ライフサイエンスコーパス: heal

1 s (e.g., cancer, heart attack, stroke, wound healing).

2 ntegration with sensing, and ability to self-heal.

3 mage by shallowing and widening wounds until healed.

4 n the animal studies indicate a proper wound healing.

5 at coalesce into clots which assist in wound healing.

6 n and phenotypic changes in cancer and wound healing.

7 be reactivated and play roles in adult wound healing.

8 cally and/or electronically facilitate wound healing.

9 microcurrent electrotherapy on palatal wound healing.

10 2(Cre+)) resulted in improved diabetic wound healing.

11 inflammation, cell proliferation, and wound healing.

12 ed, showing rapid vacancy migration and self-healing.

13 ro slows keratinocyte migration during wound healing.

14 for Zn alloys when considering bone fracture healing.

15 d IL-6 levels associated with improved wound healing.

16 injury and subsequently improving aged bone healing.

17 anscriptional landscape that influence wound healing.

18 rotein 1 (LRG1) in normal and diabetic wound healing.

19 ensure efficient, spatially restricted wound healing.

20 tissues results in delayed wound closure and healing.

21 lular creatine, barrier formation, and wound healing.

22 lerated the bone repair early from 7 days of healing.

23 ifferentiation and HO formation during wound healing.

24 raluminal polyamines that promote epithelial healing.

25 MaR1 potently accelerated extraction socket healing.

26 stabilize the injury site and promote wound healing.

27 omotes epithelial barrier function and wound healing.

28 critical for embryonic development and wound healing.

29 rovide a new therapeutic avenue for fracture healing.

30 trix (ECM) production, chemotaxis, and wound healing.

31 mosome ends are recapped by de novo telomere healing.

32 noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing.

33 cy of ARP as compared with unassisted socket healing.

34 that affected invasion, migration, and wound healing.

35 nocytes (Mo)/macrophages (MPhi) and impaired healing.

36 s crucial to embryonic development and wound healing.

37 beta (TGFbeta) play a critical role in wound healing.

38 thin the wound bed to overcome stalled wound healing.

39 on integrins, cellular migration, and wound healing.

40 the NPWT system in order to accelerate wound healing.

41 hanges in collagen organization during wound healing.

42 dicating a potential important role in wound healing.

43 tendon environment as the driver of scarless healing.

44 )-derived coatings to regulate scar-mediated healing.

45 ell dispersion, neuronal survival, and wound healing.

46 acteristics that might reproduce pASCs wound healing ability.

47 ither a provisional crown (test) or standard healing abutment (control) after immediate implant place

48 uncovered and connected to the corresponding healing abutments.

49 derivatives showed promising in vitro wound-healing activity.

50 Long-term bone healing/adaptation after a dental implant treatment star

51 The epithelium was fully healed after 6-8 days.

52 mg) twice daily for 45 days, and all lesions healed after this treatment.

53 the achievement of histo-endoscopic mucosal healing after induction therapy is associated with lower

54 d leukocytes in the diseased heart, improved healing after infarction and attenuated heart failure.

55 compare the healing outcome between natural healing after molar tooth extraction and two different t

56 We conclude that early healing after orthopaedic trauma must be allowed prior t

57 on the efficacy and safety of various wound healing agents to improve chronic diabetic wounds.

58 reting hMSC lines as short-term, local wound healing agents with superior therapeutic efficacy over w

59 Following 2 to 8 months of healing, all implants were uncovered and connected to th

60 ectric crystalline lattice that enables self-healing and a reprogrammable stiffness for dynamic tunin

61 th types of microglia significantly improved healing and axon regrowth.

62 voir of bioactive molecules to support wound healing and bone regeneration.

63 and keloid scars result from abnormal wound healing and can have a variable response to a number of

64 tained cell migration is essential for wound healing and cancer metastasis.

65 re of collagen type I is a hallmark of wound healing and cancer that is commonly attributed to myofib

66 We report on in vitro wound-healing and cell-growth studies under the influence of r

67 herapy protocol may accelerate palatal wound healing and decrease patient discomfort after FGG harves

68 ks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surge

69 nective tissue deposition, suggesting vessel healing and durable vessel occlusion.

70 ells, which are active participants in wound healing and fibrogenic processes.

71 ix protein that has important roles in wound healing and fibrosis.

72 so doing, to promote barrier function, wound healing and hair growth, while limiting cancer developme

73 ribosomal proteins, and initiation of wound healing and humoral immune responses.

74 lial homeostasis, tissue regeneration, wound healing and immune modulation.

75 le in organ development and repair, in wound healing and in numerous pathological processes such as c

76 been associated with decreased bone fracture healing and increased rates of nonunion in elderly patie

77 ent and impaired inflammation impedes tissue healing and is a characteristic of chronic wounds.

78 ned from the significant literature on wound healing and macrophage response to implanted biomaterial

79 Wound healing and Matrigel invasion assay, sphere formation as

80 Besides applications to wound healing and metastatic cancer, these studies are relevan

81 icantly reduce both corneal epithelial wound healing and nerve density in diabetic mice.

82 show that Hdac3 is required for optimal bone healing and osteoclast fusion, potentially via its regul

83 ng developmental stages, angiogenesis, wound healing and other processes.

84 nflammatory process and perhaps initiate the healing and regeneration process of the periodontium.

85 properties play an important role in tissue healing and regeneration, activation of TLR3 may help to

86 popularity in the field of periodontal wound healing and regeneration.

87 nderlying angiogenesis, fertilization, wound healing and regeneration.

88 in) plays an important role in cardiac wound healing and remodeling.

89 lts cancer progression as a result of tissue healing and remodelling of the blood vasculature, causin

90 in collaboration with the Collaborative for Healing and Renewal in Medicine (CHARM) network, the aut

91 ding in Hydra, suggesting that Hydra's wound-healing and self-organization capabilities may employ si

92 insights into the process of diabetic wound healing and suggest topical mast cell stabilization as a

93 he angiogenic process during cutaneous wound healing and the regulatory roles played by catecholamine

94 e resolution phase of inflammation, bridging healing and tissue regeneration.

95 sponses, activities that contribute to wound healing and tissue repair.

96 o pathway-focused RT-PCR gene arrays ("wound healing" and "neurogenesis") to evaluate tissue samples

97 The short- (bone healing) and long-term (bone remodeling) effects of init

98 fragility, wrinkles, laxity, impaired wound healing, and a microenvironment conducive to cancer.

99 oles in hemostasis, tumor development, wound healing, and atherogenesis.

100 sticity, stretchability, self-recovery, self-healing, and energy dissipation.

101 n the involvement of adipose tissue in wound healing, and may help to uncover and develop fat-related

102 f fibroblast heterogeneity during skin wound healing, and on open questions that must be addressed to

103 ears cutaneous bacterial infection, promotes healing, and protects against reinfection.

104 cular abnormalities, poor postinfection lung healing, and subsequent pulmonary failure.

105 nesis is one of such critical events in bone healing, and we previously reported the stimulatory effe

106 nflammatory, anticancer, antidiabetic, wound healing, anti-HIV, anti-anxiety and antidepressant, etc.

107 the challenges inherent to therapy-mediated healing are due to comorbidities of disease and aging th

108 Two mechanisms of self-healing are identified: viscoelastic shape memory (VESM)

109 /cell delivery, thrombus ablation, and wound healing are reviewed from these viewpoints.

110 ntroduced for analyzing a standardized wound healing assay by observing cell growth and quantifying c

111 The wound-healing assay demonstrated that, at concentrations of 0.

112 ents of cell proliferation, apoptosis, wound healing assay, as well as reverse-phase protein arrays,

113 Using an in vitro wound healing assay, cell migration was evaluated 2, 4, 6, and

114 Subsequent in vitro wound-healing assays also confirmed that M2 and M13 accelerate

115 aluated on sparse real-world data from wound healing assays with varying initial cell densities [2].

116 by intracellular calcium measurements, wound healing assays, and synthetic activation by gene array a

117 or inflammatory diseases and defective wound healing associated with aging and diabetes.

118 entage of study participants with epithelial healing at 3 days, 3 weeks, and 3 months, infiltrate or

119 are active processes that mediate epithelial healing at mucosal surfaces.

120 ts suggest that Gal-3 is essential for wound healing because it regulates the dynamics of macrophage

121 wound: proportion of newly formed bone (bone healing/BH), number of cells stained for tartrate-resist

122 and its up-regulation is required for wound healing but is also involved in fibrosis.

123 rmal processes such as development and wound healing, but can go awry, as in oncogenesis and fibrosis

124 ethods have shown promise in monitoring bone healing, but no quantitative method to assess regenerate

125 Large skin wounds in adult mice can heal by regenerating new hair follicles and adipocytes i

126 ibrotic effects are of promise for improving healing by balancing the primary defensive functions and

127 been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect

128 kpile of adenosine, resulting in accelerated healing by promoting both osteoblastogenesis and angioge

129 r surgery or traumatic injury, corneal wound healing can cause a scarring response that stiffens the

130 l plasticity underlying embryogenesis, wound healing, cancer metastasis and drug resistance.

131 hase with a high interfacial energy and self-healing capabilities, development of "anode-free" Li bat

132 Moreover, a decrease in wound healing capacity in hTERT-MCPyV gene-expressing HK was o

133 erapeutic capability to motivate canonically healing cells toward improved behavior; enhancing our ab

134 e and mouse models of angiogenesis and wound healing confirmed these predicted deficiencies and demon

135 After 2 weeks, the healed defects were evaluated using microcomputed tomogr

136 of treatments available to both prevent and heal digital ulcers, some of which are also used in Rayn

137 t roles of fibroblasts in ECM biology, wound healing, diseases, and aging.

138 Perpetual cycles of wounding and healing drive fibrosis in DDEB and RDEB, as well as the

139 phisticated repair machineries to detect and heal DSBs.

140 The ability of morphing electronics to self-heal during implantation surgery allows a reconfigurable

141 M13-NL) demonstrated excellent in vivo wound-healing effects, and these activities were better than t

142 The wound healing efficacy of the fabricated dressings was evaluat

143 ing motions in response to stimuli, and self-heal efficiently, capturing some of the essential featur

144 development of hydraulically amplified self-healing electrostatic (HASEL) actuators, a new class of

145 Striking similarities between wound healing, epimorphic regeneration and the progression of

146 During wound healing, expression of AP-1B (and ARH in AP-1B-positive

147 obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentia

148 Roth's Large (MRL/MpJ) mice exhibit improved healing following acute tendon injuries, but the driver

149 demonstrate functional improvements to bone healing following local beta-NGF injections which result

150 regates, and CDN-dictated stiffness and self-healing functions of hydrogels.

151 cludes innovative anomaly detection and self-healing functions that improve the efficiency of data pr

152 ificant upregulation of SERPINB1 and IL33 in healing gingiva.

153 that grafting seedlings and allowing time to heal graft wounds prior to spring transplanting or doubl

154 8 to 10 weeks) or long-term (18 to 20 weeks) healing group.

155 cells (ASCs) have potential to improve wound healing; however, their equivalents from domestic animal

156 udy is the first to report on the miRNome of healing human gingiva and to provide an integrative anal

157 s ranging from recyclable thermosets to self-healing hydrogels.

158 and lower tumour necrosis factor-alpha), pro-healing immune profiles (high insulin-like growth factor

159 I 91 to 98) of 151 patients, whereas lesions healed in 140 (96%, 91 to 99) of 146 patients in the RC8

160 In the RS8 group, lesions healed in 144 (95%, 95% CI 91 to 98) of 151 patients, wh

161 After surgery, NK was healed in all patients after a mean period of 3.9 months

162 reased, with nearly half of the breaks being healed in rqh1Delta rad55Delta or rqh1Delta exo1Delta ce

163 Here, we report that K dendrites can be healed in situ in a K-metal battery.

164 their regenerative potential, and improving healing in a complex tissue environment.

165 ment with miR-19b and miR-20a improved wound healing in a mouse model of type 2 diabetes.

166 ium cobalt oxide cathode to achieve dendrite healing in a practical full-cell device.

167 cts of MaR1 on tooth extraction socket wound healing in a preclinical rat model.

168 this work we report the acceleration of self-healing in alternating/random hydrophobic acrylic-based

169 ducing bacterial load and accelerating wound healing in an excisional wound model.

170 ibute to sustained inflammation and impaired healing in chronic wounds.

171 Mast cells have been shown to regulate wound healing in diabetes.

172 eceptors promotes angiogenesis and expedites healing in diabetic wounds.

173 that Hdac3 promotes M2 activation and tissue healing in inflammatory conditions.

174 ory function of WDR26 in FPR1-mediated wound healing in intestinal epithelial cells.

175 ich negatively regulates FPR1-mediated wound healing in intestinal epithelial cells.

176 and their combination significantly hastened healing in ischemic methicillin-resistant Staphylococcus

177 e, an osteoanabolic agent that improves bone healing in preclinical studies and in chronic periodonti

178 der Waals (vdW) forces which facilitate self-healing in relatively narrow copolymer compositional ran

179 Furthermore, the rapid and consistent wound healing in seedling grafts along with lateral shoot form

180 s that could be used to facilitate scar-free healing in the adult mammalian nervous system.

181 key contributor to intestinal mucosal wound healing in vivo.

182 d of neointimal coverage and completeness of healing, including endothelialization.

183 Outcome variables were early healing index (EHI) at 7, 14, and 30 days, self-reported

184 , CEACAM1, and VCAM1), called the endoscopic healing index [EHI], using samples from 278 patients wit

185 The NIH Helping to End Addiction Long-term (HEAL) Initiative is a trans-agency effort to provide sci

186 be considered recovered when the wounds have healed; instead, burn injury leads to long-term profound

187 or the remodeling phase during which regions healed into bone adapt their apparent density with respe

188 Wound healing is characterized by cell and extracellular matri

189 Delayed wound healing is commonly associated with diabetes.

190 However, the soft tissue healing is technically sensitive to the surgical procedu

191 The healing is triggered by current-controlled, self-heating

192 r, the influence on peri-implant soft tissue healing is unclear.

193 expression in three settings: in vitro wound healing, live lymph node sections and a live tumor micro

194 perties for covalent materials, such as self-healing materials, covalent adaptable networks (CANs) an

195 g from sensing to molecular release and self-healing materials.

196 The concept may be applicable to other self-healing mechanisms involving reversible covalent bonding

197 Since two autonomous self-healing mechanisms result from viscoelastic behavior not

198 tural photosystems exhibit a variety of self-healing mechanisms.

199 In an excisional wound healing model, i.p. MV administration accelerated wound

200 Using an endoscopic biopsy-based wound healing model, we report that RvE1 is locally produced i

201 ding area to the center in an in vitro wound healing model.

202 Improvement in mechanical properties of healing MRL/MpJ vs C57Bl/6 tendons that were isolated fr

203 and 2 diabetic full-thickness splinted wound healing murine model enhanced the microcirculatory blood

204 u beams show high robustness and have a self-healing nature.

205 healthy volunteers to study effects on wound healing (NCT04045405; NCT03603431).

206 The healing of broken chromosomes by de novo telomere additi

207 es bone morphogenic protein 2 (BMP2) driving healing of calvarial defects in 4 weeks by a mechanism m

208 Hdac3 within myeloid progenitors accelerates healing of cortical bone defects.

209 he management of angiogenesis to promote the healing of dermal wounds.

210 d human dental pulp stem cells (DPSC) on the healing of experimental periodontal defects in rats.

211 difference in the amount of shrinkage during healing of free soft tissue autografts (FSTAs) using dif

212 The healing of large bone defects has been investigated for

213 CN allowed the healing of NK in all patients as well as improvement of

214 on-skin electronics demonstrates accelerated healing of skin wounds.

215 errupt that process and encourage growth and healing of the "baby lung" of severe acute respiratory d

216 At 1 week, healing of the 15 sites was uneventful.

217 ing the 12-month follow-up period to promote healing of the fracture.

218 s of atherosclerotic complications favor the healing of wounded arteries, whereas the immobilization

219 ced replication (BIR) is a mechanism used to heal one-ended DNA double-strand breaks, such as those f

220 vely followed a group of patients who either healed or developed nonhealing chronic DFUs.

221 this mechanism in studies in vivo, in wound healing or angiogenesis, in which fibrin is contracted b

222 tissue shares features with mammalian wound healing or fibrosis.

223 nt, which we called histo-endoscopic mucosal healing (or histo-endoscopic mucosal improvement).

224 een achieved in creating biodegradable, self-healing, or breathable, on-skin electronics.

225 the multivariate parameters critical to self-healing organic fluorophore design.

226 hort study was to histologically compare the healing outcome between natural healing after molar toot

227 on-sutured sites display similar early wound healing outcomes and patient-reported outcomes.

228 y aimed to determine and compare soft tissue healing outcomes following implant placement in grafted

229 three from the nSG during the first week of healing (P >0.05).

230 icit anti-inflammatory responses and promote healing, pathways ending with cell membrane rupture may

231 ported outcomes were assessed during a 14-wk healing period.

232 l changes in SA and thickness over a 3-month healing period.

233 threads differentiated into bone during the healing phase but resorbed during remodeling.

234 ts of initial implant micromotion during the healing phase were studied.

235 of intraoperative evidence of spontaneously healed posterior scleral perforation in a severe ballist

236 of microglia in neonatal mice disrupts this healing process and stalls the regrowth of axons, sugges

237 emoattraction of cells critical to the wound healing process, eCRT induces abundant neo-dermal extrac

238 ry of small molecules to improve the post-MI healing process.

239 variety of immunological reactions and wound healing process.

240 r their potential to contribute to the wound healing process.

241 lling determine outcomes of inflammation and healing processes.

242 ing point for the development of novel wound-healing promoters.

243 an element used for adding strength and self-healing properties to load-bearing materials.

244 r compositions can significantly impact self-healing properties.

245 , 2.5, and 5 mM) significantly reduced wound healing rates, whereas nicotine at a concentration of 10

246 Reduced wound healing ratios and nerve densities were not fully rescue

247 for 8 and 20 weeks, respectively) had slower healing ratios than wild-type diabetic mice.

248 s, were found and were presumed to represent healed RCNs.

249 mmune system is inextricably linked to wound healing/remodeling in the ischemically injured heart, th

250 onclusion, we demonstrate that an endogenous healing response can be safely induced in tendon by mean

251 njuries, but the driver of this regenerative healing response remains unknown.

252 hus due to an acute inflammatory-based wound-healing response that rejuvenates the infarcted area of

253 at while most of the gland underwent a wound-healing response that resolved by day 14, a small region

254 ne marrow cells is required for normal wound healing, revealing a physiological role for this glycopr

255 e was an inverse association between mucosal healing risk of future small bowel adenocarcinoma (HR, 0

256 ally evaluate healing (using photographs and Healing Score Index) on Days 1, 5, 14, and 21.

257 oreover, the conservative measure of corneal healing showed statistical significance at week 4 (key s

258 eviously demonstrated that chick fetal wound healing shows a regenerative phenotype regarding the cel

259 itude, resulting in an increase of the wound-healing speed of up to 135 +/- 85% as compared to an int

260 At the healed stage, a filling of the corneal defect by a hypor

261 The tissue distribution in the healed state was then used as the initial condition for

262 randomized clinical pictures, then assessed healing status conventionally (<0.5 mm of fluorescein st

263 Pro-healing stent coatings may facilitate reendothelializati

264 The Montreal Protocol has begun to heal the Antarctic ozone hole and avoided more global wa

265 res to create stretchable interconnects that heal the damage mechanically and electrically.

266 iRNA/mRNA expression during human oral wound healing; the results offer novel insights into the parti

267 ity of SERPINB1 and IL-33 as potential wound healing therapeutic targets.

268 ndothelial cells, it accelerates endothelial healing through activation of nuclear ERalpha in smooth

269 NF-kappaB may contribute to fibrotic tendon healing through both inflammation-dependent and inflamma

270 icit of Gal-3 affected the dynamics of wound healing, thus aggravating the evolution of remodeling an

271 By survival curve analysis median healing time for cure was 102 for Sb v group and 60 days

272 d to increase the cure rate and decrease the healing time.

273 t often damages host cells and lengthens the healing time.

274 sulfate are reported and correlated with the healing time.

275 protein-based adhesives and fibers in wound healing, tissue regeneration, drug delivery, biosensors,

276 re fibroblastic cells that function in wound healing, tissue repair and fibrosis, and arise from bone

277 lds have great potential for improving wound healing treatments by providing controlled drug delivery

278 elp to uncover and develop fat-related wound healing treatments.

279 feration, colony formation, migration, wound healing, tumor growth, and lung metastasis.

280 fibers and films capable of autonomous self-healing under ambient conditions.

281 nt, increased bacterial killing and improved healing upon a secondary infection.

282 were left undisturbed to clinically evaluate healing (using photographs and Healing Score Index) on D

283 emphasis on perioperative infections, wound healing, vascular complications, cancer propagation, as

284 d fibrosis through the temporal evolution of healing, ventricular remodeling, and function after myoc

285 Wound-healing was also impaired in PSW compared to controls at

286 Clinical healing was documented.

287 were created using an Algerbrush, and wound healing was monitored over time.

288 the LCD1 patients, corneal epithelial wound healing was significantly delayed in TGFBI-R124C mice.

289 Soft tissue healing was uneventful in all patients.

290 associated with skin blood supply and wound healing were altered.

291 s in normal dermal wounds and thereby delays healing, whereas the stimulation of dopamine D1 receptor

292 is an essential step during cutaneous wound healing, which supports cells at the wound site with nut

293 provides a brief overview of cutaneous wound healing with discussion on how extracellular matrix prot

294 ion resembling the remodeling phase of wound healing, with increased matrix metalloproteinase express

295 vely removed without scarring, with complete healing within 2 weeks.

296 es were found for complicated perineal wound healing within 30 days (RR 1.30; 95% CI 0.92-1.82), chro

297 Approximately 10% of fractures will not heal without intervention.

298 n was compromised supporting the notion that healed wounds with a history of biofilm infection are li

299 hair follicles with arrector pili muscles in healed wounds.

300 stant Staphylococcus aureus infected delayed healing wounds in rats with DM2.