219 nition site requires both the acyl chain and head group of the PI for a productive interaction, and i

220 se (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, an

221 The amino alcohol head group of the sphingosine backbone is recognized thr

222 ctroscopy showed that the sulfur atom of the head group of the sulfonated PFASs retained an oxidation

223 ebrate rhodopsin, perturbations of the polar head groups of lipid molecules are detected.

224 different growing vectors identified for the head groups of M-MPEP and mavoglurant and by the unexpec

225 Liposomes composed of lipids containing head groups of phosphatidylcholine (PC), phosphatidyleth

226 nding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phos

227 of C1Bdelta as an interaction site with the head groups of phosphatidylserine, a known activator of

228 interaction and binding the acyl chains and head groups of phospholipid substrates.

229 y be important in interacting with the polar head groups of phospholipids.

230 olecules can be accommodated between the two head groups of the bolaform without addition of electrol

231 deposition of AuNP on the hydrophilic amine head groups of the DOPE.

232 restingly, the highly polar or charged lipid head groups of the simulated membranes were found to int

233 C form closed inclusion complexes with lipid head groups of viral membranes, thereby altering lipid o

234 idylinositol-4,5-bisphosphate molecules, the head groups of which occupy positively charged pockets i

235 end insignificantly on the aromatic ring or "head" group of 1.

236 coketide alkyl chain; however, the phosphate head-group of PM is shifted approximately 6 A in relatio

237 8-rings and bacterial c10- or c11-rings, the head-groups of cardiolipin molecules became associated s

238 ipid translocation by coordinating the polar head-groups of transiting phospholipids.

239 evealed a predominant effect of the aromatic head group on the intrinsic activity of our ligands, as

240 sorption of alkaline ionomer cation-exchange head groups on electrocatalysts surfaces, and (v) the po

241 The charged head groups on the dihexosamine backbone have also been

242 ide hormones interacts with the phospholipid head groups on the surface of the vesicles and that Tyr

243 Of the five different head groups, only ethanolamine showed appreciable activi

244 s formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydr

245 across the membrane, the phosphatidylserine head group passes near isoleucine-364 (I364) and that I3

246 ngage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respectiv

247 ho-base methylation pathway, which forms the head-group phosphocholine through the triple methylation

248 portions oriented inward and the hydrophilic head groups positioned outward to interact with the aque

249 of annexin V was the same regardless of the head group present on the anionic phospholipids tested (

250 ng the phosphoserine and phosphoethanolamine head groups, presented on albumin, were shown to signal

251 he dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creat

252 ydrocarbon tail with a modified polyphenolic head group promotes efficient cellular uptake and modera

253 UCILS with two chiral centers on the polymer head group provided overall higher enantioresolution for

254 ity and specificity with the -OH terminating head group providing a slightly better signal than the -

255 We find that amino acids involved in head group recognition and the hydrophobicity of flexibl

256 rotonation of which is required for PtdIns3P head group recognition as revealed by NMR.

257 e landscape, and we have proposed that lipid head group recognition might determine the timing of Aux

258 hese data show that lyso-PLs bearing various head groups redundantly mobilize G2A latent within secre

259 n which the metal centers embed in the lipid head group region and the central void, created by the b

260 The pyrophosphate group stays in the bilayer head group region.

261 ly trimethylated lysine residue in the lipid head-group region of the membrane.

262 nts modify the dipole potential of the lipid head-group region.

263 that neither a conformational change in the head group relative to the membrane surface nor the pres

264 phosphoethanolamine or phosphocholine polar head group, respectively, to the diacylglycerol backbone

265 cohol concentrations in the order parameter, head group rotational relaxation time, and alcohol/lipid

266 monolayers (SAMs) of alkanethiolates with Fc head groups (SC(11)Fc) in SAM-based tunneling junctions

267 SAMs) of alkanethiolates with ferrocene (Fc) head groups (SC(11)Fc), and SAMs of alkanethiolates lack

268 annel in the TCR, which shunted phospholipid head groups sideways along the CD1b-TCR interface, witho

269 critical role of subphase factors and lipid head-group specificity in the formation and stability of

270 Moreover, the receptor binding head group stabilizes the 4HB stalk as part of the gener

271 We observe that charges on the lipid head groups strongly determine the ability of actin to a

272 e, electrostatic interactions with the lipid head groups strongly slow down water dynamics, whereas p

273 e exhibited by phospholipids with protonated head groups, such as phosphatidylserine and phosphatidyl

274 carboxylic acid, (b) alcohol, and (c) methyl head group terminations.

275 on-associated Ags, phosphorylcholine (PC), a head group that becomes exposed during programmed cell d

276 associated with CD1b lacked the hydrophilic head group that is generally needed for antigen recognit

277 functionalized with alkyl chains containing head groups that mimic the IL cation.

278 length, saturation, and branching and carry head groups that vary in size and charge.

279 ximal beta-linked sugar of the trisaccharide head group to adopt the typical binding orientation of a

280 addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p.

281 a role in "conformational switching" of the head group to facilitate F-HN interaction and triggering

282 c field along the C-C bond that connects the head group to the hydrocarbon tail as the key microscopi

283 ng of differentially phosphorylated inositol head groups to specific protein domains.

284 r limited its interactions with phospholipid head-groups to facilitate pseudopilin membrane escape.

285 roup toward the water phase and the cationic head group toward the oil phase, thus also implying a qu

286 water play a key role in driving the anionic head group toward the water phase and the cationic head

287 le ligands built from classical dopaminergic head groups (type 3 and 4) typically elicit more balance

288 e indicates that the protein recognizes this head group via an aromatic box, a typical choline-bindin

289 removing highly abundant phosphatidylcholine head groups via phospholipase C treatment.

290 ng of the neutral loss of the phosphocholine head group was verified.

291 of our ligands, as ligands with a carvedilol head group were devoid of agonistic activity.

292 e acyl chains were well localized, the lipid head groups were not.

293 ion when positively charged and zwitterionic head groups were present on the lipids, possibly due to

294 s were ubiquitous membrane lipids with polar head groups, whereas stimulatory compounds were apolar o

295 4E10 used its CDRH1 loop to bind the lipid head groups, while its CDRH3 interacted with the hydroph

296 nd replacement of the tetrahydroisoquinoline head group with other D2R "privileged structures" genera

297 ons involves the combination of carbohydrate head groups with different scaffolds and linkers generat

298 AOT has sulfonate head groups with sodium counterions that form the interf

299 ences in the direct interaction of the lipid head groups with specific amino acid residues alone but

300 We find that orthosteric "head" groups with small 7-substituents were important to